Recombinant Human GRK5, GST-tagged, Active
Cat.No. : | GRK5-324H |
Product Overview : | Recombinant human full-length GRK5 was expressed by baculovirus inSf9 cellsusing an N-terminal GST tag. MW=95kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | GRK5-324H |
Description : | GRK5 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. GRK5 plays a role in regulating the motility of polymorphonuclear leukocytes (PMNs). Desensitization of G protein-coupled receptors regulates the number of polymorphonuclear leukocytes (PMNs), as well as their motility and ability to stop upon contact with pathogens or target cells, and this desensitization is mediated by GRK5. |
Source : | Sf9 insect cells using baculovirus. |
Sequence : | Full-length. |
Applications : | Kinase Assay, Western Blot. |
Storage And Stability : | Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : | GRK5 G protein-coupled receptor kinase 5 [ Homo sapiens ] |
Synonyms : | GRK5; G protein-coupled receptor kinase 5; GPRK5;EC2.7.11.16; G protein-coupled receptor kinase |
Gene ID : | 2869 |
mRNA Refseq : | NM_005308 |
Protein Refseq : | NP_005299 |
UniProt ID : | P34947 |
Chromosome Location : | 10q24-qter |
MIM : | 600870 |
Pathway : | G protein-coupled receptor kinase;Endocytosis; Signaling by GPCR |
Function : | ATP binding; protein binding; nucleotide binding; transferase activity;G-protein coupled receptor kinase activity; phospholipid binding; protein kinase C binding; signal transducer activity |
Products Types
◆ Recombinant Protein | ||
GRK5-2366R | Recombinant Rat GRK5 Protein, His (Fc)-Avi-tagged | +Inquiry |
GRK5-760H | Recombinant Human GRK5 protein(Met1-Ser590), His-tagged | +Inquiry |
Grk5-1051M | Recombinant Mouse Grk5 Protein, MYC/DDK-tagged | +Inquiry |
GRK5-5356H | Recombinant Human GRK5 Protein, GST-tagged | +Inquiry |
GRK5-2359H | Recombinant Human GRK5 Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
GRK5-640HCL | Recombinant Human GRK5 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionStrategies include developing GRK5 inhibitors for potential use in heart disease and Alzheimer’s.
Certain GRK5 polymorphisms are associated with hypertension and heart failure risk.
GRK5 has been linked to Alzheimer’s disease through its role in tau phosphorylation.
It phosphorylates activated GPCRs, promoting β-arrestin binding and receptor internalization.
GRK5 is widely expressed but has notable levels in the heart and brain.
It regulates cardiac contractility and blood pressure, influencing heart function.
GRK5 phosphorylates and desensitizes GPCRs, modulating their signaling.
Customer Reviews (3)
Write a reviewGood product, fast delivery.
Highly recommend, very satisfied.
Worked perfectly, great quality.
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