IL13

  • Official Full Name

    interleukin 13

  • Background

    This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
  • Synonyms

    ALRH; BHR1; P600; IL-13; interleukin-13; allergic rhinitis; Bronchial hyperresponsiveness-1 (bronchial asthma); NC30; Tralokinumab; 1044515-88-9; Lebrikizumab; 953400-68-5; Anrukinzumab (= IMA-638); 910649-32-0;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • GMP Proteins
    • Therapeutic Proteins
    • Transfected Stable Cell Lines
    • Antibody
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Bovine
    • Canine
    • Cattle
    • Chicken
    • Cotton Rat
    • Cynomolgus
    • Cynomolgus Monkey
    • Dog
    • Equine
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Rhesus monkey
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293F
    • Human
    • Human Cell
    • Mammalian cell
    • Mammalian Cell
    • Rat
    • Yeast
    • Tag :
    • APC
    • Fc
    • hFc
    • Myc
    • HIgG1 Fc
    • tagged
    • His
    • His (Fc)
    • Avi
    • His(C
    • ter)
    • His|Biotin
    • His|DDK
    • His|GST
    • His|T7
    • human|IgG1|Fc
    • mFc
    • N/A
    • N
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Bovine IL13-234B Active Recombinant Bovine Interleukin 13 Yeast N/A
    Canine IL13-2191C Active Recombinant Canine IL13 protein, His-tagged HEK293 His
    Canine IL13-62C Recombinant Canine IL-13 Yeast N/A
    Cattle IL13-854C Recombinant Cattle IL13 protein, His & GST-tagged E.coli His/GST
    Chicken IL13-4154C Recombinant Chicken IL13 Mammalian Cell His
    Chicken IL13-58C Recombinant Chicken IL-13 Yeast N/A
    Cotton Rat Il13-415C Active Recombinant Cotton Rat Il13, His-tagged CHO His
    Cynomolgus IL13-1568C Recombinant Cynomolgus IL13 protein, His-tagged HEK293 His
    Cynomolgus IL13-308C Recombinant Cynomolgus IL13 protein HEK293 N/A
    Cynomolgus Monkey IL13-1894CCL Recombinant Cynomolgus IL13 cell lysate Human Cell N/A
    Cynomolgus Monkey IL13-373C Recombinant Cynomolgus IL13, His tagged Human Cell His
    Dog IL13-855D Recombinant Dog IL13 protein, His & T7-tagged E.coli His/T7
    Equine IL13-252E Recombinant Equine Interleukin 13 Yeast N/A
    Human IL13-505H Recombinant Human IL13 Protein
    Human IL13-124H Recombinant Human IL13 protein E.coli N/A
    Human IL13-28497TH Recombinant Human IL13 E.coli N/A
    Human IL13-1251H Active Recombinant Human IL13 E.coli N/A
    Human IL13-432HG GMP Recombinant Human IL13 protein HEK293
    Human IL13-504H Recombinant Human IL13 Protein, Fc-tagged Fc
    Human IL13-14149H Recombinant Human IL13, His-tagged E.coli His
    Human IL13-001HCL Recombinant Human IL13 cell lysate CHO N/A
    Human IL13-120H Recombinant Human IL13 Protein, His-tagged Human Cell His
    Human IL13-P041H Recombinant Human IL13 therapeutic protein N/A
    Human IL13-370H Active Recombinant Human IL13 CHO N/A
    Human IL13-2922HCL Recombinant Human IL13 cell lysate Human Cell N/A
    Human IL13-29107TH Recombinant Human IL13 E.coli N/A
    Human IL13-16H Recombinant Human IL13, His-Biotin-tagged E.coli His/Biotin
    Human IL13-287H Recombinant Human IL13, StrepII-tagged Human Cell Strep II
    Human IL13-4328HG GMP Recombinant Human IL12A protein E.coli N/A
    Human IL13-328H Active Recombinant Human IL13 Human N/A
    Human IL13-481H Active Recombinant Human Interleukin 13 E.coli N/A
    Human IL13-50H Active Recombinant Human Interleukin 13, MIgG2a Fc-tagged CHO Fc
    Human IL13-856H Recombinant Human IL13 protein, His & T7-tagged E.coli His/T7
    Human IL13-147H Recombinant Human IL13 protein, hFc-tagged HEK293 hFc
    Human IL13-52H Active Recombinant Human Interleukin 13, HIgG1 Fc-tagged HEK293 HIgG1 Fc-tagged
    Human IL13-165H Recombinant Human IL13 protein E.coli N/A
    Human IL13-519HB Recombinant Human IL13 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Human IL13-44H Recombinant Human Interleukin 13, His-tagged E.coli His
    Human IL13-53H Active Recombinant Human Interleukin 13, HIgG1 Fc-tagged, mutant CHO Fc
    Human IL13-335H Recombinant Human IL13 Protein, His/DDK-tagged HEK293 His/DDK
    Human IL-13-3015H Recombinant Human IL-13 protein, His-tagged E.coli His
    Human IL13-365H Active Recombinant Human IL13 protein, Fc-tagged HEK293 Fc
    Human IL13-22H Recombinant Human IL13 protein E.coli N/A
    Human IL13-229H Recombinant Human IL13 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human IL13-1002H Recombinant Human IL13 Protein, His-tagged HEK293F N-His
    Human IL13-3589H Recombinant Human IL13 protein, His-tagged HEK293 His
    Human IL13-143H Recombinant Active Human IL13 Protein, His-tagged(C-ter) E.coli His(C-ter)
    Human IL13-589H Recombinant Human IL13 protein, His-Avi-tagged HEK293 His-Avi
    Human IL13-132H Recombinant Human IL13 Protein E.coli
    Human IL13-138H Human Interleukin-13 (rDNA derived) Reference standard N/A
    Human IL13-255I Recombinant Human IL13 Protein CHO
    Human IL13-4324H Recombinant Human IL13 protein, hFc-Myc-tagged Mammalian cell hFc-Myc
    Human IL13-458H Recombinant Human IL13 protein, His-tagged HEK293 His
    Human DMABT-H19232 Rat Anti-IL13 Monoclonal Antibody Rat APC
    Human IL13-459H Recombinant Human IL13 protein, hFc-tagged HEK293 hFc
    Human IL13-4325H Recombinant Human IL13 protein, hFc-tagged Mammalian cell hFc
    Human IL13-230H Recombinant Human IL13(Gly21­-Asn132) Protein, C-mFc-tagged HEK293 mFc
    Mouse IL13-60M Recombinant Mouse IL-13 Yeast N/A
    Mouse Il13-087M Recombinant Mouse Il13 Protein E.coli
    Mouse IL13-133M Recombinant Mouse IL13 Protein E.coli
    Mouse Il13-089M Recombinant Mouse Il13 Protein E.coli
    Mouse IL13-1569M Recombinant Mouse IL13 protein, His-tagged HEK293 His
    Mouse Il13-16M Active Recombinant Mouse Il13 Human Cell N/A
    Mouse Il13-038I Recombinant Mouse Il13 Protein (111 aa) E.coli
    Mouse Il13-090M Recombinant Mouse Il13 Protein E.coli
    Mouse Il13-088M Recombinant Mouse Il13 Protein E.coli
    Mouse Il13-256I Recombinant Mouse Il13 Protein, His-tagged CHO His
    Mouse Il13-144M Recombinant Active Mouse IL13 Protein, His-tagged(C-ter) E.coli His(C-ter)
    Mouse Il13-629M Recombinant Mouse Il13 protein E.coli N/A
    Mouse Il13-01M Active Recombinant Mouse Il13 Protein, His-Tagged E.coli His
    Mouse Il13-857M Recombinant Mouse Il13 protein, His-tagged E.coli His
    Mouse IL13-1336MCL Recombinant Mouse IL13 cell lysate Human Cell N/A
    Pig IL13-1985P Recombinant Pig IL13 protein E.coli N/A
    Pig IL13-1003P Recombinant Pig IL13 Protein, His-tagged E.coli N-His
    Pig IL13-262S Active Recombinant Swine Interleukin 13 Yeast N/A
    Rabbit IL13-4350R Recombinant Rabbit IL13 Protein Yeast N/A
    Rat Il13-858R Recombinant Rat Il13 protein, His & T7-tagged E.coli His/T7
    Rat Il13-580R Recombinant Rat Il13 protein E.coli N/A
    Rat IL13-2681R Recombinant Rat IL13 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat Il13-87R Recombinant Rat Il13 protein E.coli N/A
    Rat IL13-3026R Recombinant Rat IL13 Protein Mammalian Cell His
    Rat IL13-2681R-B Recombinant Rat IL13 Protein Pre-coupled Magnetic Beads HEK293
    Rat Il13-008I Recombinant Rat Il13 Protein (110 aa) E.coli
    Rat Il13-1661R Recombinant Rat Il13 Protein, His-tagged E.coli N-His
    Rhesus IL13-542R Recombinant Rhesus IL13 protein E.coli N/A
    Rhesus Macaque IL13-2052R Recombinant Rhesus Macaque IL13 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus Macaque IL13-2052R-B Recombinant Rhesus Macaque IL13 Protein Pre-coupled Magnetic Beads HEK293
    Rhesus Macaque IL13-146R Recombinant Rhesus Interleukin 13 CHO N/A
    Rhesus Macaque IL13-2231R Recombinant Rhesus monkey IL13 Protein, His-tagged Mammalian Cell His
    Rhesus monkey IL13-1660R Recombinant Rhesus monkey IL13 Protein, His-tagged E.coli N-His
    Zebrafish IL13-4328Z Recombinant Zebrafish IL13 Protein Yeast N/A
    Zebrafish IL13-7888Z Recombinant Zebrafish IL13 Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • IL13 Related Articles
    • IL13 Related Gene Family

    IL13 involved in several pathways and played different roles in them. We selected most pathways IL13 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Fc epsilon RI signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interactionIL20;GM13306;TNFRSF10A;CRFB2;GDF5;FLT4;GM2506;TP-1;CXCL12A
    Jak-STAT signaling pathwayLEPA;BCL2L1;THPO;IL24;IL2RA;IFNPHI3;GRB2;IFNAR2;GHRA
    Fc epsilon RI signaling pathwayLYN;AKT2;TNF;PIK3CG;PIK3R1;MAPK10;NRAS;IL3;PLA2G4C
    MeaslesIRF3;FAS;Fasl;TYK2;IFNG;IRF7;OAS1;IL2RB;OAS1B
    AsthmaHLA-DMA;HLA-DRB5;CD40;EPX;CCL11;FCER1G;HLA-DOA;HLA-DRB3;H2-AB1
    Inflammatory bowel disease (IBD)NFATC1;IL5;TLR4;IL12B;Il4ra;SMAD3;Il2;STAT3;IL23

    IL13 has several biochemical functions, for example, cytokine activity, interleukin-13 receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL13 itself. We selected most functions IL13 had, and list some proteins which have the same functions with IL13. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activityGm13290;IL17D;IL10;HMGB1B;GDF6B;IFNPHI1;IL19;BMP1;BMP10
    interleukin-13 receptor binding
    protein bindingPSMA7;TRIM22;CD164;NIPA2;NR1H4;WBP1;MED18;MLKL;HAGH

    IL13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL13 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL13.

    IL13RA1

    Tripp, C; Campbell, A; et al. THE CHARACTERIZATION OF RPC4046, A NOVEL ANTI-IL13 MONOCLONAL ANTIBODY THAT BLOCKS BINDING TO IL-13 RECEPTOR alpha 1 AND alpha 2 IN DEVELOPMENT FOR EOSINOPHILIC ESOPHAGITIS: RESULTS OF A FIRST-IN-HUMAN STUDY.. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY 113:A104-A105(2014).
    Wilson, AD; et al. Immune responses to ectoparasites of horses, with a focus on insect bite hypersensitivity. PARASITE IMMUNOLOGY 36:558-570(2014).
    IL
    • Q&As
    • Reviews

    Q&As (10)

    Ask a question
    How does flow cytometry help quantify IL13 receptor expression on different cell populations? 12/29/2022

    Flow cytometry quantifies IL13 receptor expression on cells.

    What are the benefits of using transgenic animal models to study IL13's in vivo functions? 07/05/2022

    Transgenic models illuminate IL13's in vivo functions.

    Could you explain the role of ELISA in quantifying IL13 secretion levels in cell cultures? 02/23/2022

    ELISA quantifies IL13 secretion in cell cultures accurately.

    How can siRNA knockdown experiments reveal IL13's effects on specific cellular processes? 06/13/2021

    siRNA knockdown uncovers IL13's specific cellular effects.

    How does co-immunoprecipitation identify interacting partners in IL13-mediated signaling complexes? 07/28/2019

    Co-immunoprecipitation identifies IL13 signaling partners.

    What techniques can differentiate IL13-mediated signaling pathways from IL4 pathways? 07/23/2019

    Differential techniques distinguish IL13 and IL4 signaling pathways.

    Could you elaborate on the use of reporter gene assays to assess IL13-driven transcriptional activity? 12/16/2018

    Reporter gene assays gauge IL13-driven transcription.

    Can you describe the applications of microarray analysis in profiling IL13-induced gene expression changes? 11/14/2018

    Microarray analysis profiles IL13-induced gene expression.

    What experimental methods determine the impact of IL13 on tissue remodeling processes? 08/04/2018

    Experimental methods reveal IL13's impact on tissue remodeling.

    How does site-directed mutagenesis help identify critical residues in IL13 receptor binding? 07/04/2018

    Site-directed mutagenesis identifies key residues in IL13 receptor binding.

    Customer Reviews (3)

    Write a review
    Reviews
    11/29/2021

      Effective in Th2 cell differentiation. -

      04/22/2020

        Good for cytokine assays. -

        01/26/2019

          High yield in expression. -

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