Recombinant Human Chemokine (C-C Motif) Ligand 3 CCL3-156H

Recombinant Human Chemokine (C-C Motif) Ligand 3


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Recombinant Human Chemokine (C-C Motif) Ligand 3

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Cat.No. : CCL3-156H Optional Service: Optional requirements on this protein
Product Overview : Recombinant human chemokine (C-C motif) ligand 3 was expressed inSf21 cells.
Description : Macrophage Inflammatory Proteins (MIP) belong to the family of chemotactic cytokines known as chemokines. In humans, there are two major forms, MIP-1α and MIP-1β that are now officially named CCL3 and CCL4 respectively. Both are major factors produced by macrophages after they are stimulated with bacterial endotoxins. They activate human granulocytes (neutrophils, eosinophils and basophils) which can lead to acute neutrophilic inflammation. They also induce the synthesis and release of other pro-inflammatory cytokines such as interleukin 1 (IL-1), IL-6 and TNF-α from fibroblasts and macrophages. The genes for CCL3 and CCL4 are both located on human chromosome 17.
Source : Sf21 cells.
Analysis Note : The biological activity is measured by its ability to chemoattract cultured human monocytes or mouse BaF/3 cells transfected with human CCR5.
Physical Form : Lyophilized from a 0.2 μm filtered solution of 30% acetonitrile and 0.1% trifluoroacetic acid containing 0.5 mg bovine serum albumin.
Assay : ≥97% (SDS-PAGE and N-terminal analysis).
Form : Lyophilized powder.
Total Impurities : Endotoxin, tested.
Suitability : Cell culture tested.
Storage Temp : −20°C.
PDB rendering based on 1b50. :

Gene Name : CCL3 chemokine (C-C motif) ligand 3 [ Homo sapiens ]
Synonyms : chemokine (C-C motif) ligand 3; MIP1A; SCYA3; G0S19-1; LD78ALPHA; MIP-1-alpha; CCL3; LD78 alpha beta; small inducible cytokine A3 (homologous to mouse Mip-1a); SIS-beta; G0/G1 switch regulatory protein 19-1; G0S19-1 protein; LD78 alpha beta; Macrophage inflammatory protein 1-alpha; PAT 464.1; Small-inducible cytokine A3; Tonsillar lymphocyte LD78 alpha protein; C-C motif chemokine 3; Small-inducible cytokine A3; Short name=MIP-1-alpha; Tonsillar lymphocyte LD78 alpha protein; G0/G1 switch regulatory protein 19-1; Short name=G0S19-1 protein; SIS-beta; PAT 464.1
Gene ID : 6348
mRNA Refseq : NM_002983
Protein Refseq : NP_002974
MIM : 182283
UniProt ID : P10147
Chromosome Location : 17q11-q21
Pathway : Cytokine-cytokine receptor Toll-like receptor signaling pathway; Chemokine signaling pathway; Cytokine-cytokine receptor interaction
Function : chemoattractant activity; chemokine activity; signal transducer activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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