CCL3
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Official Full Name
chemokine (C-C motif) ligand 3 -
Overview
CCL3, also known as Macrophage inflammatory protein-1α (MIP-1α), is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes (Wolpe et al., 1988). Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha and beta. -
Synonyms
Ccl3;chemokine (C-C motif) ligand 3;Mip1a;Scya3;G0S19-1;AI323804;MIP1-(a);LD78alpha;MIP-1alpha;MIP1-alpha;C-C motif chemokine 3;TY-5;L2G25B;MIP1 (a);SIS-alpha;MIP-1 alpha;MIP-1-alpha;OTTMUSP00000000942;small inducible cytokine A3;small-inducible cytokine A3;heparin-binding chemotaxis protein;macrophage inflammatory protein-1alpha;macrophage inflammatory protein 1-alpha
Recombinant Proteins
- Human
- Mouse
- Cotton Rat
- Rat
- Equine
- Rhesus macaque
- Dog
- E.coli
- yeast
- Wheat Germ
- Mammalian Cells
- Yeast
- Sf21 Cells
- Insect Cells
- HEK293
- Human Cells
- CHO
- In Vitro Cell Free System
- Non
- His
- GST
- Avi
- Fc
- DDK
- Myc
Involved Pathway
CCL3 involved in several pathways and played different roles in them. We selected most pathways CCL3 participated on our site, such as Cytokine-cytokine receptor interaction,Chemokine signaling pathway,Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rheumatoid arthritis | ATP6V1A,HLA-DRB1,ATP6V0C,HLA-DPA1,HLA-DMB,HLA-DPB1,CCL3L1,CXCL6,GM-CSF,IL6 |
| Toll-like receptor signaling pathway | NFKB1,NFKBIAA,IL12BA,IFNAR1,TAB2,STAT1A,CXCL11,MAP2K4B,IL1B,MAPK1 |
| Chemokine signaling pathway | CCR3,CCR8,PARD3,Ccl9,RAC1,STAT5B,PRKACG,Adcy4,HRAS,ITK |
| Cytokine-cytokine receptor interaction | IFNAR2,ACVR2B,IL17RA,CXCL3,PDGFC,Ccl27a,CXCL12B,CCL17,EDA,OSM |
| Salmonella infection | MAPK12B,IFNG,TLR5B,PFN3,CASPA,PFN2,WAS,NFKB1,MAPK14B,IFNGR1 |
| Chagas disease (American trypanosomiasis) | FADD,PPP2CA,IKBKB,C1QB,PIK3R3,PIK3CA,CXCL8,ACE,CD3G,TGFB2 |
Protein Function
CCL3 has several biochemical functions, for example, CCR1 chemokine receptor binding,CCR5 chemokine receptor binding,calcium-dependent protein kinase C activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL3 itself. We selected most functions CCL3 had, and list some proteins which have the same functions with CCL3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| CCR1 chemokine receptor binding | CCL5,CREB3,CCL4,CCL23,CCL7 |
| kinase activity | MTOR,PKN2,BAIAP2L1A,MAPK12B,NME2B.1,CDK5R1,CKMB,AGPHD1,PRKCHA,LMTK2 |
| protein kinase activity | RASSF2,PRKG2,ERBB4A,RIPK1L,MAP3K1,IKBKAP,EIF2AK3,ERBB3A,PIK3CG,PKDCCA |
| chemoattractant activity | MIF,SAA2,LGALS3,CCL16,CCL5,VEGFB,FGF2,PDGFB,HMGB1,SAA4 |
| CCR5 chemokine receptor binding | CNIH4,STAT3,CCL5,JAK1,CCL4 |
| protein binding | EXOSC3,FNDC3B,SFPI1,SLC22A7,PNMA2,MAFG,C14orf166,APIP,SRPK3,PRDX4 |
| calcium-dependent protein kinase C activity | PRKCG,ALPK2,PRKCA |
| chemokine activity | CCL27,CCL7,CCL19,CCL27B,CCL3L1,CXCL10,CXCL8B.3,PF4V1,Ccl12,CCL33.3 |
| phospholipase activator activity | PDPK1,GM2A,APOC2,ARHGAP6,CCL8,CCL5 |
Interacting Protein
CCL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL3.
IDE
Resources
Research Area
NeuroinflammationInflammatory Mediators
Cytokines and Growth Factors Secreted by VSMC
Regulatory T Cells (Tregs)
CC Chemokines
Related Services
Related Products
References
- Suviolahti, E; Ge, SL; et al. Genes associated with antibody-dependent cell activation are overexpressed in renal biopsies from patients with antibody-mediated rejection. TRANSPLANT IMMUNOLOGY 32:9-17(2015).
- Gouwy, M; De Buck, M; et al. Serum amyloid A chemoattracts immature dendritic cells and indirectly provokes monocyte chemotaxis by induction of cooperating CC and CXC chemokines. EUROPEAN JOURNAL OF IMMUNOLOGY 45:101-112(2015).
