IL12A

  • Official Full Name

    interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)

  • Background

    Interleukin 12 (IL12) is an important cytokine produced by a variety of immune effector cells that leads to a type 1 helper T cell (Th1) response. IL12 also directs T cells to the skin via induction of cutaneous lymphocyte antigen (CLA) expression. Interleukin 12 is a heterodimeric cytokine (p70), composed of two covalently linked subunits, p35 and p40.
  • Synonyms

    IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); NKSF1; interleukin-12 subunit alpha; CLMF; cytotoxic lymphocyte maturation factor 1; p35; IL 12; subunit p35; IL 12A; IL35 subunit; interleuk;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • GMP Proteins
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Dog
    • Feline
    • Human
    • Mouse
    • Pig
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • CHO
    • E. coli
    • E.coli
    • HEK293
    • Human Cell
    • Human cells
    • Insect Cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Sf9 Insect Cell
    • Yeast
    • Tag :
    • Fc
    • hFc
    • His
    • His (Fc)
    • Avi
    • His(C
    • ter)
    • His|Fc
    • His|S
    • His|T7
    • human|IgG1|Fc
    • N/A
    • N
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Chicken IL12A-7141C Recombinant Chicken IL12A Mammalian Cell His
    Cynomolgus Monkey IL12A-190C Recombinant Cynomolgus IL12A Human Cell N/A
    Cynomolgus Monkey IL12A & IL12B-001CCL Recombinant Cynomolgus IL12A & IL12B cell lysate Human Cell N/A
    Cynomolgus Monkey IL12A-001CCL Recombinant Cynomolgus IL12A cell lysate Human Cell N/A
    Cynomolgus Monkey IL12A-191C Recombinant Cynomolgus IL12A, Fc-tagged Human Cell Fc
    Dog IL12A-1000D Recombinant Dog IL12A Protein, His-tagged E.coli N-His
    Feline IL12B&IL12A-903F Active Recombinant Feline IL12B&IL12A Sf21 Insect Cell N/A
    Human IL12A-2435HCL Recombinant Human IL12A cell lysate Human Cell N/A
    Human IL12A-112H Recombinant Human IL12A HEK293 N/A
    Human IL12A-139H Recombinant Active Human IL12A Protein, His-tagged(C-ter) E.coli His(C-ter)
    Human IL12A-4327HG Recombinant Human IL12A protein CHO N/A
    Human IL12A&IL27B-853HCL Recombinant Human IL12A&IL27B cell lysate Human Cell N/A
    Human IL12A-219H Recombinant Human IL12A Sf21 Insect Cell N/A
    Human IL12A-75H Recombinant Human IL12A Protein Human Cell
    Human IL12A-25H Recombinant Human IL12 Protein, Animal Free Human cells
    Human IL12A-309H Recombinant Human IL12A protein, Fc-tagged HEK293 human/IgG1/Fc
    Human IL12A-132H Recombinant Human interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35), His-tagged E.coli His
    Human IL12A-165H Rcombinant Human IL12A, His-Fc-tagged Human Cell His/Fc
    Human IL12A-113H Active Recombinant Human IL12A HEK293 N/A
    Human IL12A-27H Active Recombinant Human IL12A/IL12B protein Insect Cell N/A
    Human IL12A-850H Recombinant Human IL12A protein, His & S-tagged E.coli His/S
    Human IL35-12H Recombinant Human IL12A/IL27B protein, Fc-tagged HEK293 Fc
    Human IL12A & IL12B-1908HCL Recombinant Human IL12A & IL12B cell lysate Human Cell N/A
    Human IL12A-129HG GMP Recombinant Human IL12A Protein Insect Cell N/A
    Human IL12A-310H Recombinant Human IL12A Protein HEK293 N/A
    Human IL12A-587H Recombinant Human IL12A protein, His-tagged E.coli His
    Human IL12A-315H Recombinant Human IL12A, His tagged Human Cell His
    Human IL12A-501H Recombinant Human IL12A Protein, Fc-tagged Fc
    Human IL12A-062H Recombinant Human IL12 Protein E. coli
    Human IL12A & IL12B-357H Recombinant Human IL12A & IL12B protein HEK293 N/A
    Human IL12A-42H Recombinant Human IL12A, His-tagged E.coli N/A
    Human IL12A-0255H Recombinant Human IL12A protein, Fc-tagged HEK293 Fc
    Human IL12-21H Recombinant Human Interleukin-12 E.coli N/A
    Human IL12A-26973TH Recombinant Human IL12A protein CHO N/A
    Human IL12A-47H Recombinant Human IL12A Yeast N/A
    Human IL12A-29635TH Recombinant Human IL12A, His-tagged E.coli His
    Mouse Il12a-851M Recombinant Mouse Il12a protein, His & T7-tagged E.coli His/T7
    Mouse IL12A & IL12B-1782MCL Recombinant Mouse IL12A & IL12B cell lysate Human Cell N/A
    Mouse IL12A & IL12B-1780MCL Recombinant Mouse IL12A & IL12B cell lysate Human Cell N/A
    Mouse IL12A & IL12B-1779MCL Recombinant Mouse IL12A & IL12B cell lysate Human Cell N/A
    Mouse Il12a-209M Recombinant Murine Interleukin 12a CHO N/A
    Mouse Il12a-226M Recombinant Mouse Interleukin 12a Sf21 Insect Cell N/A
    Mouse Il12a-01M Active Recombinant Mouse Il12a Protein, His-Tagged E.coli His
    Mouse IL12A & IL12B-1781MCL Recombinant Mouse IL12A & IL12B cell lysate Human Cell N/A
    Mouse Il12a-211M Recombinant Murine Interleukin 12a, P35-P40 CHO N/A
    Mouse Il12a-227M Recombinant Mouse Interleukin 12a, P40 Sf21 Insect Cell N/A
    Mouse Il12a-140M Recombinant Active Mouse IL12A Protein, His-tagged(C-ter) E.coli His(C-ter)
    Mouse Il12a-086M Recombinant Mouse Il12a Protein CHO
    Mouse Il12a-210M Recombinant Murine Interleukin 12a, P35-P40 Sf9 Insect Cell N/A
    Mouse Il12a-228M Recombinant Mouse Interleukin 12a, P80 CHO N/A
    Pig IL12A-852P Recombinant Pig IL12A protein, His & T7-tagged E.coli His/T7
    Rat Il12a-853R Recombinant Rat Il12a protein, His & T7-tagged E.coli His/T7
    Rat Il12b&Il12a-748R Active Recombinant Rat Il12b&Il12a Sf21 Insect Cell N/A
    Rat IL12A-2680R-B Recombinant Rat IL12A Protein Pre-coupled Magnetic Beads HEK293
    Rat IL12A-3025R Recombinant Rat IL12A Protein Mammalian Cell His
    Rat IL12A-2680R Recombinant Rat IL12A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus IL12A-9483R Recombinant Rhesus IL12A protein, hFc-tagged HEK293 hFc
    Rhesus Macaque IL12A-2050R Recombinant Rhesus Macaque IL12A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus Macaque IL12A-2229R Recombinant Rhesus monkey IL12A Protein, His-tagged Mammalian Cell His
    Rhesus Macaque IL12A-2050R-B Recombinant Rhesus Macaque IL12A Protein Pre-coupled Magnetic Beads HEK293
    Zebrafish IL12A-1637Z Recombinant Zebrafish IL12A Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • IL12A Related Articles
    • IL12A Related Gene Family
    • IL12A Related Research Area
    • IL12A Related Signal Pathway

    IL12A involved in several pathways and played different roles in them. We selected most pathways IL12A participated on our site, such as Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL12A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interactionINHBC;TNFSF10;Cxcl15;KITLGA;ACVR2AA;CCL4;PDGFRB;PRL;TNFB
    Toll-like receptor signaling pathwayIKBKG;TLR2-2;IFNA16;PIK3CB;IL12B;CCL3L3;LY96;TLR2-1;TLR1LB
    RIG-I-like receptor signaling pathwayIFNW1;MAP3K1;MAPK11;RNF125;SIKE1;IL12B;IFNPHI3;IL-8;CASP10
    Jak-STAT signaling pathwayHRAS;AKT2;IL11;CSH1;CSH;STAT3;RAF1;AKT3A;TYK2
    Type I diabetes mellitusHLA-B;HLA-DRB4;HSPD1;CD80;GAD2;Il2;CPE;HLA-DRB1;INS
    PertussisC1S;C1QB;C4A;MAPK10;ITGB1;IL12B;TICAM2;MYD88;C4BP
    LegionellosisC3;HSPD1;IL18;VCP;NFKB2;CR1;EEF1A2;TNF;RAB1
    LeishmaniasisTLR2;H2-AA;FCGR4;C3;MAPK3;HLA-DPA1;Itgam&Itgb2;TRAF6;ITGB1
    Chagas disease (American trypanosomiasis)PLCB3;TLR2;CCL2;CXCL8;TICAM1;NOS2;C1QA;C1QB;IL12B
    African trypanosomiasisPRKCB;MYD88;F2RL1;PRKCG;IL18;IL1B2;HBB-B2;IL12B;Fasl
    MalariaIL-8;HBB;CD40LG;THBS4;KLRC4-KLRK1;HBA1;LRP1;TLR9;TLR2
    ToxoplasmosisLAMA5;TNF;TGFB1;LAMB1;RELA;TRAF6;PIK3CB;PIK3R2;MAPK9
    AmoebiasisFN1;ACTN3;PRKACA;TGFB2;LAMA2;PLCB4;HSPB1;COL4A4;PIK3R1
    TuberculosisCAMK2B;HLA-DRB1;NFYA;ITGAM;BAD;IFNA2;MRC1;IL1B;ITGAX
    MeaslesPIK3CA;RCHY1;NFKBIB;IL2RB;FCGR2B;IFNA14;CD3D;CBLB;CD209B
    Influenza ANFKBIA;TLR4;CPSF4;HLA-DOA;MAP2K6;CXCL10;HLA-DRB3;PRSS3;CCL5
    Herpes simplex infectionCUL1A;STAT2;FB06F03;DAXX;NXF1;CD74A;GTF2I;CSNK2A2A;EEF1DA
    Inflammatory bowel disease (IBD)IL17A;NFKB1;IL4R;IL18;IL5;HLA-DPA1;Il4ra;STAT3;TGFB1
    Allograft rejectionFasl;CD40;FAS;IL10;HLA-DPB1;HLA-DRB1;HLA-DQA1;GZMB;HLA-F

    IL12A has several biochemical functions, for example, contributes_to cytokine activity, contributes_to growth factor activity, interleukin-12 beta subunit binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL12A itself. We selected most functions IL12A had, and list some proteins which have the same functions with IL12A. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to cytokine activityCLCF1;IL12B;CRLF1;IL12A
    contributes_to growth factor activityIL12A;IL12B
    interleukin-12 beta subunit binding
    interleukin-12 receptor bindingIL12A;IL12B;JAK2;IL12BA
    interleukin-27 binding
    protein bindingANP32B;ATXN3;METTL21C;EPHA10;BTN2A2;FRS2;PELP1;FAM189B;GRAMD3
    protein heterodimerization activityHER5;PANX1;UNC13A;ADRB1;DRAP1;UGT1A9;H2AFZ;SYT10;LIFR

    IL12A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL12A here. Most of them are supplied by our site. Hope this information will be useful for your research of IL12A.

    IL12B; IL12RB1

    Senapati, S; Gutierrez-Achury, J; et al. Evaluation of European coeliac disease risk variants in a north Indian population. EUROPEAN JOURNAL OF HUMAN GENETICS 23:530-535(2015).
    Ruffell, B; Chang-Strachan, D; et al. Macrophage IL-10 Blocks CD8(+) T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells. CANCER CELL 26:623-637(2014).
    IL
    • Q&As
    • Reviews

    Q&As (10)

    Ask a question
    How do mass spectrometry-based techniques reveal post-translational modifications on IL12A? 08/18/2022

    Mass spectrometry identifies IL12A's post-translational modifications and their roles.

    What strategies validate IL12A's role in immune response modulation using knockout models? 06/12/2022

    Knockout models validate IL12A's roles in immune response modulation.

    How do protein footprinting assays unveil IL12A's binding interfaces with receptor partners? 06/26/2021

    Protein footprinting assays reveal IL12A's binding interfaces with receptors.

    What experimental methods quantify IL12A's secretion kinetics and stability in cell culture? 12/17/2020

    ELISA and stability assays quantify IL12A secretion and stability in culture.

    Can you discuss the use of SPR in characterizing IL12A's interactions with antibodies and inhibitors? 10/25/2020

    SPR characterizes IL12A's interactions with antibodies and inhibitors.

    What cellular assays assess IL12A's ability to induce cytokine production in immune cells? 05/19/2019

    Cellular assays gauge IL12A's cytokine induction in immune cells.

    How does isothermal titration calorimetry provide insights into IL12A's binding affinity with receptors? 06/05/2018

    Isothermal titration calorimetry measures IL12A's binding affinity with receptors.

    What techniques evaluate the impact of IL12A genetic variants on protein structure and function? 03/08/2018

    Structural biology techniques analyze IL12A genetic variant impacts.

    Could you elaborate on the use of site-directed mutagenesis in probing IL12A's functional domains? 11/23/2017

    Site-directed mutagenesis probes IL12A's functional domains and interactions.

    How does in vivo bioluminescence imaging track IL12A expression dynamics in living organisms? 02/16/2017

    Bioluminescence imaging tracks IL12A expression dynamics in vivo.

    Customer Reviews (3)

    Write a review
    Reviews
    01/14/2021

      Suitable for co-immunoprecipitation. -

      12/21/2020

        Consistent in bioactivity. -

        11/16/2020

          Good for receptor binding studies. -

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