Recombinant Human TPO, MYC/DDK-tagged

• Cat.No.: TPO-24H
• Product Overview: Recombinant Human TPO, transcript variant 1, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined.
• Source: HEK293 cells
• Species: Human
• Tag: MYC/DDK
• Molecular Mass: 102.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: TPO thyroid peroxidase [ Homo sapiens (human) ]
• Official Symbol: TPO
• Synonyms: TPO; thyroid peroxidase; TPX; TDH2A; MSA; thyroperoxidase; EC 1.11.1.8; EC 1.11.1; OTTHUMP00000115535; OTTHUMP00000115536; thyroid microsomal antigen; NP_000538.3; NP_001193673.1; NP_001193674.1; NP_783650.1; NP_783652.1; NP_783653.1
• Gene ID: 7173
• mRNA Refseq: NM_000547
• Protein Refseq: NP_000538
• MIM: 606765
• UniProt ID: P07202
• Chromosome Location: 2p25
• Pathway: Amine-derived hormones; Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Jak-STAT signaling pathway
• Function: calcium ion binding; iodide peroxidase activity; peroxidase activity