Native Human Coagulation Factor XII (Hageman factor)


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Native Human Coagulation Factor XII (Hageman factor)

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Cat.No. : F12-5397H
Product Overview : HumanFactor beta-XIIa is a single chain polypeptide activated from homogeneous Human F12 by an autoactivation process with dextran sulfate.
Description : Human F12is generated in vivo by kallikrein cleavage of Factor alpha-XIIa and containsthe catalytic light chain and the C-terminal peptide of the heavy chain of Factoralpha-XIIa. Human Factor beta-XIIa is activated from homogeneous Human FactorXII by an autoactivation process with Dextran Sulfate followed byrepurification to isolate Factor alpha-XIIa and Factor beta-XIIa. Completeactivation is observed on SDSPAGE.
Source : Human plasma
Species : Human
Form : Frozen liquidcontaining 4 mM Sodium acetate Buffer + 0.15 M NaCl, pH 5.3.
Bio-activity : Determined byClotting Assay.
Molecular Mass : 30 kDa
Endotoxin : < 0.1 ng/μg ofprotein.>
Purity : ≥95% by SDS-PAGEanalysis.
Storage : Store at-80°C. Stable for 3 years from delivery. Avoid repeated freeze-thaw cycles.
Concentration : 2.0 mg/ml
Gene Name : F12 coagulation factor XII (Hageman factor) [ Homo sapiens ]
Official Symbol : F12
Synonyms : F12; coagulation factor XII (Hageman factor); coagulation factor XII; Hageman factor; beta-factor XIIa part 1; beta-factor XIIa part 2; coagulation factor XIIa heavy chain; coagulation factor XIIa light chain; HAF; HAE3; HAEX;
Gene ID : 2161
mRNA Refseq : NM_000505
Protein Refseq : NP_000496
MIM : 610619
UniProt ID : P00748
Chromosome Location : 5q33-qter
Pathway : Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; Hemostasis, organism-specific biosystem; Intrinsic Pathway, organism-specific biosystem;
Function : binding; misfolded protein binding; peptidase activity; protein binding; serine-type endopeptidase activity;

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