Recombinant Human E2F1, MYC/DDK-tagged E2F1-238H

Recombinant Human E2F1, MYC/DDK-tagged

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Recombinant Human E2F1, MYC/DDK-tagged

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Cat.No. : E2F1-238H
Product Overview : Recombinant Human E2F1 fussed with MYC/DDK tag at C-terminal was expressed in HEK293 cells.
Description : The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
Source : HEK293 cells
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 46.7 kDa
Purity : >80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : E2F1 E2F transcription factor 1 [ Homo sapiens ]
Official Symbol : E2F1
Synonyms : RBP3; E2F-1; RBAP1; RBBP3; transcription factor E2F1; PBR3; PRB-binding protein E2F-1; RBAP-1; RBBP-3; retinoblastoma-associated protein 1; retinoblastoma-binding protein 3
Gene ID : 1869
mRNA Refseq : NM_005225
Protein Refseq : NP_005216
MIM : 189971
UniProt ID : Q01094
Chromosome Location : 20q11.2
Pathway : Activation of BH3-only proteins, organism-specific biosystem; Activation of PUMA and translocation to mitochondria, organism-specific biosystem; Apoptosis, organism-specific biosystem
Function : DNA binding; core promoter binding; sequence-specific DNA binding

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