Recombinant Human chemokine (C-C motif) ligand 5, His-tagged

Cat.No. : CCL5-61H
Product Overview : Recombinant Human CCL5 comprises a 68 amino acid fragment (24-91) corresponding to the mature RANTES protein and is expressed in E. coli with an amino-terminal hexahistidine tag.
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Cat. No. : CCL5-61H
Description : CCL5 (acronym for Regulated upon Activation, Normal T-cell Expressed, and presumably Secreted) is a member of the beta (CC) chemokine subfamily and is predominantly produced from T cells and platelets. RANTES has been shown to be a chemoattractant factor for monocytes, CD4+/CD45RO+ T lymphocytes and basophils. It has also been shown to induce the proliferation and activation of killer cells and may act as a HIV suppressive factor.
Source : E.coli.
Purity : >95% by SDS-PAGE
Form : Liquid
Storage : Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
Gene Name : CCL5 chemokine (C-C motif) ligand 5 [ Homo sapiens ]
Synonyms : CCL5; D17S136E; MGC17164; RANTES; SCYA5; SISd; TCP228; chemokine (C-C motif) ligand 5; small inducible cytokine A5; SIS-delta; beta-chemokine RANTES; T-cell specific protein p288; T-cell specific RANTES protein; small inducible cytokine A5 (RANTES); small inducible cytokine subfamily A (Cys-Cys), member 5; regulated upon activation, normally T-expressed, and presumably secreted; CCL5; Chemokine (C-C motif) ligand 5; T-cell specific RANTES protein; T-cell; specific protein P288; beta chemokine RANTES precursor; SIS delta; EoCP; Eosinophil-chemotactic cytokine; T-cell specific RANTES protein; T-cell-specific protein RANTES; small inducible cytokine A5.
Gene ID : 6352
mRNA Refseq : NM_002985
Protein Refseq : NP_002976
MIM : 187011
UniProt ID : P13501
Chromosome Location : 17q11.2-q12
Pathway : Cytokine-cytokine receptor interaction; Epithelial cell signaling in Helicobacter pylori infection; Toll-like receptor signaling pathway; :Signaling by GPCR
Function : chemoattractant activity; chemokine activity; signal transducer activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are the potential clinical applications of CCL5 inhibitors? 10/24/2021

CCL5 inhibitors may be used to control inflammation in diseases like rheumatoid arthritis or as an adjuvant in cancer therapy.

Can CCL5 be used to stimulate the immune system in cancer treatment? 10/24/2020

CCL5-based immunotherapies are being explored to enhance the immune response against cancer cells.

Can CCL5 be used as a diagnostic marker for diseases? 08/14/2019

It can serve as a biomarker for some diseases, but it is usually used in conjunction with other markers for more accurate diagnostics.

What are the clinical implications of elevated CCL5 levels? 02/20/2019

Elevated CCL5 levels are associated with inflammation and may be indicative of certain diseases such as rheumatoid arthritis or HIV infection.

Are there any CCL5-targeted therapies in development? 05/18/2018

Yes, there are ongoing efforts to develop therapies that modulate CCL5 activity, particularly in diseases involving inflammation.

Customer Reviews (3)

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Reviews
08/17/2021

    This specificity enables precise quantification and characterization of CCL5 and its interactions with other molecules or proteins of interest.

    06/23/2019

      Its exceptional performance, coupled with its ability to generate clear and precise protein bands, make it an indispensable tool in achieving accurate and reliable results.

      06/20/2016

        The CCL5 protein exhibits a high degree of specificity in various assays, ensuring accurate and reliable results.

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