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Recombinant Human GRK5, GST-tagged, Active

Cat.No. : GRK5-324H
Product Overview : Recombinant human full-length GRK5 was expressed by baculovirus inSf9 cellsusing an N-terminal GST tag. MW=95kDa.
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Cat. No. : GRK5-324H
Description : GRK5 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. GRK5 plays a role in regulating the motility of polymorphonuclear leukocytes (PMNs). Desensitization of G protein-coupled receptors regulates the number of polymorphonuclear leukocytes (PMNs), as well as their motility and ability to stop upon contact with pathogens or target cells, and this desensitization is mediated by GRK5.
Source : Sf9 insect cells using baculovirus.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : GRK5 G protein-coupled receptor kinase 5 [ Homo sapiens ]
Synonyms : GRK5; G protein-coupled receptor kinase 5; GPRK5;EC2.7.11.16; G protein-coupled receptor kinase
Gene ID : 2869
mRNA Refseq : NM_005308
Protein Refseq : NP_005299
UniProt ID : P34947
Chromosome Location : 10q24-qter
MIM : 600870
Pathway : G protein-coupled receptor kinase;Endocytosis; Signaling by GPCR
Function : ATP binding; protein binding; nucleotide binding; transferase activity;G-protein coupled receptor kinase activity; phospholipid binding; protein kinase C binding; signal transducer activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What therapeutic strategies are being explored involving GRK5 modulation? 08/21/2022

Strategies include developing GRK5 inhibitors for potential use in heart disease and Alzheimer’s.

Are there known genetic mutations in GRK5 associated with specific health conditions? 04/16/2022

Certain GRK5 polymorphisms are associated with hypertension and heart failure risk.

How is GRK5 implicated in neurodegenerative diseases? 09/06/2021

GRK5 has been linked to Alzheimer’s disease through its role in tau phosphorylation.

How does GRK5 regulate G protein-coupled receptor (GPCR) activity? 05/04/2020

It phosphorylates activated GPCRs, promoting β-arrestin binding and receptor internalization.

In which tissues or cell types is GRK5 predominantly expressed? 01/23/2020

GRK5 is widely expressed but has notable levels in the heart and brain.

What role does GRK5 play in cardiovascular function? 01/08/2020

It regulates cardiac contractility and blood pressure, influencing heart function.

What is the main function of GRK5 in cellular signaling? 04/06/2019

GRK5 phosphorylates and desensitizes GPCRs, modulating their signaling.

Customer Reviews (3)

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Reviews
09/06/2021

    Good product, fast delivery.

    05/08/2021

      Highly recommend, very satisfied.

      03/05/2021

        Worked perfectly, great quality.

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