Cat. No. : |
EPOR-4114H |
Product Overview : |
A DNA sequence encoding the extracellular domain ( Met 1 - Pro 250 ) of human EPOR ( NP_000112.1 ) linked with the extracellular domain ( Trp 17 - Trp 443 ) of human CD131 ( NP_000386.1 ) by a peptide linker was fused with the Fc region of human IgG1 at the C-terminus. |
Description : |
EPOR is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 1 subfamily. |
Source : |
Human |
Host : |
Human Cells |
Form : |
Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
Purity : |
> 90 % as determined by SDS-PAGE |
Endotoxin : |
< 1.0 EU per μg protein as determined by the LAL method |
Stability : |
Samples are stable for up to twelve months from date of receipt at -70°C. |
Predicted N terminal : |
Ala 25 |
Molecular Mass : |
The recombinant human EPOR&CD131 / Fc chimera is a disulfide-linked homodimer of EPOR & CD131-Fc heterodimer. The reduced EPOR & CD131-Fc comprises 906 amino acids and has a calculated molecular mass of 101 kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 125 kDa in SDS-PAGE under reducing conditions. |
Storage : |
Store it under sterile conditions at -70°C upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles. |
Pathways : |
Cytokine-cytokine receptor interaction; EPO Receptor Signaling; EPO signaling pathway; Hematopoietic cell lineage; Jak-STAT siqnaling pathway; Kit Receptor Siqnaling Pathway; Paxillin-independent events mediated by a4b1 and a4b7; Siqnaling events mediated by Stem cell factor (c-Kit) |
Renderingof 1CN4 : |
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