Recombinant Human CSF1 Protein (159 aa)

Cat.No. : CSF1-335C
Product Overview : Recombinant human Macrophage Colony-Stimulating Factor 1 (rhM-CSF) produced in E. coli is a disulfide-linked homodimer containing two non-glycosylated polypeptide chains of 159 amino acids each. A fully biologically active molecule, rhM-CSF has a molecular mass of 28 kDa analyzed by non-reducing SDS-PAGE and is obtained by proprietary refolding and chromatographic techniques.
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  • Gene Information
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Description : Macrophage Colony-Stimulating Factor 1 (M-CSF), involved especially in monocytopoiesis, is a hematopoietic growth factor. In mammals, it exits three isoforms, which invariably share an N-terminal 32-aa signal peptide, a 149-residue growth factor domain, a 21-residue transmembrane region and a 37-aa cytoplasmictail. The biological activity of human M-CSF is maintained within the 149-aa growth factor domain, and it is only active in the disulfide-linked dimeric form, which is bonded at Cys63.
Source : E. coli
Species : Human
Form : Sterile Filtered White lyophilized (freeze-dried) powder.
Bio-activity : ED50 of 1 - 3 ng/mL, measured by cell proliferation assay of M-NFS-60, corresponding to a specific activity of 3.3 5-1 × 10^6 units/mg.
Molecular Mass : 28 kDa, observed by non-reducing SDS-PAGE.
Protein Length : 159
Endotoxin : < 1 EU/μg, determined by LAL method.
Purity : > 95% as analyzed by non-reducing SDS-PAGE.
Storage : Lyophilized recombinant human Macrophage Colony-Stimulating Factor 1 (rhM-CSF) remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, rhM-CSF should be stable up to 2 weeks at 4 centigrade or up to 3 months at -20 centigrade.
Storage Buffer : Lyophilized after extensive dialysis against 50 mM Tris-HCl, pH 8.0.
Reconstitution : Reconstituted in ddH2O or PBS or Tris-HCl, pH 8.0 at 100 μg/mL.
Gene Name : CSF1 colony stimulating factor 1 (macrophage) [ Homo sapiens ]
Official Symbol : CSF1
Synonyms : CSF1; colony stimulating factor 1 (macrophage); macrophage colony-stimulating factor 1; M CSF; MCSF; MGC31930; lanimostim; CSF-1;
Gene ID : 1435
mRNA Refseq : NM_000757
Protein Refseq : NP_000748
MIM : 120420
UniProt ID : P09603

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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