Cat. No. :	EPHA2-300H
Product Overview :	Recombinant human EPHA2 (561-end) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW=72kDa.
Description :	EPHA2 is a member of the ephrin receptor subfamily of protein-tyrosine kinases that bind the ephrin-A ligand and have diverse cellular function. EPHA2 has been shown to be an oncoprotein of importance in a range of cancers. EPHA2 is overexpressed in several human cancer types and promotes malignancy through a mechanism involving RhoA-dependent destabilization of adherens junctions. EPHA2 overexpression induces a FAK-dependent increase in MMP-2 expression and invasiveness and this process that can be reversed by ligation of EPHA2.
Source :	Sf9 insect cellsusing baculovirus.
Sequence :	561-end.
Applications :	Kinase Assay, Western Blot.
Storage And Stability :	Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Name :	EPHA2 EPH receptor A2 [ Homo sapiens ]
Synonyms :	EPHA2; EPH receptor A2; ECK; ARCC2; protein tyrosine kinase; soluble EPHA2 variant 1; soluble EPHA2 variant 1; epithelial cell receptor protein tyrosine kinase; ephrin receptor EphA2; EC 2.7.10.1
Gene ID :	1969
mRNA Refseq :	NM_004431
Protein Refseq :	NP_004422
MIM :	176946
UniProt ID :	P29317
Chromosome Location :	1p36
Pathway :	Axon guidance
Function :	ATP binding; ephrin receptor activity; nucleotide binding; protein binding; receptor activity; transferase activity

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