• Official Full Name

    chemokine (C-C motif) ligand 5

  • Background

    This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
  • Synonyms

    CCL5; chemokine (C-C motif) ligand 5; SISd; eoCP; SCYA5; RANTES; TCP228; D17S136E; SIS-delta; C-C motif chemokine 5; beta-chemokine RANTES; T-cell specific protein p288; eosinophil chemotactic cytokine; small inducible cytokine subfamily A (Cys-Cys), member 5; regulated upon activation, normally T-expressed, and presumably secreted;
    • Type:
    • Recombinant Proteins
    • GMP Proteins
    • Cell & Tissue Lysates
    • Transfected Stable Cell Lines
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Bovine
    • Cattle
    • Chicken
    • Cotton Rat
    • Cynomolgus Monkey
    • Dog
    • Guinea pig
    • Horse
    • Human
    • Mouse
    • Mouse/Rat
    • Pig
    • Rabbit
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Rhesus monkey
    • Swine
    • Source :
    • CHO
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Human Cells
    • Mammalian Cell
    • Mammalian cells
    • Mouse
    • Wheat Germ
    • Yeast
    • Tag :
    • Biotin
    • C
    • Fc
    • His
    • GST
    • mucin
    • His (Fc)
    • Avi
    • His|GST
    • His|S
    • His|T7
    • Myc
    • DDK
    • Myc|DDK
    • N/A
    • N
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Bovine CCL5-132B Recombinant Bovine Chemokine (C-C motif) Ligand 5 Yeast N/A
    Cattle CCL5-1206C Recombinant Cattle CCL5 Protein, His-tagged E.coli N-His
    Chicken CCL5-3492C Recombinant Chicken CCL5 Mammalian Cell His
    Cotton Rat Ccl5-385C Active Recombinant Cotton Rat Ccl5 E.coli N/A
    Cynomolgus Monkey CCL5-4397C Recombinant Cynomolgus Monkey CCL5 Protein Yeast N/A
    Dog CCL5-770D Recombinant Dog CCL5 protein, His & S-tagged E.coli His/S
    Guinea pig Ccl5-772G Recombinant Guinea pig Ccl5 protein, His & GST-tagged E.coli His/GST
    Horse CCL5-771H Recombinant Horse CCL5 protein, His & T7-tagged E.coli His/T7
    Human CCL5-024H Recombinant Human CCL5 Protein
    Human CCL5-512H Active Recombinant Mouse Chemokine (C-C motif) Ligand 5, HIgG1 Fc-tagged CHO Fc
    Human CCL5-513HG GMP Recombinant Human CCL5 protein, Fc-tagged HEK293 Fc
    Human CCL5-773H Recombinant Human CCL5 protein, His & T7-tagged E.coli His/T7
    Human CCL5-1081H Recombinant Human CCL5 Protein (Ser24-Ser91), C-Fc and His tagged Mammalian cells C-Fc and His
    Human CCL5-302H Recombinant Human CCL5 protein, His-tagged E.coli His
    Human CCL5-352H Recombinant Human CCL5 Protein, His & mucin-tagged HEK293 His & mucin
    Human CCL5-0642H Recombinant Human CCL5 Protein, GST-Tagged Wheat Germ GST
    Human CCL5-1118H Recombinant Human CCL5 Protein (Ser24-Ser91), GST tagged E.coli GST
    Human CCL5-27H Recombinant Human CCL5 Protein E.coli
    Human CCL5-2706HCL Recombinant Human CCL5 cell lysate Human Cell N/A
    Human CCL5-85H Recombinant Human CCL5, His tagged Human Cell His
    Human CCL5-301H Recombinant Human CCL5 protein E.coli N/A
    Human CCL5-032H Recombinant Human CCL5 Protein, Biotinylated
    Human CCL5-61H Recombinant Human chemokine (C-C motif) ligand 5, His-tagged E.coli His
    Human CCL5-125H Recombinant Human Chemokine (C-C Motif) Ligand 5 Mammalian cells N/A
    Human CCL5-81H Active Recombinant Human CCL5 protein HEK293 N/A
    Human CCL5-510H Active Recombinant Mouse Chemokine (C-C motif) Ligand 5, MIgG2a Fc-tagged CHO Fc
    Human CCL5-511H Active Recombinant Mouse Chemokine (C-C motif) Ligand 5, HIgG1 Fc-tagged, mutant CHO Fc
    Human CCL5-114H Active Human CCL5 N/A
    Human CCL5-2625H Recombinant Human CCL5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CCL5-120H Human Rantes (rDNA derived) Reference standard N/A
    Human CCL5-43H Recombinant Human CCL5 Protein E.coli
    Human CCL5-82H Recombinant Human CCL5 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CCL5-57H Recombinant Human CCL5 Protein, Biotin-tagged E.coli Biotin
    Human CCL5-151H Recombinant Human CCL5 Protein, His-tagged Human Cells His
    Human CCL5-165C Recombinant Human CCL5 Protein (68 aa) HEK293
    Human CCL5-059C Recombinant Human CCL5 Protein (68 aa) E.coli
    Human CCL5-521H Recombinant Human CCL5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human CCL5-521H-B Recombinant Human CCL5 Protein Pre-coupled Magnetic Beads HEK293
    Human CCL5-1464H Recombinant Human CCL5 Protein (Ser24-Ser91), N-GST tagged E.coli N-GST
    Mouse Ccl5-259M Active Recombinant Mouse Chemokine (C-C motif) Ligand 5 Mouse N/A
    Mouse CCL5-1397M Recombinant Mouse CCL5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse CCL5-1397M-B Recombinant Mouse CCL5 Protein Pre-coupled Magnetic Beads HEK293
    Mouse Ccl5-616M Recombinant Mouse Ccl5 protein E.coli N/A
    Mouse Ccl5-774M Recombinant Mouse Ccl5 protein, His & GST-tagged E.coli His/GST
    Mouse Ccl5-2040M Recombinant Mouse Ccl5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Ccl5-133M Recombinant Mouse Ccl5 Protein E.coli
    Mouse CCL5-2977M Recombinant Mouse CCL5 Protein Mammalian Cell His
    Mouse Ccl5-2039M Recombinant Mouse Ccl5 Protein E. coli
    Mouse/Rat Ccl5-28M Recombinant Mouse/Rat CCL5 Protein E.coli
    Mouse/Rat Ccl5-29M Recombinant Mouse/Rat CCL5 Protein E.coli
    Mouse/Rat Ccl5-30M Recombinant Mouse/Rat CCL5 Protein E.coli
    Pig CCL5-147S Recombinant Swine Chemokine (C-C motif) Ligand 5 Yeast N/A
    Pig CCL5-775P Recombinant Pig CCL5 protein, His & T7-tagged E.coli His/T7
    Pig CCL5-22S Recombinant Swine CCL5 Yeast N/A
    Rabbit CCL5-4353R Recombinant Rabbit CCL5 Protein Yeast N/A
    Rat Ccl5-104R Recombinant Rat Chemokine (C-C Motif) Ligand 5 E.coli N/A
    Rat CCL5-312R Recombinant Rat CCL5 protein, His-tagged Yeast His
    Rhesus CCL5-3411R Recombinant Rhesus CCL5 protein E.coli N/A
    Rhesus Macaque CCL5-693R Recombinant Rhesus monkey CCL5 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque CCL5-521R Recombinant Rhesus Macaque CCL5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus Macaque CCL5-521R-B Recombinant Rhesus Macaque CCL5 Protein Pre-coupled Magnetic Beads HEK293
    Rhesus monkey CCL5-776R Recombinant Rhesus monkey CCL5 protein, His-tagged E.coli His
    Swine CCL5-4354S Recombinant Swine CCL5 Protein Yeast N/A
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • CCL5 Related Articles
    • CCL5 Related Gene Family
    • CCL5 Related Research Area

    CCL5 involved in several pathways and played different roles in them. We selected most pathways CCL5 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interactionPF4;TNFSF12;IL1R1;IL12A;NT5C3;IL15;EDA;CXCR6;GM10591
    Chemokine signaling pathwayGRK4;PIK3CB;CCL18;DOCK2;NFKBIA;CCL15;RAF1;Cxcl15;CCL4L1
    Toll-like receptor signaling pathwayTLR5;IRF3;CD86;IFNPHI1;CCL3L1;TLR2;IFNA13;STAT1A;MAPK12A
    NOD-like receptor signaling pathwayIL8L2;HSP90B1;NFKB1;MAPK10;CXCL1;MAPK1;TAB2;NLRP3;IL-8
    Cytosolic DNA-sensing pathwayADAR;POLR3G;POLR2E;IFNA3;POLR3B;Ifna11;POLR3F;POLR3K;NFKBIAA
    TNF signaling pathwayCXCL3;BAG4;IKBKB;TRAF3;PIK3CD;IL18R1;TRAF2;MMP14;MAPK8
    Prion diseasesMAPK1;C6;C5;C8B;ELK1;NCAM1;NCAM2;FYN;MAP2K1
    Epithelial cell signaling in Helicobacter pylori infectionATP6V0A1;MAPK12;IL-8;ATP6V0A2;GIT1;ATP6V1F;CDC42;ATP6V1E1;ATP6V1B1
    Chagas disease (American trypanosomiasis)PLCB3;PIK3CG;PPP2R1A;LOC100033925;IL12A;BDKRB2;TGFB3;MAPK13;TGFB1
    Herpes simplex infectionCYCSB;TTC6;ARNTL1B;IFNA21;HMGN1;HCFC1;MAPK10;TLR2;NFKBIAA
    Rheumatoid arthritisATP6V1E2;Ctsl;LTB;HLA-DOB;ATP6V0A2;IL18;CXCL12;TNFSF13B;VEGFA

    CCL5 has several biochemical functions, for example, CCR1 chemokine receptor binding, CCR4 chemokine receptor binding, CCR5 chemokine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL5 itself. We selected most functions CCL5 had, and list some proteins which have the same functions with CCL5. You can find most of the proteins on our site.

    Function Related Protein
    CCR1 chemokine receptor bindingCREB3;CCL7;CCL4;CCL5;CCL23;CCL3
    CCR4 chemokine receptor binding
    CCR5 chemokine receptor bindingCCL5;CCL3;STAT3;CNIH4;JAK1;CCL4
    chemoattractant activityBMP4;VEGFB;FIGF;SAA3;VEGFA;CCL15;PDGFB;CCL16;LGALS3
    chemokine activityCCL16;CCL39.1;CXCL11.8;XCL2;CCL24;CCL33.3;CXCL11;XCL1;CCL6
    chemokine receptor antagonist activity
    chemokine receptor bindingCCL19;CCL21B;CXCL12;Ccl21c;CCL25;XCL1;Ccl21a;CCL5;CCRL2
    phosphatidylinositol phospholipase C activityPLCD3A;PLCB2;PLCH2;PLCB1;PLCD3;PLCD1B;EDNRA;PLCG2;PLCD4
    phospholipase activator activityCCL5;CCL8;APOC2;CCL3;GM2A;ARHGAP6;PDPK1
    protein bindingSYVN1;TMEM190;NR4A3;CXCL2;TNNI3K;SLC19A2;PHC3;NFIL3;HSP90B1
    protein homodimerization activityHINT2;TCF3A;ATPIF1B;NR4A2;EFR3A;Anks6;SLC16A1;GJC3;PDGFB
    protein kinase activityTNNI3K;PLK5;SYK;SLKA;PRKDC;FASTKD1;MAP3K12;CSNK1DB;STK38A
    protein self-associationMDH2;ABCD3;AGTR1B;SLC9A3R1;TRP53;VAMP2;ADAM8;SHANK3;NKX3-1
    receptor signaling protein tyrosine kinase activator activity

    CCL5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL5.


    Yin, Q; Fan, Q; et al. Spinal NF-kappa B and Chemokine Ligand 5 Expression during Spinal Glial Cell Activation in a Neuropathic Pain Model. PLOS ONE 10:-(2015).
    Ricciardi, A; Dalton, JP; et al. Evaluation of the immune response and protective efficacy of Schistosoma mansoni Cathepsin B in mice using CpG dinucleotides as adjuvant. VACCINE 33:346-353(2015).
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