Recombinant Cattle CCL5 Protein, His-tagged
|Product Overview :
|Recombinant Cattle CCL5 Protein (Ser24-Ser91) with His tag was expressed in E. coli.
- Gene Information
- Related Products
|This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms.
|Molecular Mass :
|Predicted Molecular Mass: 9.4 kDa
|Protein length :
|Positive Control; Immunogen; SDS-PAGE; WB.
|The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
|Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
|Storage Buffer :
|PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
|Reconstitute in PBS or others.
|Gene Name :
|CCL5 C-C motif chemokine ligand 5 [ Bos taurus (cattle) ]
|Official Symbol :
|CCL5; C-C motif chemokine ligand 5; RANTES; C-C motif chemokine 5; SIS-delta; T-cell-specific protein RANTES; chemokine (C-C motif) ligand 5; small-inducible cytokine A5
|Gene ID :
|mRNA Refseq :
|Protein Refseq :
|UniProt ID :
|◆ Recombinant Protein
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (5)Ask a question
CCL5 inhibitors may be used to control inflammation in diseases like rheumatoid arthritis or as an adjuvant in cancer therapy.
CCL5-based immunotherapies are being explored to enhance the immune response against cancer cells.
It can serve as a biomarker for some diseases, but it is usually used in conjunction with other markers for more accurate diagnostics.
Elevated CCL5 levels are associated with inflammation and may be indicative of certain diseases such as rheumatoid arthritis or HIV infection.
Yes, there are ongoing efforts to develop therapies that modulate CCL5 activity, particularly in diseases involving inflammation.
Customer Reviews (3)Write a review
This specificity enables precise quantification and characterization of CCL5 and its interactions with other molecules or proteins of interest.
Its exceptional performance, coupled with its ability to generate clear and precise protein bands, make it an indispensable tool in achieving accurate and reliable results.
The CCL5 protein exhibits a high degree of specificity in various assays, ensuring accurate and reliable results.
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