Rat Tnfa Crystal Structure

Cat. No.: Tnf-577R
Product Overview: A DNA sequence encoding the mature form of rat Tnfμ ( P16599 ) ( Leu 80 - Leu 235 ) was expressed and purified, with an initial Met at the N-terminus.
Description: Tnf is the prototypic cytokine of the the Tnf superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation.
Source: Native
Host: E. coli
Form: Lyophilized from sterile PBS , pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.
Purity: > 93 % as determined by SDS-PAGE
Endotoxin: μ1.0 EU per μg protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70°C.
Predicted N terminal: Met
Molecular Mass: The recombinant rat Tnfμ consisting of 157 amino acids and has a calculated molecular mass of 17.4 kDa. It migrates as an approximately 15 kDa band in SDS-PAGE under reducing conditions.
Storage: Store it under sterile conditions at -70°C upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles.
Gene Name: Tnf tumor necrosis factor (TNF superfamily, member 2) [ Rattus norvegicus ]
Official Symbol: Tnf
Synonyms: Tnf; tumor necrosis factor (TNF superfamily, member 2); Tnfa; RATTNF; MGC124630; TNF-alpha; tumor necrosis factor; TNF-a; cachectin; tumor necrosis factor alpha; tumor necrosis factor-alpha; tumor necrosis factor, alpha (cachetin); tumor necrosis factor superfamily member 2; tumor necrosis factor superfamily, member 2; tumor necrosis factor ligand superfamily member 2
Gene ID: 24835
mRNA Refseq: NM_012675
Protein Refseq: NP_036807
UniProt ID: TNFA_RAT
Chromosome Location: 20p12
Pathway: Adipogenesis; Allograft rejection; Amoebiasis; Apoptosis; Asthema; Death Receptor Signalling; Influenza A; Leishmaniasis; Malaria; Osteoclast differentiation; Pertussis; Rheumatoid arthritis; Toxoplasmosis; Tuberculosis; Type I diabetes mellitus
Function: Cytokine activity; identical protein binding; protease binding; transcription regulatory region DNA binding; tumor necrosis factor receptor binding

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