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CX3CL1

  • Official Full Name

    chemokine (C-X3-C motif) ligand 1

  • Overview

    The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1.
  • Synonyms

    CX3CL1; chemokine (C-X3-C motif) ligand 1; NTN; NTT; CXC3; CXC3C; SCYD1; ABCD-3; C3Xkine; fractalkine; neurotactin; fractalkine; C-X3-C motif chemokine 1; small-inducible cytokine D1; CX3C membrane-anchored chemokine; small inducible cytokine subfamily D (Cys-X3-Cys), member-1; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Canine
  • Chicken
  • Cynomolgus
  • Cynomolgus/Rhesus
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293 cells
  • HEK293F
  • Human Cell
  • Human Cells
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Spodoptera Frugiperda
  • Yeast
  • Biotin
  • C
  • His
  • Avi
  • Fc
  • Flag
  • GST
  • hFc
  • His (Fc)
  • His|T7
  • SUMO
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CX3CL1-103H Active Human CX3CL1, Biotin-tagged Biotin
Human CX3CL1-286H Active Recombinant Human CX3CL1, HIgG1 Fc-tagged CHO Fc
Human CX3CL1-27741TH Active Recombinant Human CX3CL1 protein, FLAG-tagged HEK293 Flag
Human CX3CL1-281H Active Recombinant Human CX3CL1, MIgG2a Fc-tagged CHO Fc
Human CX3CL1-051H Active Recombinant Human CX3CL1 protein, His/Avi-tagged, Biotinylated HEK293 cells His/Avi Gln25-Thr338
Human CX3CL1-86H Recombinant Human CX3CL1 protein, His-tagged HEK293 His Met1-Arg339
Human CX3CL1-123H Recombinant Human Chemokine (C-X3-C Motif) Ligand 1 Mammalian cells N/A
Human CX3CL1-11712H Recombinant Human CX3CL1, GST-tagged E.coli GST 90-245a.a.
Human CX3CL1-114H Recombinant Human chemokine (C-X3-C motif) ligand 1, His-tagged E.coli His
Human CX3CL1-765H Recombinant Human CX3CL1 protein, His-tagged E.coli His Trp81~Ala336 (Accession # P78423)
Human CX3CL1-766H Recombinant Human CX3CL1 protein, His & T7-tagged E.coli His/T7 Gln25~Pro332 (Accession # P78423)
Human CX3CL1-039H Recombinant Human CX3CL1 Protein HEK293 N/A
Human CX3CL1-3019HCL Recombinant Human CX3CL1 cell lysate Human Cell N/A
Human CX3CL1-283C Active Recombinant Human CX3CL1 Protein (315 aa) CHO 315
Human CX3CL1-278H Recombinant Human CX3CL1 Protein, His-tagged Human Cells His
Human CX3CL1-2769H Recombinant Human CX3CL1 protein, His-SUMO-tagged E.coli His-SUMO 25-100aa
Human CX3CL1-481H Recombinant Human CX3CL1 Protein, Biotinylated 397
Human CX3CL1-223H Recombinant Human CX3CL1 protein E.coli N/A 76
Human CX3CL1-01H Recombinant Human CX3CL1 Protein, His-Tagged Insect Cell His 323aa
Human CX3CL1-878H Recombinant Human CX3CL1 Protein, His-tagged E.coli N-His Gln25-Pro332
Human CX3CL1-4386H-B Recombinant Human CX3CL1 Protein Pre-coupled Magnetic Beads HEK293
Human CX3CL1-3177H Recombinant Human CX3CL1 Protein (Gln25-Arg339), C-His tagged Mammalian cells C-His Gln25-Arg339
Human CX3CL1-482H Recombinant Human CX3CL1 Protein 397
Human CX3CL1-90H Recombinant Human CX3CL1 Protein, Biotin-tagged E.coli Biotin
Human CX3CL1-2221HF Recombinant Full Length Human CX3CL1 Protein, GST-tagged In Vitro Cell Free System GST 397 amino acids
Human CX3CL1-3040H Recombinant Human CX3CL1 protein, His-tagged, Biotinylated HEK293 His Gln 25-Gln 341
Human CX3CL1-399H Recombinant Human CX3CL1 protein, His-tagged HEK293 His 317
Human CX3CL1-2201H Recombinant Human CX3CL1 Protein (Asp90-Gln245), N-His tagged E.coli N-His Asp90-Gln245
Mouse Cx3cl1-379M Active Recombinant Mouse Chemokine (C-X3-C motif) Ligand 1 E.coli N/A
Mouse Cx3cl1-380M Active Recombinant Mouse Chemokine (C-X3-C motif) Ligand 1, His-tagged Spodoptera Frugiperda His
Mouse Cx3cl1-225M Active Recombinant Mouse Cx3cl1 E.coli N/A
Mouse Cx3cl1-950M Active Recombinant Mouse Cx3cl1 E.coli N/A Leu22-Lys105
Mouse Cx3cl1-951M Active Recombinant Mouse Cx3cl1 Protein, His-tagged Sf21 Insect Cell His Gln25-Arg337
Mouse Cx3cl1-127M Recombinant Mouse Chemokine (C-X3-C Motif) Ligand 1 Sf21 Insect Cell N/A
Mouse CX3CL1-4094M Recombinant Mouse CX3CL1 Protein Mammalian Cell His
Mouse Cx3cl1-767M Recombinant Mouse Cx3cl1 protein, His-tagged E.coli His Gln83~Pro330 (Accession # O35188)
Mouse Cx3cl1-949M Recombinant Mouse Cx3cl1 protein E.coli N/A 76
Mouse CX3CL1-2092M-B Recombinant Mouse CX3CL1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Cx3cl1-2385M Active Recombinant Mouse Cx3cl1 Protein E.coli Leu22-Lys105
Mouse Cx3cl1-345M Recombinant Mouse Cx3cl1 protein, His-tagged Yeast His Gln25-Lys105
Mouse CX3CL1-2092M Recombinant Mouse CX3CL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Cx3cl1-5746M Recombinant Mouse Cx3cl1 Protein (Gln25-Arg337), C-His tagged Mammalian cells C-His Gln25-Arg337
Mouse Cx3cl1-261M Recombinant Mouse Cx3cl1 Protein, Gln25-Thr336, C-His-Avi tagged, Biotinylated HEK293 C-His-Avi Gln25-Thr336
Mouse Cx3cl1-879M Recombinant Mouse Cx3cl1 Protein, His-tagged HEK293F N-His Gln83-Pro330
Rat Cx3cl1-460R Active Recombinant Rat Chemokine (C-X3-C motif) Ligand 1 Spodoptera Frugiperda N/A
Rat Cx3cl1-992R Active Recombinant Rat Cx3cl1 Sf21 Insect Cell N/A Gln25-Thr334
Rat Cx3cl1-128R Recombinant Rat Cx3cl1 Chemokine (C-X3-C Motif) Ligand 1 Sf21 Insect Cell N/A
Rat Cx3cl1-633R Recombinant Rat Cx3cl1 protein E.coli N/A 76
Rat Cx3cl1-768R Recombinant Rat Cx3cl1 protein, His-tagged E.coli His Trp81~Gln337 (Accession # O55145)
Rat CX3CL1-1683R Recombinant Rat CX3CL1 Protein Mammalian Cell His
Rat CX3CL1-1342R Recombinant Rat CX3CL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Cx3cl1-880R Recombinant Rat Cx3cl1 Protein, His-tagged E.coli N-His Gln83-Pro328
Rat Cx3cl1-189C Active Recombinant Rat Cx3cl1 Protein (310 aa) HEK293 310
Rat CX3CL1-1342R-B Recombinant Rat CX3CL1 Protein Pre-coupled Magnetic Beads HEK293
Bovine CX3CL1-4319B Recombinant Bovine CX3CL1 Protein Yeast N/A 76aa
Canine CX3CL1-177C Recombinant Canine CX3CL1, Fc tagged Human Cell Fc
Canine CX3CL1-176C Recombinant Canine CX3CL1, LEVLFQ tagged Human Cell Fc
Canine CX3CL1-840CCL Recombinant Canine CX3CL1 cell lysate Human Cell N/A
Canine CX3CL1-926C Recombinant Canine CX3CL1 Protein (Met1-Gly100), His-tagged HEK293 His Met1-Gly100
Cynomolgus CX3CL1-1879C Recombinant Cynomolgus CX3CL1 protein, His-tagged HEK293 His Gly 24 - Ala 352
Cynomolgus/Rhesus CX3CL1-187C Recombinant Cynomolgus/Rhesus CX3CL1 protein, hFc-tagged HEK293 hFc Met1-Gly100
Cynomolgus/Rhesus CX3CL1-344C Recombinant Cynomolgus/Rhesus CX3CL1 protein(Met1-Gly100), His-tagged HEK293 C-His Met1-Gly100
Mus musculus (Mouse) RFL35151MF Recombinant Full Length Mouse Fractalkine(Cx3Cl1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (25-395)
Rattus norvegicus (Rat) RFL18747RF Recombinant Full Length Rat Fractalkine(Cx3Cl1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (25-393)
Rhesus Macaque CX3CL1-1102R Recombinant Rhesus monkey CX3CL1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CX3CL1-927R Recombinant Rhesus Macaque CX3CL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CX3CL1-927R-B Recombinant Rhesus Macaque CX3CL1 Protein Pre-coupled Magnetic Beads HEK293
Chicken CX3CL1-3510C Recombinant Chicken CX3CL1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CX3CL1 involved in several pathways and played different roles in them. We selected most pathways CX3CL1 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CX3CL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionEDAR;INHBC;IL13;CXCR5;CCR1L1;Il4ra;IL-8;LTA;CSF3R
Chemokine signaling pathwayCCL21;GNG12;GNG4;GNB2;GNG11;CCL3L3;CCL1;CCL17;CCL28
TNF signaling pathwayMAP2K6;RPS6KA5;TRAF5;MAPK1;FOS;IL15;MLKL;SELE;NFKBIA

CX3CL1 has several biochemical functions, for example, CCR chemokine receptor binding, chemokine activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CX3CL1 itself. We selected most functions CX3CL1 had, and list some proteins which have the same functions with CX3CL1. You can find most of the proteins on our site.

Function Related Protein
CCR chemokine receptor bindingCX3CL1;CCL34A.4;CCL1;CCL11;CCL20B;CCL13;XCL2;CCL3L3;CCL34B.1
chemokine activityCXCL18B;CXCL2;CCL35.1;CCL5;CCL24;CCL34B.9;CCL23;CXL34B.11;CXCL8B.3
protein bindingTRAF4;CNBP;SULT1A1;SASS6;MAD1L1;TTPA;CCND3;HIST1H2AG;CNOT10
receptor bindingTESPA1;ABL2;HNF4A;CRTAM;UCN2;HLA-E;BMP3;CD58;NRXN1

CX3CL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CX3CL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CX3CL1.

Gene Family

Chemokines Cytokines

Research Area

Related articles

Herbst, RS; Soria, JC; et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. NATURE 515:563-+(2014).
Salvador, R; Aridgides, D; et al. Parasite-Derived Neurotrophic Factor/trans-Sialidase of Trypanosoma cruzi Links Neurotrophic Signaling to Cardiac Innate Immune Response. INFECTION AND IMMUNITY 82:3687-3696(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
In what ways is CX3CL1 linked to the modulation of pain perception and neuropathic pain conditions? 04/30/2021

CX3CL1 is involved in pain modulation, and its dysregulation is associated with neuropathic pain conditions. Understanding its role may lead to the development of novel analgesic therapies.

Are there any ongoing clinical trials targeting CX3CL1 for therapeutic purposes? 09/14/2020

Yes, several clinical trials are investigating the therapeutic potential of targeting CX3CL1 in various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases.

In cardiovascular diseases, how does CX3CL1 impact inflammation and vascular function? 03/23/2020

CX3CL1 contributes to inflammation in cardiovascular diseases and affects vascular function. Studying its role helps in understanding the pathophysiology of conditions like atherosclerosis.

How does CX3CL1 influence the recruitment and activation of immune cells in the context of inflammation? 01/06/2019

CX3CL1 acts as a chemoattractant, facilitating the recruitment and activation of immune cells at the site of inflammation, playing a pivotal role in immune response regulation.

How is CX3CL1 being investigated for its potential as a biomarker in various diseases? 05/19/2016

Researchers are exploring CX3CL1 as a potential biomarker for diseases such as rheumatoid arthritis and certain cancers, aiming to develop diagnostic tools and monitor disease progression.

Customer Reviews (3)

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Reviews
03/15/2022

    the CX3CL1 protein's compatibility with various experimental techniques further supports its usability.

    08/06/2021

      One of the standout features of the CX3CL1 protein is the excellent technical support provided by the manufacturer.

      06/03/2021

        Whether I need to study protein-protein interactions, protein localization, or protein folding, the CX3CL1 protein consistently delivers precise and meaningful data.

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