Recombinant Mouse Il12 Protein, Fc tagged

• Cat.No.: Il12a-086M
• Product Overview: The mouse IL-12 complex composed of the p40 subunit (aa 1-335) and the p35 subunit (aa 23-215) fused through a polypeptide linker to the Fc region of human IgG1 was expressed in CHO.

Specification

• Species: Mouse
• Source: CHO
• Tag: Fc
• Protein Length: p40 subunit: 1-335 aa p35 subunit: 23-215 aa
• Description: Enables interleukin-12 beta subunit binding activity. Contributes to cytokine activity. Acts upstream of or within several processes, including T-helper 1 cell activation; defense response to protozoan; and positive regulation of T cell activation. Located in cell surface; cytoplasm; and extracellular space. Part of interleukin-12 complex. Is expressed in brain; lung; small intestine; testis; and thymus. Human ortholog(s) of this gene implicated in hepatitis C; hepatocellular carcinoma; and primary biliary cholangitis. Orthologous to human IL12A (interleukin 12A).
• Form: Lyophilized from 0.2μm filtered solution in PBS.
• Molecular Mass: ~100-110 kDa (SDS-PAGE, reducing conditions)
• Endotoxin: <0.06 EU/μg protein (LAL test).
• Purity: ≥98% (SDS-PAGE)
• Notes: Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution.
• Storage: Short Term Storage: +4 centigrade Long Term Storage: -20 centigrade Stable for at least 1 year after receipt when stored at -20 centigrade. Working aliquots are stable for up to 3 months when stored at -20 centigrade.
• Shipping: BLUE ICE
• Reconstitution: Reconstitute at 100 μg/mL in sterile PBS.

Gene Information

• Gene Name: Il12a interleukin 12a [ Mus musculus (house mouse) ]
• Official Symbol: Il12a
• Synonyms: Il12a; interleukin 12a; p35; Ll12a; Il-12a; IL-12p35
• Gene ID: 16159
• mRNA Refseq: NM_008351
• Protein Refseq: NP_032377
• UniProt ID: P43431
• Gene Name 2: Il12b interleukin 12b [ Mus musculus (house mouse) ]
• Official Symbol 2: Il12b
• Synonyms 2: Il12b; interleukin 12b; p40; Il-12b; Il12p40; Il-12p40; interleukin-12 subunit beta; CLMF p40; IL-12 p40 subunit; IL-12 subunit p40; IL-23 subunit p40; cytotoxic lymphocyte maturation factor 40 kDa subunit; interleukin-12 p40 subunit
• Gene ID 2: 16160
• mRNA Refseq 2: NM_001303244
• Protein Refseq 2: NP_001290173
• UniProt ID 2: P43432