CCL5

  • Official Full Name

    chemokine (C-C motif) ligand 5

  • Overview

    This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
  • Synonyms

    CCL5; chemokine (C-C motif) ligand 5; SISd; eoCP; SCYA5; RANTES; TCP228; D17S136E; SIS-delta; C-C motif chemokine 5; beta-chemokine RANTES; T-cell specific protein p288; eosinophil chemotactic cytokine; small inducible cytokine subfamily A (Cys-Cys), member 5; regulated upon activation, normally T-expressed, and presumably secreted;

  • Recombinant Proteins
  • GMP Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Canine
  • Cattle
  • Chicken
  • Cotton Rat
  • Cynomolgus Monkey
  • Dog
  • Feline
  • Guinea pig
  • Horse
  • Human
  • Mouse
  • Mouse/Rat
  • Pig
  • Rabbit
  • Rat
  • Rhesus
  • Rhesus Macaque
  • Rhesus monkey
  • Swine
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Human Cells
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • Mouse
  • Wheat Germ
  • Yeast
  • Biotin
  • C
  • Fc
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • mucin
  • His|GST
  • His|S
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CCL5-81H Active Recombinant Human CCL5 protein HEK293 N/A 68 amino acids
Human CCL5-512H Active Recombinant Mouse Chemokine (C-C motif) Ligand 5, HIgG1 Fc-tagged CHO Fc
Human CCL5-511H Active Recombinant Mouse Chemokine (C-C motif) Ligand 5, HIgG1 Fc-tagged, mutant CHO Fc
Human CCL5-114H Active Human CCL5 N/A
Human CCL5-510H Active Recombinant Mouse Chemokine (C-C motif) Ligand 5, MIgG2a Fc-tagged CHO Fc
Human CCL5-513HG Active GMP Recombinant Human CCL5 protein, Fc-tagged HEK293 Fc DNA sequence encoding Human CCL 5(NP_002976.2) was expressed with Fc tag at the C-terminal.
Human CCL5-82H Recombinant Human CCL5 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CCL5-301H Recombinant Human CCL5 protein E.coli N/A 68
Human CCL5-85H Recombinant Human CCL5, His tagged Human Cell His
Human CCL5-61H Recombinant Human chemokine (C-C motif) ligand 5, His-tagged E.coli His
Human CCL5-125H Recombinant Human Chemokine (C-C Motif) Ligand 5 Mammalian cells N/A
Human CCL5-773H Recombinant Human CCL5 protein, His & T7-tagged E.coli His/T7 Ser24~Ser91 (Accession # P13501)
Human CCL5-0642H Recombinant Human CCL5 Protein, GST-Tagged Wheat Germ GST
Human CCL5-2706HCL Recombinant Human CCL5 cell lysate Human Cell N/A
Human CCL5-302H Recombinant Human CCL5 protein, His-tagged E.coli His 24-91aa
Human CCL5-024H Recombinant Human CCL5 Protein 91
Human CCL5-151H Recombinant Human CCL5 Protein, His-tagged Human Cells His
Human CCL5-352H Recombinant Human CCL5 protein, His&mucin-tagged HEK293 His&mucin Met1-Ser91 & Phe103-Gln341
Human CCL5-3993HFL Recombinant Full Length Human CCL5 protein, Flag-tagged Mamanlian cells Flag
Human CCL5-1081H Recombinant Human CCL5 Protein (Ser24-Ser91), C-Fc and His tagged Mammalian cells C-Fc and His Ser24-Ser91
Human CCL5-059C Active Recombinant Human CCL5 Protein (68 aa) E.coli 68
Human CCL5-1464H Recombinant Human CCL5 Protein (Ser24-Ser91), N-GST tagged E.coli N-GST Ser24-Ser91
Human CCL5-27H Active Recombinant Human CCL5 Protein E.coli
Human CCL5-211H Recombinant Human CCL5 Protein, Mature chain, Tag Free, Biotinylated E.coli Tag Free Mature chain
Human CCL5-120H Human Rantes (rDNA derived) Reference standard N/A
Human CCL5-43H Recombinant Human CCL5 Protein E.coli 67 amino acid
Human CCL5-1068HFL Active Recombinant Full Length Human CCL5 Protein, C-Flag-tagged Mammalian cells Flag
Human CCL5-2625H Recombinant Human CCL5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CCL5-032H Recombinant Human CCL5 Protein, Biotinylated 91
Human CCL5-165C Active Recombinant Human CCL5 Protein (68 aa) HEK293 68
Human CCL5-57H Recombinant Human CCL5 Protein, Biotin-tagged E.coli Biotin
Human CCL5-521H Recombinant Human CCL5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CCL5-2954HF Recombinant Full Length Human CCL5 Protein, GST-tagged In Vitro Cell Free System GST 91 amino acids
Human CCL5-521H-B Recombinant Human CCL5 Protein Pre-coupled Magnetic Beads HEK293
Mouse Ccl5-259M Active Recombinant Mouse Chemokine (C-C motif) Ligand 5 Mouse N/A
Mouse Ccl5-616M Recombinant Mouse Ccl5 protein E.coli N/A 68
Mouse CCL5-2977M Recombinant Mouse CCL5 Protein Mammalian Cell His
Mouse Ccl5-774M Recombinant Mouse Ccl5 protein, His & GST-tagged E.coli His/GST Ser24~Ser91 (Accession # P30882)
Mouse CCL5-1397M Recombinant Mouse CCL5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CCL5-1397M-B Recombinant Mouse CCL5 Protein Pre-coupled Magnetic Beads HEK293
Mouse Ccl5-133M Active Recombinant Mouse Ccl5 Protein E.coli
Mouse Ccl5-2040M Recombinant Mouse Ccl5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Ccl5-2039M Active Recombinant Mouse Ccl5 Protein E.coli
Rat Ccl5-104R Recombinant Rat Chemokine (C-C Motif) Ligand 5 E.coli N/A
Rat CCL5-312R Recombinant Rat CCL5 protein, His-tagged Yeast His Ser25-Ser92
Rhesus monkey CCL5-776R Recombinant Rhesus monkey CCL5 protein, His-tagged E.coli His Ser24~Ser91 (Accession # Q8HYQ1)
Rabbit CCL5-4353R Recombinant Rabbit CCL5 Protein Yeast N/A 68aa
Dog CCL5-770D Recombinant Dog CCL5 protein, His & S-tagged E.coli His/S Ser24~Ser91 (Accession # Q8HYS0)
Bovine CCL5-132B Recombinant Bovine Chemokine (C-C motif) Ligand 5 Yeast N/A
Canine CCL5-424C Recombinant Canine CCL5 Protein E.coli Ser24-Ser91
Cattle CCL5-1206C Recombinant Cattle CCL5 Protein, His-tagged E.coli N-His Ser24-Ser91
Cotton Rat Ccl5-385C Active Recombinant Cotton Rat Ccl5 E.coli N/A
Cynomolgus Monkey CCL5-4397C Recombinant Cynomolgus Monkey CCL5 Protein Yeast N/A 68aa
Feline CCL5-427F Recombinant Feline CCL5 Protein E.coli Tyr26-Asn92 (Lys84Tyr and Gly85 del)
Guinea pig Ccl5-772G Recombinant Guinea pig Ccl5 protein, His & GST-tagged E.coli His/GST Ser24~Ser91 (Accession # P97272)
Horse CCL5-771H Recombinant Horse CCL5 protein, His & T7-tagged E.coli His/T7 Ser24~Ser91 (Accession# Q8MKD0)
Mouse/Rat Ccl5-28M Active Recombinant Mouse/Rat CCL5 Protein E.coli
Mouse/Rat Ccl5-29M Active Recombinant Mouse/Rat CCL5 Protein E.coli
Mouse/Rat Ccl5-30M Active Recombinant Mouse/Rat CCL5 Protein E.coli
Rhesus CCL5-3411R Recombinant Rhesus CCL5 protein E.coli N/A 68
Rhesus Macaque CCL5-693R Recombinant Rhesus monkey CCL5 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CCL5-521R Recombinant Rhesus Macaque CCL5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CCL5-521R-B Recombinant Rhesus Macaque CCL5 Protein Pre-coupled Magnetic Beads HEK293
Swine CCL5-4354S Recombinant Swine CCL5 Protein Yeast N/A 172aa
Pig CCL5-147S Recombinant Swine Chemokine (C-C motif) Ligand 5 Yeast N/A
Pig CCL5-775P Recombinant Pig CCL5 protein, His & T7-tagged E.coli His/T7 Ser24~Ser91 (Accession # Q2EN89)
Pig CCL5-22S Recombinant Swine CCL5 Yeast N/A
Chicken CCL5-3492C Recombinant Chicken CCL5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CCL5 involved in several pathways and played different roles in them. We selected most pathways CCL5 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionCCR9;Il23a; Il12b;FLT3LG;IL-15RA;IL7R;TNFRSF11A;CXCL9;CXCL10;PF4
Chemokine signaling pathwayLOC100033925;CXCR5;GSK3A;PIK3R1;GNG13;CCR1;GM2506;KRAS;ARRB2
Toll-like receptor signaling pathwayIFNAR2;CXCL11;IFNAR1;FOS;MAP2K3;RIPK1;IFNPHI3;CD40;IL12B
NOD-like receptor signaling pathwayNAIP6;NLRC4;TNFAIP3;IL6;TAB2;CARD18;MAPK3;CXCL2;BIRC3
Cytosolic DNA-sensing pathwayCASPA;IFNA17;POLR2EB;IFNPHI3;POLR3C;RIPK1;RELA;IL33;CCL5
TNF signaling pathwayFAS;PGAM5;MAP2K3;CREB5;CXCL10;SELE;AKT1;PIK3CD;CFLAR
Prion diseasesFYN;SOD1;CCL5;C1QA;Hc;IL6;MAP2K1;ELK1;C8A
Epithelial cell signaling in Helicobacter pylori infectionATP6AP1;GIT1;ATP6V1E2;IL-8;TJP1;ATP6V0D1;ATP6V1G1;ATP6V0A2;LYN
Chagas disease (American trypanosomiasis)PPP2R2B;FADD;FAS;PIK3R2;IL10;PLCB2;PLCB1;AKT2;CD3G
Influenza APIK3CD;TNFRSF1A;RSAD2;MAP2K4;TNF;TNFRSF10D;FAS;IVNS1ABP;HLA-DQA2
Herpes simplex infectionALYREF;IFNAR1;CDC34A;PILRA;TAF10;HLA-DPA1;IFNA13;TNFRSF14;EIF2S1B
Rheumatoid arthritisATP6V1B2;CD28;CCL2;MMP1;IL6;IL18;GM-CSF;ACP5;MMP3

CCL5 has several biochemical functions, for example, CCR1 chemokine receptor binding, CCR4 chemokine receptor binding, CCR5 chemokine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL5 itself. We selected most functions CCL5 had, and list some proteins which have the same functions with CCL5. You can find most of the proteins on our site.

Function Related Protein
CCR1 chemokine receptor bindingCREB3;CCL3;CCL7;CCL5;CCL4;CCL23
CCR4 chemokine receptor binding
CCR5 chemokine receptor bindingSTAT3;CNIH4;CCL3;CCL5;JAK1;CCL4
chemoattractant activityNTF3;CXCL12A;VEGFC;FGF10;CCL5;SAA1;FIGF;LGALS3;BMP4
chemokine activityCcl21c;CCL39.1;CXCL10;CCL33.3;Ccl21a;CXCL12A;CCL34B.1;CCL34B.9;CCL13
chemokine receptor antagonist activity
chemokine receptor bindingCCL25;S100A14;CCL19;CCL5;CCL21;Ccl21c;CCL21B;XCL1;Ccl21a
heparin bindingSLIT1A;ELANE;MMP7;APLP2;RSPO2;NRP2;VTN;KNG1;ZNF207
phosphatidylinositol phospholipase C activityCCKBR;CASR;BDKRB2;PLCG1;PLCD1A;CCR5;PLCB4;PLCH2;PLCH1
phospholipase activator activityCCL8;APOC2;PDPK1;CCL5;GM2A;CCL3;ARHGAP6
protein bindingMLLT6;SSRP1;TSSK3;IGBP1;PTPN14;ZNF524;MSRB3;ADORA2A;CCP110
protein homodimerization activityIKZF3;BMP4;SYT14;NR0B1;HHEX;BNIP3L;RAG1;FLNA;DAPK3
protein kinase activityMAPK12A;EPHA4B;CDK1;PDK3;PRKACBB;NPR2;CSNK2A2A;EPHB2B;ANKK1
protein self-associationMALT1;CTSC;CCDC88C;NKX3-1;AXIN1;SYP;AGA;ZNF496;AGXT
receptor signaling protein tyrosine kinase activator activity

CCL5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL5.

DPP4; CCR5; BCAR3; BAG4; CHEK2; KRAS; TGFB1; CDH1; PTPN1; WT1; SLC2A5; APC; PHB; RANGAP1; RELA; TRIP6

Gene Family

GPCRs Chemokines Cytokines

Research Area

Related articles

Yin, Q; Fan, Q; et al. Spinal NF-kappa B and Chemokine Ligand 5 Expression during Spinal Glial Cell Activation in a Neuropathic Pain Model. PLOS ONE 10:-(2015).
Ricciardi, A; Dalton, JP; et al. Evaluation of the immune response and protective efficacy of Schistosoma mansoni Cathepsin B in mice using CpG dinucleotides as adjuvant. VACCINE 33:346-353(2015).
  • Reviews
  • Q&As

Customer Reviews (3)

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Reviews
08/17/2021

    This specificity enables precise quantification and characterization of CCL5 and its interactions with other molecules or proteins of interest.

    06/23/2019

      Its exceptional performance, coupled with its ability to generate clear and precise protein bands, make it an indispensable tool in achieving accurate and reliable results.

      06/20/2016

        The CCL5 protein exhibits a high degree of specificity in various assays, ensuring accurate and reliable results.

        Q&As (5)

        Ask a question
        What are the potential clinical applications of CCL5 inhibitors? 10/24/2021

        CCL5 inhibitors may be used to control inflammation in diseases like rheumatoid arthritis or as an adjuvant in cancer therapy.

        Can CCL5 be used to stimulate the immune system in cancer treatment? 10/24/2020

        CCL5-based immunotherapies are being explored to enhance the immune response against cancer cells.

        Can CCL5 be used as a diagnostic marker for diseases? 08/14/2019

        It can serve as a biomarker for some diseases, but it is usually used in conjunction with other markers for more accurate diagnostics.

        What are the clinical implications of elevated CCL5 levels? 02/20/2019

        Elevated CCL5 levels are associated with inflammation and may be indicative of certain diseases such as rheumatoid arthritis or HIV infection.

        Are there any CCL5-targeted therapies in development? 05/18/2018

        Yes, there are ongoing efforts to develop therapies that modulate CCL5 activity, particularly in diseases involving inflammation.

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