Active Recombinant Mouse Ccl5 Protein

• Cat.No.: Ccl5-133M
• Product Overview: Purified recombinant protein of Mouse chemokine (C-C motif) ligand 5 (Ccl5 / RANTES) (Ser24-Ala91) without tag was expressed in E.coli.

Specification

• Description: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.
• Source: E. coli
• Species: Mouse
• Bio-activity: Bioactivity was measured by its ability to chemoattract Baf3-hCCR5 cells in a dose dependent manner.
• Molecular Mass: 7.8 kDa
• Endotoxin: Less than 0.01 ng per µg protein as determined by the LAL method
• Purity: >90%, as determined by Coomassie stained SDS-PAGE.
• Stability: Unopened vial can be stored between 2 centigrade and 8 centigrade for up to 2 weeks, at -20 centigrade for up to 6 months, or at -70 centigrade or below until the expiration date. Aliquots can be stored between 2 centigrade and 8 centigrade for up to one week and stored at -20 centigrade or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: Protein formulated and vialed at >50 ug/mL in specified buffer
• Storage Buffer: 0.1 M Glycine, pH3.0

Gene Information

• Gene Name: Ccl5 chemokine (C-C motif) ligand 5 [ Mus musculus (house mouse) ]
• Official Symbol: Ccl5
• Synonyms: Ccl5 chemokine (C-C motif) ligand 5; SISd; Scya5; RANTES; TCP228; MuRantes; C-C motif chemokine 5; SIS-delta; T-cell-specific protein RANTES; small-inducible cytokine A5
• Gene ID: 20304
• mRNA Refseq: NM_013653
• Protein Refseq: NP_038681
• UniProt ID: P30882

Reviews

08/17/2021

This specificity enables precise quantification and characterization of CCL5 and its interactions with other molecules or proteins of interest.

06/23/2019

Its exceptional performance, coupled with its ability to generate clear and precise protein bands, make it an indispensable tool in achieving accurate and reliable results.

06/20/2016

The CCL5 protein exhibits a high degree of specificity in various assays, ensuring accurate and reliable results.

Q&As

What are the potential clinical applications of CCL5 inhibitors?

CCL5 inhibitors may be used to control inflammation in diseases like rheumatoid arthritis or as an adjuvant in cancer therapy.

Can CCL5 be used to stimulate the immune system in cancer treatment?

CCL5-based immunotherapies are being explored to enhance the immune response against cancer cells.

Can CCL5 be used as a diagnostic marker for diseases?

It can serve as a biomarker for some diseases, but it is usually used in conjunction with other markers for more accurate diagnostics.

What are the clinical implications of elevated CCL5 levels?

Elevated CCL5 levels are associated with inflammation and may be indicative of certain diseases such as rheumatoid arthritis or HIV infection.

Are there any CCL5-targeted therapies in development?

Yes, there are ongoing efforts to develop therapies that modulate CCL5 activity, particularly in diseases involving inflammation.