"TPO" Related Products


Recombinant Human TPO, MYC/DDK-tagged

Cat.No.: TPO-24H
Product Overview: Recombinant Human TPO, transcript variant 1, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.
Description: This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined.
Source: HEK293 cells
Species: Human
Molecular Mass: 102.8 kDa
Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration: >50 ug/mL as determined by microplate BCA method
Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name: TPO thyroid peroxidase [ Homo sapiens (human) ]
Official Symbol: TPO
Synonyms: TPO; thyroid peroxidase; TPX; TDH2A; MSA; thyroperoxidase; EC; EC 1.11.1; OTTHUMP00000115535; OTTHUMP00000115536; thyroid microsomal antigen; NP_000538.3; NP_001193673.1; NP_001193674.1; NP_783650.1; NP_783652.1; NP_783653.1
Gene ID: 7173
mRNA Refseq: NM_000547
Protein Refseq: NP_000538
MIM: 606765
UniProt ID: P07202
Chromosome Location: 2p25
Pathway: Amine-derived hormones; Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Jak-STAT signaling pathway
Function: calcium ion binding; iodide peroxidase activity; peroxidase activity

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