Recombinant Human CLIC1, His-tagged
Cat.No. : | CLIC1-27816TH |
Product Overview : | Recombinant full-length Human CLIC1 with N terminal His tag, amino acids 1-241, 261 amino acids with tag, MWt 29 kDa, |
- Specification
- Gene Information
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Description : | Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. |
Conjugation : | HIS |
Source : | E. coli |
Tissue specificity : | Expression is prominent in heart, placenta, liver, kidney and pancreas. |
Form : | Liquid |
Purity : | >90% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, 100mM Sodium chloride, pH 8 |
Storage : | Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : | MGSSHHHHHH SSGLVPRGSH MAEEQPQVEL FVKAGSDGAK IGNCPFSQRL FMVLWLKGVT FNVTTVDTKR RTETVQKLCP GGQLPFLLYGTEVHTDTNKI EEFLEAVLCP PRYPKLAALN PESNTAGLDI FAKFSAYIKN SNPALNDNLE KGLLKALKVL DNYLTSPLPE EVDETSAEDEGVSQRKFLDG NELTLADCNL LPKLHIVQVV CKKYRGFTIP EAFRGVHRYL SNAYAREEFA STCPDDEEIE LAYEQVAKAL K |
Sequence Similarities : | Belongs to the chloride channel CLIC family.Contains 1 GST C-terminal domain. |
Gene Name : | CLIC1 chloride intracellular channel 1 [ Homo sapiens ] |
Official Symbol : | CLIC1 |
Synonyms : | CLIC1; chloride intracellular channel 1; chloride intracellular channel protein 1; NCC27; p64CLCP; |
Gene ID : | 1192 |
mRNA Refseq : | NM_001288 |
Protein Refseq : | NP_001279 |
MIM : | 602872 |
Uniprot ID : | O00299 |
Chromosome Location : | 6p21.3 |
Function : | chloride channel activity; protein binding; voltage-gated chloride channel activity; voltage-gated ion channel activity; |
Products Types
◆ Recombinant Protein | ||
CLIC1-1106R | Recombinant Rat CLIC1 Protein, His (Fc)-Avi-tagged | +Inquiry |
CLIC1-1477H | Recombinant Human CLIC1 Protein, GST-tagged | +Inquiry |
CLIC1-620H | Recombinant Human CLIC1 Protein, His-tagged | +Inquiry |
Clic1-519M | Recombinant Mouse Clic1 Protein, MYC/DDK-tagged | +Inquiry |
CLIC1-11958Z | Recombinant Zebrafish CLIC1 | +Inquiry |
◆ Lysates | ||
CLIC1-7448HCL | Recombinant Human CLIC1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCLIC1 protein promotes cancer cell proliferation, migration, and invasion, making it a potential target for cancer therapy.
Several clinical trials are investigating the efficacy of CLIC1 protein-targeted therapies in various types of cancer, including breast, lung, and colorectal cancer.
CLIC1 protein has been linked to cardiac hypertrophy, fibrosis, and arrhythmias, suggesting its involvement in the pathogenesis of cardiovascular diseases.
Yes, targeting CLIC1 protein has shown promise in preclinical studies as a potential therapeutic approach for neurodegenerative diseases.
CLIC1 protein has been implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's, where it may play a role in neuronal dysfunction and neuroinflammation.
Customer Reviews (3)
Write a reviewWith the manufacturer's outstanding technical support, you can be assured that any challenges you encounter will be efficiently addressed.
Its superior quality, combined with the manufacturer's exceptional technical support, provides researchers with the confidence they need to conduct successful experiments and obtain meaningful results.
Researchers who have utilized the CLIC1 protein laud its reliability and effectiveness in their studies.
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