Active Recombinant Mouse Interleukin 4 Receptor, Alpha, Fc-tagged

• Cat.No.: Il4ra-5662M
• Product Overview: RecombinantMouse Il4ra protein was expressed in Murine myeloma celllinewith the Fc part of Human IgG1 Pro100-Lys330 (C-terminus) and MouseIl4ra Ile26-Arg233 (N-terminus).

Specification

• Cat. No.: Il4ra-5662M
• Description: Il4ra isa widely expressed 140 kDa transmembrane glycoprotein in the class I cytokinereceptor family. Il4ra plays an important role in Th2-biased immuneresponses, alternative macrophage activation, mucosal immunity, allergic inflammation,tumor progression, and atherogenesis. Mature mouse Il4ra consists of a 208amino acid (aa) extracellular domain (ECD) that contains a ligand bindingregion and one fibronectin type-III domain, a 24 aa transmembrane segment, anda 553 aa cytoplasmic domain that contains one Box 1 motif and one ITIM motif.
• Source: Mammalian cells
• Form: Lyophilizedfrom a 0.2 μm filtered solution in PBS.
• N-terminalSequence: Ile26
• MolecularWeight: 51 kDa
• Activity: Measuredby its ability to inhibit the IL-4-dependent proliferation of HT-2 mouse helperT cells. The ED50 for this effect is typically 0.05-0.2 μg/mL in the presenceof 3 ng/mL of recombinant mouse IL-4.
• Endotoxin Level: <1.0EU per 1μg of the protein by the LAL method.
• SDS-PAGE: 65-85kDa, reducing conditions.
• Purity: >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution: 100 μg/mLin sterile PBS
• Storage: Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to-70°C under sterile conditions after reconstitution.
• Protein length: Ile26-Arg233

Gene Information

• Gene Name: Il4ra interleukin 4 receptor,alpha [ Mus musculus ]
• Official Symbol: Il4ra
• Synonyms: Il4ra; interleukin 4receptor, alpha; Il4r; interleukin-4 receptor subunit alpha; IL-4RA;IL-4R-alpha; IL-4R subunit alpha; IL-4 receptor alpha chain; IL-4 receptorsubunit alpha; CD124
• Gene ID: 16190
• mRNA Refseq: NM_001008700
• Protein Refseq: NP_001008700
• UniProt ID: Q544A9
• Chromosome Location: 7
• Pathway: Cytokine-cytokinereceptor interaction; Hematopoietic cell lineage; IL-4 signaling Pathway;Inflammatory Response Pathway; Jak-STAT signaling pathway
• Function: cytokine receptoractivity; protein binding; receptor activity

Reviews

11/02/2022

Easy to use, high stability, remarkable effect.

01/13/2022

Good application performance in immune detection, such as ELISA, western blot and so on.

09/30/2021

High synthesis efficiency and yield.

Q&As

Can recombinant Il4ra be used to prevent disease?

Il4ra is mainly used for treatment, and it has not been reported that it can be used to prevent disease.

Is Il4ra safe for use in pregnant or lactating women?

The safety of Il4ra has not been adequately studied in pregnant or lactating women and should be used with caution.

What is the action mechanism of Il4ra?

Mechanism of action of Il4ra is to regulate the immune response by inhibiting the Il4 signaling pathway.

How to guarantee the production process and quality control of Il4ra?

The production process and quality control of Il4ra require strict compliance with relevant regulations and standards, including Good Manufacturing practice (GMP), to ensure their safety and effectiveness.

How long should the treatment course of Il4ra be?

The length of treatment for Il4ra depends on the nature of the disease and the patient's response to treatment, and generally lasts from several weeks to several months.

What are the reports on the progress of clinical trials of Il4ra?

There are a number of clinical trials underway for recombinant Il4ra, which have shown some efficacy in the treatment of asthma, autoimmune diseases, etc.