TNF

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TNF

Official Full Name tumor necrosis factor
Background This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]
Synonyms TNF; tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNF-a; cachectin; APC1 protein; TNF, monocyte-derived; TNF, macrophage-derived; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2;
    • Species :
    • Bovine
    • Canine
    • Cattle
    • Cotton Rat
    • Cynomolgus
    • Cynomolgus Monkey
    • Dog
    • Equine
    • Ferret
    • Guinea Pig
    • Horse
    • Human
    • Mouse
    • Pig
    • Porcine
    • Rabbit
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Rhesus monkey
    • Sheep
    • Woodchuck
    • Source :
    • Barley Grain
    • CHO
    • E. coli
    • E.coli
    • HEK293
    • HEK293F
    • HEK293T
    • Hordeum Vulgare
    • Human Cell
    • Human cells
    • Insect Cell
    • Mammalian Cell
    • Mouse
    • Nicotiana Benthamiana
    • P.pastoris
    • Steptomyces lividans
    • Streptomyces Lividans
    • Yeast
    • Tag :
    • Alexa Fluor 488
    • Fc
    • FLAG
    • His
    • Avi
    • DDK
    • MBP
    • S
    • T7
    • His-Avi
    • HQ
    • Met
    • Myc/DDK
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TNF-02H Recombinant Human TNF Protein, His-tagged Nicotiana Benthamiana His
    Human TNF-151H Recombinant Human TNF Protein, His-tagged Human cells His
    Woodchuck TNF-2306W Recombinant Woodchuck TNF protein, His-tagged Insect Cell His
    Human DMABT-H19209 Mouse Anti-TNF Monoclonal Antibody Mouse Alexa Fluor 488
    Human TNF-001H Recombinant Human TNF Protein, His-tagged E.coli His
    Human TNF-106HG GMP Recombinant Human TNF Protein E.coli N/A
    Human TNF-1106HG GMP Recombinant Human TNF protein HEK293
    Human TNF-1171H Recombinant Human TNF Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human TNF-1452H Recombinant Human TNF E.coli N/A
    Human TNF-154H Recombinant Human TNF protein HEK293 N/A
    Human TNF-171H Recombinant Human TNF Protein, Biotinylated E.coli N/A
    Human TNF-1914H Recombinant Human Tumor Necrosis Factor, HQ-tagged Hordeum Vulgare HQ
    Human TNF-194H Recombinant Human Tumor Necrosis Factor E.coli N/A
    Human TNF-2001H Recombinant Human TNF Protein, His-tagged E.coli His
    Human TNF-213H Recombinant Human TNF, StrepII-tagged Human Cell Strep II
    Human TNF-234H Recombinant Human TNF Protein, Fc-tagged HEK293 Fc
    Human TNF-235H Recombinant Human TNF protein, His/S-tagged E.coli His/S
    Human TNF-241H Recombinant Human TNF protein, His/DDK-tagged HEK293 His/DDK
    Human TNF-242H Recombinant Human TNF protein E.coli N/A
    Human TNF-243H Recombinant Human TNF protein, His-tagged E.coli His
    Human TNF-244H Recombinant Human TNF protein, His-tagged E.coli His
    Human TNF-245H Recombinant Human TNF protein E.coli N/A
    Human TNF-246H Recombinant Human TNF protein E.coli N/A
    Human TNF-24H Recombinant Human Tumor Necrosis Factor alpha-1a E.coli N/A
    Human TNF-25H Recombinant Human Mutant Tumor Necrosis Factor Alpha E.coli N/A
    Human TNF-279H Recombinant Human TNF, Biotinylated HEK293 N/A
    Human TNF-30942TH Recombinant Human TNF N/A
    Human TNF-30945TH Recombinant Human TNF, His-tagged His
    Human TNF-311H Recombinant Human TNF protein, His-Avi-tagged HEK293 His-Avi
    Human TNF-3315H Recombinant Human TNF protein, His-tagged HEK293 His
    Human TNF-346H Recombinant Human TNF protein, His/MBP-tagged E.coli His/MBP
    Human TNF-347H Recombinant Human TNF protein, His/MBP-tagged E.coli His/MBP
    Human TNF-35H Recombinant Human TNF, His-tagged Barley Grain His
    Human TNF-361H Recombinant Human TNF protein, His & Avi-tagged, Biotinylated HEK293 His/Avi
    Human TNF-378H Recombinant Human Tumor Necrosis Factor HEK293 N/A
    Human TNF-379H Recombinant Human Tumor Necrosis Factor, His-tagged E.coli His
    Human TNF-38H Recombinant Human TNF protein E.coli N/A
    Human TNF-408H Recombinant Human TNF Protein, FLAG-tagged HEK293T FLAG
    Human TNF-412H Recombinant Human TNF protein, FLAG-tagged HEK293 FLAG
    Human TNF-413H Recombinant Human TNF, Fc Chimera CHO Fc
    Human TNF-431H Recombinant Human TNF Yeast N/A
    Human TNF-4342HG GMP Recombinant Human TNF protein E.coli N/A
    Human TNF-43H Human Tumour Necrosis Factor alpha ( rDNA derived) Reference standard N/A
    Human TNF-511H Recombinant Human TNF protein, low endotoxin (HPLC-verified) HEK293
    Human TNF-63H Recombinant Human TNF Protein, FLAG-tagged E.coli FLAG
    Human TNF-72H Recombinant Human TNF, His-tagged E.coli N/A
    Human TNF-76H Recombinant Human Tumor Necrosis Factor-Alpha Variant, biologically active E.coli N/A
    Human TNF-897HCL Recombinant Human TNF 293 Cell Lysate HEK293 N/A
    Mouse Tnf-140M Recombinant Mouse Tnf Protein E.coli
    Mouse TNF-1998M Recombinant Mouse TNF Protein E.coli N/A
    Mouse Tnf-22M Recombinant Mouse Tnf Protein E.coli N/A
    Mouse Tnf-236M Recombinant Mouse Tnf protein, His/S-tagged E.coli His/S
    Mouse Tnf-310M Recombinant Mouse Tumor Necrosis Factor Streptomyces Lividans N/A
    Mouse Tnf-331M Recombinant Murine Tumor Necrosis Factor Steptomyces lividans N/A
    Mouse Tnf-371M Recombinant Mouse Tumor Necrosis Factor Mouse N/A
    Mouse Tnf-456MG GMP Recombinant Mouse Tnf protein, His-tagged HEK293 His
    Mouse Tnf-484M Recombinant Mouse Tnf protein E.coli N/A
    Mouse Tnf-484MB Recombinant Mouse Tnf protein, Biotinylated E. coli
    Mouse Tnf-494M Recombinant Mouse Tnf protein, His-tagged HEK293F His
    Mouse Tnf-495M Recombinant Mouse Tnf Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
    Mouse Tnf-509M Recombinant Mouse Tnf Streptomyces Lividans N/A
    Mouse Tnf-533M Recombinant Mouse Tnf protein, His-tagged E.coli His
    Mouse Tnf-538M Recombinant Mouse Tnf protein, His-tagged HEK293F His
    Mouse TNF-64M Recombinant Mouse TNF-alpha Soluble, FLAG-tagged Flag
    Mouse Tnf-6539M Recombinant Mouse Tnf Protein E. coli
    Mouse Tnf-6540M Recombinant Mouse Tnf Protein E. coli
    Mouse Tnf-6541M Recombinant Mouse Tnf Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Tnf-67M Recombinant Mouse Tnf protein, His-tagged Insect Cell His
    Mouse Tnf-7357M Recombinant Mouse Tnf Protein E.coli
    Mouse TNF-818M Recombinant Mouse TNF Protein (Leu80-Leu235), His-tagged, Biotinylated E.coli His
    Rat TNF-1071R Recombinant Rat TNF Protein E.coli N/A
    Rat Tnf-108R Recombinant Rat Tnf, His-tagged E.coli His
    Rat Tnf-109RG GMP Recombinant Rat Tnf protein, His-tagged HEK293 His
    Rat Tnf-237R Recombinant Rat Tnf protein, His/S-tagged E.coli His/S
    Rat Tnf-381R Recombinant Rat Tnf P.pastoris N/A
    Rat Tnf-564R Recombinant Rat Tnf protein, His-tagged E.coli His
    Rat Tnf-577R Rat Tnfa Crystal Structure N/A
    Rat TNF-6193R Recombinant Rat TNF Protein Mammalian Cell His
    Rat Tnf-71R Recombinant Rat Tnf protein E.coli N/A
    Rat TNF-97R Recombinant Rat TNF, Flag-tagged E.coli Flag
    Cynomolgus Monkey TNF-1038C Recombinant Cynomolgus TNF Protein, His-tagged Mammalian Cell His
    Cynomolgus Monkey TNF-1168C Recombinant Cynomolgus TNF Protein E.coli N/A
    Cynomolgus TNF-1168CB Recombinant Cynomolgus TNF protein, Biotinylated E. coli
    Rhesus TNF-1387R Recombinant Rhesus TNF protein E.coli N/A
    Rhesus Macaque TNF-4860R Recombinant Rhesus monkey TNF Protein, His-tagged Mammalian Cell His
    Rhesus monkey TNF-566R Recombinant Rhesus monkey TNF protein, His & T7-tagged E.coli His/T7
    Dog TNF-379D Recombinant Dog Tumor Necrosis Factor P.pastoris N/A
    Canine TNF-480C Recombinant Canine TNF, None tagged E.coli N/A
    Canine TNF-504C Recombinant Canine TNF, Met-tagged E.coli Met
    Dog TNF-558D Recombinant Dog TNF protein, His-tagged E.coli His
    Canine TNF-782C Recombinant Canine TNF protein E.coli N/A
    Bovine TNF-378B Recombinant Bovine Tumor Necrosis Factor P.pastoris N/A
    Bovine TNF-716B Recombinant Bovine TNF Protein E.coli N/A
    Rabbit Tnf-311R Recombinant Rabbit TNF protein E.coli N/A
    Rabbit TNF-565R Recombinant Rabbit TNF protein, His & T7-tagged E.coli His/T7
    Rabbit TNF-668R Recombinant Rabbit TNF, Met-tagged E.coli Met
    Rabbit TNF-796R Recombinant Rabbit Tumor Necrosis Factor E.coli N/A
    Ferret TNF-1022F Recombinant Ferret TNF Protein E.coli N/A
    Guinea Pig Tnf-308P Recombinant Guinea Pig Tnf Yeast N/A
    Pig TNF-309P Recombinant Porcine Tumor Necrosis Factor E.coli N/A
    Pig TNF-33 Tumor necrosis factor alpha Fc-tagged HEK293 N/A
    Pig TNF-369S Recombinant Swine Tumor Necrosis Factor (TNF Superfamily, Member 2) Yeast N/A
    Equine TNF-380H Recombinant Horse Tumor Necrosis Factor P.pastoris N/A
    Cotton Rat Tnf-391C Recombinant Cotton Rat Tnf, Met-tagged E.coli Met
    Porcine TNF-5525P Recombinant Porcine Tumor Necrosis Factor E.coli N/A
    Cattle TNF-557C Recombinant Cattle TNF protein, His & T7-tagged E.coli His/T7
    Horse TNF-559H Recombinant Horse TNF protein, His & T7-tagged E.coli His/T7
    Sheep TNF-562S Recombinant Sheep TNF protein, His & T7-tagged E.coli His/T7
    Pig TNF-563P Recombinant Pig TNF protein, His-tagged E.coli His
    Equine TNF-666E Recombinant Equine TNF, Met-tagged E.coli Met
    Pig TNF-79P Recombinant Porcine Tumor Necrosis Factor-Alpha, biologically active E.coli N/A

    TNF involved in several pathways and played different roles in them. We selected most pathways TNF participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway MRAS; ARR3B; GRB2A; NGF; ARRB2A; ARR3A; RELB; MAP2K2B; ATF4B1; FGF20
    Cytokine-cytokine receptor interaction IL12B; NT5C3; CCR5; CCL11; IL17B; CCL21B; IL22; TGFBR2; IFNB1; LIFR
    NF-kappa B signaling pathway PLCG1; GADD45B; TNFSF14; CCL19; BLNK; TNFRSF11A; IL1B; CFLAR; CD40; XIAP
    Sphingolipid signaling pathway PPP2CA; BID; SPTLC1; LASS1; AKT1; MAP2K2; LOC100328615; MAPK9; SMPD2; GNA12
    mTOR signaling pathway TSC1B; PRKCBA; PIK3CB; PDPK1; TSC1; PRR5; ULK1; MAPK3; ULK2; RRAGCA
    Apoptosis IL1A; AKT1; GZMF; STK24B; NMT1; TNFSF10; CASP3A; PIK3R3A; CAPN2; RELA
    TGF-beta signaling pathway NODAL; TGFB1A; ROCK1; BMPR1A; NOG; TGFB3; INHBA; ID1; SMAD4; RHOAC
    Osteoclast differentiation NOX1; TGFBR1; FCGR2A; MAPK11; FCGR3A; NFKBIA; NCF4; MAP2K6; LILRA1; TNFRSF11A
    Antigen processing and presentation RFXANK; HSPA1L; IFI30; LGMN; KIR2DS5; HLA-DPB1; KIR3DL2; TAP1; HLA-DRB3; HLA-E
    Toll-like receptor signaling pathway PIK3R3A; CD14; IL1B; IFNA3; CCL5; TNF; TLR1LA; AKT1; TLR1LB; MAP2K7
    NOD-like receptor signaling pathway HSP90B1; NFKBIA; MAPK12B; LOC100033925; TRAF6; CASP8; CCL2; TAB2; NFKBIAB; TNF
    RIG-I-like receptor signaling pathway NLRX1; NFKBIB; MAPK9; NT5C3; IFNA1; PL10; IFNA5; RELA; IL12A; IFNW1
    Hematopoietic cell lineage Kitl; IL3RA; CD1C; IL1R1; ITGA6; FLT3LG; CD37; CD8B1; CD1E; DNTT
    Natural killer cell mediated cytotoxicity IFNA16; MAP2K1; KLRC4-KLRK1; GZMB; IFNB1; KLRD1; FCGR3A; SYK; MAPK3; BID
    T cell receptor signaling pathway MAPK9; CD8A; CBL; Il2; AKT1; PPP3CB; PDCD1; LCK; ZAP70; PPP3CC
    Fc epsilon RI signaling pathway MAP2K2; MAPK1; MAPK8; MAPK9; MAPK12; VAV2; MAPK11; MAP2K4; PIK3CD; PIK3CG
    TNF signaling pathway MAPK12; RELA; BCL3; RPS6KA5; AKT1; MMP14; MMP9; Ccl12; SOCS3; PGAM5
    Adipocytokine signaling pathway G6PCA.1; G6PCA.2; TNFRSF1A; AKT1; AKT2; POMCA; ACSL1; CHUK; RXRBA; ACSL4
    Type II diabetes mellitus SOCS4; HK3; PIK3R2; ADIPOQ; MAPK1; PRKCE; IRS4; IRS2; PRKCD; SLC2A4
    Insulin resistance PIK3R3B; MAPK8B; NR1H3; NR1H2; TNF; NOS3; RPS6KA2; PTPN11A; CREB1A; G6PC3
    Non-alcoholic fatty liver disease (NAFLD) PRKAA1; ERN1; SREBF1; UQCRB; GSK3A; TNF; NDUFA1; NDUFB11; IRS2; INS
    Type I diabetes mellitus H2-Q10; H2-AA; IL1A; IL12B; HLA-DOA; FAS; HLA-DRB5; INS; FASLG; INS2
    Alzheimers disease CAPN2; NDUFV1; NDUFA5; GRIN2B; SDHC; NDUFB11; SNCA; NDUFA10; NDUFC2-KCTD14; IL1B
    Amyotrophic lateral sclerosis (ALS) BID; PRPH; TNFRSF1A; MAPK13; TOMM40L; MAPK11; APAF1; MAPK14; TRP53; MAP3K5
    Pertussis IL1B; MAPK12; CXCL6; C2; GM5077; IRF1; C4A; IL1A; Il23a; NFKB1
    Legionellosis C3; VCP; SAR1A; TNF; RAB1; CXCL1; BCL2L13; CR1; NLRC4; NFKB2
    Leishmaniasis PTPN6; Itgam&Itgb2; H2-AB1; FCGR2A; MAPK12; HLA-DQA2; HLA-DOA; MAP3K7; TNF; FOS
    Chagas disease (American trypanosomiasis) IL10; PPP2R2C; FADD; PPP2R1A; TLR2; CFLAR; CCL3; RELA; CCL5; CD3D
    African trypanosomiasis IL6; ICAM1; FASLG; HBA2; HBB; TNF; HBA-A2; VCAM1; IL18; THOP1
    Malaria TGFB1; IFNG; TLR2; HBB-B2; ITGB2; KLRC4-KLRK1; IL6; COMP; MET; LRP1
    Toxoplasmosis IFNGR1; MAPK8; BCL2; AKT1; SOCS1; IL12B; HLA-DPB1; NFKBIB; HLA-DRB1; TAB2
    Amoebiasis CSF2; CXCL1; ITGB2; GNA11; GNAS; ACTN4; TNF; PRKCG; PIK3CA; IL1R1
    Tuberculosis IL12A; CD74; KSR1; HLA-DRB5; BCL2; MYD88; CASP8; IFNA12; HLA-DOB; H2-AB1
    Hepatitis C IKBKG; Ifna11; PDPK1; OAS3; TNF; IFNA6; STAT1; IL-8; MAPK12; IFNA1
    Hepatitis B IL6; IRF3; IRF7; MAP2K4; IFNA8; TLR4; TLR3; RELA; SMAD4; Casp3
    Influenza A IFNA12; PRSS3; IRF7; IL18; KPNA1; IFNA2; NXF1; LOC100686744; GSK3B; IFNGR2
    HTLV-I infection TP53; PRKACA; GM-CSF; NFKBIA; KRAS; TNFRSF1A; PDGFB; MSX2; MAPK8; TRP53INP1
    Herpes simplex infection IFNB; CD74; MAVS; IRF9; TAF6L; TLR2; IFNGR1; NFKBIAA; IFNA17; CSNK2A2A
    Proteoglycans in cancer MAPK13; TGFB2; ACTG1; ARHGEF12; IGF2; FZD5; GAB1; MAP2K2; WNT9B; MTOR
    Asthma EPX; RNASE3; HLA-DMA; TNF; PRG2; HLA-DOB; FCER1A; HLA-DRB4; H2-AA; IL10
    Inflammatory bowel disease (IBD) IL21R; IL22; RORC; HLA-DOA; IL2RG; IL5; TGFB2; HLA-DPA1; SMAD2; IL12RB1
    Systemic lupus erythematosus HLA-DQA2; HIST1H2AG; C1RA; HIST1H2AK; HIST1H2AF; HLA-DPA1; GM14478; CD86; C1QC; H2-AB1
    Rheumatoid arthritis ATP6V1C2; MMP1A; H2-AA; CCL3L1; ICAM1; ITGB2L; ATP6V1E1; ATP6AP1; Il23a; Il12b; TLR2
    Allograft rejection CD28; HLA-F; HLA-DOA; CD40; Il2; IL4; HLA-DQA2; HLA-DRB1; HLA-DRA; HLA-E
    Graft-versus-host disease GZMB; HLA-G; HLA-B; IL1B; H2-AB1; HLA-DPA1; FASLG; FAS; HLA-DRB4; Fasl
    Hypertrophic cardiomyopathy (HCM) PRKAA1; CACNB4; ITGA5; MYL3; CACNA2D1; TGFB3; PRKAG3; ACE; TNNC1; CACNB2
    Dilated cardiomyopathy TGFB2; SGCG; ITGB7; ITGA6; CACNB3; ATP2A2; TPM3; PRKACA; CACNG2; CACNA2D3

    TNF has several biochemical functions, for example, cytokine activity, identical protein binding, protease binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNF itself. We selected most functions TNF had, and list some proteins which have the same functions with TNF. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity CMTM6; TNFSF12; Kitl; VSTM1; VEGFA; CMTM2; NAMPT; CMTM3; IL11; BMP7A
    identical protein binding SRPX2; APIP; UHRF1; ERBB3; ZHX2; SLIT2; E2F7; FUS; VIM; SDCBP
    protease binding Casp3; MALT1; INSL3; TIMP4; SERPINA5; CNTNAP2; POLG; TRIP4; BCL10; TIMP3
    protein binding FAM32A; ALDOC; ORAI3; SNX31; CHD4; FYB; CABP5; COIL; TMEM41A; ZBTB26
    transcription regulatory region DNA binding TRP63; AIRE; GRHL1; NR1D1; CBX4; FOXA2; GATA5; RFX3; RELA; TCF7L1B
    tumor necrosis factor receptor binding TNFSF9; TRIM37; TNFSF12; TNFSF15; LTB; TNFSF13; TNF; TNFSF4; TRAF2; TNFSF13B

    TNF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNF here. Most of them are supplied by our site. Hope this information will be useful for your research of TNF.

    TNFRSF1A; RIPK1; BIRC2; crmE

    Li, XY; Yue, Y; et al. Extracellular, but not intracellular HMGB1, facilitates self-DNA induced macrophage activation via promoting DNA accumulation in endosomes and contributes to the pathogenesis of lupus nephritis. MOLECULAR IMMUNOLOGY 65:177-188(2015).
    Lee, JS; Kwon, DS; et al. Mechanism of macrophage activation induced by polysaccharide from Cordyceps militaris culture broth. CARBOHYDRATE POLYMERS 120:29-37(2015).

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