CCL5
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Official Full Name
chemokine (C-C motif) ligand 5
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Background
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013] -
Synonyms
CCL5; chemokine (C-C motif) ligand 5; SISd; eoCP; SCYA5; RANTES; TCP228; D17S136E; SIS-delta; C-C motif chemokine 5; beta-chemokine RANTES; T-cell specific protein p288; eosinophil chemotactic cytokine; small inducible cytokine subfamily A (Cys-Cys), member 5; regulated upon activation, normally T-expressed, and presumably secreted;
- Involved Pathway
- Protein Function
- Interacting Protein
- CCL5 Related Articles
- CCL5 Related Gene Family
- CCL5 Related Research Area
CCL5 involved in several pathways and played different roles in them. We selected most pathways CCL5 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | PF4;TNFSF12;IL1R1;IL12A;NT5C3;IL15;EDA;CXCR6;GM10591 |
| Chemokine signaling pathway | GRK4;PIK3CB;CCL18;DOCK2;NFKBIA;CCL15;RAF1;Cxcl15;CCL4L1 |
| Toll-like receptor signaling pathway | TLR5;IRF3;CD86;IFNPHI1;CCL3L1;TLR2;IFNA13;STAT1A;MAPK12A |
| NOD-like receptor signaling pathway | IL8L2;HSP90B1;NFKB1;MAPK10;CXCL1;MAPK1;TAB2;NLRP3;IL-8 |
| Cytosolic DNA-sensing pathway | ADAR;POLR3G;POLR2E;IFNA3;POLR3B;Ifna11;POLR3F;POLR3K;NFKBIAA |
| TNF signaling pathway | CXCL3;BAG4;IKBKB;TRAF3;PIK3CD;IL18R1;TRAF2;MMP14;MAPK8 |
| Prion diseases | MAPK1;C6;C5;C8B;ELK1;NCAM1;NCAM2;FYN;MAP2K1 |
| Epithelial cell signaling in Helicobacter pylori infection | ATP6V0A1;MAPK12;IL-8;ATP6V0A2;GIT1;ATP6V1F;CDC42;ATP6V1E1;ATP6V1B1 |
| Chagas disease (American trypanosomiasis) | PLCB3;PIK3CG;PPP2R1A;LOC100033925;IL12A;BDKRB2;TGFB3;MAPK13;TGFB1 |
| Influenza A | MX1;VDAC1;DNAJC3;IL6;HSPA1A;TNFRSF10D;MAPK1;CASP1;KPNA2 |
| Herpes simplex infection | CYCSB;TTC6;ARNTL1B;IFNA21;HMGN1;HCFC1;MAPK10;TLR2;NFKBIAA |
| Rheumatoid arthritis | ATP6V1E2;Ctsl;LTB;HLA-DOB;ATP6V0A2;IL18;CXCL12;TNFSF13B;VEGFA |
CCL5 has several biochemical functions, for example, CCR1 chemokine receptor binding, CCR4 chemokine receptor binding, CCR5 chemokine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL5 itself. We selected most functions CCL5 had, and list some proteins which have the same functions with CCL5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| CCR1 chemokine receptor binding | CREB3;CCL7;CCL4;CCL5;CCL23;CCL3 |
| CCR4 chemokine receptor binding | |
| CCR5 chemokine receptor binding | CCL5;CCL3;STAT3;CNIH4;JAK1;CCL4 |
| chemoattractant activity | BMP4;VEGFB;FIGF;SAA3;VEGFA;CCL15;PDGFB;CCL16;LGALS3 |
| chemokine activity | CCL16;CCL39.1;CXCL11.8;XCL2;CCL24;CCL33.3;CXCL11;XCL1;CCL6 |
| chemokine receptor antagonist activity | |
| chemokine receptor binding | CCL19;CCL21B;CXCL12;Ccl21c;CCL25;XCL1;Ccl21a;CCL5;CCRL2 |
| heparin binding | FGF4;LIPH;FMOD;LRPAP1;SMOC2;PTCH1;PTPRF;APOH;PLA2G5 |
| phosphatidylinositol phospholipase C activity | PLCD3A;PLCB2;PLCH2;PLCB1;PLCD3;PLCD1B;EDNRA;PLCG2;PLCD4 |
| phospholipase activator activity | CCL5;CCL8;APOC2;CCL3;GM2A;ARHGAP6;PDPK1 |
| protein binding | SYVN1;TMEM190;NR4A3;CXCL2;TNNI3K;SLC19A2;PHC3;NFIL3;HSP90B1 |
| protein homodimerization activity | HINT2;TCF3A;ATPIF1B;NR4A2;EFR3A;Anks6;SLC16A1;GJC3;PDGFB |
| protein kinase activity | TNNI3K;PLK5;SYK;SLKA;PRKDC;FASTKD1;MAP3K12;CSNK1DB;STK38A |
| protein self-association | MDH2;ABCD3;AGTR1B;SLC9A3R1;TRP53;VAMP2;ADAM8;SHANK3;NKX3-1 |
| receptor signaling protein tyrosine kinase activator activity |
CCL5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL5.
DPP4; CCR5; BCAR3; BAG4; CHEK2; KRAS; TGFB1; CDH1; PTPN1; WT1; SLC2A5; APC; PHB; RANGAP1; RELA; TRIP6
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