IL12A
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Official Full Name
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
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Background
Interleukin 12 (IL12) is an important cytokine produced by a variety of immune effector cells that leads to a type 1 helper T cell (Th1) response. IL12 also directs T cells to the skin via induction of cutaneous lymphocyte antigen (CLA) expression. Interleukin 12 is a heterodimeric cytokine (p70), composed of two covalently linked subunits, p35 and p40. -
Synonyms
IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); NKSF1; interleukin-12 subunit alpha; CLMF; cytotoxic lymphocyte maturation factor 1; p35; IL 12; subunit p35; IL 12A; IL35 subunit; interleuk;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL12A Related Articles
- IL12A Related Gene Family
- IL12A Related Research Area
- IL12A Related Signal Pathway
IL12A involved in several pathways and played different roles in them. We selected most pathways IL12A participated on our site, such as Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL12A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | INHBC;TNFSF10;Cxcl15;KITLGA;ACVR2AA;CCL4;PDGFRB;PRL;TNFB |
| Toll-like receptor signaling pathway | IKBKG;TLR2-2;IFNA16;PIK3CB;IL12B;CCL3L3;LY96;TLR2-1;TLR1LB |
| RIG-I-like receptor signaling pathway | IFNW1;MAP3K1;MAPK11;RNF125;SIKE1;IL12B;IFNPHI3;IL-8;CASP10 |
| Jak-STAT signaling pathway | HRAS;AKT2;IL11;CSH1;CSH;STAT3;RAF1;AKT3A;TYK2 |
| Type I diabetes mellitus | HLA-B;HLA-DRB4;HSPD1;CD80;GAD2;Il2;CPE;HLA-DRB1;INS |
| Pertussis | C1S;C1QB;C4A;MAPK10;ITGB1;IL12B;TICAM2;MYD88;C4BP |
| Legionellosis | C3;HSPD1;IL18;VCP;NFKB2;CR1;EEF1A2;TNF;RAB1 |
| Leishmaniasis | TLR2;H2-AA;FCGR4;C3;MAPK3;HLA-DPA1;Itgam&Itgb2;TRAF6;ITGB1 |
| Chagas disease (American trypanosomiasis) | PLCB3;TLR2;CCL2;CXCL8;TICAM1;NOS2;C1QA;C1QB;IL12B |
| African trypanosomiasis | PRKCB;MYD88;F2RL1;PRKCG;IL18;IL1B2;HBB-B2;IL12B;Fasl |
| Malaria | IL-8;HBB;CD40LG;THBS4;KLRC4-KLRK1;HBA1;LRP1;TLR9;TLR2 |
| Toxoplasmosis | LAMA5;TNF;TGFB1;LAMB1;RELA;TRAF6;PIK3CB;PIK3R2;MAPK9 |
| Amoebiasis | FN1;ACTN3;PRKACA;TGFB2;LAMA2;PLCB4;HSPB1;COL4A4;PIK3R1 |
| Tuberculosis | CAMK2B;HLA-DRB1;NFYA;ITGAM;BAD;IFNA2;MRC1;IL1B;ITGAX |
| Measles | PIK3CA;RCHY1;NFKBIB;IL2RB;FCGR2B;IFNA14;CD3D;CBLB;CD209B |
| Influenza A | NFKBIA;TLR4;CPSF4;HLA-DOA;MAP2K6;CXCL10;HLA-DRB3;PRSS3;CCL5 |
| Herpes simplex infection | CUL1A;STAT2;FB06F03;DAXX;NXF1;CD74A;GTF2I;CSNK2A2A;EEF1DA |
| Inflammatory bowel disease (IBD) | IL17A;NFKB1;IL4R;IL18;IL5;HLA-DPA1;Il4ra;STAT3;TGFB1 |
| Allograft rejection | Fasl;CD40;FAS;IL10;HLA-DPB1;HLA-DRB1;HLA-DQA1;GZMB;HLA-F |
IL12A has several biochemical functions, for example, contributes_to cytokine activity, contributes_to growth factor activity, interleukin-12 beta subunit binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL12A itself. We selected most functions IL12A had, and list some proteins which have the same functions with IL12A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to cytokine activity | CLCF1;IL12B;CRLF1;IL12A |
| contributes_to growth factor activity | IL12A;IL12B |
| interleukin-12 beta subunit binding | |
| interleukin-12 receptor binding | IL12A;IL12B;JAK2;IL12BA |
| interleukin-27 binding | |
| protein binding | ANP32B;ATXN3;METTL21C;EPHA10;BTN2A2;FRS2;PELP1;FAM189B;GRAMD3 |
| protein heterodimerization activity | HER5;PANX1;UNC13A;ADRB1;DRAP1;UGT1A9;H2AFZ;SYT10;LIFR |
IL12A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL12A here. Most of them are supplied by our site. Hope this information will be useful for your research of IL12A.
IL12B; IL12RB1
- Q&As
- Reviews
Q&As (10)
Ask a questionMass spectrometry identifies IL12A's post-translational modifications and their roles.
Knockout models validate IL12A's roles in immune response modulation.
Protein footprinting assays reveal IL12A's binding interfaces with receptors.
ELISA and stability assays quantify IL12A secretion and stability in culture.
SPR characterizes IL12A's interactions with antibodies and inhibitors.
Cellular assays gauge IL12A's cytokine induction in immune cells.
Isothermal titration calorimetry measures IL12A's binding affinity with receptors.
Structural biology techniques analyze IL12A genetic variant impacts.
Site-directed mutagenesis probes IL12A's functional domains and interactions.
Bioluminescence imaging tracks IL12A expression dynamics in vivo.
Customer Reviews (3)
Write a reviewSuitable for co-immunoprecipitation. -
Consistent in bioactivity. -
Good for receptor binding studies. -
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