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Recombinant Human interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35), His-tagged

Cat.No. : IL12A-132H
Product Overview : Human RecombinantInterleukin-12 p35 His produced in E. coli is single, a nonglycosylated,polypeptide chain containing 197 amino acids fragment (57-253) with anamino-terminal hexahistidine tag.
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Cat. No. : IL12A-132H
Description : This gene encodes asubunit of a cytokine that acts on T and natural killer cells, and has abroad array of biological activities. The cytokine is a disulfide-linkedheterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kDsubunit that is a member of the cytokine receptor family. This cytokine isrequired for the T-cell-independent induction of interferon (IFN)-gamma, andis important for the differentiation of both Th1 and Th2 cells.
Source : E. coli
Species : Human
Form : Interleukin-12 p35His-Tag is supplied in 20 mM Tris HCL pH 8 + 0.5 mM DTT + 50% glycerol.
Purity : Greater than 95.0%as determined by analysis by RP-HPLC and SDS-PAGE.
Storage : Store at 2-4°C ifentire vial will be used within 2-4 weeks. Store, frozen at -20°C for longerperiods of time. Please avoid freeze-thaw cycles.
OfficialSymbol : IL12A
Pathways : Africantrypanosomiasis; Allograft rejection; Amoebiasis; Chagas disease (Americantrypanosomiasis); Cytokine-cytokine receptor interaction; Herpes simplexinfection; IL12-mediated signaling events; IL27-mediated signaling events;Influenza A; Jak-STAT signaling pathway; Legionellosis; Leishmaniasis;Measles; Pertussis; RIG-I-like receptor signaling pathway
Gene Name : IL12A interleukin 12A (naturalkiller cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1,p35) [ Homo sapiens ]
Synonyms : IL12A; Interleukin12A (natural killer cell stimulatory factor 1, cytotoxic lymphocytematuration factor 1, p35); P35; CLMF; NFSK; NKSF1; IL-12A; interleukin-12subunit alpha; CLMF p35; IL35 subunit; IL-12 subunit p35; IL-12, subunit p35;OTTHUMP00000213703; OTTHUMP00000213704; OTTHUMP00000213705; interleukin 12,p35; interleukin-12 alpha chain; NF cell stimulatory factor chain 1; NK cellstimulatory factor chain 1; cytotoxic lymphocyte maturation factor 1, p35;cytotoxic lymphocyte maturation factor 35 kDa subunit; natural killer cellstimulatory factor 1, 35 kD subunit; Interleukin-12 subunit alpha; Cytotoxic lymphocyte maturation factor 35 kDa subunit
Gene ID : 3592
mRNA Refseq : NM_000882
Protein Refseq : NP_000873
MIM : 161560
UniProt ID : P29459
Chromosome Location : 3p12-q13.2
Function : interleukin-12 betasubunit binding ; Contributes to cytokine activity; contributes togrowth factor activity; interleukin-12 receptor binding; interleukin-27binding; protein heterodimerization activity; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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How do mass spectrometry-based techniques reveal post-translational modifications on IL12A? 08/18/2022

Mass spectrometry identifies IL12A's post-translational modifications and their roles.

What strategies validate IL12A's role in immune response modulation using knockout models? 06/12/2022

Knockout models validate IL12A's roles in immune response modulation.

How do protein footprinting assays unveil IL12A's binding interfaces with receptor partners? 06/26/2021

Protein footprinting assays reveal IL12A's binding interfaces with receptors.

What experimental methods quantify IL12A's secretion kinetics and stability in cell culture? 12/17/2020

ELISA and stability assays quantify IL12A secretion and stability in culture.

Can you discuss the use of SPR in characterizing IL12A's interactions with antibodies and inhibitors? 10/25/2020

SPR characterizes IL12A's interactions with antibodies and inhibitors.

What cellular assays assess IL12A's ability to induce cytokine production in immune cells? 05/19/2019

Cellular assays gauge IL12A's cytokine induction in immune cells.

How does isothermal titration calorimetry provide insights into IL12A's binding affinity with receptors? 06/05/2018

Isothermal titration calorimetry measures IL12A's binding affinity with receptors.

What techniques evaluate the impact of IL12A genetic variants on protein structure and function? 03/08/2018

Structural biology techniques analyze IL12A genetic variant impacts.

Could you elaborate on the use of site-directed mutagenesis in probing IL12A's functional domains? 11/23/2017

Site-directed mutagenesis probes IL12A's functional domains and interactions.

How does in vivo bioluminescence imaging track IL12A expression dynamics in living organisms? 02/16/2017

Bioluminescence imaging tracks IL12A expression dynamics in vivo.

Customer Reviews (3)

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Reviews
01/14/2021

    Suitable for co-immunoprecipitation.

    12/21/2020

      Consistent in bioactivity.

      11/16/2020

        Good for receptor binding studies.

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