TNF

  • Official Full Name

    tumor necrosis factor

  • Overview

    This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]

  • Synonyms

    TNF;tumor necrosis factor;DIF;TNFA;TNFSF2;TNF-alpha;TNF-a;cachectin;APC1 protein;TNF, monocyte-derived;TNF, macrophage-derived;tumor necrosis factor-alpha;tumor necrosis factor ligand superfamily member 2

Recombinant Proteins

  • Human
  • Bovine
  • Mouse
  • Ferret
  • Rat
  • Cynomolgus/Rhesus
  • Rabbit
  • Pig
  • Cotton Rat
  • Canine
  • Equine
  • Rhesus macaque
  • Cynomolgus
  • Guinea Pig
  • Dog
  • Porcine
  • Cattle
  • Horse
  • Sheep
  • Sus scrofa (Pig)
  • Macaca mulatta
  • Goat
  • Mus musculus
  • Felis catus
  • Oryctolagus cuniculus
  • Woodchuck
  • Guinea pig
  • HEK293
  • E.coli
  • Streptomyces Lividans
  • Yeast
  • P.pastoris
  • CHO
  • Human Cells
  • Mammalian Cells
  • Hordeum Vulgare
  • Steptomyces lividans
  • Insect Cells
  • Mouse
  • Nicotiana Benthamiana
  • Flag
  • Non
  • Avi
  • His
  • Fc
  • HQ
  • S
  • MBP
  • T7
  • Alexa Fluor
  • DDK
  • Myc
  • GST
  • SUMO
  • B2M
Cat.# Product name Source (Host) Species Tag Protein Length Price
TNF-412H Active Recombinant Human TNF protein, FLAG-tagged HEK293 Human Flag 85-233;18-111 a.a.
TNF-20B Active Recombinant Bovine TNF Protein E.coli Bovine 78-234
TNF-716B Active Recombinant Bovine TNF Protein E.coli Bovine Non 78-234 aa
TNF-24H Recombinant Human Tumor Necrosis Factor alpha-1a E.coli Human Non
Tnf-484M Recombinant Mouse Tnf protein E.coli Mouse Non 157
Tnf-495M Active Recombinant Mouse Tnf Protein, His-Avi-tagged, Biotinylated HEK293 Mouse Avi&His 80-235 a.a.
TNFSF11-208HAF488 Recombinant Human TNFSF11 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Human Fc 443
TNFSF11-208HAF555 Recombinant Human TNFSF11 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Human Fc 443
TNFSF11-208HAF647 Recombinant Human TNFSF11 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Human Fc 443
TNFSF11-208HF Recombinant Human TNFSF11 Protein, Fc-tagged, FITC conjugated HEK293 Human Fc 443
TNF-154H Active Recombinant Human TNF protein HEK293 Human Non
TNF-1022F Recombinant Ferret TNF protein(Val77-Leu233) E.coli Ferret Non 77-233 a.a.
TNF-1071R Active Recombinant Rat TNF protein E.coli Rat Non Leu80-Leu235
TNF-1168C Active Recombinant Cynomolgus/Rhesus TNF protein E.coli Cynomolgus/Rhesus Non Val77-Leu233
TNF-1452H Active Recombinant Human TNF E.coli Human Non 157 a.a.
TNF-171H Active Recombinant Human TNF Protein, Biotinylated E.coli Human Non Val77-Leu233
TNF-234H Active Recombinant Human TNF protein, hFc-tagged HEK293 Human Fc 77-233 a.a.
TNF-242H Active Recombinant Human TNF protein E.coli Human Non
TNF-246H Active Recombinant Human TNF protein E.coli Human Non Val77-Leu233
Tnf-310M Active Recombinant Mouse Tumor Necrosis Factor Streptomyces Lividans Mouse Non
Tnf-311R Active Recombinant Rabbit TNF protein E.coli Rabbit Non
TNF-361H Active Recombinant Human TNF protein, His-Avi-tagged, Biotinylated HEK293 Human Avi&His Val77-Leu233
TNF-369S Active Recombinant Swine Tumor Necrosis Factor (TNF Superfamily, Member 2) Yeast Pig Non
Tnf-381R Active Recombinant Rat Tnf P.pastoris Rat Non
Tnf-391C Active Recombinant Cotton Rat Tnf, Met-tagged E.coli Cotton Rat 1-156 a.a.
TNF-431H Active Recombinant Human TNF Yeast Human Non
TNF-480C Active Recombinant Canine TNF E.coli Canine Non Val 77-Leu 233
TNF-504C Active Recombinant Canine TNF protein E.coli Canine Non 77-233 a.a.
Tnf-509M Active Recombinant Mouse Tnf Streptomyces Lividans Mouse Non
TNF-666E Active Recombinant Equine TNF, Met-tagged E.coli Equine 78-234 a.a.
TNF-668R Active Recombinant Rabbit TNF, Met-tagged E.coli Rabbit 79-234 a.a.
Tnf-003T Active Recombinant Rat Tnf Protein (157 aa) E.coli Rat 157
Tnf-014M Active Recombinant Mouse tumor necrosis factor Protein, His&Flag tagged HEK293 Mouse Flag&His 80-235aa
Tnf-016T Active Recombinant Mouse Tnf Protein (157 aa) E.coli Mouse 157
Tnf-019R Active Recombinant Rat tumor necrosis factor Protein, His&Flag tagged HEK293 Rat Flag&His 80-235aa
TNF-01HG Active GMP Recombinant Human TNF Protein CHO Human
Tnf-01M Active Recombinant Mouse Tnf Protein, His-Tagged E.coli Mouse His
TNF-106HG Active GMP Recombinant Human TNF Protein E.coli Human Non 77-233 a.a.
TNF-11HG Active Recombinant Human TNF Protein (Val77-Leu233), GMP Grade, Animal-Free E.coli Human Val77-Leu233
Tnf-147T Active Recombinant Rat Tnf Protein (157 aa) P.pastoris Rat 157
TNF-149T Active Recombinant Human TNF Protein (157 aa) P.pastoris Human 157
TNF-150H GMP Recombinant Human TNF , His-tagged E.coli Human His
TNF-1609C Active Recombinant Canine TNF protein, His-tagged HEK293 Canine His 22-338 a.a.
TNF-1610R Active Recombinant Rhesus macaque TNF protein, His-tagged HEK293 Rhesus macaque His 26-340 a.a.
TNF-202P Active Recombinant Pig TNF Protein (Leu77-Leu232), C-His tagged, Animal-free, Carrier-free E.coli Pig His Leu77-Leu232
TNF-2158C Active Recombinant Canine TNF protein, His-tagged HEK293 Canine His Val 77 - Leu 233
TNF-242HA Active Recombinant Human TNF protein, APC labeled E.coli Human Non
TNF-249H Active Recombinant Human TNF Protein E.coli Human
TNF-250M Active Recombinant Mouse TNF Protein E.coli Mouse
TNF-251R Active Recombinant Rat TNF Protein E.coli Rat
TNF-290H Active Recombinant Human TNF Protein (Val77-Leu233), C-His tagged, Animal-free, Carrier-free E.coli Human His Val77-Leu233
TNF-303T Active Recombinant Rhesus Macaque TNF Protein (157 aa) E.coli Rhesus macaque 157
TNF-304T Active Recombinant Human TNF Protein (157 aa) E.coli Human 157
Tnf-305T Active Recombinant Mouse Tnf Protein (163 aa), His-tagged E.coli Mouse His 163
TNF-306T Active Recombinant Human TNF Protein (164 aa), His-tagged E.coli Human His 164
TNF-307H Recombinant Active Human TNF Protein, His-tagged(C-ter) E.coli Human His
TNF-307T Active Recombinant Bovine TNF Protein (80 aa) E.coli Bovine 80
Tnf-308M Recombinant Active Mouse TNF Protein, His-tagged(C-ter) E.coli Mouse His
Tnf-456MG Active GMP Recombinant Mouse Tnf protein HEK293 Mouse DNA sequence encoding NP_038721.1 was expressed with His tag at the C-terminal.
TNF-49H Active Recombinant Human TNF Protein, Animal Free Human Cells Human
TNF-5343H Active Recombinant Human TNF protein Yeast Human Non
Tnf-6539M Active Recombinant Mouse Tnf Protein E.coli Mouse
Tnf-6540M Active Recombinant Mouse Tnf Protein E.coli Mouse Leu80-Leu235
TNF-732H Active Recombinant Human TNF Protein E.coli Human Non
Tnf-733M Active Recombinant Mouse Tnf Protein E.coli Mouse Non
Tnf-84M Active Recombinant Mouse Tnf Protein (Leu80-Leu235), C-His tagged, Animal-free, Carrier-free E.coli Mouse His Leu80-Leu235
TNF-1038C Recombinant Cynomolgus TNF Protein, His-tagged Mammalian Cells Cynomolgus His
Tnf-108R Recombinant Rat Tnf, His-tagged E.coli Rat His
Tnf-124M Recombinant Mouse Tumor Necrosis Factor E.coli Mouse Non
TNF-1387R Recombinant Rhesus TNF protein E.coli Rhesus macaque Non 157
TNF-1914H Recombinant Human Tumor Necrosis Factor, HQ-tagged Hordeum Vulgare Human HQ
TNF-194H Recombinant Human Tumor Necrosis Factor E.coli Human Non
TNF-235H Recombinant Human TNF protein, His/S-tagged E.coli Human His&S
Tnf-236M Recombinant Mouse Tnf protein, His/S-tagged E.coli Mouse His&S
Tnf-237R Recombinant Rat Tnf protein, His/S-tagged E.coli Rat His&S
TNF-241H Recombinant Human TNF protein, His/DDK-tagged HEK293 Human Flag&His
TNF-243H Recombinant Human TNF protein, His-tagged E.coli Human His 164
TNF-244H Recombinant Human TNF protein, His-tagged E.coli Human His
TNF-245H Recombinant Human TNF protein E.coli Human Non 158
TNF-25H Recombinant Human Mutant Tumor Necrosis Factor Alpha E.coli Human Non
TNF-279H Recombinant Human TNF, Biotinylated HEK293 Human Non
Tnf-308P Active Recombinant Guinea Pig Tnf Yeast Guinea Pig Non
TNF-30945TH Recombinant Human TNF, His-tagged Human His Full L.
TNF-309P Recombinant Porcine Tumor Necrosis Factor E.coli Pig Non
TNF-33 Tumor necrosis factor alpha Fc-tagged HEK293 Pig Non
TNF-3315H Active Recombinant Human TNF protein, His-tagged HEK293 Human His Val 77 - Leu 233
Tnf-331M Recombinant Murine Tumor Necrosis Factor Steptomyces lividans Mouse Non
TNF-346H Recombinant Human TNF protein, His/MBP-tagged E.coli Human His&MBP 1-30 aa
TNF-347H Recombinant Human TNF protein, His/MBP-tagged E.coli Human His&MBP 57-255 aa
TNF-35H Recombinant Human TNF protein, His-tagged Insect Cells Human His
Tnf-371M Recombinant Mouse Tumor Necrosis Factor Mouse Mouse Non
TNF-378B Recombinant Bovine Tumor Necrosis Factor P.pastoris Bovine Non
TNF-378H Recombinant Human Tumor Necrosis Factor HEK293 Human Non
TNF-379D Recombinant Dog Tumor Necrosis Factor P.pastoris Dog Non
TNF-379H Recombinant Human Tumor Necrosis Factor, His-tagged E.coli Human His 77-233 a.a.
TNF-380H Recombinant Horse Tumor Necrosis Factor P.pastoris Equine Non
TNF-38H Recombinant Human TNF protein E.coli Human Non 151
TNF-408H Active Recombinant Human TNF Protein, FLAG-tagged HEK293 Human Flag 85-233;18-111 a.a.
TNF-413H Recombinant Human TNF, Fc Chimera CHO Human Fc 85-233 a.a.
Tnf-429M Recombinant Mouse Tumor Necrosis Factor, FLAG-tagged E.coli Mouse Flag
TNF-4860R Recombinant Rhesus monkey TNF Protein, His-tagged Mammalian Cells Rhesus macaque His
Tnf-494M Recombinant Mouse Tnf protein, His-tagged HEK293 Mouse His Gly57~Leu235
TNF-511H Recombinant Human TNF protein, low endotoxin (HPLC-verified) HEK293 Human 157
Tnf-533M Recombinant Mouse Tnf protein, His-tagged E.coli Mouse His Leu80~Leu235
Tnf-538M Recombinant Mouse Tnf protein, His-tagged HEK293 Mouse His Gly57~Leu235
TNF-5525P Recombinant Porcine Tumor Necrosis Factor E.coli Porcine Non
TNF-557C Recombinant Cattle TNF protein, His & T7-tagged E.coli Cattle His&T7 Met1~Leu234
TNF-558D Recombinant Dog TNF protein, His-tagged E.coli Dog His Leu63~Leu233
TNF-559H Recombinant Horse TNF protein, His & T7-tagged E.coli Horse His&T7 Leu78~Leu234
TNF-562S Recombinant Sheep TNF protein, His & T7-tagged E.coli Sheep His&T7 Leu78~Leu234
TNF-563P Recombinant Pig TNF protein, His-tagged E.coli Pig His Leu77~Leu232
Tnf-564R Recombinant Rat Tnf protein, His-tagged E.coli Rat His Leu80~Leu235
TNF-565R Recombinant Rabbit TNF protein, His & T7-tagged E.coli Rabbit His&T7 Leu80~Leu235
TNF-566R Recombinant Rhesus monkey TNF protein, His & T7-tagged E.coli Rhesus macaque His&T7 Val77~Leu233
Tnf-577R Rat Tnfa Crystal Structure Rat Non 80-235 a.a.
TNF-6193R Recombinant Rat TNF Protein Mammalian Cells Rat His
TNF-63H Active Recombinant Human TNF Protein, FLAG-tagged E.coli Human Flag
TNF-64M Recombinant Mouse TNF-alpha Soluble, FLAG-tagged Mouse Flag 77-235 a.a.
Tnf-67M Recombinant Mouse Tnf protein, His-tagged Insect Cells Mouse His
Tnf-71R Recombinant Rat Tnf protein E.coli Rat Non 156
TNF-72H Recombinant Human TNF, His-tagged E.coli Human Non 77-233 a.a.
TNF-76H Recombinant Human Tumor Necrosis Factor-Alpha Variant, biologically active E.coli Human Non 158 amino acids
TNF-796R Recombinant Rabbit Tumor Necrosis Factor E.coli Rabbit Non
TNF-79P Recombinant Porcine Tumor Necrosis Factor-Alpha, biologically active E.coli Pig Non
TNF-97R Recombinant Rat TNF, Flag-tagged E.coli Rat Flag
TNF-897HCL Recombinant Human TNF 293 Cell Lysate HEK293 Human Non
DMABT-H19209 Mouse Anti-TNF Monoclonal Antibody Mouse Human Alexa Fluor
RFL17774SF Recombinant Full Length Pig Tumor Necrosis Factor(Tnf) Protein, His-Tagged E.coli Sus scrofa (Pig) His Full L. Full Length (1-232)
RFL20611BF Recombinant Full Length Bovine Tumor Necrosis Factor(Tnf) Protein, His-Tagged E.coli Bovine His Full L. Full Length (1-234)
RFL20634MF Recombinant Full Length Macaca Mulatta Tumor Necrosis Factor(Tnf) Protein, His-Tagged E.coli Macaca mulatta His Full L. Full Length (1-233)
RFL2227CF Recombinant Full Length Goat Tumor Necrosis Factor(Tnf) Protein, His-Tagged E.coli Goat His Full L. Full Length (1-234)
RFL31243EF Recombinant Full Length Horse Tumor Necrosis Factor(Tnf) Protein, His-Tagged E.coli Horse His Full L. Full Length (1-234)
RFL33114MF Recombinant Full Length Mouse Tumor Necrosis Factor(Tnf) Protein, His-Tagged E.coli Mus musculus His Full L. Full Length (1-235)
RFL6340FF Recombinant Full Length Cat Tumor Necrosis Factor(Tnf) Protein, His-Tagged E.coli Felis catus His Full L. Full Length (1-233)
RFL9676OF Recombinant Full Length Rabbit Tumor Necrosis Factor(Tnf) Protein, His-Tagged E.coli Oryctolagus cuniculus His Full L. Full Length (1-235)
TNF-001H Recombinant Human TNF Protein, His-tagged E.coli Human His 77-233
TNF-0059H Recombinant Human TNF Protein HEK293 Human
TNF-02H Recombinant Human TNF Protein, His-tagged Nicotiana Benthamiana Human His 77-233
TNF-069H Recombinant Human TNF Protein Human 233
TNF-0806H Recombinant Human TNF protein, Fc-tagged HEK293 Human Fc 77-233 a.a.
TNF-0807M Active Recombinant Mouse TNF protein, His-tagged HEK293 Mouse His 80-235 a.a.
Tnf-109RG Active GMP Recombinant Rat Tnf protein HEK293 Rat DNA sequence encoding Rat TNF-ɑ(NP_036807.1) was expressed with His tag at the C-terminal.
TNF-1106HG Active GMP Recombinant Human TNF protein HEK293 Human
TNF-1166M Recombinant Mouse TNF protein(Leu80-Leu235), Biotinylated E.coli Mouse Non Leu80-Leu235
TNF-1168CB Recombinant Cynomolgus TNF protein, Biotinylated E.coli Cynomolgus 77-233 a.a.
TNF-1171H Recombinant Human TNF Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
TNF-13HFL Active Recombinant Full Length Human TNF Protein, C-Flag-tagged HEK293 Human Flag Full L.
Tnf-140M Recombinant Mouse Tnf Protein E.coli Mouse
Tnf-148T Active Recombinant Mouse Tnf Protein (152 aa) P.pastoris Mouse 152
TNF-151H Recombinant Human TNF Protein, His-tagged Human Cells Human His
TNF-1998M Recombinant Mouse TNF Protein E.coli Mouse Non
TNF-2001H Recombinant Human TNF Protein, His-tagged E.coli Human His Val77-Leu233
TNF-209HFL Active Recombinant Full Length Human TNF Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
TNF-2217H Recombinant Human TNF Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
TNF-2217H-B Recombinant Human TNF Protein Pre-coupled Magnetic Beads HEK293 Human
Tnf-22M Recombinant Mouse Tnf Protein E.coli Mouse Non 80-235 a.a.
TNF-2306W Recombinant Woodchuck TNF protein, His-tagged Insect Cells Woodchuck His 57-233aa
TNF-2487H Recombinant Human TNF Protein (Val77-Leu233), His tagged E.coli Human His Val77-Leu233
TNF26470H Recombinant Human TNF (77-233) Protein Human
TNF-311H Recombinant Human TNF protein, His-Avi-tagged HEK293 Human Avi&His Val77-Leu233
TNF-3596B Recombinant Bovine TNF protein, His-tagged E.coli Bovine His 78-234aa
TNF-3597B Recombinant Bovine TNF protein, GST-tagged E.coli Bovine GST 78-234aa
Tnf-3598M Recombinant Mouse Tnf protein, His-SUMO-tagged E.coli Mouse His&SUMO 57-235aa
TNF-3599S Recombinant Sheep TNF protein, GST-tagged E.coli Sheep GST 78-234aa
Tnf-3766M Recombinant Mouse Tnf Protein (Leu80-Leu235), N-His tagged E.coli Mouse His Leu80-Leu235
TNF-432G Recombinant Goat TNF Protein, His-tagged E.coli Goat His Arg79-Leu234
TNF-4336W Recombinant Woodchuck TNF protein, His-B2M-tagged E.coli Woodchuck B2M&His 57-233aa
Tnf-433G Recombinant Guinea pig Tnf Protein, His-tagged E.coli Guinea pig His Gly57-Leu234
TNF-4342HG GMP Recombinant Human TNF protein E.coli Human Non 158
TNF-434H Recombinant Human TNF Protein, His-tagged E.coli Human His Val77-Leu233
Tnf-435M Recombinant Mouse Tnf Protein, His-tagged E.coli Mouse His Leu80-Leu235
TNF-436P Recombinant Pig TNF Protein, His-tagged E.coli Pig His Gly57-Leu232
TNF-437R Recombinant Rabbit TNF Protein, His&GST-tagged E.coli Rabbit GST&His Met1-Val214+KHHHHHHHH
Tnf-438R Recombinant Rat Tnf Protein, His&hFc-tagged CHO Rat Fc&His Leu80-Leu235
TNF-43H Human Tumour Necrosis Factor alpha ( rDNA derived) Reference standard Human Non
TNF-4456D Recombinant Dog TNF Protein (Val77-Leu233), N-His tagged Mammalian Cells Dog His Val77-Leu233
TNF-4532H Recombinant Human TNF protein, His-tagged Yeast Human His 78-233aa
TNF-4674R Recombinant Rhesus Macaque TNF Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
TNF-4674R-B Recombinant Rhesus Macaque TNF Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
Tnf-484MB Recombinant Mouse Tnf protein, Biotinylated E.coli Mouse 80-235 a.a.
TNF-51H Recombinant Human TNF Protein E.coli Human Full L.
TNF-529H Recombinant Human TNF Protein, Biotinylated Human 233
TNF-530H Recombinant Human TNF Protein, Biotinylated Human 233
TNF-531H Recombinant Human TNF Protein Human 233
TNF-532H Recombinant Human TNF Protein, His-tagged Human His 233
TNF-54H Recombinant Human TNF Protein E.coli Human 77-233 a.a.
TNF-5534S Recombinant Sheep TNF protein, His-tagged Yeast Sheep His 78-234aa
TNF-55H Recombinant Human TNF Protein, His-tagged E.coli Human His 77-233 a.a.
TNF-5850R Recombinant Rat TNF Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
TNF-5850R-B Recombinant Rat TNF Protein Pre-coupled Magnetic Beads HEK293 Rat
TNF-62H Recombinant Human TNF Protein E.coli Human
TNF-6471H Recombinant Human TNF Protein (Gly57-Leu233), N-His tagged E.coli Human His Gly57-Leu233
TNF-6472H Recombinant Human TNF Protein (Val77-Leu233), N-His tagged Mammalian Cells Human His Val77-Leu233
Tnf-6541M Recombinant Mouse Tnf Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
TNF-734H Recombinant Human TNF Protein (Val77-Leu233), C-6×His-tagged HEK293 Human His Val77-Leu233
Tnf-7357M Recombinant Mouse Tnf Protein E.coli Mouse 80-235
TNF-781C Recombinant Cynomolgus Monkey TNF Protein, His (Fc)-Avi-tagged HEK293 Cynomolgus Avi&Fc&His
TNF-781C-B Recombinant Cynomolgus Monkey TNF Protein Pre-coupled Magnetic Beads HEK293 Cynomolgus
TNF-782C Recombinant Canine TNF protein E.coli Canine Non 157
TNF-79H Recombinant Human TNF Protein E.coli Human Non
TNF-818M Recombinant Mouse TNF Protein (Leu80-Leu235), His-tagged, Biotinylated E.coli Mouse His Leu80-Leu235

    Involved Pathway

    TNF involved in several pathways and played different roles in them. We selected most pathways TNF participated on our site, such as MAPK signaling pathway,Cytokine-cytokine receptor interaction,NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Allograft rejection HLA-DRA,GZMB,IL12B,HLA-DQA2,Fasl,HLA-DOA,HLA-DRB4,IL12A,HLA-DQB1,MICA
    mTOR signaling pathway VEGFA,RRAGC,PIK3R2,RRAGD,PIK3CB,RRAGCB,EIF4E2,PRR5,VEGFAB,EIF4E1C
    Apoptosis HIST1H1D,IRAK4,CLSPN,HIST1H1A,CTNNB1,GZMF,FAS,STK26,PIK3R5,PIK3R1
    Amoebiasis COL4A6,Casp3,PIK3R2,LAMB2,CD14,PIK3CD,IFNG,COL4A4,IL1R1,COL5A2
    T cell receptor signaling pathway MAPK13,PDPK1,CD3G,NFKB1,IL5,MUC1,CD4,PRKCQ,CD40LG,PPP3CC
    NOD-like receptor signaling pathway Ccl12,IL6,HSP90AA1.1,RIPK2,IKBKB,HSP90AA1.2,MAPK13,CASPA,NLRP3,BIRC2
    Hepatitis C IFNA10,EIF2AK4,TRADD,TP53,BRAF,IKBKE,PPP2R2C,RAF1,SCARB1,IL-8
    Non-alcoholic fatty liver disease (NAFLD) UQCRC2,PKLR,SOCS3,TNFRSF1A,PIK3R5,PRKAG1,COX6A2,COX6B2,IL-8,RXRA
    Hepatitis B CREB3L2,NFATC4,CASP10,IL6,IRF3,DDB2,PIK3CG,APAF1,TP53,STAT2

    Protein Function

    TNF has several biochemical functions, for example, cytokine activity,identical protein binding,protease binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNF itself. We selected most functions TNF had, and list some proteins which have the same functions with TNF. You can find most of the proteins on our site.

    Function Related Protein
    identical protein binding APOA1,HJURP,SH3GLB1,AGXT2L1,IFI203,CASC3,COIL,CDC42BPA,PRC1,ADIPOQ
    protein binding VPS54,GTF2I,HFE2,HNRNPA2B1,HSBP1,RBM4,RNH1,FIG4,GNS,HMGB2
    protease binding Cstb,NFRKB,ADAMTS4,HSPD1,INS,SRI,CAST,SERPINA1A,CRADD,ITGB1
    tumor necrosis factor receptor binding BRE,TRAF4,TNFSF12,TNFSF10L3,CD70,TNFSF13,ERAP1,TNFB,Fasl,TRADD
    transcription regulatory region DNA binding ARID5B,GLI1,SALL1A,CTNNB1,MTERFD1,CCNT1,XRCC6,RREB1,NKX2-5,PPARG
    cytokine activity WNT1,Kitl,GREM1A,CCL19A.1,GDF6,SP100,GREM2,BMP7,TXLNA,GDF6B

    Interacting Protein

    TNF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNF here. Most of them are supplied by our site. Hope this information will be useful for your research of TNF.

    TNFRSF1A;RIPK1;BIRC2;crmE

    Resources

    References

    • Li, XY; Yue, Y; et al. Extracellular, but not intracellular HMGB1, facilitates self-DNA induced macrophage activation via promoting DNA accumulation in endosomes and contributes to the pathogenesis of lupus nephritis. MOLECULAR IMMUNOLOGY 65:177-188(2015).
    • Lee, JS; Kwon, DS; et al. Mechanism of macrophage activation induced by polysaccharide from Cordyceps militaris culture broth. CARBOHYDRATE POLYMERS 120:29-37(2015).

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