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Active Recombinant Mouse Chemokine (C-X3-C motif) Ligand 1, His-tagged

Cat.No. : Cx3cl1-380M
Product Overview : Recombinantmouse Cx3cl1 protein was expressed in Spodopterafrugiperda, Sf 21 (baculovirus), with a C-terminal 6-His-tagged.Gln25-Arg337.
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Cat. No. : Cx3cl1-380M
Description : Cx3cl1 is a largecytokine protein of 373 amino acids; it contains multiple domains and is theonly known member of the CX3C chemokine family. It is alsocommonly known under the names fractalkine (in humans) and neurotactin (in mice).The polypeptide structure of Cx3cl1 differs from thetypical structure of other chemokines.
Source : Spodopterafrugiperda, Sf 21 (baculovirus)-derived
Form : Lyophilized from a0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
N-terminal Sequence : No results obtained:Gln25 predicted
Molecular Weight : 34 kDa
Activity : Measured by itsability to chemoattract freshly isolated human peripheral blood lymphocytes(PBL). The ED50 for this effect is typically 0.2-0.6 μg/mL. Measuredby its ability to chemoattract human CX3CR1 transfected BaF3 mouse pro-Bcells. The ED50 for this effect is typically 0.03-0.12 μg/mL.
Endotoxin Level : <1.0 EU per 1 μgof the protein by the LAL method.
Purity : >97%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : Reconstitute at 10μg/mL in sterile PBS that containing at least 0.1% human or bovine serumalbumin.
Storage : Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20to -70°C under sterile conditions after reconstitution.
Gene Name : Cx3cl1chemokine (C-X3-C motif) ligand 1 [ Mus musculus ]
Official Symbol : Cx3cl1
Synonyms : Cx3cl1; chemokine (C-X3-Cmotif) ligand 1; CX3C; Cxc3; Scyd1; ABCD-3; AB030188; AI848747;D8Bwg0439e; fractalkine; neurotactin; C-X3-C motif chemokine 1; small-induciblecytokine D1; CX3C membrane-anchored chemokine; small inducible cytokinesubfamily D, 1; Fkn; Cx3C
Gene ID : 20312
mRNA Refseq : NM_009142
Protein Refseq : NP_033168
UniProt ID : O35188
Chromosome Location : 8
Pathway : Chemokine receptorsbind chemokines; Chemokine signaling pathway; Class A/1 (Rhodesian-likereceptors); Cytokine-cytokine receptor interaction; GPCR ligand binding;Peptide ligand-binding receptors; Signal Transduction; Signaling by GPCR
Function : chemokine activity; cytokineactivity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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In what ways is CX3CL1 linked to the modulation of pain perception and neuropathic pain conditions? 04/30/2021

CX3CL1 is involved in pain modulation, and its dysregulation is associated with neuropathic pain conditions. Understanding its role may lead to the development of novel analgesic therapies.

Are there any ongoing clinical trials targeting CX3CL1 for therapeutic purposes? 09/14/2020

Yes, several clinical trials are investigating the therapeutic potential of targeting CX3CL1 in various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases.

In cardiovascular diseases, how does CX3CL1 impact inflammation and vascular function? 03/23/2020

CX3CL1 contributes to inflammation in cardiovascular diseases and affects vascular function. Studying its role helps in understanding the pathophysiology of conditions like atherosclerosis.

How does CX3CL1 influence the recruitment and activation of immune cells in the context of inflammation? 01/06/2019

CX3CL1 acts as a chemoattractant, facilitating the recruitment and activation of immune cells at the site of inflammation, playing a pivotal role in immune response regulation.

How is CX3CL1 being investigated for its potential as a biomarker in various diseases? 05/19/2016

Researchers are exploring CX3CL1 as a potential biomarker for diseases such as rheumatoid arthritis and certain cancers, aiming to develop diagnostic tools and monitor disease progression.

Customer Reviews (3)

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Reviews
03/15/2022

    the CX3CL1 protein's compatibility with various experimental techniques further supports its usability.

    08/06/2021

      One of the standout features of the CX3CL1 protein is the excellent technical support provided by the manufacturer.

      06/03/2021

        Whether I need to study protein-protein interactions, protein localization, or protein folding, the CX3CL1 protein consistently delivers precise and meaningful data.

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