Active Recombinant Mouse Chemokine (C-X3-C motif) Ligand 1, His-tagged
Cat.No. : | Cx3cl1-380M |
Product Overview : | Recombinantmouse Cx3cl1 protein was expressed in Spodopterafrugiperda, Sf 21 (baculovirus), with a C-terminal 6-His-tagged.Gln25-Arg337. |
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- Gene Information
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Cat. No. : | Cx3cl1-380M |
Description : | Cx3cl1 is a largecytokine protein of 373 amino acids; it contains multiple domains and is theonly known member of the CX3C chemokine family. It is alsocommonly known under the names fractalkine (in humans) and neurotactin (in mice).The polypeptide structure of Cx3cl1 differs from thetypical structure of other chemokines. |
Source : | Spodopterafrugiperda, Sf 21 (baculovirus)-derived |
Form : | Lyophilized from a0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein. |
N-terminal Sequence : | No results obtained:Gln25 predicted |
Molecular Weight : | 34 kDa |
Activity : | Measured by itsability to chemoattract freshly isolated human peripheral blood lymphocytes(PBL). The ED50 for this effect is typically 0.2-0.6 μg/mL. Measuredby its ability to chemoattract human CX3CR1 transfected BaF3 mouse pro-Bcells. The ED50 for this effect is typically 0.03-0.12 μg/mL. |
Endotoxin Level : | <1.0 EU per 1 μgof the protein by the LAL method. |
Purity : | >97%,by SDS-PAGE under reducing conditions and visualized by silver stain. |
Reconstitution : | Reconstitute at 10μg/mL in sterile PBS that containing at least 0.1% human or bovine serumalbumin. |
Storage : | Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20to -70°C under sterile conditions after reconstitution. |
Gene Name : | Cx3cl1chemokine (C-X3-C motif) ligand 1 [ Mus musculus ] |
Official Symbol : | Cx3cl1 |
Synonyms : | Cx3cl1; chemokine (C-X3-Cmotif) ligand 1; CX3C; Cxc3; Scyd1; ABCD-3; AB030188; AI848747;D8Bwg0439e; fractalkine; neurotactin; C-X3-C motif chemokine 1; small-induciblecytokine D1; CX3C membrane-anchored chemokine; small inducible cytokinesubfamily D, 1; Fkn; Cx3C |
Gene ID : | 20312 |
mRNA Refseq : | NM_009142 |
Protein Refseq : | NP_033168 |
UniProt ID : | O35188 |
Chromosome Location : | 8 |
Pathway : | Chemokine receptorsbind chemokines; Chemokine signaling pathway; Class A/1 (Rhodesian-likereceptors); Cytokine-cytokine receptor interaction; GPCR ligand binding;Peptide ligand-binding receptors; Signal Transduction; Signaling by GPCR |
Function : | chemokine activity; cytokineactivity |
Products Types
◆ Recombinant Protein | ||
Cx3cl1-879M | Recombinant Mouse Cx3cl1 Protein, His-tagged | +Inquiry |
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Cx3cl1-2385M | Active Recombinant Mouse Cx3cl1 Protein | +Inquiry |
CX3CL1-927R | Recombinant Rhesus Macaque CX3CL1 Protein, His (Fc)-Avi-tagged | +Inquiry |
CX3CL1-283C | Active Recombinant Human CX3CL1 Protein (315 aa) | +Inquiry |
◆ Lysates | ||
CX3CL1-3019HCL | Recombinant Human CX3CL1 cell lysate | +Inquiry |
CX3CL1-840CCL | Recombinant Canine CX3CL1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCX3CL1 is involved in pain modulation, and its dysregulation is associated with neuropathic pain conditions. Understanding its role may lead to the development of novel analgesic therapies.
Yes, several clinical trials are investigating the therapeutic potential of targeting CX3CL1 in various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases.
CX3CL1 contributes to inflammation in cardiovascular diseases and affects vascular function. Studying its role helps in understanding the pathophysiology of conditions like atherosclerosis.
CX3CL1 acts as a chemoattractant, facilitating the recruitment and activation of immune cells at the site of inflammation, playing a pivotal role in immune response regulation.
Researchers are exploring CX3CL1 as a potential biomarker for diseases such as rheumatoid arthritis and certain cancers, aiming to develop diagnostic tools and monitor disease progression.
Customer Reviews (3)
Write a reviewthe CX3CL1 protein's compatibility with various experimental techniques further supports its usability.
One of the standout features of the CX3CL1 protein is the excellent technical support provided by the manufacturer.
Whether I need to study protein-protein interactions, protein localization, or protein folding, the CX3CL1 protein consistently delivers precise and meaningful data.
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