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TNF

  • Official Full Name

    tumor necrosis factor

  • Background

    This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]

  • Synonyms

    TNF; tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNF-a; cachectin; APC1 protein; TNF, monocyte-derived; TNF, macrophage-derived; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2;
    • Type:
    • Recombinant Proteins
    • Protein Pre-coupled Magnetic Beads
    • Transfected Stable Cell Lines
    • Antibody
    • GMP Proteins
    • Cell & Tissue Lysates
    • Species :
    • Bos taurus (Bovine)
    • Bovine
    • Canine
    • Cattle
    • Cotton Rat
    • Cynomolgus
    • Cynomolgus Monkey
    • Cynomolgus/Rhesus
    • Dog
    • Equine
    • Equus caballus (Horse)
    • Felis catus (Cat) (Felis silvestris catus)
    • Ferret
    • Goat
    • Guinea pig
    • Guinea Pig
    • Horse
    • Human
    • Macaca mulatta (Rhesus macaque)
    • Mouse
    • Mus musculus (Mouse)
    • Oryctolagus cuniculus (Rabbit)
    • Pig
    • Porcine
    • Rabbit
    • Rat
    • Rhesus
    • Rhesus macaque
    • Rhesus Macaque
    • Rhesus monkey
    • Sheep
    • Sus scrofa (Pig)
    • Woodchuck
    • Source :
    • Barley Grain
    • CHO
    • CHO-K1
    • E. coli
    • E.coli
    • E.coli expression system
    • HEK293
    • HEK293 cells
    • HEK293F
    • HEK293T
    • Hordeum Vulgare
    • Human Cell
    • Human cells
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Mouse
    • Nicotiana Benthamiana
    • P. pastoris
    • P.pastoris
    • Steptomyces lividans
    • Streptomyces Lividans
    • Yeast
    • Tag :
    • Alexa Fluor 488
    • C
    • 6×His
    • Fc
    • Flag
    • FLAG
    • GST
    • hFc
    • His
    • His (Fc)
    • Avi
    • His(C
    • ter)
    • His|Avi
    • His|DDK
    • His|MBP
    • His|S
    • His|T7
    • B2M
    • SUMO
    • HQ
    • Met
    • Myc
    • DDK
    • N/A
    • N
    • Strep II
    • Tag Free
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Bos taurus (Bovine) RFL20611BF Recombinant Full Length Bovine Tumor Necrosis Factor(Tnf) Protein, His-Tagged E.coli expression system His
    Bovine TNF-378B Recombinant Bovine Tumor Necrosis Factor P.pastoris N/A
    Bovine TNF-716B Recombinant Bovine TNF Protein E.coli N/A
    Bovine TNF-3596B Recombinant Bovine TNF protein, His-tagged E.coli His
    Bovine TNF-307T Recombinant Bovine TNF Protein (80 aa) E.coli
    Bovine TNF-3597B Recombinant Bovine TNF protein, GST-tagged E.coli GST
    Bovine TNF-20B Recombinant Bovine TNF Protein E.coli
    Canine TNF-504C Recombinant Canine TNF protein E.coli N/A
    Canine TNF-2158C Active Recombinant Canine TNF protein, His-tagged HEK293 His
    Canine TNF-1609C Recombinant Canine TNF protein, His-tagged HEK293 His
    Canine TNF-782C Recombinant Canine TNF protein E.coli N/A
    Canine TNF-480C Active Recombinant Canine TNF E.coli N/A
    Cattle TNF-557C Recombinant Cattle TNF protein, His & T7-tagged E.coli His/T7
    Cotton Rat Tnf-391C Active Recombinant Cotton Rat Tnf, Met-tagged E.coli Met
    Cynomolgus TNF-1168CB Recombinant Cynomolgus TNF protein, Biotinylated E. coli
    Cynomolgus Monkey TNF-781C Recombinant Cynomolgus Monkey TNF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Cynomolgus Monkey TNF-1038C Recombinant Cynomolgus TNF Protein, His-tagged Mammalian Cell His
    Cynomolgus Monkey TNF-781C-B Recombinant Cynomolgus Monkey TNF Protein Pre-coupled Magnetic Beads HEK293
    Cynomolgus/Rhesus TNF-1168C Recombinant Cynomolgus/Rhesus TNF protein E.coli N/A
    Dog TNF-558D Recombinant Dog TNF protein, His-tagged E.coli His
    Dog TNF-379D Recombinant Dog Tumor Necrosis Factor P.pastoris N/A
    Equine TNF-666E Active Recombinant Equine TNF, Met-tagged E.coli Met
    Equine TNF-380H Recombinant Horse Tumor Necrosis Factor P.pastoris N/A
    Equus caballus (Horse) RFL31243EF Recombinant Full Length Horse Tumor Necrosis Factor(Tnf) Protein, His-Tagged E.coli expression system His
    Felis catus (Cat) (Felis silvestris catus) RFL6340FF Recombinant Full Length Cat Tumor Necrosis Factor(Tnf) Protein, His-Tagged E.coli expression system His
    Ferret TNF-1022F Active Recombinant Ferret TNF Protein E.coli N/A
    Goat TNF-432G Recombinant Goat TNF Protein, His-tagged E.coli N-His
    Goat RFL2227CF Recombinant Full Length Goat Tumor Necrosis Factor(Tnf) Protein, His-Tagged E.coli expression system His
    Guinea Pig Tnf-308P Recombinant Guinea Pig Tnf Yeast N/A
    Guinea pig Tnf-433G Recombinant Guinea pig Tnf Protein, His-tagged E.coli N-His
    Horse TNF-559H Recombinant Horse TNF protein, His & T7-tagged E.coli His/T7
    Human TNF-154H Active Recombinant Human TNF protein HEK293 N/A
    Human TNFSF11-208HF Recombinant Human TNFSF11 Protein, Fc-tagged, FITC conjugated HEK293 Fc
    Human TNFSF11-208HAF647 Recombinant Human TNFSF11 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
    Human TNF-43H Human Tumour Necrosis Factor alpha ( rDNA derived) Reference standard N/A
    Human TNF-431H Active Recombinant Human TNF Yeast N/A
    Human TNF-01HG Active GMP Recombinant Human TNF Protein CHO-K1
    Human TNF-311H Recombinant Human TNF protein, His-Avi-tagged HEK293 His-Avi
    Human TNF-3315H Recombinant Human TNF protein, His-tagged HEK293 His
    Human TNF-408H Recombinant Human TNF Protein, FLAG-tagged HEK293T FLAG
    Human TNF-0806H Recombinant Human TNF protein, Fc-tagged HEK293 Fc
    Human TNF-151H Recombinant Human TNF Protein, His-tagged Human cells His
    Human TNF-347H Recombinant Human TNF protein, His/MBP-tagged E.coli His/MBP
    Human TNF-72H Recombinant Human TNF, His-tagged E.coli N/A
    Human TNF-307H Recombinant Active Human TNF Protein, His-tagged(C-ter) E.coli His(C-ter)
    Human DMABT-H19209 Mouse Anti-TNF Monoclonal Antibody Mouse Alexa Fluor 488
    Human TNF-242H Active Recombinant Human TNF protein E.coli N/A
    Human TNF-30945TH Recombinant Human TNF, His-tagged His
    Human TNF-49H Recombinant Human TNF Protein, Animal Free Human cells
    Human TNF-2001H Recombinant Human TNF Protein, His-tagged E.coli His
    Human TNF-244H Recombinant Human TNF protein, His-tagged E.coli His
    Human TNF-35H Recombinant Human TNF, His-tagged Barley Grain His
    Human TNF-209HFL Recombinant Full Length Human TNF Protein, C-Flag-tagged Mammalian cells Flag
    Human TNF-001H Recombinant Human TNF Protein, His-tagged E.coli His
    Human TNF-25H Recombinant Human Mutant Tumor Necrosis Factor Alpha E.coli N/A
    Human TNF-213H Recombinant Human TNF, StrepII-tagged Human Cell Strep II
    Human TNF-194H Recombinant Human Tumor Necrosis Factor E.coli N/A
    Human TNF-1106HG GMP Recombinant Human TNF protein HEK293
    Human TNF-511H Recombinant Human TNF protein, low endotoxin (HPLC-verified) HEK293
    Human TNF-24H Recombinant Human Tumor Necrosis Factor alpha-1a E.coli N/A
    Human TNF-378H Recombinant Human Tumor Necrosis Factor HEK293 N/A
    Human TNF-30942TH Recombinant Human TNF N/A
    Human TNF-897HCL Recombinant Human TNF 293 Cell Lysate HEK293 N/A
    Human TNF-234H Recombinant Human TNF protein, hFc-tagged HEK293 hFc
    Human TNF-38H Recombinant Human TNF protein E.coli N/A
    Human TNF-1452H Active Recombinant Human TNF E.coli N/A
    Human TNF-279H Recombinant Human TNF, Biotinylated HEK293 N/A
    Human TNF-235H Recombinant Human TNF protein, His/S-tagged E.coli His/S
    Human TNF-76H Recombinant Human Tumor Necrosis Factor-Alpha Variant, biologically active E.coli N/A
    Human TNF-413H Recombinant Human TNF, Fc Chimera CHO Fc
    Human TNF-1914H Recombinant Human Tumor Necrosis Factor, HQ-tagged Hordeum Vulgare HQ
    Human TNF-241H Recombinant Human TNF protein, His/DDK-tagged HEK293 His/DDK
    Human TNF-106HG GMP Recombinant Human TNF Protein E.coli N/A
    Human TNF-412H Active Recombinant Human TNF protein, FLAG-tagged HEK293 FLAG
    Human TNF-434H Recombinant Human TNF Protein, His-tagged E.coli N-His
    Human TNF-171H Active Recombinant Human TNF Protein, Biotinylated E.coli N/A
    Human TNF-35H Recombinant Human TNF protein, His-tagged Insect Cell His
    Human TNF-63H Recombinant Human TNF Protein, FLAG-tagged E.coli FLAG
    Human TNFSF11-208HAF555 Recombinant Human TNFSF11 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
    Human TNF-249H Recombinant Human TNF Protein E.coli
    Human TNF-1171H Recombinant Human TNF Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human TNF-379H Recombinant Human Tumor Necrosis Factor, His-tagged E.coli His
    Human TNF-62H Recombinant Human TNF Protein E.coli
    Human TNF-54H Recombinant Human TNF Protein E.coli
    Human TNF-246H Active Recombinant Human TNF protein E.coli N/A
    Human TNF-346H Recombinant Human TNF protein, His/MBP-tagged E.coli His/MBP
    Human TNF-149T Recombinant Human TNF Protein (157 aa) P. pastoris
    Human TNF-55H Recombinant Human TNF Protein, His-tagged E.coli His
    Human TNF-361H Recombinant Human TNF protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Human TNF-4342HG GMP Recombinant Human TNF protein E.coli N/A
    Human TNF-306T Recombinant Human TNF Protein (164 aa), His-tagged E.coli His
    Human TNF-0059H Recombinant Human TNF Protein HEK293 cells
    Human TNF-2217H Recombinant Human TNF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human TNF-243H Recombinant Human TNF protein, His-tagged E.coli His
    Human TNF-530H Recombinant Human TNF Protein, Biotinylated
    Human TNF-02H Recombinant Human TNF Protein, His-tagged Nicotiana Benthamiana His
    Human TNF26470H Recombinant Human TNF (77-233) Protein
    Human TNF-245H Recombinant Human TNF protein E.coli N/A
    Human TNF-2217H-B Recombinant Human TNF Protein Pre-coupled Magnetic Beads HEK293
    Human TNF-51H Recombinant Human TNF Protein E.coli
    Human TNF-11HG Recombinant Human TNF Protein (Val77-Leu233), GMP Grade, Animal-Free E.coli
    Human TNF-304T Recombinant Human TNF Protein (157 aa) E.coli
    Human TNF-069H Recombinant Human TNF Protein
    Human TNF-532H Recombinant Human TNF Protein, His-tagged His
    Human TNF-529H Recombinant Human TNF Protein, Biotinylated
    Human TNF-732H Recombinant Human TNF Protein E.coli Tag Free
    Human TNF-531H Recombinant Human TNF Protein
    Human TNF-734H Recombinant Human TNF Protein (Val77-Leu233), C-6×His-tagged HEK293 C-6×His
    Human TNFSF11-208HAF488 Recombinant Human TNFSF11 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
    Macaca mulatta (Rhesus macaque) RFL20634MF Recombinant Full Length Macaca Mulatta Tumor Necrosis Factor(Tnf) Protein, His-Tagged E.coli expression system His
    Mouse Tnf-733M Recombinant Mouse Tnf Protein E.coli Tag Free
    Mouse Tnf-3598M Recombinant Mouse Tnf protein, His-SUMO-tagged E.coli His-SUMO
    Mouse Tnf-305T Recombinant Mouse Tnf Protein (163 aa), His-tagged E.coli His
    Mouse Tnf-01M Active Recombinant Mouse Tnf Protein, His-Tagged E.coli His
    Mouse Tnf-016T Recombinant Mouse Tnf Protein (157 aa) E.coli
    Mouse Tnf-67M Recombinant Mouse Tnf protein, His-tagged Insect Cell His
    Mouse TNF-250M Recombinant Mouse TNF Protein E.coli
    Mouse Tnf-236M Recombinant Mouse Tnf protein, His/S-tagged E.coli His/S
    Mouse Tnf-148T Recombinant Mouse Tnf Protein (152 aa) P. pastoris
    Mouse Tnf-140M Recombinant Mouse Tnf Protein E.coli
    Mouse Tnf-7357M Recombinant Mouse Tnf Protein E.coli
    Mouse Tnf-308M Recombinant Active Mouse TNF Protein, His-tagged(C-ter) E.coli His(C-ter)
    Mouse Tnf-494M Recombinant Mouse Tnf protein, His-tagged HEK293F His
    Mouse Tnf-484M Recombinant Mouse Tnf protein E.coli N/A
    Mouse Tnf-22M Recombinant Mouse Tnf Protein E.coli N/A
    Mouse TNF-0807M Recombinant Mouse TNF protein, His-tagged HEK293 His
    Mouse Tnf-538M Recombinant Mouse Tnf protein, His-tagged HEK293F His
    Mouse Tnf-371M Recombinant Mouse Tumor Necrosis Factor Mouse N/A
    Mouse TNF-64M Recombinant Mouse TNF-alpha Soluble, FLAG-tagged Flag
    Mouse TNF-1998M Recombinant Mouse TNF Protein E.coli N/A
    Mouse Tnf-456MG GMP Recombinant Mouse Tnf protein HEK293
    Mouse Tnf-331M Recombinant Murine Tumor Necrosis Factor Steptomyces lividans N/A
    Mouse Tnf-495M Recombinant Mouse Tnf Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
    Mouse TNF-818M Recombinant Mouse TNF Protein (Leu80-Leu235), His-tagged, Biotinylated E.coli His
    Mouse Tnf-6539M Recombinant Mouse Tnf Protein E. coli
    Mouse Tnf-6540M Recombinant Mouse Tnf Protein E. coli
    Mouse Tnf-6541M Recombinant Mouse Tnf Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Tnf-484MB Recombinant Mouse Tnf protein, Biotinylated E. coli
    Mouse Tnf-435M Recombinant Mouse Tnf Protein, His-tagged E.coli N-His
    Mouse Tnf-533M Recombinant Mouse Tnf protein, His-tagged E.coli His
    Mouse Tnf-509M Active Recombinant Mouse Tnf Streptomyces Lividans N/A
    Mouse Tnf-310M Active Recombinant Mouse Tumor Necrosis Factor Streptomyces Lividans N/A
    Mus musculus (Mouse) RFL33114MF Recombinant Full Length Mouse Tumor Necrosis Factor(Tnf) Protein, His-Tagged E.coli expression system His
    Oryctolagus cuniculus (Rabbit) RFL9676OF Recombinant Full Length Rabbit Tumor Necrosis Factor(Tnf) Protein, His-Tagged E.coli expression system His
    Pig TNF-79P Recombinant Porcine Tumor Necrosis Factor-Alpha, biologically active E.coli N/A
    Pig TNF-33 Tumor necrosis factor alpha Fc-tagged HEK293 N/A
    Pig TNF-309P Recombinant Porcine Tumor Necrosis Factor E.coli N/A
    Pig TNF-369S Active Recombinant Swine Tumor Necrosis Factor (TNF Superfamily, Member 2) Yeast N/A
    Pig TNF-436P Recombinant Pig TNF Protein, His-tagged E.coli N-His
    Pig TNF-563P Recombinant Pig TNF protein, His-tagged E.coli His
    Porcine TNF-5525P Recombinant Porcine Tumor Necrosis Factor E.coli N/A
    Rabbit TNF-668R Active Recombinant Rabbit TNF, Met-tagged E.coli Met
    Rabbit Tnf-311R Active Recombinant Rabbit TNF protein E.coli N/A
    Rabbit TNF-796R Recombinant Rabbit Tumor Necrosis Factor E.coli N/A
    Rabbit TNF-565R Recombinant Rabbit TNF protein, His & T7-tagged E.coli His/T7
    Rabbit TNF-437R Recombinant Rabbit TNF Protein, His&GST-tagged E.coli N-His&GST
    Rat Tnf-109RG GMP Recombinant Rat Tnf protein HEK293
    Rat Tnf-71R Recombinant Rat Tnf protein E.coli N/A
    Rat Tnf-381R Active Recombinant Rat Tnf P.pastoris N/A
    Rat Tnf-438R Recombinant Rat Tnf Protein, His&hFc-tagged CHO N-His and C-hFc
    Rat TNF-251R Recombinant Rat TNF Protein E.coli
    Rat Tnf-577R Rat Tnfa Crystal Structure N/A
    Rat Tnf-237R Recombinant Rat Tnf protein, His/S-tagged E.coli His/S
    Rat Tnf-564R Recombinant Rat Tnf protein, His-tagged E.coli His
    Rat Tnf-003T Recombinant Rat Tnf Protein (157 aa) E.coli
    Rat Tnf-147T Recombinant Rat Tnf Protein (157 aa) P. pastoris
    Rat TNF-5850R Recombinant Rat TNF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat TNF-6193R Recombinant Rat TNF Protein Mammalian Cell His
    Rat TNF-1071R Recombinant Rat TNF protein E.coli N/A
    Rat TNF-5850R-B Recombinant Rat TNF Protein Pre-coupled Magnetic Beads HEK293
    Rat TNF-97R Recombinant Rat TNF, Flag-tagged E.coli Flag
    Rat Tnf-108R Recombinant Rat Tnf, His-tagged E.coli His
    Rhesus TNF-1387R Recombinant Rhesus TNF protein E.coli N/A
    Rhesus macaque TNF-1610R Recombinant Rhesus macaque TNF protein, His-tagged HEK293 His
    Rhesus Macaque TNF-4674R-B Recombinant Rhesus Macaque TNF Protein Pre-coupled Magnetic Beads HEK293
    Rhesus Macaque TNF-303T Recombinant Rhesus Macaque TNF Protein (157 aa) E.coli
    Rhesus Macaque TNF-4860R Recombinant Rhesus monkey TNF Protein, His-tagged Mammalian Cell His
    Rhesus Macaque TNF-4674R Recombinant Rhesus Macaque TNF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus monkey TNF-566R Recombinant Rhesus monkey TNF protein, His & T7-tagged E.coli His/T7
    Sheep TNF-3599S Recombinant Sheep TNF protein, GST-tagged E.coli GST
    Sheep TNF-562S Recombinant Sheep TNF protein, His & T7-tagged E.coli His/T7
    Sheep TNF-5534S Recombinant Sheep TNF protein, His-tagged Yeast His
    Sus scrofa (Pig) RFL17774SF Recombinant Full Length Pig Tumor Necrosis Factor(Tnf) Protein, His-Tagged E.coli expression system His
    Woodchuck TNF-4336W Recombinant Woodchuck TNF protein, His-B2M-tagged E.coli His-B2M
    Woodchuck TNF-2306W Recombinant Woodchuck TNF protein, His-tagged Insect Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • TNF Related Articles

    TNF involved in several pathways and played different roles in them. We selected most pathways TNF participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathwayMAP2K7;RRAS2;MAPK8B;NTRK2B;FGFR4;PLA2G4C;FGF10;MAPK11;RPS6KAL
    Cytokine-cytokine receptor interactionCCR8;EGFRA;NGFR;VEGFB;BMPR1A;IL1A;BMPR2;BMPR1BB;VEGFAA
    NF-kappa B signaling pathwayIL1R1;LYN;TRAF2;ZAP70;IL-8;NFKB1;NFKBIA;TRADD;LCK
    Sphingolipid signaling pathwayGNAI2;TNF;SGMS1;LASS4;NSMAF;PRKCG;GAB2;PPP2R2C;PPP2R1B
    mTOR signaling pathwayEIF4E2;INS2;POLDIP3;PDPK1B;PIK3R3;RHEB;PDPK1;PRKCG;EIF4E1C
    ApoptosisPIK3R3;PPP3CB;CASP4;CASP3A;DSG1;IKBKB;BCL2L11;PIK3CA;HIST1H1D
    TGF-beta signaling pathwayTGFBR2;BMP7B;ACVR2B;CHRD;SMAD9;RHOAB;BMPR1AB;TNF;PPP2CA
    Osteoclast differentiationFCGR2C;MAPK11;CALCR;OSCAR;NCF1;LILRA2;CAMK4;FHL2;AKT2
    Antigen processing and presentationHLA-DOA;HLA-DQA1;HSPA5;HLA-F;B2M;HSPA1A;HLA-DQB1;PSME1;KIR2DS2
    Toll-like receptor signaling pathwayRAC1;MAPK3;TLR2-2;TLR5B;MAPK14B;MAP3K7;PIK3R5;IFNA16;TLR1LB
    NOD-like receptor signaling pathwayPSTPIP1;IKBKB;TAB2;NFKB1;MAP3K7;MAPK8B;NLRC4;HSP90AA1.2;IL8L1
    RIG-I-like receptor signaling pathwayIFNA6;CASP10;IFNA13;IKBKE;IFNA14;IKBKG;MAPK12;TRADD;RNF207B
    Hematopoietic cell lineageIL7R;IL11;FCGR1;ITGA2;CD3E; CD3D;GP5;TFRC;THPO;CSF1
    Natural killer cell mediated cytotoxicityKIR2DS3;PIK3R5;IFNA12;KIR2DS5;GZMB;LCK;IFNA1;FASLG;PPP3CC
    T cell receptor signaling pathwayCBL;MAPK11;PIK3R5;DEF6A;CD4;FOS;PIK3CG;PDCD1;CD3E; CD3D
    Fc epsilon RI signaling pathwayHRAS;PIK3R1;AKT2;SYK;LAT;MAPK1;KRAS;PIK3CD;GAB2
    TNF signaling pathwayPIK3R1;PIK3R5;PTGS2;LTA;MAPK13;PIK3CB;ATF4;TNFAIP3;MAP2K7
    Adipocytokine signaling pathwayADIPOR1;G6PCA.2;ACSBG2;ACSBG1;AKT2;PRKAG3B;PRKAB1A;G6PC3;G6PCA.1
    Type II diabetes mellitusMTOR;INS1;PIK3R3;SOCS4;CACNA1G;PIK3R2;PDX1;MAPK9;PRKCD
    Insulin resistancePPP1CB;AKT1;SREBF1;PRKAG3;PTPN11A;PRKAB2;PRKCE;INSR;FOXO1A
    Non-alcoholic fatty liver disease (NAFLD)UQCR11;COX5A;NDUFA7;RELA;PRKAA2;NDUFA1;MAP3K11;PRKAG1;CYCS
    Type I diabetes mellitusHLA-DQB1;HLA-DRB4;Fasl;HLA-DMA;ICA1;GZMB;PTPRN2;HLA-DQA1;INS1
    Alzheimers diseaseNDUFA4L2;ATP2A1;COX7A2;NDUFA6;NDUFS1;NDUFB4;PPP3R1;SDHD;UQCRB
    Amyotrophic lateral sclerosis (ALS)GRIN2D;PPP3CA;TNFRSF1A;GRIN2A;TNFRSF1B;CCS;PRPH;PPP3R1;SOD1
    PertussisC4BPB;TNF;C2;CALM2;C1R;CALM1;ITGA5;GNAI3;C1RA
    LegionellosisEEF1A1;TLR4;IL12A;CR1;MYD88;BNIP3;CASP9;HSPA6;NLRC4
    LeishmaniasisMAPK12;NFKBIA;ITGB2L;IRAK4;HLA-DMA;HLA-DRB1;IFNGR1;IL12A;TRAF6
    Chagas disease (American trypanosomiasis)PIK3R1;GNAO1;TICAM1;AKT1;IL1B;IL1B2;PIK3CG;PLCB2;SMAD2
    African trypanosomiasisTNF;GNAQ;IL6;HBB;MYD88;IL18;APOA1;F2RL1;ICAM1
    MalariaITGB2;CCL2;THBS1;TLR2;THBS2;IL6;ITGB2L;GYPC;KLRC4-KLRK1
    ToxoplasmosisIFNGR1;IFNGR2;TGFB1;ITGA6;STAT1;PPIF;LAMA2;BIRC2;HLA-DRB5
    AmoebiasisSERPINB1C;ARG1;CD14;C8A;LAMA2;IL6;LAMA1;SERPINB1;CXCL1
    TuberculosisIL1B;CALM3;IFNG;KSR1;IL10RA;FCGR3;IL1A;FCGR4;MAPK11
    Hepatitis CIL-8;SOCS3;IFNA1;MAPK13;MAPK3;CLDN2;LDLR;PIK3R3;Ifna11
    Hepatitis BIL6;TLR2;BIRC5;PCNA;IFN-a;IFNA16;Fasl;DDX58;RAF1
    Influenza AMAPK1;HSPA8;HSPA1B;STAT1;AGFG1;OAS1B;TLR7;HLA-DRB5;HSPA1A
    HTLV-I infectionFZD1;POLE3;XIAP;PIK3CD;WNT1;TRP53;HLA-DRA;POLD1;HLA-DMB
    Herpes simplex infectionHLA-DRB3;IKBKE;C3A.2;DAXX;TAF3;MYD88;TYK2;HLA-F;MCRS1
    Proteoglycans in cancerDDX5;RRAS2;CBL;FASLG;PIK3CG;HSPB2;RRAS;AKT1;CAMK2G
    AsthmaHLA-DQB1;HLA-DRB1;HLA-DQA2;MS4A2;EPX;HLA-DRB3;IL9;HLA-DRB5;IL5
    Inflammatory bowel disease (IBD)Il23a; Il12b;HLA-DPA1;SMAD2;IL21;IL13;TGFB3;TGFB2;IL1B;IFNG
    Systemic lupus erythematosusHIST2H2BB;HIST1H2AA;HIST1H4N;HIST1H4I;HLA-DRA;IFNG;C1QA;ELANE;HLA-DRB5
    Rheumatoid arthritisCXCL5;CXCL6;CXCL1;TGFB1;ATP6V0E2;IL15;FOS;HLA-DMB;HLA-DPB1
    Allograft rejectionCD40;H2-Q10;HLA-DQA1;HLA-DOB;IL5;HLA-DRB4;H2-AB1;HLA-DRB3;IL12B
    Graft-versus-host diseaseHLA-C;TNF;HLA-DRB4;HLA-DRB1;HLA-F;HLA-A;HLA-B;KIR2DL1;IL1A
    Hypertrophic cardiomyopathy (HCM)CACNB3;CACNG1;PRKAG1;ITGA2;ACTC1;ITGA1;CACNA2D3;ITGAV;ATP2A2
    Dilated cardiomyopathyITGB5;CACNA2D4;ITGB7;ACTG1;CACNA2D1;DAG1;CACNG4;MYL2;GNAS

    TNF has several biochemical functions, for example, cytokine activity, identical protein binding, protease binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNF itself. We selected most functions TNF had, and list some proteins which have the same functions with TNF. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activityBMP7A;IL34;CCL38A.5;IL7;FAM3C;AREG;IL9;TNFSF8;IL17B
    identical protein bindingDES;UBE4A;PACSIN2;ALCAMA;CLDN10;MVK;SNX8;TP73;MICALL1
    protease bindingCD28;TNFAIP3;INS2;CHL1;TIMP2;NFRKB;POLG;SERPINB13;SERPINF2
    protein bindingNGFRB;TRIM15;CD14;IGFN1;CIB3;ADAM9;SENP7;RAB17;TXK
    transcription regulatory region DNA bindingRFX6;CCNT1;GABPB1;KLF11;TRP63;WT1;TFAP2A;ZFP513;TNF
    tumor necrosis factor receptor bindingTNFSF11;TNFSF10L;TNFB;TRAF6;FADD;TRAF2;CD70;TNFSF15;CD40LG

    TNF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNF here. Most of them are supplied by our site. Hope this information will be useful for your research of TNF.

    TNFRSF1A; RIPK1; BIRC2; crmE

    Li, XY; Yue, Y; et al. Extracellular, but not intracellular HMGB1, facilitates self-DNA induced macrophage activation via promoting DNA accumulation in endosomes and contributes to the pathogenesis of lupus nephritis. MOLECULAR IMMUNOLOGY 65:177-188(2015).
    Lee, JS; Kwon, DS; et al. Mechanism of macrophage activation induced by polysaccharide from Cordyceps militaris culture broth. CARBOHYDRATE POLYMERS 120:29-37(2015).
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