CX3CL1
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Official Full Name
chemokine (C-X3-C motif) ligand 1
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Overview
The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1. -
Synonyms
CX3CL1; chemokine (C-X3-C motif) ligand 1; NTN; NTT; CXC3; CXC3C; SCYD1; ABCD-3; C3Xkine; fractalkine; neurotactin; fractalkine; C-X3-C motif chemokine 1; small-inducible cytokine D1; CX3C membrane-anchored chemokine; small inducible cytokine subfamily D (Cys-X3-Cys), member-1; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bovine
- Canine
- Chicken
- Cynomolgus
- Cynomolgus/Rhesus
- Gln25-Gln341
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- C-His
- CHO
- E.coli
- E.coli expression system
- HEK293
- HEK293 cells
- HEK293F
- Human Cell
- Human Cells
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf21 Insect Cell
- Spodoptera Frugiperda
- Yeast
- Biotin
- C
- His
- Fc
- Flag
- GST
- Avi
- SUMO
- T7
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
CX3CL1 involved in several pathways and played different roles in them. We selected most pathways CX3CL1 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CX3CL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | CXCL6;IL17A;FLT1;XCL1;CSF1;PDGFB;Ifna11;IFNA6;PF4 |
| Chemokine signaling pathway | CXCL14;CCL23;PIK3R3;PRKACA;PIK3CB;Ccl21a;XCL1;CXCR2;PREX1 |
| TNF signaling pathway | LIF;FADD;PTGS2;MAPK11;MAP3K5;CX3CL1;MAPK1;RIPK1;LTA |
CX3CL1 has several biochemical functions, for example, CCR chemokine receptor binding, chemokine activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CX3CL1 itself. We selected most functions CX3CL1 had, and list some proteins which have the same functions with CX3CL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| CCR chemokine receptor binding | CCL14;CCL34B.1;CCL34B.4;CX3CL1;CXCL32B.1;XCL1;CCL19A.2;CCL35.1;CCL20 |
| chemokine activity | CXCL12;CCL14;XCL1;CCL35.1;CCL25;CXCL5;CCL34A.4;CXCL16;Ccl12 |
| protein binding | NUFIP2;HM13;OTUD7B;DNAJB1;AP1S2;SLC35A2;TEK;ICAM4;SERPING1 |
| receptor binding | BMP2;NPFFL;FGF13A;GSTM2;SRI;WNT7A;TNFSF14;TNFSF13;ECI2 |
CX3CL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CX3CL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CX3CL1.
Gene Family
Research Area
Related articles
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Customer Reviews (3)
Write a reviewthe CX3CL1 protein's compatibility with various experimental techniques further supports its usability.
One of the standout features of the CX3CL1 protein is the excellent technical support provided by the manufacturer.
Whether I need to study protein-protein interactions, protein localization, or protein folding, the CX3CL1 protein consistently delivers precise and meaningful data.
Q&As (5)
Ask a questionCX3CL1 is involved in pain modulation, and its dysregulation is associated with neuropathic pain conditions. Understanding its role may lead to the development of novel analgesic therapies.
Yes, several clinical trials are investigating the therapeutic potential of targeting CX3CL1 in various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases.
CX3CL1 contributes to inflammation in cardiovascular diseases and affects vascular function. Studying its role helps in understanding the pathophysiology of conditions like atherosclerosis.
CX3CL1 acts as a chemoattractant, facilitating the recruitment and activation of immune cells at the site of inflammation, playing a pivotal role in immune response regulation.
Researchers are exploring CX3CL1 as a potential biomarker for diseases such as rheumatoid arthritis and certain cancers, aiming to develop diagnostic tools and monitor disease progression.
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