| Description : |
This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
102.9 kDa |
| AA Sequence : |
MRALAVLSVTLVMACTEAFFPFISR GKELLWGKPEESRVSSVLEESKRLV DTAMYATMQRNLKKRGILSAAQLLS FSKLPEPTSGVIARAAEIMETSIQA MKRKVNLKTQQSQHPTDALSEDLLS IIANMSGCLPYMLPPKCPNTCLANK YRPITGACNNRDHPRWGASNTALAR WLPPVYEDGFSQPRGWNPGFLYNGF PLPPVREVTRHVIQVSNEVVTDDDR YSDLLMAWGQYIDHDIAFTPQSTSK AAFGGGADCQMTCENQNPCFPIQLP EEARPAAGTACLPFYRSSAACGTGD QGALFGNLSTANPRQQMNGLTSFLD ASTVYGSSPALERQLRNWTSAEGLL RVHARLRDSGRAYLPFVPPRAPAAC APEPGIPGETRGPCFLAGDGRASEV PSLTALHTLWLREHNRLAAALKALN AHWSADAVYQEARKVVGALHQIITL RDYIPRILGPEAFQQYVGPYEGYDS TANPTVSNVFSTAAFRFGHATIHPL VRRLDASFQEHPDLPGLWLHQAFFS PWTLLRGGGLDPLIRGLLARPAKLQ VQDQLMNEELTERLFVLSNSSTLDL ASINLQRGRDHGLPGYNEWREFCGL PRLETPADLSTAIASRSVADKILDL YKHPDNIDVWLGGLAENFLPRARTG PLFACLIGKQMKALRDGDWFWWENS HVFTDAQRRELEKHSLSRVICDNTG LTRVPMDAFQVGKFPEDFESCDSIT GMNLEAWRETFPQDDKCGFPESVEN GDFVHCEESGRRVLVYSCRHGYELQ GREQLTCTQEGWDFQPPLCKDVNEC ADGAHPPCHASARCRNTKGGFQCLC ADPYELGDDGRTCVDSGRLPRVTWI SMSLAALLIGGFAGLTSTVICRWTR TGTKSTLPISETGGGTPELRCGKHQ AVGTSPQRAAAQDSEQESAGMEGRD THRLPRALTRPLEQKLISEEDLAAN DILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
