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| Cat.No.: | Tf-566R |
| Product Overview: | A DNA sequence encoding the rat TF (NP_001013128.1) (Met1-Ser698) was expressed with a polyhistidine tag at the C-terminus. |
| Description: | Transferrin, also known as Serotransferrin, Beta-1 metal-binding globulin, TF, is a secreted protein which belongs to the transferrin family. It is expressed by the liver and secreted in plasma and contains two transferrin-like domains. Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. When a transferrin protein loaded with iron encounters a transferrin receptor on the surface of a cell, it binds to it and, as a consequence, is transported into the cell in a vesicle. Transferrin isa glycoprotein that binds iron very tightly but reversibly. Although iron bound to transferrin is less than 0.1% (4 mg) of the total body iron, it is the most important iron pool, with the highest rate of turnover (25 mg/24 h). Defects in transferrin are the cause of a transferrinemia (ATRAF) which is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia. Transferrin is also associated with the innate immune system. |
| Source: | Human Cells |
| Species: | Rat |
| Tag: | His |
| Form: | Lyophilized from sterile PBS, pH7.4. |
| Molecular Mass: | The recombinant rat TF comprises 690 amino acids and predicts a molecular mass of 76 kDa. The apparent molecular mass of the recombinant protein is approximately 89 kDa in SDS-PAGE under reducing conditions. |
| Protein length: | Met1-Ser698 |
| Endotoxin: | < 1.0 eu per μg of the protein as determined by the LAL method. |
| Purity: | >95 % as determined by SDS-PAGE |
| Stability: | Samples are stable for up to twelve months from date of receipt at -70℃ |
| Storage: | Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Reconstitution: | Hardcopy of COA with reconstitution instruction is sent along with the products. |
| Gene Name: | Tf transferrin [ Rattus norvegicus ] |
| Official Symbol: | Tf |
| Synonyms: | TF; transferrin; serotransferrin; siderophilin; beta-1 metal-binding globulin; liver regeneration-related protein LRRG03; Tfn; Trf; MGC93500; |
| Gene ID: | 24825 |
| mRNA Refseq: | NM_001013110 |
| Protein Refseq: | NP_001013128 |
| Pathway: | Mineral absorption, organism-specific biosystem; Mineral absorption, conserved biosystem; |
| Function: | ferric iron binding; ferric iron transmembrane transporter activity; metal ion binding; |
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