| Cat. No.: | CCL22-1874H |
| Product Overview: | Recombinant HumanCCL22 is a 8.0 kDa protein containing 67 amino acid residues. Its molecularweight is 8000 Dalton. |
| Description: | CCL22 is a proteinthat in humans is encoded by the CCL22 gene. The protein encoded by this geneis secreted by dendritic cells and macrophages, and elicits its effects onits target cells by interacting with cell surface chemokine receptors such asCCR4. The gene for CCL22 is located in human chromosome 16 in a cluster withother chemokines called CX3CL1 and CCL17. |
| Source: | E. coli |
| Species: | Human |
| Form: | Lyophilized |
| Molecular Weight: | 8.0 kDa |
| Purity: | Greater than 99% bySDS-PAGE and HPLC analyses. |
| Endotoxin Level: | < 0.1 ng/µg ofMDC |
| Biological Activity: | Determined by achemotaxis assay using human T-cells. Significant chemotaxis was achievedusing a concentration of 10.0-100 ng/ml. |
| Reconstitution: | Centrifuge vialprior to opening. The lyophilized MDC is soluble in water and most aqueousbuffers. The lyophilized human MDC can be reconstituted in water to aconcentration of 1.0 mg/ml. This solution can be diluted into other bufferedsolutions or stored frozen at -20°C for future use. |
| Storage: | Thelyophilized protein, though stable at room temperature, is best storeddesiccated below 0°C. Reconstituted MDC should be stored in working aliquotsat -20°C. Avoid repeated freeze-thaw cycles. |
| OfficialSymbol: | CCL22 |
| Gene Name: | CCL22 chemokine (C-C motif) ligand 22 [Homo sapiens ] |
| Synonyms: | CCL22; chemokine(C-C motif) ligand 22; MDC; ABCD-1; SCYA22; STCP-1; DC/B-CK; MGC34554;A-152E5.1; small inducible cytokine A22; CC chemokine STCP-1;macrophage-derived chemokine; stimulated T cell chemotactic protein 1; smallinducible cytokine subfamily A (Cys-Cys), member 22; Macrophage-derivedchemokine; Small-inducible cytokine A22; Stimulated T-cell chemotacticprotein 1; MDC(1-69) |
| Gene ID: | 6367 |
| mRNA Refseq: | NM_002990 |
| Protein Refseq: | NP_002981 |
| MIM: | 602957 |
| UniProt ID: | O00626 |
| Chromosome Location: | 16q13 |
| Pathway: | Chemokine receptorsbind chemokines; Chemokine signaling pathway; Cytokine-cytokine receptorinteraction; Class A/1 (Rhodopsin-like receptors); GPCR ligand binding;Peptide ligand-binding receptors; Signal Transduction; Signaling by GPCR |
| Function: | chemokine activity |
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