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| Cat. No.: | IL17A-113H |
| Product Overview: | Recombinant Human Interleukin 17A encoding the human IL-17A protein sequence (containing the signalpeptide sequence, and the mature IL-17A sequence) was expressed in modified human293 cells. |
| Description: | Interleukin-17 (IL-17) is a 155 amino acid protein that is a disulfide linked, homodimeric,secreted glycoprotein with one N-linked glycosylation site. IL-17 is also referred to as IL-17A. Other members include IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. IL-17 binds tothe cell surfacer receptor IL-17R. IL-17 is secreted by a subset of T cells called T-helper 17 (Th-17) cells. IL-23 is thought to mediate the production of IL-17 by Th-17 cells. |
| Source: | Human 293 cells. |
| Amino Acid Sequence: | GITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA. |
| Molecular Mass: | Under reducing conditions Apollo IL-17A hcx migrates as two bands at approximately 16and 22 kDa on SDS-PAGE due to post-translational modifications. |
| pI: | Apollo IL-17A hcx has a predicted pI of 8.62. |
| Glycosylation: | Apollo IL-17A hcx contains N--linked oligosaccharides. |
| Purity: | >95%, as determined by SDS-PAGE, visualised by Coomassie Brilliant Blue. |
| Formulation: | When reconstituted in 0.5 ml sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose. |
| Reconstitution: | It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial. |
| Storage: | Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-termstorage at 4°C and longer-term storage of aliquots at -18 to -20°C is recommended. Repeated freeze thawing is not recommended. |
| Activity: | The activity of IL-17A is measured by its ability to induce IL-6 production in NHDF cells. The ED50is typically between 0.5 and 1.5 ng/ml. |
| Gene Name: | 17A interleukin 17A [ Homo sapiens ] |
| Synonyms: | IL17A; interleukin 17A; IL17; CTLA8; IL-17; IL-17A; toxic T-lymphocyte-associated antigen 8; otoxic T-lymphocyte-associated protein 8; cytotoxic T-lymphocyte-associated serine esterase 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8) |
| Gene ID: | 3605 |
| mRNA Refseq: | NM_002190 |
| Protein Refseq: | NP_002181 |
| UniProt ID: | Q16552 |
| Chromosome Location: | 6p12 |
| MIM: | 603149 |
| Pathway: | Cytokine-cytokine receptor interaction |
| Function: | cytokine activity |
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