CCL3
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Official Full Name
chemokine (C-C motif) ligand 3
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Overview
CCL3, also known as Macrophage inflammatory protein-1α (MIP-1α), is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes (Wolpe et al., 1988). Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha and beta. -
Synonyms
Ccl3; chemokine (C-C motif) ligand 3; Mip1a; Scya3; G0S19-1; AI323804; MIP1-(a); LD78alpha; MIP-1alpha; MIP1-alpha; C-C motif chemokine 3; TY-5; L2G25B; MIP1 (a); SIS-alpha; MIP-1 alpha; MIP-1-alpha; OTTMUSP00000000942; small inducible cytokine A3; small-inducible cytokine A3; heparin-binding chemotaxis protein; macrophage inflammatory protein-1alpha; macrophage inflammatory protein 1-alpha;
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- Involved Pathway
- Protein Function
- Interacting Protein
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CCL3 involved in several pathways and played different roles in them. We selected most pathways CCL3 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | CXCR3.1;BMPR1AA;IL18R1;CCL27B;IL13;IL20RB;IL1R1;CXCL10;CNTF |
| Chemokine signaling pathway | CCR5;SHC2;HCK;CXCR5;LYN;VAV3;GNB3;XCL2;CCL24 |
| Toll-like receptor signaling pathway | STAT1B;IFNA12;AKT3A;IFNA17;MAP2K4A;IL8L1;IFNB;IFNA21;IFNA4 |
| Salmonella infection | KLC1A;WASB;TLR5;RAB7;ARPC5B;IFNGR1;PFN1;FLNC;IFNG |
| Chagas disease (American trypanosomiasis) | CD3E; CD3D;PLCB1;TNF;MAPK12;PIK3CB;CD3D;TGFB3;BDKRB2;Il2 |
| Rheumatoid arthritis | ATP6V1A;CCL20;ATP6V1C1;CTLA4;HLA-DOB;HLA-DMB;HLA-DMA;Ctsl;ATP6V0D2 |
CCL3 has several biochemical functions, for example, CCR1 chemokine receptor binding, CCR5 chemokine receptor binding, calcium-dependent protein kinase C activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL3 itself. We selected most functions CCL3 had, and list some proteins which have the same functions with CCL3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| CCR1 chemokine receptor binding | CCL4;CCL7;CCL3;CREB3;CCL23;CCL5 |
| CCR5 chemokine receptor binding | CCL4;CCL3;CCL5;JAK1;STAT3;CNIH4 |
| calcium-dependent protein kinase C activity | PRKCA;ALPK2;CCL3;PRKCG |
| chemoattractant activity | CCL5;NTF3;HMGB2;VEGFA;VHL;FGF7;CXCL12B;FGF10;LGALS3 |
| chemokine activity | Ccl21a;CCL24;CCL34B.9;CCL21B;CXCL12;CXCL5;Ccl9;CCL35.2;CXCL11.8 |
| identical protein binding | Serpina1b;CASC3;LDHB;HAND2;TARDBP;GCC2;PRNP;PSME3;IRF3 |
| kinase activity | TGFBR1A;MASTL;PTK2AA;MKNK2B;PAK2A;CDK5R1B;PRKAR1AA;GM4922;NUCKS1A |
| phospholipase activator activity | PDPK1;APOC2;GM2A;CCL5;CCL3;CCL8;ARHGAP6 |
| protein binding | RECQL4;PTGFRN;OGG1;CHAF1A;XAB2;PDIA4;LIMD2;PLAU;GSTK1 |
| protein kinase activity | PHKG1B;GC2;TEX14;KDRL;SIK2A;SGK2A;GC3;LTK;CLK4B |
CCL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL3.
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