Recombinant Bovine Interleukin 17A

• Cat.No.: IL17A-236B
• Product Overview: Recombinant Bovine IL-17A was expressed inYeast. MW= 17.4 kDa (132 aa).

Specification

• Species: Bovine
• Source: Yeast
• Tag: Non
• Description: Interleukin-17A is a protein that in humans is encoded by the IL17A gene. The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
• Formulation/ Reconstitution: Lyophilized. Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.
• Purification: Ion-exchange chromatography.
• Purity: >95% as visualized by SDS-PAGE analysis.
• Amino Acid Sequence: KAGVIIPQSP GCPPTEDKNF PQHVRVNLNI VNRSTNSRRP TDYHKRSTSP WTLHRNEDPE RYPSVIWEAK CSHSGCINAE GKVDHHMNSV TIQQEILVLR RESQHCPHSF RLEKMLVAVG CTCVTPIVRH LA.
• Bioactivity: In testing.
• Stability And Storage: Stable for up to twelve months from date of receipt at -20°C. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.

Gene Information

• Gene Name: IL17A interleukin 17A [ Bos taurus ]
• Synonyms: interleukin 17A; IL17A; IL17; IL-17; interleukin-17A; IL-17A; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
• Gene ID: 282863
• mRNA Refseq: NM_001008412.1
• Protein Refseq: NP_001008412.1
• UniProt ID: Q687Y7
• Chromosome Location: 23
• Pathway: Cytokine-cytokine receptor interaction
• Function: cytokine activity