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Active Recombinant Human CSF1 Protein (159 aa)

Cat.No. : CSF1-335C
Product Overview : Recombinant human Macrophage Colony-Stimulating Factor 1 (rhM-CSF) produced in E. coli is a disulfide-linked homodimer containing two non-glycosylated polypeptide chains of 159 amino acids each. A fully biologically active molecule, rhM-CSF has a molecular mass of 28 kDa analyzed by non-reducing SDS-PAGE and is obtained by proprietary refolding and chromatographic techniques.
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Description : Macrophage Colony-Stimulating Factor 1 (M-CSF), involved especially in monocytopoiesis, is a hematopoietic growth factor. In mammals, it exits three isoforms, which invariably share an N-terminal 32-aa signal peptide, a 149-residue growth factor domain, a 21-residue transmembrane region and a 37-aa cytoplasmictail. The biological activity of human M-CSF is maintained within the 149-aa growth factor domain, and it is only active in the disulfide-linked dimeric form, which is bonded at Cys63.
Source : E. coli
Species : Human
Form : Sterile Filtered White lyophilized (freeze-dried) powder.
Bio-activity : ED50 of 1 - 3 ng/mL, measured by cell proliferation assay of M-NFS-60, corresponding to a specific activity of 3.3 5-1 × 10^6 units/mg.
Molecular Mass : 28 kDa, observed by non-reducing SDS-PAGE.
Protein Length : 159
AA Sequence : MEEVSEYCSHMIGSGHLQSLQRLID SQMETSCQITFEFVDQEQLKDPVCY LKKAFLLVQDIMEDTMRFRDNTPNA IAIVQLQELSLRLKSCFTKDYEEHD KACVRTFYETPLQLLEKVKNVFNET KNLLDKDWNIFSKNCNNSFAECSSQ GHERQSEGS
Endotoxin : < 1 EU/μg, determined by LAL method.
Purity : > 95% as analyzed by non-reducing SDS-PAGE.
Storage : Lyophilized recombinant human Macrophage Colony-Stimulating Factor 1 (rhM-CSF) remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, rhM-CSF should be stable up to 2 weeks at 4 centigrade or up to 3 months at -20 centigrade.
Storage Buffer : Lyophilized after extensive dialysis against 50 mM Tris-HCl, pH 8.0.
Reconstitution : Reconstituted in ddH2O or PBS or Tris-HCl, pH 8.0 at 100 μg/mL.
Gene Name : CSF1 colony stimulating factor 1 (macrophage) [ Homo sapiens ]
Official Symbol : CSF1
Synonyms : CSF1; colony stimulating factor 1 (macrophage); macrophage colony-stimulating factor 1; M CSF; MCSF; MGC31930; lanimostim; CSF-1;
Gene ID : 1435
mRNA Refseq : NM_000757
Protein Refseq : NP_000748
MIM : 120420
UniProt ID : P09603

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does CSF1 affect cancer progression? 09/20/2022

CSF1 is implicated in tumor-associated macrophages, influencing tumor growth, invasion, and the tumor microenvironment.

What are the potential side effects of CSF1 therapy? 07/11/2022

Side effects may include immune-related adverse events, inflammation, and alterations in white blood cell counts.

Can CSF1 therapy be combined with other treatments? 08/26/2020

Yes, there is ongoing research on combining CSF1-targeted therapies with other immunotherapies or conventional treatments to enhance efficacy.

What are the challenges in developing CSF1-based therapies? 09/26/2019

Challenges include maintaining the balance of immune responses, potential off-target effects, and variability in patient responses.

In what ways is CSF1 being researched for neurological disorders? 10/01/2018

Studies are exploring its role in neuroinflammation, neuroprotection, and potential therapeutic interventions for conditions like Alzheimer's disease.

Customer Reviews (3)

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Reviews
10/30/2017

    The CSF1 protein is renowned for its exceptional quality and reliability, making it an ideal choice to fulfill my experimental requirements.

    03/10/2017

      With its high purity and stability, this protein ensures dependable and accurate results, which are crucial for the success of my research endeavors.

      06/09/2016

        Whether it is for investigating cellular pathways, studying protein functions, or exploring signaling cascades, the CSF1 protein offers unparalleled versatility and performance.

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