IL12A Protein

IL12A

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IL12A

Official Full Name interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
Background Interleukin 12 (IL12) is an important cytokine produced by a variety of immune effector cells that leads to a type 1 helper T cell (Th1) response. IL12 also directs T cells to the skin via induction of cutaneous lymphocyte antigen (CLA) expression. Interleukin 12 is a heterodimeric cytokine (p70), composed of two covalently linked subunits, p35 and p40.
Synonyms IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); NKSF1; interleukin-12 subunit alpha; CLMF; cytotoxic lymphocyte maturation factor 1; p35; IL 12; subunit p35; IL 12A; IL35 subunit; interleuk
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Dog
    • Feline
    • Human
    • Mouse
    • Pig
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • CHO
    • E. coli
    • E.coli
    • HEK293
    • Human Cell
    • Human cells
    • Insect Cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Sf9 Insect Cell
    • Yeast
    • Tag :
    • Fc
    • hFc
    • His
    • His(C-ter)
    • S
    • T7
    • human
    • IgG1
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL12A-113H Active Recombinant Human IL12A HEK293 N/A Inquiry
    Human IL12A-27H Active Recombinant Human IL12A/IL12B protein Insect Cell N/A Inquiry
    Rat Il12b&Il12a-748R Active Recombinant Rat Il12b&Il12a Sf21 Insect Cell N/A Inquiry
    Feline IL12B&IL12A-903F Active Recombinant Feline IL12B&IL12A Sf21 Insect Cell N/A Inquiry
    Mouse Il12a-01M Active Recombinant Mouse Il12a Protein, His-Tagged E.coli His Inquiry
    Human IL35-12H Recombinant Human IL12A/IL27B protein, Fc-tagged HEK293 Fc Inquiry
    Human IL12-21H Recombinant Human Interleukin-12 E.coli N/A Inquiry
    Human IL12A & IL12B-357H Recombinant Human IL12A & IL12B protein HEK293 N/A Inquiry
    Human IL12A-112H Recombinant Human IL12A HEK293 N/A Inquiry
    Human IL12A-132H Recombinant Human interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35), His-tagged E.coli His Inquiry
    Human IL12A-165H Rcombinant Human IL12A, His-Fc-tagged Human Cell His/Fc Inquiry
    Human IL12A-219H Recombinant Human IL12A Sf21 Insect Cell N/A Inquiry
    Human IL12A-26973TH Recombinant Human IL12A protein CHO N/A Inquiry
    Human IL12A-29635TH Recombinant Human IL12A, His-tagged E.coli His Inquiry
    Human IL12A-309H Recombinant Human IL12A protein, Fc-tagged HEK293 human/IgG1/Fc Inquiry
    Human IL12A-310H Recombinant Human IL12A Protein HEK293 N/A Inquiry
    Human IL12A-315H Recombinant Human IL12A, His tagged Human Cell His Inquiry
    Human IL12A-42H Recombinant Human IL12A, His-tagged E.coli N/A Inquiry
    Human IL12A-47H Recombinant Human IL12A Yeast N/A Inquiry
    Human IL12A-587H Recombinant Human IL12A protein, His-tagged E.coli His Inquiry
    Human IL12A-850H Recombinant Human IL12A protein, His & S-tagged E.coli His/S Inquiry
    Mouse Il12a-209M Recombinant Murine Interleukin 12a CHO N/A Inquiry
    Mouse Il12a-210M Recombinant Murine Interleukin 12a, P35-P40 Sf9 Insect Cell N/A Inquiry
    Mouse Il12a-211M Recombinant Murine Interleukin 12a, P35-P40 CHO N/A Inquiry
    Mouse Il12a-226M Recombinant Mouse Interleukin 12a Sf21 Insect Cell N/A Inquiry
    Mouse Il12a-227M Recombinant Mouse Interleukin 12a, P40 Sf21 Insect Cell N/A Inquiry
    Mouse Il12a-228M Recombinant Mouse Interleukin 12a, P80 CHO N/A Inquiry
    Mouse Il12a-851M Recombinant Mouse Il12a protein, His & T7-tagged E.coli His/T7 Inquiry
    Rat IL12A-3025R Recombinant Rat IL12A Protein Mammalian Cell His Inquiry
    Rat Il12a-853R Recombinant Rat Il12a protein, His & T7-tagged E.coli His/T7 Inquiry
    Cynomolgus Monkey IL12A-190C Recombinant Cynomolgus IL12A Human Cell N/A Inquiry
    Cynomolgus Monkey IL12A-191C Recombinant Cynomolgus IL12A, Fc-tagged Human Cell Fc Inquiry
    Rhesus Macaque IL12A-2229R Recombinant Rhesus monkey IL12A Protein, His-tagged Mammalian Cell His Inquiry
    Chicken IL12A-7141C Recombinant Chicken IL12A Mammalian Cell His Inquiry
    Zebrafish IL12A-1637Z Recombinant Zebrafish IL12A Mammalian Cell His Inquiry
    Pig IL12A-852P Recombinant Pig IL12A protein, His & T7-tagged E.coli His/T7 Inquiry
    Human IL12A & IL12B-1908HCL Recombinant Human IL12A & IL12B cell lysate Human Cell N/A Inquiry
    Human IL12A&IL27B-853HCL Recombinant Human IL12A&IL27B cell lysate Human Cell N/A Inquiry
    Human IL12A-2435HCL Recombinant Human IL12A cell lysate Human Cell N/A Inquiry
    Mouse IL12A & IL12B-1779MCL Recombinant Mouse IL12A & IL12B cell lysate Human Cell N/A Inquiry
    Mouse IL12A & IL12B-1780MCL Recombinant Mouse IL12A & IL12B cell lysate Human Cell N/A Inquiry
    Mouse IL12A & IL12B-1781MCL Recombinant Mouse IL12A & IL12B cell lysate Human Cell N/A Inquiry
    Mouse IL12A & IL12B-1782MCL Recombinant Mouse IL12A & IL12B cell lysate Human Cell N/A Inquiry
    Cynomolgus Monkey IL12A & IL12B-001CCL Recombinant Cynomolgus IL12A & IL12B cell lysate Human Cell N/A Inquiry
    Cynomolgus Monkey IL12A-001CCL Recombinant Cynomolgus IL12A cell lysate Human Cell N/A Inquiry
    Human IL12A-062H Recombinant Human IL12 Protein E. coli Inquiry
    Dog IL12A-1000D Recombinant Dog IL12A Protein, His-tagged E.coli N-His Inquiry
    Human IL12A-139H Recombinant Active Human IL12A Protein, His-tagged(C-ter) E.coli His(C-ter) Inquiry
    Mouse Il12a-140M Recombinant Active Mouse IL12A Protein, His-tagged(C-ter) E.coli His(C-ter) Inquiry
    Human IL12A-25H Recombinant Human IL12 Protein, Animal Free Human cells Inquiry
    Human IL12A-75H Recombinant Human IL12A Protein Human Cell Inquiry
    Rhesus IL12A-9483R Recombinant Rhesus IL12A protein, hFc-tagged HEK293 hFc Inquiry
    Human IL12A-129HG GMP Recombinant Human IL12A Protein Insect Cell N/A Inquiry
    Human IL12A-4327HG Recombinant Human IL12A protein CHO N/A Inquiry
    Mouse Il12a-086M Recombinant Mouse Il12a Protein CHO Inquiry

    IL12A involved in several pathways and played different roles in them. We selected most pathways IL12A participated on our site, such as Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL12A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction TGFB1; IFNAR2; IL3; CCR6A; CCL27B; EDAR; CXCL12A; Kitl; IL7; CXCL8
    Toll-like receptor signaling pathway CXCL8B.3; TLR8; IFNA1; IL12A; PIK3R3; AKT3A; IFNA14; IL12B; RAC1; CCL4L2
    RIG-I-like receptor signaling pathway NFKBIAA; IFNA14; RELA; IRF7; Ifna11; IFNA16; TRIM25; IFNA12; TBKBP1; IL-8
    Jak-STAT signaling pathway PIK3R3; LEP; SOCS7; SOS1; IL13RA1; CNTF; HRASB; JAK2B; PTPN11B; PIAS4B
    Type I diabetes mellitus LTA; HLA-A; HLA-DRB3; HLA-DQA1; HLA-C; ICA1; H2-Q10; HLA-DMB; IL1A; HLA-DRB4
    Pertussis RELA; MAPK13; CASP1; CASP7; GNAI1; CXCL5; GNAI3; C1S; MAPK12; NLRP3
    Legionellosis HSPA8; IL6; Casp3; RAB1; BCL2L13; ITGAM; C3; TLR5; ITGB2L; CLK1
    Leishmaniasis IL1B; FOS; HLA-DRB3; HLA-DQB1; IRAK4; HLA-DQA2; TRAF6; PTGS2; ITGB1; ITGAM
    Chagas disease (American trypanosomiasis) TGFBR2; CCL3L1; TLR9; IKBKB; PIK3R1; CFLAR; NOS2; CCL5; BDKRB2; MAP2K4
    African trypanosomiasis FAS; THOP1; IDO1; IL12A; FASLG; HPR; IL18; HBB-B1; IL10; PLCB4
    Malaria IFNG; IL12A; VCAM1; HBA2; CD40LG; HBB; IL1B; IL6; Ccl12; TLR2
    Toxoplasmosis LAMA3; TNFRSF1A; TLR2; TGFB3; HLA-DOB; IRAK4; CD40; HSPA2; PIK3CG; HLA-DOA
    Amoebiasis COL27A1; ADCY1; COL4A4; AASS; CD14; COL2A1; TLR4; COL5A2; ITGAM; RELA
    Tuberculosis NOS2; ATP6V0C; CD209C; TNF; HLA-DMA; IFNA1; VDR; HLA-DQA1; FCGR3; NFYA
    Measles AKT1; STAT5A; OAS1; IL6; Fasl; IRF7; TNFRSF10C; Cd209g; STAT5B; MX1
    Influenza A IFNA21; AKT2; OAS1; Fasl; IL8L1; TNFRSF10B; MAP2K4; CPSF4; HSPA1B; TNFRSF1A
    Herpes simplex infection OAS3; HLA-DMA; FOS; HLA-G; CCL5; EIF2S1B; TAP2; PPP1CC; NXF2; TYK2
    Inflammatory bowel disease (IBD) IL5; IL6; IL4R; TGFB2; IL22; HLA-DPA1; IL21; RORC; H2-AB1; IL1A
    Allograft rejection HLA-F; IL12A; IL4; IFNG; HLA-DQB1; HLA-DQA2; MICA; HLA-DOB; CD80; HLA-DQA1

    IL12A has several biochemical functions, for example, contributes_to cytokine activity, contributes_to growth factor activity, interleukin-12 beta subunit binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL12A itself. We selected most functions IL12A had, and list some proteins which have the same functions with IL12A. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to cytokine activity CLCF1; IL12B; IL12A; CRLF1
    contributes_to growth factor activity IL12A; IL12B
    interleukin-12 beta subunit binding IL12A
    interleukin-12 receptor binding IL12BA; JAK2; IL12A; IL12B
    interleukin-27 binding IL12A
    protein binding SOX4; KRT25; CBLN3; SELL; COLQ; NIPSNAP1; FAM206A; FKBP4; CD82; CCNL2
    protein heterodimerization activity HIST1H2BL; TGFB2; Bcl2a1b; CABYR; YWHAE; BDKRB2; HIST2H2AA4; SMAD3; ATP4A; HIST1H2AF

    IL12A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL12A here. Most of them are supplied by our site. Hope this information will be useful for your research of IL12A.

    IL12B; IL12RB1

    Senapati, S; Gutierrez-Achury, J; et al. Evaluation of European coeliac disease risk variants in a north Indian population. EUROPEAN JOURNAL OF HUMAN GENETICS 23:530-535(2015).
    Ruffell, B; Chang-Strachan, D; et al. Macrophage IL-10 Blocks CD8(+) T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells. CANCER CELL 26:623-637(2014).

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