Recombinant Human E2F1, MYC/DDK-tagged
Cat.No. : | E2F1-238H |
Product Overview : | Recombinant Human E2F1 fussed with MYC/DDK tag at C-terminal was expressed in HEK293 cells. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. |
Source : | HEK293 cells |
Species : | Human |
Tag : | MYC/DDK |
Form : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 46.7 kDa |
Purity : | >80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | E2F1 E2F transcription factor 1 [ Homo sapiens ] |
Official Symbol : | E2F1 |
Synonyms : | RBP3; E2F-1; RBAP1; RBBP3; transcription factor E2F1; PBR3; PRB-binding protein E2F-1; RBAP-1; RBBP-3; retinoblastoma-associated protein 1; retinoblastoma-binding protein 3 |
Gene ID : | 1869 |
mRNA Refseq : | NM_005225 |
Protein Refseq : | NP_005216 |
MIM : | 189971 |
UniProt ID : | Q01094 |
Chromosome Location : | 20q11.2 |
Pathway : | Activation of BH3-only proteins, organism-specific biosystem; Activation of PUMA and translocation to mitochondria, organism-specific biosystem; Apoptosis, organism-specific biosystem |
Function : | DNA binding; core promoter binding; sequence-specific DNA binding |
Products Types
◆ Recombinant Protein | ||
E2F1-3002H | Recombinant Human E2F1 Protein, GST-tagged | +Inquiry |
E2f1-2707M | Recombinant Mouse E2f1 Protein, Myc/DDK-tagged | +Inquiry |
E2F1-1031H | Recombinant Human E2F1, His-tagged | +Inquiry |
E2F1-12245H | Recombinant Human E2F1, GST-tagged | +Inquiry |
E2F1-2016H | Recombinant Human E2F1 Protein (Val88-Phe437), N-His tagged | +Inquiry |
◆ Lysates | ||
E2F1-6743HCL | Recombinant Human E2F1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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