Cat. No. :	IL12A-42H
Product Overview :	Recombinant Human Interleukin-10 produced inE.Coliis single, a non-glycosylated, Polypeptide chain containing 160 amino acids fragment (19-178) and having a total molecular mass of 18.6 kDa with an amino-terminal His-tagged. The IL-10 His-Tag is purified by proprietary chromatographic techniques.
Description :	Interleukin-10 is a multifunctional cytokine produced by a variety of cell types including T helper cells activated B cells and activated macrophages. Interleukin-10 regulates immune-mediated inflammation and modulates the function of cells such as lymphocytes, monocytes, natural killer cells and dendritic cells.
Source :	Escherichia Coli.
Physical Appearance :	Sterile Filtered clear solution (0.083mg/1ml)
Purity :	Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation :	Interleukin-12 p35 His-Tag is supplied in 20mM Tris HCL pH=8, 0.5 mM DTT and 50% glycerol.
Storage :	Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
PDB rendering based on 1f45 :

Gene Name :	IL12A interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) [ Homo sapiens ]
Synonyms :	NKSF1; CTL maturation factor (TCMF); Cytotoxic lymphocyte maturation factor 35 kDa subunit (CLMF p35); TSF; Edodekin-alpha; IL-12 p35; SGT2; FLJ39002; CLMF; IL-12A; NFSK; P35; Cytotoxic lymphocyte maturation factor 35 kDa subunit; IL-12 subunit p35; IL-12, subunit p35; NF cell stimulatory factor chain 1; cytotoxic lymphocyte maturation factor 1, p35; interleukin 12, p35; interleukin 12A; interleukin 12A (natural killer cell stimulatory factor 1,cytotoxic lymphocytematuration factor 1, p35); interleukin-12 alpha chain; natural killer cell stimulatory factor 1, 35 kD subunit 2; IL12A.
Gene ID :	3592
mRNA Refseq :	NM_000882
Protein Refseq :	NP_000873
MIM :	161560
UniProt ID :	P29459
Chromosome Location :	3q25.33-q26
Pathway :	Allograft rejection; Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; RIG-I-like receptor signaling pathway; Toll-like receptor signaling pathway; Type I diabetes mellitus
Function :	contributes_to cytokine activity; contributes_to growth factor activity; interleukin-12 beta subunit binding; interleukin-12 receptor binding; interleukin-27 binding; protein binding; protein heterodimerization activity

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