Recombinant Full Length Human Bone Morphogenetic Protein Receptor Type-1A(Bmpr1A) Protein, His-Tagged

• Cat.No.: RFL24140HF
• Product Overview: Recombinant Full Length Human Bone morphogenetic protein receptor type-1A(BMPR1A) Protein (P36894) (24-532aa), fused to N-terminal His tag, was expressed in E. coli.

Specification

• Source: E.coli expression system
• Species: Homo sapiens (Human)
• Tag: His
• Form: Lyophilized powder
• Protein length: Full Length of Mature Protein (24-532)
• AA Sequence: QNLDSMLHGTGMKSDSDQKKSENGV TLAPEDTLPFLKCYCSGHCPDDAIN NTCITNGHCFAIIEEDDQGETTLAS GCMKYEGSDFQCKDSPKAQLRRTIE CCRTNLCNQYLQPTLPPVVIGPFFD GSIRWLVLLISMAVCIIAMIIFSSC FCYKHYCKSISSRRRYNRDLEQDEA FIPVGESLKDLIDQSQSSGSGSGLP LLVQRTIAKQIQMVRQVGKGRYGEV WMGKWRGEKVAVKVFFTTEEASWFR ETEIYQTVLMRHENILGFIAADIKG TGSWTQLYLITDYHENGSLYDFLKC ATLDTRALLKLAYSAACGLCHLHTE IYGTQGKPAIAHRDLKSKNILIKKN GSCCIADLGLAVKFNSDTNEVDVPL NTRVGTKRYMAPEVLDESLNKNHFQ PYIMADIYSFGLIIWEMARRCITGG IVEEYQLPYYNMVPSDPSYEDMREV VCVKRLRPIVSNRWNSDECLRAVLK LMSECWAHNPASRLTALRIKKTLAK MVESQDVKI
• Purity: Greater than 90% as determined by SDS-PAGE.
• Applications: SDS-PAGE
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Tris/PBS-based buffer, 6% Trehalose, pH 8.0
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
• Gene Name: BMPR1A
• Synonyms: 10q23del; Activin A receptor type II like kinase 3; Activin receptor like kinase 3; Activin receptor-like kinase 3; ACVRLK 3; ACVRLK3; ALK 3; ALK-3; ALK3; BMP type-1A receptor; BMPR 1A; Bmpr; BMPR-1A; Bmpr1a; BMR1A_HUMAN; Bone morphogenetic protein recept
• UniProt ID: P36894

Gene Information

• Gene Name: BMPR1A
• Synonyms: 10q23del; Activin A receptor type II like kinase 3; Activin receptor like kinase 3; Activin receptor-like kinase 3; ACVRLK 3; ACVRLK3; ALK 3; ALK-3; ALK3; BMP type-1A receptor; BMPR 1A; Bmpr; BMPR-1A; Bmpr1a; BMR1A_HUMAN; Bone morphogenetic protein recept
• UniProt ID: P36894

Reviews

11/06/2021

The enzyme activity of this protein reached the expected level and was able to play a role in the specific reaction.

10/20/2021

When experimenting with this protein, stable and repeatable results can be obtained.

03/08/2021

This product has strict quality control and complies with relevant industry standards.

Q&As

What disease might abnormal BMPR1A levels suggest?

Abnormal levels of BMPR1A may suggest skeletal dysplasia, tumors, etc., but its specificity and sensitivity need to be further studied.

Is there a mutation type of BMPR1A?

The types of mutations in BMPR1A include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.

How are mutations in BMPR1A detected and analyzed?

Mutations in BMPR1A can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.

How to study the regulatory mechanism of BMPR1A?

Studying the regulatory mechanism of BMPR1A requires a comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.

What are the applications of BMPR1A in medical treatment?

BMPR1A can be used as a biomarker in medical treatment to help monitor disease progression and treatment efficacy. In addition, therapeutics targeting BMPR1A, such as gene therapy or modulating its expression, are also being studied.

What diseases can BMPR1A deficiency or aberrant expression cause?

Deficiency or abnormal expression of BMPR1A may be related to some skeletal dysplasia diseases, tumors, etc.