Recombinant Active Mouse IL13 Protein, His-tagged(C-ter)
|Product Overview :||Recombinant Active Mouse IL13 Protein with His tag (C-ter) was expressed in E. coli.|
- Gene Information
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|Description :||This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]|
|Source :||E. coli|
|Bio-activity :||Determined by its ability to induce TF-1 cells proliferation. The ED50 for this effect is < 4 ng/mL. The specific activity of recombinant mouse IL-13 is > 2.5 x 10^5 IU/mg.|
|AA Sequence :||MPVPRSVSLPLTLKELIEELSNITQ DQTPLCNGSMVWSVDLAAGGFCVAL DSLTNISNCNAIYRTQRILHGLCNR KAPTTVSSLPDTKIEVAHFITKLLS YTKQLFRHGPF|
|Endotoxin :||Endotoxin level is less than 0.1 EU/μg of the protein, as determined by the LAL test.|
|Purity :||> 95% (by SDS-PAGE)|
|Notes :||For laboratory research only, not for drug, diagnostic or other use.|
|Storage :||Lyophilized protein should be stored at -20°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening.|
|Storage Buffer :||PBS (pH 7.4)|
|Reconstitution :||It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely.|
|Gene Name :||Il13 interleukin 13 [ Mus musculus ]|
|Official Symbol :||Il13|
|Synonyms :||IL13; interleukin 13; interleukin-13; T-cell activation protein P600; Il-13;|
|Gene ID :||16163|
|mRNA Refseq :||NM_008355|
|Protein Refseq :||NP_032381|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
Flow cytometry quantifies IL13 receptor expression on cells.
Transgenic models illuminate IL13's in vivo functions.
ELISA quantifies IL13 secretion in cell cultures accurately.
siRNA knockdown uncovers IL13's specific cellular effects.
Co-immunoprecipitation identifies IL13 signaling partners.
Differential techniques distinguish IL13 and IL4 signaling pathways.
Reporter gene assays gauge IL13-driven transcription.
Microarray analysis profiles IL13-induced gene expression.
Experimental methods reveal IL13's impact on tissue remodeling.
Site-directed mutagenesis identifies key residues in IL13 receptor binding.
Customer Reviews (3)Write a review
Effective in Th2 cell differentiation. -
Good for cytokine assays. -
High yield in expression. -
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