Recombinant Human EPH Receptor A2, GST-tagged, Active

• Cat.No.: EPHA2-300H
• Product Overview: Recombinant human EPHA2 (561-end) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW=72kDa.

Specification

• Cat. No.: EPHA2-300H
• Description: EPHA2 is a member of the ephrin receptor subfamily of protein-tyrosine kinases that bind the ephrin-A ligand and have diverse cellular function. EPHA2 has been shown to be an oncoprotein of importance in a range of cancers. EPHA2 is overexpressed in several human cancer types and promotes malignancy through a mechanism involving RhoA-dependent destabilization of adherens junctions. EPHA2 overexpression induces a FAK-dependent increase in MMP-2 expression and invasiveness and this process that can be reversed by ligation of EPHA2.
• Source: Sf9 insect cellsusing baculovirus.
• Sequence: 561-end.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: EPHA2 EPH receptor A2 [ Homo sapiens ]
• Synonyms: EPHA2; EPH receptor A2; ECK; ARCC2; protein tyrosine kinase; soluble EPHA2 variant 1; soluble EPHA2 variant 1; epithelial cell receptor protein tyrosine kinase; ephrin receptor EphA2; EC 2.7.10.1
• Gene ID: 1969
• mRNA Refseq: NM_004431
• Protein Refseq: NP_004422
• MIM: 176946
• UniProt ID: P29317
• Chromosome Location: 1p36
• Pathway: Axon guidance
• Function: ATP binding; ephrin receptor activity; nucleotide binding; protein binding; receptor activity; transferase activity