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Active Recombinant Mouse Interleukin 4 Receptor, Alpha, Fc-tagged

Cat.No. : Il4ra-5662M
Product Overview : RecombinantMouse Il4ra protein was expressed in Murine myeloma celllinewith the Fc part of Human IgG1 Pro100-Lys330 (C-terminus) and MouseIl4ra Ile26-Arg233 (N-terminus).
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Cat. No. : Il4ra-5662M
Description : Il4ra isa widely expressed 140 kDa transmembrane glycoprotein in the class I cytokinereceptor family. Il4ra plays an important role in Th2-biased immuneresponses, alternative macrophage activation, mucosal immunity, allergic inflammation,tumor progression, and atherogenesis. Mature mouse Il4ra consists of a 208amino acid (aa) extracellular domain (ECD) that contains a ligand bindingregion and one fibronectin type-III domain, a 24 aa transmembrane segment, anda 553 aa cytoplasmic domain that contains one Box 1 motif and one ITIM motif.
Source : Mammalian cells
Form : Lyophilizedfrom a 0.2 μm filtered solution in PBS.
N-terminalSequence : Ile26
MolecularWeight : 51 kDa
Activity : Measuredby its ability to inhibit the IL-4-dependent proliferation of HT-2 mouse helperT cells. The ED50 for this effect is typically 0.05-0.2 μg/mL in the presenceof 3 ng/mL of recombinant mouse IL-4.
Endotoxin Level : <1.0EU per 1μg of the protein by the LAL method.
SDS-PAGE : 65-85kDa, reducing conditions.
Purity : >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : 100 μg/mLin sterile PBS
Storage : Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to-70°C under sterile conditions after reconstitution.
Gene Name : Il4ra interleukin 4 receptor,alpha [ Mus musculus ]
Official Symbol : Il4ra
Synonyms : Il4ra; interleukin 4receptor, alpha; Il4r; interleukin-4 receptor subunit alpha; IL-4RA;IL-4R-alpha; IL-4R subunit alpha; IL-4 receptor alpha chain; IL-4 receptorsubunit alpha; CD124
Gene ID : 16190
mRNA Refseq : NM_001008700
Protein Refseq : NP_001008700
UniProt ID : Q544A9
Chromosome Location : 7
Pathway : Cytokine-cytokinereceptor interaction; Hematopoietic cell lineage; IL-4 signaling Pathway;Inflammatory Response Pathway; Jak-STAT signaling pathway
Function : cytokine receptoractivity; protein binding; receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.



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