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IL13

  • Official Full Name

    interleukin 13

  • Overview

    This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
  • Synonyms

    ALRH; BHR1; P600; IL-13; interleukin-13; allergic rhinitis; Bronchial hyperresponsiveness-1 (bronchial asthma); NC30; Tralokinumab; 1044515-88-9; Lebrikizumab; 953400-68-5; Anrukinzumab (= IMA-638); 910649-32-0;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • GMP Proteins
  • Antibody
  • Therapeutic Proteins
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Canine
  • Cat
  • Cattle
  • Chicken
  • Cotton Rat
  • Cynomolgus
  • Cynomolgus Monkey
  • Dog
  • Equine
  • Human
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • Rhesus
  • Rhesus Macaque
  • Rhesus monkey
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • HEK293F
  • Human
  • Human Cell
  • Mammalian cell
  • Mammalian Cell
  • Mammalian cells
  • Rat
  • Yeast
  • APC
  • C
  • Fc
  • His
  • hFc
  • Myc
  • HIgG1 Fc
  • tagged
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • His|Biotin
  • His|DDK
  • His|GST
  • His|T7
  • human|IgG1|Fc
  • mFc
  • N/A
  • N
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL13-1251H Active Recombinant Human IL13 E.coli N/A
Human IL13-50H Active Recombinant Human Interleukin 13, MIgG2a Fc-tagged CHO Fc
Human IL13-481H Active Recombinant Human Interleukin 13 E.coli N/A
Human IL13-328H Active Recombinant Human IL13 Human N/A
Human IL13-52H Active Recombinant Human Interleukin 13, HIgG1 Fc-tagged HEK293 HIgG1 Fc-tagged Leu25-Asn146
Human IL13-370H Active Recombinant Human IL13 CHO N/A Met 1-Asn 132
Human IL13-53H Active Recombinant Human Interleukin 13, HIgG1 Fc-tagged, mutant CHO Fc
Human IL13-365H Active Recombinant Human IL13 protein, Fc-tagged HEK293 Fc Leu 25 - Asn 146
Human IL13-22H Recombinant Human IL13 protein E.coli N/A 112
Human IL13-287H Recombinant Human IL13, StrepII-tagged Human Cell Strep II 25-146, 122 a.a.
Human IL13-856H Recombinant Human IL13 protein, His & T7-tagged E.coli His/T7 Leu25~Asn146 (Accession # P35225)
Human IL13-29107TH Recombinant Human IL13 E.coli N/A
Human IL13-16H Recombinant Human IL13, His-Biotin-tagged E.coli His/Biotin
Human IL13-165H Recombinant Human IL13 protein E.coli N/A 112
Human IL13-124H Recombinant Human IL13 protein E.coli N/A
Human IL13-147H Active Recombinant Human IL13 protein, hFc-tagged HEK293 hFc Gly21-Asn132
Human IL13-28497TH Recombinant Human IL13 E.coli N/A
Human IL13-44H Recombinant Human Interleukin 13, His-tagged E.coli His
Human IL13-14149H Recombinant Human IL13, His-tagged E.coli His 21-146a.a.
Human IL13-335H Recombinant Human IL13 Protein, His/DDK-tagged HEK293 His/DDK Gly35-Asp146
Human IL13-001HCL Recombinant Human IL13 cell lysate CHO N/A
Human IL13-2922HCL Recombinant Human IL13 cell lysate Human Cell N/A
Human IL13-138H Human Interleukin-13 (rDNA derived) Reference standard N/A
Human IL13-504H Recombinant Human IL13 Protein, Fc-tagged Fc 146
Human IL13-229H Recombinant Human IL13 protein, Fc-tagged HEK293 human/IgG1/Fc Gly21-Asn132
Human IL13-4328HG Active GMP Recombinant Human IL12A protein E.coli N/A
Human DMABT-H19232 Rat Anti-IL13 Monoclonal Antibody Rat APC
Human IL13-4307H Recombinant Human IL13 Protein (Gly35-Asn146), C-Fc tagged Mammalian cells C-Fc Gly35-Asn146
Human IL13-589H Recombinant Human IL13 protein, His-Avi-tagged HEK293 His-Avi It contains Gly21-Asn132.
Human IL13-519HB Recombinant Human IL13 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi It contains Gly21-Asn132.
Human IL13-3589H Recombinant Human IL13 protein, His-tagged HEK293 His Gly21-Asn132
Human IL13-P041H Recombinant Human IL13 therapeutic protein N/A
Human IL13-4324H Recombinant Human IL13 protein, hFc-Myc-tagged Mammalian cell hFc-Myc 21-132aa
Human IL-13-3015H Recombinant Human IL-13 protein, His-tagged E.coli His 25-146 aa
Human IL13-432HG Active GMP Recombinant Human IL13 protein HEK293 DNA sequence encoding Human IL-13 (GenBank: U31120.1) was expressed with His tag at the C-terminal.
Human IL13-1002H Recombinant Human IL13 Protein, His-tagged HEK293F N-His Leu25-Asn146
Human IL13-4325H Recombinant Human IL13 protein, hFc-tagged Mammalian cell hFc 25-146aa
Human IL13-143H Recombinant Active Human IL13 Protein, His-tagged(C-ter) E.coli His(C-ter)
Human IL13-120H Recombinant Human IL13 Protein, His-tagged Human Cell His Leu25-Asn146
Human IL13-132H Active Recombinant Human IL13 Protein E.coli
Human IL13-230H Recombinant Human IL13(Gly21­-Asn132) Protein, C-mFc-tagged HEK293 mFc
Human IL13-255I Active Recombinant Human IL13 Protein CHO
Human IL13-505H Recombinant Human IL13 Protein 146
Human IL13-458H Active Recombinant Human IL13 protein, His-tagged HEK293 His Gly35-Asn146
Human IL13-3107H Recombinant Human IL13 Protein (Pro36-Asn146), N-His tagged E.coli N-His Pro36-Asn146
Human IL13-459H Active Recombinant Human IL13 protein, hFc-tagged HEK293 hFc Gly29-Asn146
Human IL13-3108H Recombinant Human IL13 Protein (Pro21-Asn132), His tagged E.coli His Pro21-Asn132
Human IL13-179H Active Recombinant Human IL13 Protein (Gly35-Asn146), C-His tagged, Animal-free, Carrier-free E.coli C-His Gly35-Asn146
Mouse Il13-16M Active Recombinant Mouse Il13 Human Cell N/A
Mouse Il13-01M Active Recombinant Mouse Il13 Protein, His-Tagged E.coli His
Mouse Il13-087M Active Recombinant Mouse Il13 Protein E.coli
Mouse IL13-60M Recombinant Mouse IL-13 Yeast N/A
Mouse Il13-629M Recombinant Mouse Il13 protein E.coli N/A 111
Mouse Il13-857M Recombinant Mouse Il13 protein, His-tagged E.coli His Pro22~Phe131
Mouse IL13-1336MCL Recombinant Mouse IL13 cell lysate Human Cell N/A
Mouse Il13-5697M Recombinant Mouse Il13 Protein (Pro22-Phe131), C-His tagged Mammalian cells C-His Pro22-Phe131
Mouse Il13-5696M Recombinant Mouse Il13 Protein (Ser26-Phe131), C-His tagged Mammalian cells C-His Ser26-Phe131
Mouse Il13-089M Recombinant Mouse Il13 Protein E.coli
Mouse Il13-49M Active Recombinant Mouse Il13 Protein (Pro22-Fhe131), C-His tagged, Animal-free, Carrier-free E.coli C-His Pro22-Fhe131
Mouse Il13-256I Active Recombinant Mouse Il13 Protein, His-tagged CHO His
Mouse Il13-088M Recombinant Mouse Il13 Protein E.coli
Mouse Il13-090M Active Recombinant Mouse Il13 Protein E.coli
Mouse IL13-133M Active Recombinant Mouse IL13 Protein E.coli
Mouse IL13-1569M Active Recombinant Mouse IL13 protein, His-tagged HEK293 His Ala19-Phe131
Mouse Il13-038I Active Recombinant Mouse Il13 Protein (111 aa) E.coli 111
Mouse Il13-144M Recombinant Active Mouse IL13 Protein, His-tagged(C-ter) E.coli His(C-ter)
Rat Il13-87R Recombinant Rat Il13 protein E.coli N/A 111
Rat IL13-3026R Recombinant Rat IL13 Protein Mammalian Cell His
Rat Il13-580R Recombinant Rat Il13 protein E.coli N/A 113
Rat Il13-858R Recombinant Rat Il13 protein, His & T7-tagged E.coli His/T7 Pro22~His131 (Accession# P42203)
Rat Il13-1661R Recombinant Rat Il13 Protein, His-tagged E.coli N-His Pro22-His131
Rat IL13-2681R Recombinant Rat IL13 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat IL13-2681R-B Recombinant Rat IL13 Protein Pre-coupled Magnetic Beads HEK293
Rat Il13-008I Active Recombinant Rat Il13 Protein (110 aa) E.coli 110
Rhesus monkey IL13-1660R Recombinant Rhesus monkey IL13 Protein, His-tagged E.coli N-His Val37- Asn132
Rabbit IL13-4350R Recombinant Rabbit IL13 Protein Yeast N/A 112aa
Dog IL13-855D Recombinant Dog IL13 protein, His & T7-tagged E.coli His/T7 Ser19~Arg131 (Accession# Q9N0W9)
Dog IL13-7542D Recombinant Dog IL13 protein(19-131aa), His-tagged E.coli N-His 19-131aa
Bovine IL13-234B Active Recombinant Bovine Interleukin 13 Yeast N/A
Canine IL13-2191C Active Recombinant Canine IL13 protein, His-tagged HEK293 His Ser 19 - Arg 131
Canine IL13-62C Recombinant Canine IL-13 Yeast N/A
Cat IL13-3170C Recombinant Cat IL13 protein(34-144aa), His-tagged E.coli N-His 34-144aa
Cattle IL13-854C Recombinant Cattle IL13 protein, His & GST-tagged E.coli His/GST Ser21~Asn132
Cotton Rat Il13-415C Active Recombinant Cotton Rat Il13, His-tagged CHO His
Cynomolgus IL13-1568C Active Recombinant Cynomolgus IL13 protein, His-tagged HEK293 His Ser21-Asn132
Cynomolgus IL13-308C Active Recombinant Cynomolgus IL13 protein HEK293 N/A Met1-Asn132
Cynomolgus IL13-373C Recombinant Cynomolgus IL13 protein(Ser21-Asn132), His-tagged HEK293 N-His Ser21-Asn132
Cynomolgus Monkey IL13-1894CCL Recombinant Cynomolgus IL13 cell lysate Human Cell N/A
Equine IL13-252E Recombinant Equine Interleukin 13 Yeast N/A
Rhesus IL13-542R Recombinant Rhesus IL13 protein E.coli N/A 114
Rhesus Macaque IL13-146R Recombinant Rhesus Interleukin 13 CHO N/A
Rhesus Macaque IL13-2231R Recombinant Rhesus monkey IL13 Protein, His-tagged Mammalian Cell His
Rhesus Macaque IL13-2052R Recombinant Rhesus Macaque IL13 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque IL13-2052R-B Recombinant Rhesus Macaque IL13 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish IL13-7888Z Recombinant Zebrafish IL13 Mammalian Cell His
Zebrafish IL13-4328Z Recombinant Zebrafish IL13 Protein Yeast N/A 141aa
Pig IL13-262S Active Recombinant Swine Interleukin 13 Yeast N/A
Pig IL13-1003P Recombinant Pig IL13 Protein, His-tagged E.coli N-His Pro25-Gly131
Pig IL13-1985P Recombinant Pig IL13 protein E.coli N/A 120aa
Chicken IL13-4154C Recombinant Chicken IL13 Mammalian Cell His
Chicken IL13-58C Recombinant Chicken IL-13 Yeast N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

IL13 involved in several pathways and played different roles in them. We selected most pathways IL13 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Fc epsilon RI signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionGM10591;IL5;CXCR1;CNTFR;IL8L2;IL18RAP;CD40;IL1A;CXCR3.2
Jak-STAT signaling pathwaySTAT3;STAT4;CNTFR;BCL2;GFAP;MCL1;SOCS1A;Ifnlr1;IFNA5
Fc epsilon RI signaling pathwayLCP2;AKT2;FCER1G;MS4A2;PLCG2;GAB2;PIK3R1;GM-CSF;GRB2
MeaslesIFNA4;Ifna11;GSK3B;NFKB1;CD209C;CBLB;IL2RA;TNFRSF10A;PIK3R1
AsthmaHLA-DPA1;MS4A2;HLA-DRB1;EPX;HLA-DOB;CD40;HLA-DRB5;IL10;HLA-DRB4
Inflammatory bowel disease (IBD)RORC;TBX21;IL17A;IL1A;HLA-DMA;TGFB2;IL5;TLR4;IL23

IL13 has several biochemical functions, for example, cytokine activity, interleukin-13 receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL13 itself. We selected most functions IL13 had, and list some proteins which have the same functions with IL13. You can find most of the proteins on our site.

Function Related Protein
cytokine activityTXLNA;TGFB3;GDF15;Cxcl15;GM13278;GDF5;TNFSF12;IL11;BMP6
interleukin-13 receptor binding
protein bindingPARN;CD37;SOX4;FBXO9;PSMD4;PTH2R;MYOZ2;CDC25C;NABP1

IL13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL13 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL13.

IL13RA1

Gene Family

IL

Research Area

Related articles

Tripp, C; Campbell, A; et al. THE CHARACTERIZATION OF RPC4046, A NOVEL ANTI-IL13 MONOCLONAL ANTIBODY THAT BLOCKS BINDING TO IL-13 RECEPTOR alpha 1 AND alpha 2 IN DEVELOPMENT FOR EOSINOPHILIC ESOPHAGITIS: RESULTS OF A FIRST-IN-HUMAN STUDY.. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY 113:A104-A105(2014).
Wilson, AD; et al. Immune responses to ectoparasites of horses, with a focus on insect bite hypersensitivity. PARASITE IMMUNOLOGY 36:558-570(2014).
  • Q&As
  • Reviews

Q&As (10)

Ask a question
How does flow cytometry help quantify IL13 receptor expression on different cell populations? 12/29/2022

Flow cytometry quantifies IL13 receptor expression on cells.

What are the benefits of using transgenic animal models to study IL13's in vivo functions? 07/05/2022

Transgenic models illuminate IL13's in vivo functions.

Could you explain the role of ELISA in quantifying IL13 secretion levels in cell cultures? 02/23/2022

ELISA quantifies IL13 secretion in cell cultures accurately.

How can siRNA knockdown experiments reveal IL13's effects on specific cellular processes? 06/13/2021

siRNA knockdown uncovers IL13's specific cellular effects.

How does co-immunoprecipitation identify interacting partners in IL13-mediated signaling complexes? 07/28/2019

Co-immunoprecipitation identifies IL13 signaling partners.

What techniques can differentiate IL13-mediated signaling pathways from IL4 pathways? 07/23/2019

Differential techniques distinguish IL13 and IL4 signaling pathways.

Could you elaborate on the use of reporter gene assays to assess IL13-driven transcriptional activity? 12/16/2018

Reporter gene assays gauge IL13-driven transcription.

Can you describe the applications of microarray analysis in profiling IL13-induced gene expression changes? 11/14/2018

Microarray analysis profiles IL13-induced gene expression.

What experimental methods determine the impact of IL13 on tissue remodeling processes? 08/04/2018

Experimental methods reveal IL13's impact on tissue remodeling.

How does site-directed mutagenesis help identify critical residues in IL13 receptor binding? 07/04/2018

Site-directed mutagenesis identifies key residues in IL13 receptor binding.

Customer Reviews (3)

Write a review
Reviews
11/29/2021

    Effective in Th2 cell differentiation.

    04/22/2020

      Good for cytokine assays.

      01/26/2019

        High yield in expression.

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