CSF1
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Official Full Name
colony stimulating factor 1 (macrophage)
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Overview
Macrophage colony-stimulating factor, or M-CSF, is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. Eukaryotic cells also produce M-CSF in order to combat intercellular viral infection. (See colony-stimulating factor.) M-CSF binds to the Colony stimulating factor 1 receptor. It may also be involved in development of the placenta. -
Synonyms
CSF1; colony stimulating factor 1 (macrophage); MCSF; MGC31930; macrophage colony-stimulating factor 1; CSF-1; lanimostim; OTTHUMP00000013362; OTTHUMP00000013363; OTTHUMP00000013364; OTTHUMP00000013365; macrophage colony stimulating factor; M-CSF;
- Recombinant Proteins
- GMP Proteins
- Cell & Tissue Lysates
- Transfected Stable Cell Lines
- Bovine
- Chicken
- Cynomolgus
- Cynomolgus/Rhesus
- Homo sapiens (Human)
- Human
- Human, Cynomolgus
- Mouse
- Mus musculus (Mouse)
- Rat
- B.mori
- Barley Grain
- CHO
- E.coli
- E.coli expression system
- HEK293
- HEK293F
- HEK293T
- Hordeum Vulgare
- Human
- Human Cell
- Human cells
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Silkworm
- Wheat Germ
- Yeast
- C
- His
- Myc
- DDK
- Fc
- GST
- His(C
- ter)
- His|GST
- His|S
- Avi
- MYC
- Myc|DDK
- N/A
- N
- Strep II
- Tag Free
- Background
- Quality Guarantee
- Case Study
- Involved Pathway
- Protein Function
- Interacting Protein
- CSF1 Related Articles
- CSF1 Related Research Area
What is csf1 protein?
Csf1, also known as colony-stimulating factor 1, is a protein that plays a crucial role in the regulation of immune cell function and development. It is primarily produced by cells of the macrophage lineage, such as monocytes and tissue-resident macrophages.
What is the function of csf1 protein?
The main function of Csf1 is to promote the survival, proliferation, and differentiation of monocytes and macrophages. It acts as a growth factor, stimulating the production of these immune cells and enhancing their ability to carry out their immune functions. Csf1 also plays a role in bone development and remodeling, as well as the regulation of female reproductive functions.
Csf1 related signaling pathway
The signaling pathway of CSF1 involves the binding of CSF1 to its receptor, CSF1R (colony-stimulating factor 1 receptor). Upon binding, CSF1 induces the dimerization and autophosphorylation of CSF1R, leading to the activation of downstream signaling molecules such as phosphatidylinositol 3-kinase (PI3K), Akt (protein kinase B), and mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinases (ERKs) and p38 MAPK.
Activation of these signaling molecules regulates various cellular processes, including cell proliferation, survival, differentiation, migration, and phagocytosis. CSF1-mediated signaling is vital for the development and function of macrophages, which are essential components of the immune system and play crucial roles in immune responses, tissue homeostasis, and inflammation.
Csf1 Related Diseases
CSF1 plays a crucial role in various diseases and conditions. Imbalances in CSF1 signaling have been implicated in the development and progression of certain cancers, such as breast cancer, ovarian cancer, and prostate cancer. Overexpression of CSF1 has been associated with increased tumor growth, angiogenesis, and metastasis.
In addition, dysregulation of CSF1 signaling has been linked to inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease. CSF1 promotes the recruitment, differentiation, and activation of macrophages, which play a key role in driving chronic inflammation in these conditions.
Biomedical Application of csf1 Protein
The biomedical applications of Csf1 protein are wide-ranging. Csf1 therapy has been explored in preclinical and clinical studies as a potential treatment for bone-related disorders like osteoporosis and osteoarthritis. Csf1 has also been investigated as a therapeutic target in inflammatory and autoimmune diseases, with the aim of modulating immune cell function and reducing inflammation. In the field of oncology, targeting Csf1 signaling has been explored as a strategy to inhibit tumor growth and metastasis by blocking the recruitment and activation of tumor-associated macrophages. Additionally, Csf1 is being investigated as a potential biomarker for disease prognosis and therapeutic response in certain cancers.
High Purity
Fig1. SDS-PAGE (CSF1-1962H)
High Bioactivity & Detection Sensitivity
Fig2. The protein has a calculated MW of 26.0 kDa. The protein migrates as 36-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
(L. Moffat, 2013)
Fig3. Confirmation of antibody specificity. Detection of porcine CSF1R via Western blot. (B) Ba/F3 parent cell line and (C) cloned pEF6pCSF1R-Ba/F3 cell line were stained with an anti-mouse IgG-FITC secondary only control (black line) and pCSF1R mAb ROS3B10 with anti-mouse IgG-FITC secondary (red line).
(Kristin A Sauter, 2014)
Fig4. Effect of anti-CSF1R treatment on Paneth and goblet cells of the intestine. (A) Four-percent, PFA-fixed, 5 μm cryosections of ileum from control (rat IgG) or anti-CSF1R-treated (M279) mice were immunostained to detect lysozyme (red) in granules of Paneth cells within intestinal crypts, counterstained with F-actin (blue); original scale bars, 50 μm.
(Jiwei Hou, 2024)
Fig5. Overexpression of CSF-1R in CD206+ M2 macrophages. (C) Immunohistochemistry staining of CSF-1R and CD206 in the lung sections of IPF patients. Representative images are shown.
CSF1 involved in several pathways and played different roles in them. We selected most pathways CSF1 participated on our site, such as Cytokine-cytokine receptor interaction, Cytokines and Inflammatory Response, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CSF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | IL20;IL3;IL7R;CXCR3;CXCR4A;M17;ACVR1B;ACKR3B;IRX1 |
| Cytokines and Inflammatory Response | CSF2;CSF3;CSF1 |
| Hematopoietic cell lineage | Il4ra;IL5RA;CD3D;CSF1;CD19;IL4;CD14;HLA-DRB3;HLA-DRB5 |
| Integrins in angiogenesis | CSF1;CSF1R;ANGPTL3;MFGE8;EDIL3 |
| Osteoclast differentiation | NFKB2;FCGR2C;FYN;SIRPB1;IL1B;LILRB5;MAPK12;NCF1;IL1A |
| PI3K-Akt signaling pathway | CSF3;LOC608458;CHAD;CSF1;COMP;CSH1;CSH;EFNA3;EFNA2 |
| Rap1 signaling pathway | EFNA2;EFNA4;LOC608458;RGS14;PFN4;CSF1 |
| Ras signaling pathway | FGF4;MAP2K2;PLA2G6;HGF;RASA4;GNG11;ELK1;GNG5;PLD1 |
CSF1 has several biochemical functions, for example, cytokine activity, growth factor activity, macrophage colony-stimulating factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CSF1 itself. We selected most functions CSF1 had, and list some proteins which have the same functions with CSF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | LFT1;GREM1;IFNB1;WNT7A;CCL20A.3;IL15;TNFSF13;CMTM3;OSM |
| growth factor activity | LACRT;IL7;INHBAB;BMP2B;TGFB2;CDNF;TDGF1;GDNFA;PRL2C3 |
| macrophage colony-stimulating factor receptor binding | IL34;STAP1;CSF1 |
| protein binding | ELN;FBLIM1;DSTN;POLDIP3;IL7;DLG1;ECSIT;HMGB3;TRDN |
| protein homodimerization activity | DDX1;ABCB10;MTUS2;PDK2;NR2F2;WHRN;ABCG2;HMGCR;C6orf108 |
CSF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CSF1.
SGTA; FHL3; NOTCH2NL; adhC; MYC
- Q&As
- Reviews
Q&As (5)
Ask a questionCSF1 is implicated in tumor-associated macrophages, influencing tumor growth, invasion, and the tumor microenvironment.
Side effects may include immune-related adverse events, inflammation, and alterations in white blood cell counts.
Yes, there is ongoing research on combining CSF1-targeted therapies with other immunotherapies or conventional treatments to enhance efficacy.
Challenges include maintaining the balance of immune responses, potential off-target effects, and variability in patient responses.
Studies are exploring its role in neuroinflammation, neuroprotection, and potential therapeutic interventions for conditions like Alzheimer's disease.
Customer Reviews (3)
Write a reviewThe CSF1 protein is renowned for its exceptional quality and reliability, making it an ideal choice to fulfill my experimental requirements.
With its high purity and stability, this protein ensures dependable and accurate results, which are crucial for the success of my research endeavors.
Whether it is for investigating cellular pathways, studying protein functions, or exploring signaling cascades, the CSF1 protein offers unparalleled versatility and performance.
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