Recombinant Human CLIC1 Protein (Lys79-Lys241), His tagged
|Product Overview :
|Recombinant human CLIC1 (Lys79-Lys241) fused with His tag was expressed in E. coli.
- Gene Information
- Related Products
|Members of the CLIC family are largely soluble proteins that possess the intriguing property of spontaneous insertion into phospholipid bilayers to form integral membrane ion channels. Chloride intracellular channel 1 (CLIC1), a newly discovered member of the chloride channel protein family, has been implicated in multiple human cancers. CLIC1 is a Chloride Intracellular Ion Channel protein that exists either in a soluble state in the cytoplasm or as a membrane bound protein. CLIC1 acts as a putative oncogene in pancreatic cancer and may represent a novel diagnostic and therapeutic target for pancreatic cancer. Intracellular chloride channel protein 1 (CLIC1) participates in inflammatory processes by regulating macrophage phagosomal functions such as pH and proteolysis. CLIC1 is a novel therapeutic target to help reduce the adaptive immune response in autoimmune diseases. The expression of CLIC1 might be closely related to the carcinogenesis, clinical biological behaviors, and prognosis of pancreatic ductal adenocarcinomas. Intracellular chloride channel 1 (CLIC1), a novel metamorphic protein, acts as a sensor of cell oxidation and is involved in inflammation.
|Lyophilized powder/frozen liquid
|Molecular Mass :
|Protein Length :
|>90% as determined by SDS-PAGE
|For research use only.
|Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
|Storage Buffer :
|Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5.
|Reconstitute in sterile water for a stock solution.
|They are shipped out with dry ice/blue ice unless customers require otherwise.
|Gene Name :
|CLIC1 chloride intracellular channel 1 [ Homo sapiens (human) ]
|Official Symbol :
|CLIC1; chloride intracellular channel 1; chloride intracellular channel protein 1; NCC27; p64CLCP; hRNCC; RNCC protein; chloride channel ABP; nuclear chloride ion channel 27; nuclear chloride ion channel protein; regulatory nuclear chloride ion channel protein; G6;
|Gene ID :
|mRNA Refseq :
|Protein Refseq :
|UniProt ID :
|◆ Recombinant Protein
|Recombinant Human CLIC1 Protein, His-tagged
|Recombinant Rat CLIC1 Protein, His (Fc)-Avi-tagged
|Recombinant Mouse Clic1 Protein, MYC/DDK-tagged
|Recombinant Human CLIC1 Protein, GST-tagged
|Recombinant Human CLIC1, GST-tagged
|Recombinant Human CLIC1 293 Cell Lysate
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (5)Ask a question
CLIC1 protein promotes cancer cell proliferation, migration, and invasion, making it a potential target for cancer therapy.
Several clinical trials are investigating the efficacy of CLIC1 protein-targeted therapies in various types of cancer, including breast, lung, and colorectal cancer.
CLIC1 protein has been linked to cardiac hypertrophy, fibrosis, and arrhythmias, suggesting its involvement in the pathogenesis of cardiovascular diseases.
Yes, targeting CLIC1 protein has shown promise in preclinical studies as a potential therapeutic approach for neurodegenerative diseases.
CLIC1 protein has been implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's, where it may play a role in neuronal dysfunction and neuroinflammation.
Customer Reviews (3)Write a review
With the manufacturer's outstanding technical support, you can be assured that any challenges you encounter will be efficiently addressed.
Its superior quality, combined with the manufacturer's exceptional technical support, provides researchers with the confidence they need to conduct successful experiments and obtain meaningful results.
Researchers who have utilized the CLIC1 protein laud its reliability and effectiveness in their studies.
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