Active Recombinant Rat Chemokine (C-X3-C motif) Ligand 1

Cat.No. : Cx3cl1-460R
Product Overview : Recombinant Rat Cx3cl1protein was expressed in Sf21. Gln25-Thr334.
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Cat. No. : Cx3cl1-460R
Description : Cx3cl1, also named neurotactin, is a member of the delta chemokinesubfamily that contains a novel C-X3-C motif. Unlike other known chemokines, Cx3cl1 is a type 1 membrane protein containing a chemokine domaintethered on a long mucinlike stalk. Rat Cx3cl1cDNA encodes a 393 amino acid (aa) residue precursor protein with two alternative(21 aa or 24 aa residue) putative signal peptides, a 76 aa residue globular chemokinedomain, a 238 aa residue stalk region rich in Gly, Pro, Ser and Thr and containingdegenerate mucinlike repeats, a 19 aa residue transmembrane segment and a 36 aaresidue cytoplasmic domain.
Source : Spodoptera frugiperda,Sf 21 (baculovirus)
Form : Lyophilized from a 0.2μm filtered solution in PBS with BSA as a carrier protein.
N-terminalSequence : No results obtained:Gln25 predicted
Molecular Weight : 33 kDa
Activity : Measuredby its ability to chemoattract mouse Cx3cl1 transfected BaF3 mouse proB cells. The ED50 forthis effect is typically 0.02-0.08 ng/mL.
Endotoxin Level : <1.0 EUper 1 μg of the protein by the LAL method.
Purity : >97%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : Reconstituteat 100 μg/mL in sterile PBS that containing at least 0.1% human or bovine serumalbumin.
Storage : Use a manualdefrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months,-20 to -70°C under sterile conditions after reconstitution.
SDS-PAGE:
Gene Name : Cx3cl1 chemokine(C-X3-C motif) ligand 1 [ Rattus norvegicus ]
Official Symbol : Cx3cl1
Synonyms : Cx3cl1; chemokine(C-X3-C motif) ligand 1; Cx3c; Scyd1; fractalkine; neurotactin; C-X3-C motif chemokine1; small-inducible cytokine D1; CX3C membrane-anchored chemokine; small induciblecytokine subfamily D, 1; Acc1; Fkn
Gene ID : 89808
mRNA Refseq : NM_134455
Protein Refseq : NP_604450
UniProt ID : O55145
Chromosome Location : 19p12
Pathway : Chemokine receptors bindchemokines; Chemokine signaling pathway; Class A/1 (Rhodopsin-like receptors);Cytokine-cytokine receptor interaction; GPCR ligand binding; Peptide ligand-bindingreceptors; Signal Transduction; Signaling by GPCR
Function : chemokine activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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In what ways is CX3CL1 linked to the modulation of pain perception and neuropathic pain conditions? 04/30/2021

CX3CL1 is involved in pain modulation, and its dysregulation is associated with neuropathic pain conditions. Understanding its role may lead to the development of novel analgesic therapies.

Are there any ongoing clinical trials targeting CX3CL1 for therapeutic purposes? 09/14/2020

Yes, several clinical trials are investigating the therapeutic potential of targeting CX3CL1 in various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases.

In cardiovascular diseases, how does CX3CL1 impact inflammation and vascular function? 03/23/2020

CX3CL1 contributes to inflammation in cardiovascular diseases and affects vascular function. Studying its role helps in understanding the pathophysiology of conditions like atherosclerosis.

How does CX3CL1 influence the recruitment and activation of immune cells in the context of inflammation? 01/06/2019

CX3CL1 acts as a chemoattractant, facilitating the recruitment and activation of immune cells at the site of inflammation, playing a pivotal role in immune response regulation.

How is CX3CL1 being investigated for its potential as a biomarker in various diseases? 05/19/2016

Researchers are exploring CX3CL1 as a potential biomarker for diseases such as rheumatoid arthritis and certain cancers, aiming to develop diagnostic tools and monitor disease progression.

Customer Reviews (3)

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Reviews
03/15/2022

    the CX3CL1 protein's compatibility with various experimental techniques further supports its usability.

    08/06/2021

      One of the standout features of the CX3CL1 protein is the excellent technical support provided by the manufacturer.

      06/03/2021

        Whether I need to study protein-protein interactions, protein localization, or protein folding, the CX3CL1 protein consistently delivers precise and meaningful data.

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