CCL3 Protein


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Official Full Name chemokine (C-C motif) ligand 3
Background CCL3, also known as Macrophage inflammatory protein-1α (MIP-1α), is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes (Wolpe et al., 1988). Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha and beta.
Synonyms Ccl3; chemokine (C-C motif) ligand 3; Mip1a; Scya3; G0S19-1; AI323804; MIP1-(a); LD78alpha; MIP-1alpha; MIP1-alpha; C-C motif chemokine 3; TY-5; L2G25B; MIP1 (a); SIS-alpha; MIP-1 alpha; MIP-1-alpha; OTTMUSP00000000942; small inducible cytokine A3; small-inducible cytokine A3; heparin-binding chemotaxis protein; macrophage inflammatory protein-1alpha; macrophage inflammatory protein 1-alpha
    • Species :
    • Cotton Rat
    • Dog
    • Equine
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • CHO
    • E. coli
    • E.coli
    • HEK293
    • HEK293F
    • HEK293T
    • Human Cell
    • Human Cells
    • In Vitro Cell Free System
    • Insect Cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Wheat Germ
    • yeast
    • Tag :
    • Biotin
    • GST
    • His
    • Myc/DDK
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CCL3-109H Active Human CCL3 N/A Inquiry
    Human CCL3-15H Active Recombinant Human CCL3 yeast N/A Inquiry
    Mouse Ccl3-14M Active Recombinant Mouse Ccl3 yeast N/A Inquiry
    Cotton Rat Ccl3-394C Active Recombinant Cotton Rat Ccl3 E.coli N/A Inquiry
    Mouse Ccl3-01M Active GMP Recombinant Mouse Ccl3 Protein, His-Tagged E.coli His Inquiry
    Human CCL3-0636H Recombinant Human CCL3 Protein E.coli N/A Inquiry
    Human CCL3-0637H Recombinant Human CCL3 Protein, GST-Tagged Wheat Germ GST Inquiry
    Human CCL3-156H Recombinant Human Chemokine (C-C Motif) Ligand 3 Sf21 Insect Cell N/A Inquiry
    Human CCL3-169H Recombinant Human Chemokine (C-C motif) Ligand 3, His-tagged E.coli His Inquiry
    Human CCL3-246H Recombinant Human CCL3, His-tagged Yeast His Inquiry
    Human CCL3-276H Recombinant Human CCL3, StrepII-tagged Human Cell Strep II Inquiry
    Human CCL3-291H Recombinant Human CCL3 protein E.coli N/A Inquiry
    Human CCL3-29859TH Recombinant Human CCL3, His-tagged E.coli His Inquiry
    Human CCL3-363H Recombinant Human Chemokine (C-C motif) Ligand 3 Insect Cell N/A Inquiry
    Human CCL3-475H Recombinant Human CCL3 protein, His-tagged HEK293F His Inquiry
    Human CCL3-705H Recombinant Human CCL3 protein, His & GST-tagged E.coli His/GST Inquiry
    Human CCL3-79H Recombinant Human Chemokine (C-C motif) Ligand 3 HEK293 N/A Inquiry
    Mouse Ccl3-292M Recombinant Mouse Ccl3 protein E.coli N/A Inquiry
    Mouse CCL3-2975M Recombinant Mouse CCL3 Protein Mammalian Cell His Inquiry
    Mouse Ccl3-706M Recombinant Mouse Ccl3 protein, His & GST-tagged E.coli His/GST Inquiry
    Mouse Ccl3-7197M Recombinant Mouse Chemokine (C-C motif) Ligand 3, His-tagged E.coli His Inquiry
    Mouse Ccl3-8705M Recombinant Mouse Ccl3, None tagged E.coli N/A Inquiry
    Rat CCL3-1213R Recombinant Rat CCL3 Protein Mammalian Cell His Inquiry
    Rat Ccl3-544R Recombinant Rat Ccl3 E.coli N/A Inquiry
    Rat Ccl3-56R Recombinant Rat Ccl3 protein E.coli N/A Inquiry
    Rat Ccl3-707R Recombinant Rat Ccl3 protein, His & GST-tagged E.coli His/GST Inquiry
    Rhesus Macaque CCL3-691R Recombinant Rhesus monkey CCL3 Protein, His-tagged Mammalian Cell His Inquiry
    Dog CCL3-704D Recombinant Dog CCL3 protein, His & GST-tagged E.coli His/GST Inquiry
    Equine CCL3-140E Recombinant Equine Chemokine (C-C motif) Ligand 3 Yeast N/A Inquiry
    Human CCL3-7723HCL Recombinant Human CCL3 293 Cell Lysate HEK293 N/A Inquiry
    Human CCL3-075C Recombinant Human CCL3 Protein (69 aa) E.coli Inquiry
    Human CCL3-151H Recombinant Human CCL3 Protein, His-tagged Human Cells His Inquiry
    Mouse Ccl3-171C Recombinant Mouse Ccl3 Protein (69 aa) HEK293 Inquiry
    Human CCL3-220C Recombinant Human CCL3 Protein CHO Inquiry
    Human CCL3-22H Recombinant Human CCL3 Protein E.coli Inquiry
    Mouse Ccl3-23M Recombinant Mouse CCL3 Protein E.coli Inquiry
    Rat CCL3-24R Recombinant Rat CCL3 Protein E.coli Inquiry
    Human CCL3-2949HF Recombinant Full Length Human CCL3 Protein, GST-tagged In Vitro Cell Free System GST Inquiry
    Human CCL3-330C Recombinant Human CCL3 Protein (70 aa) E.coli Inquiry
    Human CCL3-70H Recombinant Human CCL3 Protein E.coli Inquiry
    Human CCL3-78H Recombinant Human CCL3 Protein, Biotin-tagged E.coli Biotin Inquiry
    Human CCL3-119H Human Macrophage Inflammatory Protein-1 alpha (rDNA derived) Reference standard N/A Inquiry
    Human CCL3-4453H Recombinant Human CCL3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Mouse Ccl3-132M Recombinant Mouse Ccl3 Protein E.coli Inquiry
    Mouse Ccl3-2037M Recombinant Mouse Ccl3 Protein E. coli Inquiry
    Mouse Ccl3-2977M Recombinant Mouse Ccl3 Protein E.coli N/A Inquiry
    Mouse Ccl3-7337M Recombinant Mouse Ccl3 Protein, His-tagged E.coli His Inquiry

    CCL3 involved in several pathways and played different roles in them. We selected most pathways CCL3 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction CCL4; CLCF1; FASLG; IFNPHI3; IFNA1; IL12BA; ACKR3B; LOC100033925; CRLF2; IFNA8
    Chemokine signaling pathway PIK3R3; CCL17; PF4V1; RAP1B; CCL3L1; PIK3R2; CCL4L2; CCL7; PXN; CXCL8
    Toll-like receptor signaling pathway MAPK14A; STAT1; STAT1A; MAPK11; MAP2K2A; MAP2K2B; RIPK1L; IFNA10; MAP2K6; TLR1
    Salmonella infection KLC1B; RHOG; ARPC5L; ROCK1; RAB7B; RHOGC; IL18; IFNGR1; RILP; WASF1
    Chagas disease (American trypanosomiasis) GNAQ; CD3E; CD3D; AKT1; SERPINE1; Fasl; IL12A; PIK3R2; IFNGR1; NOS2; TGFB3
    Rheumatoid arthritis Il23a; TNFSF13; IL-8; ATP6V1B1; ATP6V0D2; IL1B; ATP6V0B; ATP6V0E; HLA-DMB; CD28

    CCL3 has several biochemical functions, for example, CCR1 chemokine receptor binding, CCR5 chemokine receptor binding, calcium-dependent protein kinase C activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL3 itself. We selected most functions CCL3 had, and list some proteins which have the same functions with CCL3. You can find most of the proteins on our site.

    Function Related Protein
    CCR1 chemokine receptor binding CCL3; CCL23; CCL5; CREB3; CCL4; CCL7
    CCR5 chemokine receptor binding CCL5; CCL4; CCL3; STAT3; JAK1; CNIH4
    calcium-dependent protein kinase C activity PRKCA; PRKCG; ALPK2; CCL3
    chemoattractant activity FGF8; MIF; CXCL12B; LGALS3; SAA4; FGF10; VEGFB; CCL3; SCG2; VEGFC
    chemokine activity CXCL1; Ccl21a; CCL38A.4; XCL1; CXCL8B.3; AMCF-II; CCL5; Ccl21c; CXCL13; CCL25B
    identical protein binding FHOD1; CLDN7; CCDC91; COL7A1; OAT; TRIM21; APPL1; GBP5; COL18A1; SRPX2
    kinase activity AK5L; CKMT2A; PFKMB; PIP5K2; CSNK1G2B; CDKN1D; MAP3K12; SBK1; BMPR1AB; SMG1
    phospholipase activator activity GM2A; PDPK1; ARHGAP6; CCL3; APOC2; CCL8; CCL5
    protein binding C7orf59; C1QTNF1; PLSCR1; NEK1; TNNI1; VPS8; ITGA7; PJA1; PASK; EPHA7
    protein kinase activity BMPR2B; PRKCZ; FASTKD3; GRK7B; RPS6KB1; PRKCDA; LIMK1; CDKL3; SNRKB; TBCK

    CCL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL3.


    Suviolahti, E; Ge, SL; et al. Genes associated with antibody-dependent cell activation are overexpressed in renal biopsies from patients with antibody-mediated rejection. TRANSPLANT IMMUNOLOGY 32:9-17(2015).
    Gouwy, M; De Buck, M; et al. Serum amyloid A chemoattracts immature dendritic cells and indirectly provokes monocyte chemotaxis by induction of cooperating CC and CXC chemokines. EUROPEAN JOURNAL OF IMMUNOLOGY 45:101-112(2015).

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