"Il4ra" Related Products


Recombinant Mouse Interleukin 4 Receptor, Alpha, Fc-tagged

Cat. No.: Il4ra-5662M
Product Overview: RecombinantMouse Il4ra protein was expressed in Murine myeloma celllinewith the Fc part of Human IgG1 Pro100-Lys330 (C-terminus) and MouseIl4ra Ile26-Arg233 (N-terminus).
Description: Il4ra isa widely expressed 140 kDa transmembrane glycoprotein in the class I cytokinereceptor family. Il4ra plays an important role in Th2-biased immuneresponses, alternative macrophage activation, mucosal immunity, allergic inflammation,tumor progression, and atherogenesis. Mature mouse Il4ra consists of a 208amino acid (aa) extracellular domain (ECD) that contains a ligand bindingregion and one fibronectin type-III domain, a 24 aa transmembrane segment, anda 553 aa cytoplasmic domain that contains one Box 1 motif and one ITIM motif.
Source: Murine myeloma cellline, NS0-derived.
Form: Lyophilizedfrom a 0.2 μm filtered solution in PBS.
N-terminalSequence: Ile26
MolecularWeight: 51 kDa
Activity: Measuredby its ability to inhibit the IL-4-dependent proliferation of HT-2 mouse helperT cells. The ED50 for this effect is typically 0.05-0.2 μg/mL in the presenceof 3 ng/mL of recombinant mouse IL-4.
Endotoxin Level: <1.0EU per 1μg of the protein by the LAL method.
SDS-PAGE: 65-85kDa, reducing conditions.
Purity: >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution: 100 μg/mLin sterile PBS
Storage: Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to-70°C under sterile conditions after reconstitution.
Gene Name: Il4ra interleukin 4 receptor,alpha [ Mus musculus ]
Official Symbol: Il4ra
Synonyms: Il4ra; interleukin 4receptor, alpha; Il4r; interleukin-4 receptor subunit alpha; IL-4RA;IL-4R-alpha; IL-4R subunit alpha; IL-4 receptor alpha chain; IL-4 receptorsubunit alpha; CD124
Gene ID: 16190
mRNA Refseq: NM_001008700
Protein Refseq: NP_001008700
UniProt ID: Q544A9
Chromosome Location: 7
Pathway: Cytokine-cytokinereceptor interaction; Hematopoietic cell lineage; IL-4 signaling Pathway;Inflammatory Response Pathway; Jak-STAT signaling pathway
Function: cytokine receptoractivity; protein binding; receptor activity

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