| Official Full Name | tumor necrosis factor |
| Background | This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008] |
| Synonyms | TNF; tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNF-a; cachectin; APC1 protein; TNF, monocyte-derived; TNF, macrophage-derived; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2; |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
TNF involved in several pathways and played different roles in them. We selected most pathways TNF participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | MRAS; ARR3B; GRB2A; NGF; ARRB2A; ARR3A; RELB; MAP2K2B; ATF4B1; FGF20 |
| Cytokine-cytokine receptor interaction | IL12B; NT5C3; CCR5; CCL11; IL17B; CCL21B; IL22; TGFBR2; IFNB1; LIFR |
| NF-kappa B signaling pathway | PLCG1; GADD45B; TNFSF14; CCL19; BLNK; TNFRSF11A; IL1B; CFLAR; CD40; XIAP |
| Sphingolipid signaling pathway | PPP2CA; BID; SPTLC1; LASS1; AKT1; MAP2K2; LOC100328615; MAPK9; SMPD2; GNA12 |
| mTOR signaling pathway | TSC1B; PRKCBA; PIK3CB; PDPK1; TSC1; PRR5; ULK1; MAPK3; ULK2; RRAGCA |
| Apoptosis | IL1A; AKT1; GZMF; STK24B; NMT1; TNFSF10; CASP3A; PIK3R3A; CAPN2; RELA |
| TGF-beta signaling pathway | NODAL; TGFB1A; ROCK1; BMPR1A; NOG; TGFB3; INHBA; ID1; SMAD4; RHOAC |
| Osteoclast differentiation | NOX1; TGFBR1; FCGR2A; MAPK11; FCGR3A; NFKBIA; NCF4; MAP2K6; LILRA1; TNFRSF11A |
| Antigen processing and presentation | RFXANK; HSPA1L; IFI30; LGMN; KIR2DS5; HLA-DPB1; KIR3DL2; TAP1; HLA-DRB3; HLA-E |
| Toll-like receptor signaling pathway | PIK3R3A; CD14; IL1B; IFNA3; CCL5; TNF; TLR1LA; AKT1; TLR1LB; MAP2K7 |
| NOD-like receptor signaling pathway | HSP90B1; NFKBIA; MAPK12B; LOC100033925; TRAF6; CASP8; CCL2; TAB2; NFKBIAB; TNF |
| RIG-I-like receptor signaling pathway | NLRX1; NFKBIB; MAPK9; NT5C3; IFNA1; PL10; IFNA5; RELA; IL12A; IFNW1 |
| Hematopoietic cell lineage | Kitl; IL3RA; CD1C; IL1R1; ITGA6; FLT3LG; CD37; CD8B1; CD1E; DNTT |
| Natural killer cell mediated cytotoxicity | IFNA16; MAP2K1; KLRC4-KLRK1; GZMB; IFNB1; KLRD1; FCGR3A; SYK; MAPK3; BID |
| T cell receptor signaling pathway | MAPK9; CD8A; CBL; Il2; AKT1; PPP3CB; PDCD1; LCK; ZAP70; PPP3CC |
| Fc epsilon RI signaling pathway | MAP2K2; MAPK1; MAPK8; MAPK9; MAPK12; VAV2; MAPK11; MAP2K4; PIK3CD; PIK3CG |
| TNF signaling pathway | MAPK12; RELA; BCL3; RPS6KA5; AKT1; MMP14; MMP9; Ccl12; SOCS3; PGAM5 |
| Adipocytokine signaling pathway | G6PCA.1; G6PCA.2; TNFRSF1A; AKT1; AKT2; POMCA; ACSL1; CHUK; RXRBA; ACSL4 |
| Type II diabetes mellitus | SOCS4; HK3; PIK3R2; ADIPOQ; MAPK1; PRKCE; IRS4; IRS2; PRKCD; SLC2A4 |
| Insulin resistance | PIK3R3B; MAPK8B; NR1H3; NR1H2; TNF; NOS3; RPS6KA2; PTPN11A; CREB1A; G6PC3 |
| Non-alcoholic fatty liver disease (NAFLD) | PRKAA1; ERN1; SREBF1; UQCRB; GSK3A; TNF; NDUFA1; NDUFB11; IRS2; INS |
| Type I diabetes mellitus | H2-Q10; H2-AA; IL1A; IL12B; HLA-DOA; FAS; HLA-DRB5; INS; FASLG; INS2 |
| Alzheimers disease | CAPN2; NDUFV1; NDUFA5; GRIN2B; SDHC; NDUFB11; SNCA; NDUFA10; NDUFC2-KCTD14; IL1B |
| Amyotrophic lateral sclerosis (ALS) | BID; PRPH; TNFRSF1A; MAPK13; TOMM40L; MAPK11; APAF1; MAPK14; TRP53; MAP3K5 |
| Pertussis | IL1B; MAPK12; CXCL6; C2; GM5077; IRF1; C4A; IL1A; Il23a; NFKB1 |
| Legionellosis | C3; VCP; SAR1A; TNF; RAB1; CXCL1; BCL2L13; CR1; NLRC4; NFKB2 |
| Leishmaniasis | PTPN6; Itgam&Itgb2; H2-AB1; FCGR2A; MAPK12; HLA-DQA2; HLA-DOA; MAP3K7; TNF; FOS |
| Chagas disease (American trypanosomiasis) | IL10; PPP2R2C; FADD; PPP2R1A; TLR2; CFLAR; CCL3; RELA; CCL5; CD3D |
| African trypanosomiasis | IL6; ICAM1; FASLG; HBA2; HBB; TNF; HBA-A2; VCAM1; IL18; THOP1 |
| Malaria | TGFB1; IFNG; TLR2; HBB-B2; ITGB2; KLRC4-KLRK1; IL6; COMP; MET; LRP1 |
| Toxoplasmosis | IFNGR1; MAPK8; BCL2; AKT1; SOCS1; IL12B; HLA-DPB1; NFKBIB; HLA-DRB1; TAB2 |
| Amoebiasis | CSF2; CXCL1; ITGB2; GNA11; GNAS; ACTN4; TNF; PRKCG; PIK3CA; IL1R1 |
| Tuberculosis | IL12A; CD74; KSR1; HLA-DRB5; BCL2; MYD88; CASP8; IFNA12; HLA-DOB; H2-AB1 |
| Hepatitis C | IKBKG; Ifna11; PDPK1; OAS3; TNF; IFNA6; STAT1; IL-8; MAPK12; IFNA1 |
| Hepatitis B | IL6; IRF3; IRF7; MAP2K4; IFNA8; TLR4; TLR3; RELA; SMAD4; Casp3 |
| Influenza A | IFNA12; PRSS3; IRF7; IL18; KPNA1; IFNA2; NXF1; LOC100686744; GSK3B; IFNGR2 |
| HTLV-I infection | TP53; PRKACA; GM-CSF; NFKBIA; KRAS; TNFRSF1A; PDGFB; MSX2; MAPK8; TRP53INP1 |
| Herpes simplex infection | IFNB; CD74; MAVS; IRF9; TAF6L; TLR2; IFNGR1; NFKBIAA; IFNA17; CSNK2A2A |
| Proteoglycans in cancer | MAPK13; TGFB2; ACTG1; ARHGEF12; IGF2; FZD5; GAB1; MAP2K2; WNT9B; MTOR |
| Asthma | EPX; RNASE3; HLA-DMA; TNF; PRG2; HLA-DOB; FCER1A; HLA-DRB4; H2-AA; IL10 |
| Inflammatory bowel disease (IBD) | IL21R; IL22; RORC; HLA-DOA; IL2RG; IL5; TGFB2; HLA-DPA1; SMAD2; IL12RB1 |
| Systemic lupus erythematosus | HLA-DQA2; HIST1H2AG; C1RA; HIST1H2AK; HIST1H2AF; HLA-DPA1; GM14478; CD86; C1QC; H2-AB1 |
| Rheumatoid arthritis | ATP6V1C2; MMP1A; H2-AA; CCL3L1; ICAM1; ITGB2L; ATP6V1E1; ATP6AP1; Il23a; Il12b; TLR2 |
| Allograft rejection | CD28; HLA-F; HLA-DOA; CD40; Il2; IL4; HLA-DQA2; HLA-DRB1; HLA-DRA; HLA-E |
| Graft-versus-host disease | GZMB; HLA-G; HLA-B; IL1B; H2-AB1; HLA-DPA1; FASLG; FAS; HLA-DRB4; Fasl |
| Hypertrophic cardiomyopathy (HCM) | PRKAA1; CACNB4; ITGA5; MYL3; CACNA2D1; TGFB3; PRKAG3; ACE; TNNC1; CACNB2 |
| Dilated cardiomyopathy | TGFB2; SGCG; ITGB7; ITGA6; CACNB3; ATP2A2; TPM3; PRKACA; CACNG2; CACNA2D3 |
TNF has several biochemical functions, for example, cytokine activity, identical protein binding, protease binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNF itself. We selected most functions TNF had, and list some proteins which have the same functions with TNF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | CMTM6; TNFSF12; Kitl; VSTM1; VEGFA; CMTM2; NAMPT; CMTM3; IL11; BMP7A |
| identical protein binding | SRPX2; APIP; UHRF1; ERBB3; ZHX2; SLIT2; E2F7; FUS; VIM; SDCBP |
| protease binding | Casp3; MALT1; INSL3; TIMP4; SERPINA5; CNTNAP2; POLG; TRIP4; BCL10; TIMP3 |
| protein binding | FAM32A; ALDOC; ORAI3; SNX31; CHD4; FYB; CABP5; COIL; TMEM41A; ZBTB26 |
| transcription regulatory region DNA binding | TRP63; AIRE; GRHL1; NR1D1; CBX4; FOXA2; GATA5; RFX3; RELA; TCF7L1B |
| tumor necrosis factor receptor binding | TNFSF9; TRIM37; TNFSF12; TNFSF15; LTB; TNFSF13; TNF; TNFSF4; TRAF2; TNFSF13B |
TNF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNF here. Most of them are supplied by our site. Hope this information will be useful for your research of TNF.
TNFRSF1A; RIPK1; BIRC2; crmE
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