Expand| Cat. No. : | EPOR-4114H |
| Product Overview : | A DNA sequence encoding the extracellular domain ( Met 1 - Pro 250 ) of human EPOR ( NP_000112.1 ) linked with the extracellular domain ( Trp 17 - Trp 443 ) of human CD131 ( NP_000386.1 ) by a peptide linker was fused with the Fc region of human IgG1 at the C-terminus. |
| Description : | EPOR is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 1 subfamily. |
| Source : | Human |
| Host : | Human Cells |
| Form : | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Purity : | > 90 % as determined by SDS-PAGE |
| Endotoxin : | < 1.0 EU per μg protein as determined by the LAL method |
| Stability : | Samples are stable for up to twelve months from date of receipt at -70°C. |
| Predicted N terminal : | Ala 25 |
| Molecular Mass : | The recombinant human EPOR&CD131 / Fc chimera is a disulfide-linked homodimer of EPOR & CD131-Fc heterodimer. The reduced EPOR & CD131-Fc comprises 906 amino acids and has a calculated molecular mass of 101 kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 125 kDa in SDS-PAGE under reducing conditions. |
| Storage : | Store it under sterile conditions at -70°C upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles. |
| Pathways : | Cytokine-cytokine receptor interaction; EPO Receptor Signaling; EPO signaling pathway; Hematopoietic cell lineage; Jak-STAT siqnaling pathway; Kit Receptor Siqnaling Pathway; Paxillin-independent events mediated by a4b1 and a4b7; Siqnaling events mediated by Stem cell factor (c-Kit) |
| Gene Name : | EPOR erythropoietin receptor [ Homo sapiens ] |
| Official Symbol : | EPOR |
| Synonyms : | EPOR; erythropoietin receptor; EPO-R; MGC138358; Erythropoietin receptor |
| Gene ID : | 2057 |
| mRNA Refseq : | NM_000121 |
| Protein Refseq : | NP_000112 |
| MIM : | 133171 |
| UniProt ID : | P19235 |
| Chromosome Location : | 19p13.3-p13.2 |
| Function : | erythropoietin receptor activity; identical protein binding; protein binding |
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