Recombinant Human E2F1, MYC/DDK-tagged


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Recombinant Human E2F1, MYC/DDK-tagged

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Cat.No. : E2F1-238H
Product Overview : Recombinant Human E2F1 fussed with MYC/DDK tag at C-terminal was expressed in HEK293 cells.
Description : The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
Source : HEK293 cells
Species : Human
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 46.7 kDa
Purity : >80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : E2F1 E2F transcription factor 1 [ Homo sapiens ]
Official Symbol : E2F1
Synonyms : RBP3; E2F-1; RBAP1; RBBP3; transcription factor E2F1; PBR3; PRB-binding protein E2F-1; RBAP-1; RBBP-3; retinoblastoma-associated protein 1; retinoblastoma-binding protein 3
Gene ID : 1869
mRNA Refseq : NM_005225
Protein Refseq : NP_005216
MIM : 189971
UniProt ID : Q01094
Chromosome Location : 20q11.2
Pathway : Activation of BH3-only proteins, organism-specific biosystem; Activation of PUMA and translocation to mitochondria, organism-specific biosystem; Apoptosis, organism-specific biosystem
Function : DNA binding; core promoter binding; sequence-specific DNA binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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