TNF

  • Official Full Name

    tumor necrosis factor

  • Overview

    This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]
  • Synonyms

    TNF; tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNF-a; cachectin; APC1 protein; TNF, monocyte-derived; TNF, macrophage-derived; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2;

  • Recombinant Proteins
  • GMP Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Antibody
  • Bos taurus (Bovine)
  • Bovine
  • Canine
  • Cattle
  • Cotton Rat
  • Cynomolgus
  • Cynomolgus Monkey
  • Cynomolgus/Rhesus
  • Dog
  • Equine
  • Equus caballus (Horse)
  • Felis catus (Cat) (Felis silvestris catus)
  • Ferret
  • Goat
  • Guinea pig
  • Guinea Pig
  • Horse
  • Human
  • Macaca mulatta (Rhesus macaque)
  • Mouse
  • Mus musculus (Mouse)
  • Oryctolagus cuniculus (Rabbit)
  • Pig
  • Porcine
  • Rabbit
  • Rat
  • Rhesus
  • Rhesus macaque
  • Rhesus Macaque
  • Rhesus monkey
  • Sheep
  • Sus scrofa (Pig)
  • Woodchuck
  • Barley Grain
  • CHO
  • CHO-K1
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293 cells
  • HEK293F
  • HEK293T
  • Hordeum Vulgare
  • Human Cell
  • Human cells
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Mouse
  • Nicotiana Benthamiana
  • P. pastoris
  • P.pastoris
  • Steptomyces lividans
  • Streptomyces Lividans
  • Yeast
  • Alexa Fluor 488
  • C
  • 6×His
  • His
  • Fc
  • Flag
  • FLAG
  • GST
  • hFc
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • His|Avi
  • His|DDK
  • His|MBP
  • His|S
  • His|T7
  • B2M
  • SUMO
  • HQ
  • Met
  • Myc
  • DDK
  • N/A
  • N
  • Strep II
  • Tag free
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TNF-154H Active Recombinant Human TNF protein HEK293 N/A
Human TNF-412H Active Recombinant Human TNF protein, FLAG-tagged HEK293 FLAG
Human TNF-246H Active Recombinant Human TNF protein E.coli N/A Val77-Leu233
Human TNF-431H Active Recombinant Human TNF Yeast N/A
Human TNF-242H Active Recombinant Human TNF protein E.coli N/A
Human TNF-1452H Active Recombinant Human TNF E.coli N/A
Human TNF-361H Active Recombinant Human TNF protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Val77-Leu233
Human TNF-234H Active Recombinant Human TNF protein, hFc-tagged HEK293 hFc Val77-Leu233
Human TNF-171H Active Recombinant Human TNF Protein, Biotinylated E.coli N/A Val77-Leu233
Human TNF-149T Active Recombinant Human TNF Protein (157 aa) P. pastoris 157
Human TNF-11HG Active Recombinant Human TNF Protein (Val77-Leu233), GMP Grade, Animal-Free E.coli Val77-Leu233
Human TNF-106HG Active GMP Recombinant Human TNF Protein E.coli N/A
Human TNF-249H Active Recombinant Human TNF Protein E.coli
Human TNF-306T Active Recombinant Human TNF Protein (164 aa), His-tagged E.coli His 164
Human TNF-304T Active Recombinant Human TNF Protein (157 aa) E.coli 157
Human TNF-01HG Active GMP Recombinant Human TNF Protein CHO-K1
Human TNF-732H Active Recombinant Human TNF Protein E.coli Tag Free
Human TNF-307H Recombinant Active Human TNF Protein, His-tagged(C-ter) E.coli His(C-ter)
Human TNF-49H Active Recombinant Human TNF Protein, Animal Free Human cells
Human TNF-290H Active Recombinant Human TNF Protein (Val77-Leu233), C-His tagged, Animal-free, Carrier-free E.coli C-His Val77-Leu233
Human TNF-242HA Active Recombinant Human TNF protein, APC labeled E.coli Tag Free
Human TNF-24H Recombinant Human Tumor Necrosis Factor alpha-1a E.coli N/A
Human TNF-244H Recombinant Human TNF protein, His-tagged E.coli His
Human TNF-413H Recombinant Human TNF, Fc Chimera CHO Fc
Human TNF-194H Recombinant Human Tumor Necrosis Factor E.coli N/A
Human TNF-408H Active Recombinant Human TNF Protein, FLAG-tagged HEK293T FLAG
Human TNF-279H Recombinant Human TNF, Biotinylated HEK293 N/A
Human TNF-63H Active Recombinant Human TNF Protein, FLAG-tagged E.coli FLAG
Human TNF-378H Recombinant Human Tumor Necrosis Factor HEK293 N/A
Human TNF-72H Recombinant Human TNF, His-tagged E.coli N/A
Human TNF-1914H Recombinant Human Tumor Necrosis Factor, HQ-tagged Hordeum Vulgare HQ
Human TNF-379H Recombinant Human Tumor Necrosis Factor, His-tagged E.coli His
Human TNF-38H Recombinant Human TNF protein E.coli N/A 151
Human TNF-30945TH Recombinant Human TNF, His-tagged His
Human TNF-25H Recombinant Human Mutant Tumor Necrosis Factor Alpha E.coli N/A
Human TNF-30942TH Recombinant Human TNF N/A
Human TNF-76H Recombinant Human Tumor Necrosis Factor-Alpha Variant, biologically active E.coli N/A 158 amino acids
Human TNF-35H Recombinant Human TNF, His-tagged Barley Grain His
Human TNF-511H Recombinant Human TNF protein, low endotoxin (HPLC-verified) HEK293 157
Human TNF-346H Recombinant Human TNF protein, His/MBP-tagged E.coli His/MBP 1-30 aa
Human TNF-35H Recombinant Human TNF protein, His-tagged Insect Cell His
Human TNF-213H Recombinant Human TNF, StrepII-tagged Human Cell Strep II 77-233, 157 a.a.
Human TNF-3315H Active Recombinant Human TNF protein, His-tagged HEK293 His Val 77 - Leu 233
Human TNF-243H Recombinant Human TNF protein, His-tagged E.coli His 164
Human TNF-347H Recombinant Human TNF protein, His/MBP-tagged E.coli His/MBP 57-255 aa
Human TNF-235H Recombinant Human TNF protein, His/S-tagged E.coli His/S
Human TNF-245H Recombinant Human TNF protein E.coli N/A 158
Human TNF-241H Recombinant Human TNF protein, His/DDK-tagged HEK293 His/DDK
Human TNF-897HCL Recombinant Human TNF 293 Cell Lysate HEK293 N/A
Human TNF-2001H Recombinant Human TNF Protein, His-tagged E.coli His Val77-Leu233
Human TNF-1171H Recombinant Human TNF Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TNF-02H Recombinant Human TNF Protein, His-tagged Nicotiana Benthamiana His 77-233
Human TNF-43H Human Tumour Necrosis Factor alpha ( rDNA derived) Reference standard N/A
Human TNF-001H Recombinant Human TNF Protein, His-tagged E.coli His 77-233
Human TNF-6471H Recombinant Human TNF Protein (Gly57-Leu233), N-His tagged E.coli N-His Gly57-Leu233
Human TNF-51H Recombinant Human TNF Protein E.coli
Human TNF-2217H Recombinant Human TNF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TNF-1106HG Active GMP Recombinant Human TNF protein HEK293
Human TNF-209HFL Active Recombinant Full Length Human TNF Protein, C-Flag-tagged Mammalian cells Flag
Human TNFSF11-208HAF488 Recombinant Human TNFSF11 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 443
Human TNF-530H Recombinant Human TNF Protein, Biotinylated 233
Human TNF-311H Recombinant Human TNF protein, His-Avi-tagged HEK293 His-Avi It contains Val77-Leu233 .
Human TNF-0806H Recombinant Human TNF protein, Fc-tagged HEK293 Fc Val77-Leu233
Human TNF-532H Recombinant Human TNF Protein, His-tagged His 233
Human TNF26470H Recombinant Human TNF (77-233) Protein
Human TNF-151H Recombinant Human TNF Protein, His-tagged Human cells His
Human TNFSF11-208HF Recombinant Human TNFSF11 Protein, Fc-tagged, FITC conjugated HEK293 Fc 443
Human TNF-54H Recombinant Human TNF Protein E.coli
Human TNF-2217H-B Recombinant Human TNF Protein Pre-coupled Magnetic Beads HEK293
Human TNFSF11-208HAF647 Recombinant Human TNFSF11 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 443
Human TNF-434H Recombinant Human TNF Protein, His-tagged E.coli N-His Val77-Leu233
Human TNF-55H Recombinant Human TNF Protein, His-tagged E.coli His
Human TNFSF11-208HAF555 Recombinant Human TNFSF11 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 443
Human TNF-4342HG GMP Recombinant Human TNF protein E.coli N/A 158
Human TNF-62H Recombinant Human TNF Protein E.coli
Human TNF-0059H Recombinant Human TNF Protein HEK293 cells
Human DMABT-H19209 Mouse Anti-TNF Monoclonal Antibody Mouse Alexa Fluor 488
Human TNF-734H Recombinant Human TNF Protein (Val77-Leu233), C-6×His-tagged HEK293 C-6×His Val77-Leu233
Human TNF-069H Recombinant Human TNF Protein 233
Human TNF-529H Recombinant Human TNF Protein, Biotinylated 233
Human TNF-531H Recombinant Human TNF Protein 233
Human TNF-2487H Recombinant Human TNF Protein (Val77-Leu233), His tagged E.coli His Val77-Leu233
Human TNF-79H Recombinant Human TNF Protein E.coli Tag free
Human TNF-6472H Recombinant Human TNF Protein (Val77-Leu233), N-His tagged Mammalian cells N-His Val77-Leu233
Mouse Tnf-509M Active Recombinant Mouse Tnf Streptomyces Lividans N/A
Mouse Tnf-310M Active Recombinant Mouse Tumor Necrosis Factor Streptomyces Lividans N/A
Mouse Tnf-305T Active Recombinant Mouse Tnf Protein (163 aa), His-tagged E.coli His 163
Mouse Tnf-6539M Active Recombinant Mouse Tnf Protein E.coli
Mouse Tnf-84M Active Recombinant Mouse Tnf Protein (Leu80-Leu235), C-His tagged, Animal-free, Carrier-free E.coli C-His Leu80-Leu235
Mouse Tnf-6540M Active Recombinant Mouse Tnf Protein E.coli Leu80-Leu235
Mouse TNF-250M Active Recombinant Mouse TNF Protein E.coli
Mouse Tnf-308M Recombinant Active Mouse TNF Protein, His-tagged(C-ter) E.coli His(C-ter)
Mouse Tnf-016T Active Recombinant Mouse Tnf Protein (157 aa) E.coli 157
Mouse Tnf-01M Active Recombinant Mouse Tnf Protein, His-Tagged E.coli His
Mouse Tnf-733M Active Recombinant Mouse Tnf Protein E.coli Tag Free
Mouse Tnf-456MG Active GMP Recombinant Mouse Tnf protein HEK293 DNA sequence encoding NP_038721.1 was expressed with His tag at the C-terminal.
Mouse Tnf-484M Recombinant Mouse Tnf protein E.coli N/A 157
Mouse TNF-64M Recombinant Mouse TNF-alpha Soluble, FLAG-tagged Flag
Mouse Tnf-533M Recombinant Mouse Tnf protein, His-tagged E.coli His Leu80~Leu235
Mouse Tnf-494M Recombinant Mouse Tnf protein, His-tagged HEK293F His Gly57~Leu235
Mouse Tnf-371M Recombinant Mouse Tumor Necrosis Factor Mouse N/A
Mouse Tnf-538M Recombinant Mouse Tnf protein, His-tagged HEK293F His Gly57~Leu235
Mouse Tnf-236M Recombinant Mouse Tnf protein, His/S-tagged E.coli His/S
Mouse Tnf-331M Recombinant Murine Tumor Necrosis Factor Steptomyces lividans N/A
Mouse Tnf-67M Recombinant Mouse Tnf protein, His-tagged Insect Cell His
Mouse Tnf-7357M Recombinant Mouse Tnf Protein E.coli 80-235
Mouse Tnf-6541M Recombinant Mouse Tnf Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Tnf-148T Active Recombinant Mouse Tnf Protein (152 aa) P. pastoris 152
Mouse Tnf-140M Recombinant Mouse Tnf Protein E.coli
Mouse Tnf-22M Recombinant Mouse Tnf Protein E.coli N/A
Mouse Tnf-484MB Recombinant Mouse Tnf protein, Biotinylated E.coli
Mouse TNF-1166M Recombinant Mouse TNF protein(Leu80-Leu235), Biotinylated E.coli N/A Leu80-Leu235
Mouse Tnf-3598M Recombinant Mouse Tnf protein, His-SUMO-tagged E.coli His-SUMO 57-235aa
Mouse Tnf-3766M Recombinant Mouse Tnf Protein (Leu80-Leu235), N-His tagged E.coli N-His Leu80-Leu235
Mouse TNF-1998M Recombinant Mouse TNF Protein E.coli N/A
Mouse Tnf-495M Active Recombinant Mouse Tnf Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
Mouse TNF-818M Recombinant Mouse TNF Protein (Leu80-Leu235), His-tagged, Biotinylated E.coli His Leu80-Leu235
Mouse TNF-0807M Active Recombinant Mouse TNF protein, His-tagged HEK293 His Leu80-Leu235
Mouse Tnf-435M Recombinant Mouse Tnf Protein, His-tagged E.coli N-His Leu80-Leu235
Rat TNF-1071R Active Recombinant Rat TNF protein E.coli N/A Leu80-Leu235
Rat Tnf-381R Active Recombinant Rat Tnf P.pastoris N/A
Rat Tnf-147T Active Recombinant Rat Tnf Protein (157 aa) P. pastoris 157
Rat Tnf-003T Active Recombinant Rat Tnf Protein (157 aa) E.coli 157
Rat TNF-251R Active Recombinant Rat TNF Protein E.coli
Rat Tnf-564R Recombinant Rat Tnf protein, His-tagged E.coli His Leu80~Leu235
Rat Tnf-237R Recombinant Rat Tnf protein, His/S-tagged E.coli His/S
Rat Tnf-71R Recombinant Rat Tnf protein E.coli N/A 156
Rat TNF-97R Recombinant Rat TNF, Flag-tagged E.coli Flag
Rat TNF-6193R Recombinant Rat TNF Protein Mammalian Cell His
Rat Tnf-108R Recombinant Rat Tnf, His-tagged E.coli His
Rat Tnf-577R Rat Tnfa Crystal Structure N/A
Rat TNF-5850R Recombinant Rat TNF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Tnf-438R Recombinant Rat Tnf Protein, His&hFc-tagged CHO N-His and C-hFc Leu80-Leu235
Rat Tnf-109RG Active GMP Recombinant Rat Tnf protein HEK293 DNA sequence encoding Rat TNF-ɑ(NP_036807.1) was expressed with His tag at the C-terminal.
Rat TNF-5850R-B Recombinant Rat TNF Protein Pre-coupled Magnetic Beads HEK293
Rhesus monkey TNF-566R Recombinant Rhesus monkey TNF protein, His & T7-tagged E.coli His/T7 Val77~Leu233 (Accession # P48094)
Rabbit TNF-668R Active Recombinant Rabbit TNF, Met-tagged E.coli Met
Rabbit Tnf-311R Active Recombinant Rabbit TNF protein E.coli N/A
Rabbit TNF-565R Recombinant Rabbit TNF protein, His & T7-tagged E.coli His/T7 Leu80~Leu235 (Accession # P04924)
Rabbit TNF-796R Recombinant Rabbit Tumor Necrosis Factor E.coli N/A
Rabbit TNF-437R Recombinant Rabbit TNF Protein, His&GST-tagged E.coli N-His&GST Met1-Val214+KHHHHHHHH
Dog TNF-558D Recombinant Dog TNF protein, His-tagged E.coli His Leu63~Leu233 (Accession # P51742)
Dog TNF-379D Recombinant Dog Tumor Necrosis Factor P.pastoris N/A
Dog TNF-4456D Recombinant Dog TNF Protein (Val77-Leu233), N-His tagged Mammalian cells N-His Val77-Leu233
Bos taurus (Bovine) RFL20611BF Recombinant Full Length Bovine Tumor Necrosis Factor(Tnf) Protein, His-Tagged E.coli expression system His Full Length (1-234)
Bovine TNF-716B Active Recombinant Bovine TNF Protein E.coli N/A 78-234 aa
Bovine TNF-20B Active Recombinant Bovine TNF Protein E.coli 78-234
Bovine TNF-307T Active Recombinant Bovine TNF Protein (80 aa) E.coli 80
Bovine TNF-378B Recombinant Bovine Tumor Necrosis Factor P.pastoris N/A
Bovine TNF-3597B Recombinant Bovine TNF protein, GST-tagged E.coli GST 78-234aa
Bovine TNF-3596B Recombinant Bovine TNF protein, His-tagged E.coli His 78-234aa
Canine TNF-504C Active Recombinant Canine TNF protein E.coli N/A Val77-Leu233
Canine TNF-480C Active Recombinant Canine TNF E.coli N/A Val 77-Leu 233
Canine TNF-2158C Active Recombinant Canine TNF protein, His-tagged HEK293 His Val 77 - Leu 233
Canine TNF-1609C Active Recombinant Canine TNF protein, His-tagged HEK293 His Ser22-Thr338
Canine TNF-782C Recombinant Canine TNF protein E.coli N/A 157
Cattle TNF-557C Recombinant Cattle TNF protein, His & T7-tagged E.coli His/T7 Met1~Leu234 (Accession # Q06599)
Cotton Rat Tnf-391C Active Recombinant Cotton Rat Tnf, Met-tagged E.coli Met
Cynomolgus TNF-1168CB Recombinant Cynomolgus TNF protein, Biotinylated E.coli
Cynomolgus Monkey TNF-1038C Recombinant Cynomolgus TNF Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey TNF-781C Recombinant Cynomolgus Monkey TNF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey TNF-781C-B Recombinant Cynomolgus Monkey TNF Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus/Rhesus TNF-1168C Active Recombinant Cynomolgus/Rhesus TNF protein E.coli N/A Val77-Leu233
Equine TNF-666E Active Recombinant Equine TNF, Met-tagged E.coli Met
Equine TNF-380H Recombinant Horse Tumor Necrosis Factor P.pastoris N/A
Equus caballus (Horse) RFL31243EF Recombinant Full Length Horse Tumor Necrosis Factor(Tnf) Protein, His-Tagged E.coli expression system His Full Length (1-234)
Felis catus (Cat) (Felis silvestris catus) RFL6340FF Recombinant Full Length Cat Tumor Necrosis Factor(Tnf) Protein, His-Tagged E.coli expression system His Full Length (1-233)
Ferret TNF-1022F Recombinant Ferret TNF protein(Val77-Leu233) E.coli N/A Val77-Leu233
Goat TNF-432G Recombinant Goat TNF Protein, His-tagged E.coli N-His Arg79-Leu234
Goat RFL2227CF Recombinant Full Length Goat Tumor Necrosis Factor(Tnf) Protein, His-Tagged E.coli expression system His Full Length (1-234)
Guinea Pig Tnf-308P Active Recombinant Guinea Pig Tnf Yeast N/A
Guinea pig Tnf-433G Recombinant Guinea pig Tnf Protein, His-tagged E.coli N-His Gly57-Leu234
Horse TNF-559H Recombinant Horse TNF protein, His & T7-tagged E.coli His/T7 Leu78~Leu234 (Accession # P29553)
Macaca mulatta (Rhesus macaque) RFL20634MF Recombinant Full Length Macaca Mulatta Tumor Necrosis Factor(Tnf) Protein, His-Tagged E.coli expression system His Full Length (1-233)
Mus musculus (Mouse) RFL33114MF Recombinant Full Length Mouse Tumor Necrosis Factor(Tnf) Protein, His-Tagged E.coli expression system His Full Length (1-235)
Oryctolagus cuniculus (Rabbit) RFL9676OF Recombinant Full Length Rabbit Tumor Necrosis Factor(Tnf) Protein, His-Tagged E.coli expression system His Full Length (1-235)
Porcine TNF-5525P Recombinant Porcine Tumor Necrosis Factor E.coli N/A
Rhesus TNF-1387R Recombinant Rhesus TNF protein E.coli N/A 157
Rhesus Macaque TNF-303T Active Recombinant Rhesus Macaque TNF Protein (157 aa) E.coli 157
Rhesus macaque TNF-1610R Active Recombinant Rhesus macaque TNF protein, His-tagged HEK293 His Ser26-Ther340
Rhesus Macaque TNF-4860R Recombinant Rhesus monkey TNF Protein, His-tagged Mammalian Cell His
Rhesus Macaque TNF-4674R Recombinant Rhesus Macaque TNF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque TNF-4674R-B Recombinant Rhesus Macaque TNF Protein Pre-coupled Magnetic Beads HEK293
Sheep TNF-562S Recombinant Sheep TNF protein, His & T7-tagged E.coli His/T7 Leu78~Leu234 (Accession # P23383)
Sheep TNF-5534S Recombinant Sheep TNF protein, His-tagged Yeast His 78-234aa
Sheep TNF-3599S Recombinant Sheep TNF protein, GST-tagged E.coli GST 78-234aa
Sus scrofa (Pig) RFL17774SF Recombinant Full Length Pig Tumor Necrosis Factor(Tnf) Protein, His-Tagged E.coli expression system His Full Length (1-232)
Woodchuck TNF-4336W Recombinant Woodchuck TNF protein, His-B2M-tagged E.coli His-B2M 57-233aa
Woodchuck TNF-2306W Recombinant Woodchuck TNF protein, His-tagged Insect Cell His 57-233aa
Pig TNF-369S Active Recombinant Swine Tumor Necrosis Factor (TNF Superfamily, Member 2) Yeast N/A
Pig TNF-202P Active Recombinant Pig TNF Protein (Leu77-Leu232), C-His tagged, Animal-free, Carrier-free E.coli C-His Leu77-Leu232
Pig TNF-79P Recombinant Porcine Tumor Necrosis Factor-Alpha, biologically active E.coli N/A
Pig TNF-33 Tumor necrosis factor alpha Fc-tagged HEK293 N/A
Pig TNF-309P Recombinant Porcine Tumor Necrosis Factor E.coli N/A
Pig TNF-563P Recombinant Pig TNF protein, His-tagged E.coli His Leu77~Leu232
Pig TNF-436P Recombinant Pig TNF Protein, His-tagged E.coli N-His Gly57-Leu232
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

TNF involved in several pathways and played different roles in them. We selected most pathways TNF participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayCACNG7;IL1R2;RAP1B;FGF1;MAPKAPK2A;FGF6A;FLNB;FGF12A;FGFR4
Cytokine-cytokine receptor interactionPDGFC;CCL3L3;ACVR1;Il4ra;KDR;IFNL3;VEGFA;TNFRSF4;TNFSF9
NF-kappa B signaling pathwayBCL2;CXCL12;GM10591;TNFRSF13C;TAB2;ERC1;TNFSF11;IRAK4;LAT
Sphingolipid signaling pathwayS1PR4;MAP2K1;TRAF2;AKT2;PLCB2;PPP2R2C;GAB2;SGPP2;TNF
mTOR signaling pathwayRB1CC1;RRAGCA;PIK3R3A;AKT1;CAB39L1;ULK3;STRADA;RPS6KB2;PIK3CD
ApoptosisCDK5RAP2;CTNNB1;NFKBIAA;DAPK1;CASP2;TNF;PIK3CD;BOK;Casp3
TGF-beta signaling pathwayBMPR2A;TGFBR1B;NBL1;BMP8A;LTBP1;ACVR1BA;GDF7;PPP2R1A;AMH
Osteoclast differentiationRELA;IFNGR1;FCGR4;FYN;CYBB;FCGR2A;MAP3K14;LILRA5;FOS
Antigen processing and presentationB2M;HLA-G;KIR2DL1;HLA-DQB1;KLRC4;Ctsl;LGMN;KIR2DS3;CD8B
Toll-like receptor signaling pathwayCCL3L3;IFNA16;MAPK8A;IL1B;IL12BA;IFNA5;IFNA10;FOS;MAPK12A
NOD-like receptor signaling pathwayCASP1;MAPK11;NLRC4;CXCL1;PYDC1;RIPK2;SGUT1;TNF;CASP8
RIG-I-like receptor signaling pathwayIFNA12;MAPK11;TRAF6;IL12BA;IFNA21;IL12A;MAPK10;MAPK9;TP-1
Hematopoietic cell lineageCD5;HLA-DRA;TNF;CD1E;ITGA1;IL1R2;Itgam&Itgb2;ITGA6;IL1R1
Natural killer cell mediated cytotoxicityPIK3CG;PPP3R2;ULBP1;HCST;HLA-A;NCR2;FYN;IFNGR1;PIK3CB
T cell receptor signaling pathwayIFNG;PTPRC;RAF1;PDPK1;GRAPA;GSK3B;IKBKB;PPP3R2;AKT2
Fc epsilon RI signaling pathwayIL3;IL13;MAP2K3;IL4;MAPK1;MAPK13;LCP2;LAT;PLA2G4A
TNF signaling pathwayICAM1;LTA;MAP3K14;PTGS2;MAPK13;MAPK12;TRAF5;CREB3L2;IL15
Adipocytokine signaling pathwayPRKAA1;LEPR;ACACB;CAMKK1A;CAMKK1;NFKBIAA;ACSL1A;PRKAB2;CD36
Type II diabetes mellitusPIK3R1;HK2;SOCS3;MAPK10;PDX1;IRS1;PKM2;INS1;PRKCE
Insulin resistancePRKCD;GSK3B;CREB3L3L;CREB3L2;STAT3;PRKAB1B;SLC27A4;OGT;SOCS3
Non-alcoholic fatty liver disease (NAFLD)NDUFA5;COX7A2;NDUFA3;PRKAG1;NDUFS6;UQCRFS1;SDHC;KCNA3;PKLR
Type I diabetes mellitusIL1B;H2-AB1;ICA1;HLA-A;CPE;HLA-F;HLA-DQB1;GAD2;HLA-C
Alzheimers diseaseNDUFAB1;NDUFS3;HSD17B10;SDHB;ITPR2;NDUFA6;SDHC;NDUFS5;NAE1
Amyotrophic lateral sclerosis (ALS)ALS2;PRPH;GRIA2;NEFH;BAX;PPP3CA;GRIA1;DAXX;MAPK14
PertussisC1QC;IL1A;ITGA5;MAPK3;CALM2;AMCF-II;NLRP3;MAPK13;IL12B
LegionellosisSAR1A;Itgam&Itgb2;HSPA8;NAIP7;BCL2L13;RAB1B;EEF1G;NAIP6;RELA
LeishmaniasisFOS;PTPN6;HLA-DRB5;NFKB1;Itgam&Itgb2;TGFB3;FCGR1;FCGR2C;ITGA4
Chagas disease (American trypanosomiasis)LOC100033925;MAPK1;BDKRB2;IL1B;MAPK8;IKBKG;FASLG;GNAI3;CCL3L3
African trypanosomiasisPRKCB;HBB-B1;Fasl;IL1B;IL12B;VCAM1;APOA1;PLCB4;IL6
MalariaCD40LG;KLRK1;TGFB1;KLRB1;IL6;DARC;PECAM1;TGFB2;SDC1
ToxoplasmosisPIK3CG;TNF;HLA-DQB1;IRAK4;CD40;HLA-DRA;IL10RA;TGFB3;PIK3CD
AmoebiasisC8G;SERPINB1C;PIK3R3;LAMC2;CXCL8;ADCY1;PIK3R5;SERPINB4;GNA15
TuberculosisMAPK1;CAMK2G;C3;IRAK1;BAD;H2-AA;BCL2;CAP18;HLA-DRB3
Hepatitis CPPP2CB;IFNA4;GRB2;MAPK10;IFNA17;IFNA13;DDX58;PPP2R1B;LDLR
Hepatitis BTGFB2;SRC;NFKBIA;HSPG2;SMAD3;YWHAZ;DDX3X;IRF7;SMAD4
Influenza ATNFRSF10D;STAT2;MAPK9;ADAR;NUP98;IRF7;CYCS;EIF2AK2;OAS1A
HTLV-I infectionTERT;WNT11;PRKACA;PTTG1;CCNB2;FDPS;WNT16;NFATC3;ATF1
Herpes simplex infectionPPP1CAB;CLOCKA;C5;HCFC1;FB06F03;SP100;HLA-DRB4;THOC4;H2-AB1
Proteoglycans in cancerARHGEF12;PTPN6;MAP2K2;CAV3;MMP2;SRC;PPP1CC;FZD3;CBL
AsthmaHLA-DMB;HLA-DRB4;EPX;HLA-DMA;IL9;CD40LG;H2-AA;HLA-DRA;CD40
Inflammatory bowel disease (IBD)IL1B;IL13;HLA-DRB3;FOXP3;HLA-DQA2;IL21R;SMAD3;RORA;IL18
Systemic lupus erythematosusHIST3H2BB-PS;SNRPB;HIST1H3H;H2AFB1;Hc;H3F3B;TNF;SSB;H3F3A
Rheumatoid arthritisATP6V1G1;ANGPT1;ATP6V0C;ATP6V1B1;ATP6V1D;ATP6V1A;ATP6V0D2;Ccl12;HLA-DMB
Allograft rejectionGZMB;HLA-DOB;H2-Q10;HLA-A;HLA-DQA1;HLA-DQA2;CD80;HLA-DMB;HLA-DQB1
Graft-versus-host diseaseHLA-DPB1;H2-Q10;KIR3DL2;HLA-DMB;Fasl;HLA-DOB;HLA-DQA1;TNF;H2-AA
Hypertrophic cardiomyopathy (HCM)ACE;PRKAG3;ACTB;ITGB6;ITGA7;SGCA;CACNB3;DAG1;TPM4
Dilated cardiomyopathySGCA;CACNA2D2;TNNC1;SGCB;ITGB1;TGFB3;ACTC1;EMD;ITGB6

TNF has several biochemical functions, for example, cytokine activity, identical protein binding, protease binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNF itself. We selected most functions TNF had, and list some proteins which have the same functions with TNF. You can find most of the proteins on our site.

Function Related Protein
cytokine activityBMP6;IL10;GREM2;CMTM6;CCL4;Ifnl2;IL36B;GDF6;GM13289
identical protein bindingUGP2;KHDRBS1;MCPH1;CEACAM16;DYNLRB1;FAS;DESI1;MUL1;SERPINB1A
protease bindingTP53;ADAM8A;TIMP4;TRP53;SERPINE1;BCL10;SERPINA1E;RYR1;HSPA6
protein bindingLITAF;STAT6;RAB8A;MTA2;RBBP8;CNOT7;GPATCH4;PRKAR2AA;NMRK1
transcription regulatory region DNA bindingNR1D1;TFAP4;KLF11;SFPQ;RFX3;HNRNPL;PROX1;SMARCA2;TBL1X
tumor necrosis factor receptor bindingLTA;CASP8;TNFSF14;Fasl;EDA;FASLG;TNFB;ERAP1;BRE

TNF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNF here. Most of them are supplied by our site. Hope this information will be useful for your research of TNF.

TNFRSF1A; RIPK1; BIRC2; crmE

Research Area

Related articles

Li, XY; Yue, Y; et al. Extracellular, but not intracellular HMGB1, facilitates self-DNA induced macrophage activation via promoting DNA accumulation in endosomes and contributes to the pathogenesis of lupus nephritis. MOLECULAR IMMUNOLOGY 65:177-188(2015).
Lee, JS; Kwon, DS; et al. Mechanism of macrophage activation induced by polysaccharide from Cordyceps militaris culture broth. CARBOHYDRATE POLYMERS 120:29-37(2015).
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