IL13 Protein

IL13

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IL13

Official Full Name interleukin 13
Background This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
Synonyms ALRH; BHR1; P600; IL-13; interleukin-13; allergic rhinitis; Bronchial hyperresponsiveness-1 (bronchial asthma); NC30; Tralokinumab; 1044515-88-9; Lebrikizumab; 953400-68-5; Anrukinzumab (= IMA-638); 910649-32-0
    • Species :
    • Bovine
    • Canine
    • Cattle
    • Chicken
    • Cotton Rat
    • Cynomolgus Monkey
    • Dog
    • Equine
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Rhesus monkey
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293F
    • Human
    • Human Cell
    • Mammalian cell
    • Rat
    • Yeast
    • Tag :
    • APC
    • Fc
    • hFc
    • hFc-Myc
    • HIgG1 Fc-tagged
    • His
    • His(C-ter)
    • Biotin
    • DDK
    • GST
    • T7
    • His-Avi
    • human
    • IgG1
    • mFc
    • N/A
    • N-His
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL13-1251H Active Recombinant Human IL13 E.coli N/A Inquiry
    Human IL13-328H Active Recombinant Human IL13 Human N/A Inquiry
    Human IL13-365H Active Recombinant Human IL13 protein, Fc-tagged HEK293 Fc Inquiry
    Human IL13-481H Active Recombinant Human Interleukin 13 E.coli N/A Inquiry
    Human IL13-50H Active Recombinant Human Interleukin 13, MIgG2a Fc-tagged CHO Fc Inquiry
    Human IL13-52H Active Recombinant Human Interleukin 13, HIgG1 Fc-tagged HEK293 HIgG1 Fc-tagged Inquiry
    Human IL13-53H Active Recombinant Human Interleukin 13, HIgG1 Fc-tagged, mutant CHO Fc Inquiry
    Mouse Il13-16M Active Recombinant Mouse Il13 Human Cell N/A Inquiry
    Bovine IL13-234B Active Recombinant Bovine Interleukin 13 Yeast N/A Inquiry
    Pig IL13-262S Active Recombinant Swine Interleukin 13 Yeast N/A Inquiry
    Cotton Rat Il13-415C Active Recombinant Cotton Rat Il13, His-tagged CHO His Inquiry
    Mouse Il13-01M Active Recombinant Mouse Il13 Protein, His-Tagged E.coli His Inquiry
    Canine IL13-2191C Active Recombinant Canine IL13 protein, His-tagged HEK293 His Inquiry
    Human IL13-124H Recombinant Human IL13 protein E.coli N/A Inquiry
    Human IL13-14149H Recombinant Human IL13, His-tagged E.coli His Inquiry
    Human IL13-147H Recombinant Human IL13, Fc tagged Human Cell Fc Inquiry
    Human IL13-165H Recombinant Human IL13 protein E.coli N/A Inquiry
    Human IL13-16H Recombinant Human IL13, His-Biotin-tagged E.coli His/Biotin Inquiry
    Human IL13-22H Recombinant Human IL13 protein E.coli N/A Inquiry
    Human IL13-28497TH Recombinant Human IL13 E.coli N/A Inquiry
    Human IL13-287H Recombinant Human IL13, StrepII-tagged Human Cell Strep II Inquiry
    Human IL13-29107TH Recombinant Human IL13 E.coli N/A Inquiry
    Human IL13-335H Recombinant Human IL13 Protein, His/DDK-tagged HEK293 His/DDK Inquiry
    Human IL13-370H Recombinant Human IL13, None tagged CHO N/A Inquiry
    Human IL13-44H Recombinant Human Interleukin 13, His-tagged E.coli His Inquiry
    Human IL13-856H Recombinant Human IL13 protein, His & T7-tagged E.coli His/T7 Inquiry
    Mouse IL13-60M Recombinant Mouse IL-13 Yeast N/A Inquiry
    Mouse Il13-629M Recombinant Mouse Il13 protein E.coli N/A Inquiry
    Mouse Il13-857M Recombinant Mouse Il13 protein, His-tagged E.coli His Inquiry
    Rat IL13-3026R Recombinant Rat IL13 Protein Mammalian Cell His Inquiry
    Rat Il13-580R Recombinant Rat Il13 protein E.coli N/A Inquiry
    Rat Il13-858R Recombinant Rat Il13 protein, His & T7-tagged E.coli His/T7 Inquiry
    Rat Il13-87R Recombinant Rat Il13 protein E.coli N/A Inquiry
    Cynomolgus Monkey IL13-308C Recombinant Cynomolgus IL13, None tagged Human Cell N/A Inquiry
    Cynomolgus Monkey IL13-373C Recombinant Cynomolgus IL13, His tagged Human Cell His Inquiry
    Rhesus Macaque IL13-146R Recombinant Rhesus Interleukin 13 CHO N/A Inquiry
    Rhesus Macaque IL13-2231R Recombinant Rhesus monkey IL13 Protein, His-tagged Mammalian Cell His Inquiry
    Rhesus IL13-542R Recombinant Rhesus IL13 protein E.coli N/A Inquiry
    Canine IL13-62C Recombinant Canine IL-13 Yeast N/A Inquiry
    Dog IL13-855D Recombinant Dog IL13 protein, His & T7-tagged E.coli His/T7 Inquiry
    Chicken IL13-4154C Recombinant Chicken IL13 Mammalian Cell His Inquiry
    Chicken IL13-58C Recombinant Chicken IL-13 Yeast N/A Inquiry
    Zebrafish IL13-7888Z Recombinant Zebrafish IL13 Mammalian Cell His Inquiry
    Equine IL13-252E Recombinant Equine Interleukin 13 Yeast N/A Inquiry
    Cattle IL13-854C Recombinant Cattle IL13 protein, His & GST-tagged E.coli His/GST Inquiry
    Human IL13-001HCL Recombinant Human IL13 cell lysate CHO N/A Inquiry
    Human IL13-2922HCL Recombinant Human IL13 cell lysate Human Cell N/A Inquiry
    Mouse IL13-1336MCL Recombinant Mouse IL13 cell lysate Human Cell N/A Inquiry
    Cynomolgus Monkey IL13-1894CCL Recombinant Cynomolgus IL13 cell lysate Human Cell N/A Inquiry
    Human IL13-1002H Recombinant Human IL13 Protein, His-tagged HEK293F N-His Inquiry
    Pig IL13-1003P Recombinant Pig IL13 Protein, His-tagged E.coli N-His Inquiry
    Human IL13-120H Recombinant Human IL13 Protein, His-tagged Human Cell His Inquiry
    Human IL13-132H Recombinant Human IL13 Protein E.coli Inquiry
    Mouse IL13-133M Recombinant Mouse IL13 Protein E.coli Inquiry
    Human IL13-143H Recombinant Active Human IL13 Protein, His-tagged(C-ter) E.coli His(C-ter) Inquiry
    Mouse Il13-144M Recombinant Active Mouse IL13 Protein, His-tagged(C-ter) E.coli His(C-ter) Inquiry
    Rhesus monkey IL13-1660R Recombinant Rhesus monkey IL13 Protein, His-tagged E.coli N-His Inquiry
    Rat Il13-1661R Recombinant Rat Il13 Protein, His-tagged E.coli N-His Inquiry
    Pig IL13-1985P Recombinant Pig IL13 protein E.coli N/A Inquiry
    Human IL13-230H Recombinant Human IL13(Gly21­-Asn132) Protein, C-mFc-tagged HEK293 mFc Inquiry
    Human IL13-4324H Recombinant Human IL13 protein, hFc-Myc-tagged Mammalian cell hFc-Myc Inquiry
    Human IL13-4325H Recombinant Human IL13 protein, hFc-tagged Mammalian cell hFc Inquiry
    Human DMABT-H19232 Rat Anti-IL13 Monoclonal Antibody Rat APC Inquiry
    Human IL13-138H Human Interleukin-13 (rDNA derived) Reference standard N/A Inquiry
    Human IL13-229H Recombinant Human IL13 protein, Fc-tagged HEK293 human/IgG1/Fc Inquiry
    Human IL13-3589H Recombinant Human IL13 protein, His-tagged HEK293 His Inquiry
    Human IL13-4328HG GMP Recombinant Human IL12A protein E.coli N/A Inquiry
    Human IL13-432HG GMP Recombinant Human IL13 protein, His-tagged HEK293 His Inquiry
    Human IL13-519HB Recombinant Human IL13 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Inquiry
    Human IL13-589H Recombinant Human IL13 protein, His-Avi-tagged HEK293 His-Avi Inquiry
    Human IL13-P041H Recombinant Human IL13 therapeutic protein N/A Inquiry
    Mouse Il13-087M Recombinant Mouse Il13 Protein E.coli Inquiry
    Mouse Il13-088M Recombinant Mouse Il13 Protein E.coli Inquiry
    Mouse Il13-089M Recombinant Mouse Il13 Protein E.coli Inquiry
    Mouse Il13-090M Recombinant Mouse Il13 Protein E.coli Inquiry
    Rabbit IL13-4350R Recombinant Rabbit IL13 Protein Yeast N/A Inquiry
    Zebrafish IL13-4328Z Recombinant Zebrafish IL13 Protein Yeast N/A Inquiry

    IL13 involved in several pathways and played different roles in them. We selected most pathways IL13 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Fc epsilon RI signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction CCL4L2; CCL19; CTF1; IL21R; IL7; TNFSF10; EPOR; FLT4; CXCR3; GM1987
    Jak-STAT signaling pathway IL12BA; SOCS2; Ifna15; PTPN2B; IRX1; IL20RA; GRB2A; GH1; IFNA2; Ifnl2
    Fc epsilon RI signaling pathway PIK3R3; FCER1A; TNF; PDPK1; IL4; MAP2K3; MAPK11; LCP2; MAP2K2; INPP5D
    Measles IFNA6; TNFRSF10C; IFNA10; FYN; IL1B; TNFRSF10B; TLR9; IRAK4; CD3E; CD3D; IL2RB
    Asthma CD40LG; MS4A2; HLA-DRB5; EPX; CD40; H2-AB1; TNF; FCER1A; HLA-DQB1; HLA-DRA
    Inflammatory bowel disease (IBD) MAF; H2-AB1; HLA-DMB; IL1B; SMAD3; IFNGR2; Il4ra; TLR2; TGFB1; TLR4

    IL13 has several biochemical functions, for example, cytokine activity, interleukin-13 receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL13 itself. We selected most functions IL13 had, and list some proteins which have the same functions with IL13. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity IL17A/F1; BMP6; IL29; IFNA12; IL15; TGFB1; GPR19; GDF10; Ccl27a; IFNA3
    interleukin-13 receptor binding IL13
    protein binding ZNF266; MYH7B; HBP1; PHLPP1; UBASH3A; ZRANB1; GMDS; OSBPL6; KIAA1958; APOO

    IL13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL13 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL13.

    IL13RA1

    Tripp, C; Campbell, A; et al. THE CHARACTERIZATION OF RPC4046, A NOVEL ANTI-IL13 MONOCLONAL ANTIBODY THAT BLOCKS BINDING TO IL-13 RECEPTOR alpha 1 AND alpha 2 IN DEVELOPMENT FOR EOSINOPHILIC ESOPHAGITIS: RESULTS OF A FIRST-IN-HUMAN STUDY.. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY 113:A104-A105(2014).
    Wilson, AD; et al. Immune responses to ectoparasites of horses, with a focus on insect bite hypersensitivity. PARASITE IMMUNOLOGY 36:558-570(2014).

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