||Human RecombinantInterleukin-12 p35 His produced in E. coli is single, a nonglycosylated,polypeptide chain containing 197 amino acids fragment (57-253) with anamino-terminal hexahistidine tag.
||This gene encodes asubunit of a cytokine that acts on T and natural killer cells, and has abroad array of biological activities. The cytokine is a disulfide-linkedheterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kDsubunit that is a member of the cytokine receptor family. This cytokine isrequired for the T-cell-independent induction of interferon (IFN)-gamma, andis important for the differentiation of both Th1 and Th2 cells.
||Interleukin-12 p35His-Tag is supplied in 20 mM Tris HCL pH 8 + 0.5 mM DTT + 50% glycerol.
||Greater than 95.0%as determined by analysis by RP-HPLC and SDS-PAGE.
||Store at 2-4°C ifentire vial will be used within 2-4 weeks. Store, frozen at -20°C for longerperiods of time. Please avoid freeze-thaw cycles.
||Africantrypanosomiasis; Allograft rejection; Amoebiasis; Chagas disease (Americantrypanosomiasis); Cytokine-cytokine receptor interaction; Herpes simplexinfection; IL12-mediated signaling events; IL27-mediated signaling events;Influenza A; Jak-STAT signaling pathway; Legionellosis; Leishmaniasis;Measles; Pertussis; RIG-I-like receptor signaling pathway