CCL3

  • Official Full Name

    chemokine (C-C motif) ligand 3

  • Overview

    CCL3, also known as Macrophage inflammatory protein-1α (MIP-1α), is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes (Wolpe et al., 1988). Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha and beta.
  • Synonyms

    Ccl3; chemokine (C-C motif) ligand 3; Mip1a; Scya3; G0S19-1; AI323804; MIP1-(a); LD78alpha; MIP-1alpha; MIP1-alpha; C-C motif chemokine 3; TY-5; L2G25B; MIP1 (a); SIS-alpha; MIP-1 alpha; MIP-1-alpha; OTTMUSP00000000942; small inducible cytokine A3; small-inducible cytokine A3; heparin-binding chemotaxis protein; macrophage inflammatory protein-1alpha; macrophage inflammatory protein 1-alpha;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Cotton Rat
  • Dog
  • Equine
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • CHO
  • E. coli
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human Cell
  • Human Cells
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Sf21 Insect Cell
  • Wheat Germ
  • yeast
  • Yeast
  • Biotin
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • N/A
  • N
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CCL3-15H Active Recombinant Human CCL3 yeast N/A
Human CCL3-109H Active Human CCL3 N/A
Human CCL3-475H Recombinant Human CCL3 protein, His-tagged HEK293F His
Human CCL3-246H Recombinant Human CCL3 protein, His-tagged Yeast His
Human CCL3-363H Recombinant Human Chemokine (C-C motif) Ligand 3 Insect Cell N/A
Human CCL3-29859TH Recombinant Human CCL3, His-tagged E.coli His
Human CCL3-0637H Recombinant Human CCL3 Protein, GST-Tagged Wheat Germ GST
Human CCL3-276H Recombinant Human CCL3, StrepII-tagged Human Cell Strep II
Human CCL3-169H Recombinant Human CCL3 protein, His-tagged E.coli His
Human CCL3-79H Recombinant Human Chemokine (C-C motif) Ligand 3 HEK293 N/A
Human CCL3-0636H Active Recombinant Human CCL3 Protein E.coli N/A
Human CCL3-291H Recombinant Human CCL3 protein E.coli N/A
Human CCL3-156H Recombinant Human Chemokine (C-C Motif) Ligand 3 Sf21 Insect Cell N/A
Human CCL3-705H Recombinant Human CCL3 protein, His & GST-tagged E.coli His/GST
Human CCL3-7723HCL Recombinant Human CCL3 293 Cell Lysate HEK293 N/A
Human CCL3-151H Recombinant Human CCL3 Protein, His-tagged Human Cells His
Human CCL3-4453H Recombinant Human CCL3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CCL3-061H Recombinant Human CCL3 Protein
Human CCL3-075C Active Recombinant Human CCL3 Protein (69 aa) E.coli
Human CCL3-330C Active Recombinant Human CCL3 Protein (70 aa) E.coli
Human CCL3-220C Active Recombinant Human CCL3 Protein CHO
Human CCL3-70H Recombinant Human CCL3 Protein E.coli
Human CCL3-1490H Recombinant Human CCL3 Protein (Ala27-Ala92), N-GST tagged E.coli N-GST
Human CCL3-020H Recombinant Human CCL3 Protein
Human CCL3-268H Active Recombinant Human CCL3 Protein (Ala27-Ala92), N-His tagged, Animal-free, Carrier-free E.coli N-His
Human CCL3-119H Human Macrophage Inflammatory Protein-1 alpha (rDNA derived) Reference standard N/A
Human CCL3-78H Recombinant Human CCL3 Protein, Biotin-tagged E.coli Biotin
Human CCL3-021H Recombinant Human CCL3 Protein, Biotinylated
Human CCL3-2949HF Recombinant Full Length Human CCL3 Protein, GST-tagged In Vitro Cell Free System GST
Human CCL3-1491H Recombinant Human CCL3 Protein (Ser24-Ala92), N-His tagged E.coli N-His
Human CCL3-22H Active Recombinant Human CCL3 Protein E.coli
Mouse Ccl3-14M Active Recombinant Mouse Ccl3 yeast N/A
Mouse Ccl3-01M Active GMP Recombinant Mouse Ccl3 Protein, His-Tagged E.coli His
Mouse Ccl3-8705M Recombinant Mouse Ccl3 protein(Ala24-Ala92) E. coli N/A
Mouse CCL3-2975M Recombinant Mouse CCL3 Protein Mammalian Cell His
Mouse Ccl3-292M Recombinant Mouse Ccl3 protein E.coli N/A
Mouse Ccl3-7197M Recombinant Mouse Chemokine (C-C motif) Ligand 3, His-tagged E.coli His
Mouse Ccl3-706M Recombinant Mouse Ccl3 protein, His & GST-tagged E.coli His/GST
Mouse CCL3-1396M Recombinant Mouse CCL3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ccl3-2037M Active Recombinant Mouse Ccl3 Protein E. coli
Mouse Ccl3-23M Active Recombinant Mouse CCL3 Protein E.coli
Mouse Ccl3-171C Active Recombinant Mouse Ccl3 Protein (69 aa) HEK293
Mouse Ccl3-2977M Recombinant Mouse Ccl3 Protein E.coli N/A
Mouse Ccl3-132M Active Recombinant Mouse Ccl3 Protein E.coli
Mouse CCL3-1396M-B Recombinant Mouse CCL3 Protein Pre-coupled Magnetic Beads HEK293
Mouse Ccl3-76M Active Recombinant Mouse Ccl3 Protein (Ala24-Ala92), N-His tagged, Animal-free, Carrier-free E.coli N-His
Mouse Ccl3-7337M Recombinant Mouse Ccl3 Protein, His-tagged E.coli His
Rat Ccl3-544R Recombinant Rat Ccl3 protein E.coli N/A
Rat CCL3-1213R Recombinant Rat CCL3 Protein Mammalian Cell His
Rat Ccl3-707R Recombinant Rat Ccl3 protein, His & GST-tagged E.coli His/GST
Rat Ccl3-56R Recombinant Rat Ccl3 protein E.coli N/A
Rat CCL3-871R-B Recombinant Rat CCL3 Protein Pre-coupled Magnetic Beads HEK293
Rat CCL3-871R Recombinant Rat CCL3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CCL3-24R Active Recombinant Rat CCL3 Protein E.coli
Dog CCL3-704D Recombinant Dog CCL3 protein, His & GST-tagged E.coli His/GST
Dog CCL3-3381D Recombinant Dog CCL3 protein, His-tagged HEK293 His
Cotton Rat Ccl3-394C Active Recombinant Cotton Rat Ccl3 E.coli N/A
Equine CCL3-140E Recombinant Equine Chemokine (C-C motif) Ligand 3 Yeast N/A
Rhesus Macaque CCL3-691R Recombinant Rhesus monkey CCL3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CCL3-519R-B Recombinant Rhesus Macaque CCL3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CCL3-519R Recombinant Rhesus Macaque CCL3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CCL3 Related Articles
  • CCL3 Related Gene Family
  • CCL3 Related Research Area

CCL3 involved in several pathways and played different roles in them. We selected most pathways CCL3 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionCXCL5;BMP7B;GDF5;IFNA16;CCR9;IL23R;IFNA6;IL1RAP;GH1
Chemokine signaling pathwayCXCL12;CCL15;CCL3;CXCR5;CCR8;GNG7;PIK3CB;GRK5;CCL21B
Toll-like receptor signaling pathwayPIK3CG;IL12B;TRAF6;PIK3R2;MAPK1;TNF;MAPK8;IRAK1;TLR4
Salmonella infectionPFN2L;KLC2;MAPK10;KLC4;NLRC4;TLR4BB;ACTB2;MYH9;ROCK1
Chagas disease (American trypanosomiasis)CCL3L3;CFLAR;IRAK1;TGFBR1;TLR9;Ccl12;MAPK11;GNA14;CALR
Rheumatoid arthritisTNF;CXCL12;HLA-DOB;HLA-DQA1;IL-8;IL23;TNFRSF11A;CXCL1;IL15

CCL3 has several biochemical functions, for example, CCR1 chemokine receptor binding, CCR5 chemokine receptor binding, calcium-dependent protein kinase C activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL3 itself. We selected most functions CCL3 had, and list some proteins which have the same functions with CCL3. You can find most of the proteins on our site.

Function Related Protein
CCR1 chemokine receptor bindingCCL4;CCL5;CCL7;CCL3;CCL23;CREB3
CCR5 chemokine receptor bindingCCL4;CCL3;STAT3;JAK1;CCL5;CNIH4
calcium-dependent protein kinase C activityALPK2;CCL3;PRKCA;PRKCG
chemoattractant activitySAA3;FGF10;FGF8;CXCL12;HGF;CCL3;SAA2;FGF7;CCL5
chemokine activityCXL34B.11;CCL19;CXCL11;CCL28;C5;CCL1;Ccl12;CCL19B;CCL27B
identical protein bindingCRYBB2;DAPK1;USP4;GCG;MTPAP;PSMD4;MAP3K13;CLDN8;ATL2
kinase activityPKMA;PI4KAA;ANKK1;SRC;EPHB2B;DYRK1AA;CMPK;WNK2;LIMK1A
phospholipase activator activityPDPK1;CCL5;ARHGAP6;CCL8;CCL3;GM2A;APOC2
protein bindingWIBG;CCNA1;SUB1;CCAR1;SHPRH;KTI12;JAG1;PLK3;AHSP
protein kinase activityCDK13;LRRK2;CCND1;WEE2;EPHA4A;GUCY2C;ACVR1BA;MKNK2A;SCYL2

CCL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL3.

IDE

Suviolahti, E; Ge, SL; et al. Genes associated with antibody-dependent cell activation are overexpressed in renal biopsies from patients with antibody-mediated rejection. TRANSPLANT IMMUNOLOGY 32:9-17(2015).
Gouwy, M; De Buck, M; et al. Serum amyloid A chemoattracts immature dendritic cells and indirectly provokes monocyte chemotaxis by induction of cooperating CC and CXC chemokines. EUROPEAN JOURNAL OF IMMUNOLOGY 45:101-112(2015).
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