The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1.
CX3CL1; chemokine (C-X3-C motif) ligand 1; NTN; NTT; CXC3; CXC3C; SCYD1; ABCD-3; C3Xkine; fractalkine; neurotactin; fractalkine; C-X3-C motif chemokine 1; small-inducible cytokine D1; CX3C membrane-anchored chemokine; small inducible cytokine subfamily D (Cys-X3-Cys), member-1; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin);
CX3CL1 involved in several pathways and played different roles in them. We selected most pathways CX3CL1 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CX3CL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
CX3CL1 has several biochemical functions, for example, CCR chemokine receptor binding, chemokine activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CX3CL1 itself. We selected most functions CX3CL1 had, and list some proteins which have the same functions with CX3CL1. You can find most of the proteins on our site.
CX3CL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CX3CL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CX3CL1.
Herbst, RS; Soria, JC; et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. NATURE 515:563-+(2014).
Salvador, R; Aridgides, D; et al. Parasite-Derived Neurotrophic Factor/trans-Sialidase of Trypanosoma cruzi Links Neurotrophic Signaling to Cardiac Innate Immune Response. INFECTION AND IMMUNITY 82:3687-3696(2014).