Recombinant Human GRK5, GST-tagged, Active GRK5-324H

Recombinant Human GRK5, GST-tagged, Active

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Recombinant Human GRK5, GST-tagged, Active

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Cat. No. : GRK5-324H
Product Overview : Recombinant human full-length GRK5 was expressed by baculovirus inSf9 cellsusing an N-terminal GST tag. MW=95kDa.
Description : GRK5 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. GRK5 plays a role in regulating the motility of polymorphonuclear leukocytes (PMNs). Desensitization of G protein-coupled receptors regulates the number of polymorphonuclear leukocytes (PMNs), as well as their motility and ability to stop upon contact with pathogens or target cells, and this desensitization is mediated by GRK5.
Source : Sf9 insect cells using baculovirus.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : GRK5 G protein-coupled receptor kinase 5 [ Homo sapiens ]
Synonyms : GRK5; G protein-coupled receptor kinase 5; GPRK5;EC2.7.11.16; G protein-coupled receptor kinase
Gene ID : 2869
mRNA Refseq : NM_005308
Protein Refseq : NP_005299
UniProt ID : P34947
Chromosome Location : 10q24-qter
MIM : 600870
Pathway : G protein-coupled receptor kinase;Endocytosis; Signaling by GPCR
Function : ATP binding; protein binding; nucleotide binding; transferase activity;G-protein coupled receptor kinase activity; phospholipid binding; protein kinase C binding; signal transducer activity

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