CSF1

  • Official Full Name

    colony stimulating factor 1 (macrophage)

  • Overview

    Macrophage colony-stimulating factor, or M-CSF, is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. Eukaryotic cells also produce M-CSF in order to combat intercellular viral infection. (See colony-stimulating factor.) M-CSF binds to the Colony stimulating factor 1 receptor. It may also be involved in development of the placenta.
  • Synonyms

    CSF1; colony stimulating factor 1 (macrophage); MCSF; MGC31930; macrophage colony-stimulating factor 1; CSF-1; lanimostim; OTTHUMP00000013362; OTTHUMP00000013363; OTTHUMP00000013364; OTTHUMP00000013365; macrophage colony stimulating factor; M-CSF;

  • Recombinant Proteins
  • GMP Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • Bovine
  • Chicken
  • Cynomolgus/Rhesus
  • Homo sapiens (Human)
  • Human
  • Human, Cynomolgus
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • B.mori
  • Barley Grain
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293F
  • HEK293T
  • Hordeum Vulgare
  • Human
  • Human Cell
  • Human cells
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Silkworm
  • Wheat Germ
  • Yeast
  • C
  • hFc
  • His
  • Myc
  • DDK
  • Fc
  • GST
  • His(C
  • ter)
  • His|GST
  • His|S
  • Avi
  • MYC
  • Myc|DDK
  • N/A
  • N
  • KSI
  • Strep II
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CSF1-426H Active Recombinant Human CSF1 Protein, His-tagged Yeast His
Human CSF1-167H Active Recombinant Human Colony Stimulating Factor 1 (Macrophage) HEK293 N/A
Human CSF1-418H Active Recombinant Human CSF1 Silkworm N/A
Human CSF1-033E Active Recombinant Human CSF1 (33-190aa), Met tagged E.coli N/A
Human CSF1-427H Active Recombinant Human CSF1 Protein HEK293 N/A
Human CSF1-565H Active Recombinant Human CSF1 protein, His-tagged HEK293 His Met1-Asn190
Human CSF1-32H Active Recombinant Human CSF1, His-tagged Barley Grain His
Human CSF1-424H Active Recombinant Human CSF1 Protein, Fc-tagged HEK293 Fc Met1-Arg255
Human CSF1-18HG Active Recombinant Human CSF1 Protein (Glu33-Ser190), GMP Grade, Animal-Free E.coli Glu33-Ser190
Human CSF1-12H Active Recombinant Human CSF1 Protein, Pre-aliquoted E.coli Glu33-Ser190, with an N-terminal Met
Human CSF1-110HG Active GMP Recombinant Human CSF1 Protein E.coli N/A
Human CSF1-420H Active Recombinant Human CSF1 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Glu 33 - Arg 255
Human CSF1-3279H Active Recombinant Human CSF1 protein(Met1-Arg255), His-tagged HEK293 C-His Met1-Arg255
Human CSF1-1962H Recombinant Human CSF1 Protein, GST-tagged Wheat Germ GST
Human CSF1-96H Recombinant Human CSF1, His-tagged E.coli His
Human CSF1-177H Recombinant Human CSF1 Protein, Mature chain, Tag Free, Biotinylated B.mori Tag Free Mature chain
Human CSF1-5383H Recombinant Human Colony Stimulating Factor 1 (macrophage) Hordeum Vulgare N/A
Human CSF1-425H Recombinant Human CSF1 protein, His-tagged HEK293 His Glu33-Arg255
Human CSF1-357H Recombinant Human Colony Stimulating Factor 1 (macrophage) Human N/A
Human CSF1-698H Recombinant Human CSF1 protein, His & GST-tagged E.coli His/GST Glu33~Ser496
Human CSF1-339H Recombinant Human Colony Stimulating Factor 1 (macrophage) Human N/A
Human CSF1-289H Recombinant Human CSF1 protein E.coli N/A 158
Human CSF1-26835TH Recombinant Human CSF1, His-tagged His
Human CSF1-1875H Recombinant Human Colony Stimulating Factor 1 (macrophage) HEK293 N/A
Human CSF1-216H Recombinant Human CSF1, StrepII-tagged Human Cell Strep II 33-191, 159 a.a.
Human CSF1-1934HCL Recombinant Human CSF1 cell lysate Human Cell N/A
Human CSF1-427HB Recombinant Human CSF1 protein(Met1-Asn190), His-tagged, Biotinylated HEK293 C-His Met1-Asn190
Human CSF1-2158H Recombinant Human CSF1 Protein, His-tagged E.coli N-His Glu33-Ser496
Human CSF1-3337H Recombinant Human CSF1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CSF1-198H Recombinant Human CSF1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human CSF1-45H Recombinant Active Human CSF1 Protein, His-tagged(C-ter) E.coli His(C-ter)
Human CSF1-2160H Recombinant Human CSF1 Protein, His-tagged E.coli N-His Glu33-Asn190
Human CSF1-4448H Recombinant Human CSF1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CSF1-4319H Recombinant Human CSF1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CSF1-4027H Recombinant Human CSF1 Protein (Glu33-Arg255), C-His tagged Mammalian cells C-His Glu33-Arg255
Human CSF1-5384H Recombinant Human CSF1 protein, His-tagged Yeast His 33-554aa
Human CSF1-2156HF Recombinant Full Length Human CSF1 Protein, GST-tagged In Vitro Cell Free System GST 554 amino acids
Human CSF1-6225H Recombinant Human CSF1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CSF1-4028H Recombinant Human CSF1 Protein (Glu33-Arg255), N-His tagged Mammalian cells N-His Glu33-Arg255
Human CSF1-27H Active Recombinant Human CSF1 Protein (Glu33-Ser190), C-His tagged, Animal-free, Carrier-free E.coli C-His Glu33-Ser190
Human CSF1-521H Recombinant Human CSF1 Protein 554
Human CSF1-335C Active Recombinant Human CSF1 Protein (159 aa) E.coli 159
Human CSF1-41H Active Recombinant Human CSF1 Protein, Animal Free Human cells
Human CSF1-94H Human Macrophage Colony Stimulating Factor(rDNA derived) Reference standard N/A
Human CSF1-083C Active Recombinant Human CSF1 Protein (1-149 aa) Silkworm 1-149
Human CSF1-603H Recombinant Human CSF1 protein, His-Avi-tagged HEK293 His-Avi Glu33-Asn190
Human CSF1-40H Active Recombinant Human CSF1 Protein E.coli
Human CSF1-223C Active Recombinant Human CSF1 Protein CHO
Human CSF1-2521H Recombinant Human CSF1 Protein (Glu33-Ser496), His tagged E.coli His Glu33-Ser496
Mouse Csf1-290M Active Recombinant Mouse Csf1 protein E.coli N/A 156 amino acid
Mouse CSF1-414M Active Recombinant Mouse CSF1 protein(Met1-Glu262), His-tagged HEK293 C-His Met1-Glu262
Mouse Csf1-522M Active Recombinant Mouse Csf1 protein HEK293 N/A Met1-Glu262
Mouse Csf1-041E Active Recombinant Mouse Csf1 (33-262aa), Met tagged E.coli N/A
Mouse Csf1-01M Active GMP Recombinant Mouse Csf1 Protein, His-Tagged E.coli His
Mouse CSF1-40M Recombinant Mouse M-CSF Yeast N/A
Mouse Csf1-95M Recombinant Mouse Csf1 E.coli N/A
Mouse Csf1-178M Recombinant Mouse Csf1 protein, His/S-tagged E.coli His/S
Mouse Csf1-100M Recombinant Mouse Csf1 protein E.coli N/A 230
Mouse Csf1-699M Recombinant Mouse Csf1 protein, His-tagged E.coli His Lys33~Ser204
Mouse CSF1-001MCL Recombinant Mouse CSF1 cell lysate Human Cell N/A
Mouse Csf1-222C Active Recombinant Mouse Csf1 Protein CHO
Mouse Csf1-1283M Recombinant Mouse Csf1 Protein, His-tagged E.coli N-His Glu262-Leu432
Mouse Csf1-18M Active Recombinant Mouse Csf1 Protein (Lys33-Pro187), C-His tagged, Animal-free, Carrier-free E.coli C-His Lys33-Pro187
Mouse CSF1-41M Active Recombinant Mouse CSF1 Protein E.coli
Mouse Csf1-334C Active Recombinant Mouse Csf1 Protein (156 aa) E.coli 156
Mouse Csf1-041M Active Recombinant Mouse Csf1 Protein HEK293
Mouse Csf1-1107M Recombinant Mouse Csf1 Protein, His-tagged HEK293F N-His Lys33-Glu262
Mouse Csf1-1106M Recombinant Mouse Csf1 Protein, His-tagged HEK293F N-His Lys33-Glu262
Mouse Csf1-6753M Recombinant Mouse Csf1 Protein (Lys33-Glu262) Mammalian cells Tag Free Lys33-Glu262
Mouse Csf1-042M Active Recombinant Mouse Csf1 Protein E.coli
Mouse Csf1-2159M Recombinant Mouse Csf1 Protein, His-tagged E.coli N-His Lys33-Glu262
Mouse Csf1-043M Recombinant Mouse Csf1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Csf1-115MG Active GMP Recombinant Mouse Csf1 protein HEK293 DNA sequence encoding Mouse M-CSF(NP_031804.3) was expressed with His tag at the C-terminal.
Mouse Csf1-46M Recombinant Active Mouse CSF1 Protein, His-tagged(C-ter) E.coli His(C-ter)
Rat Csf1-12R Active Recombinant Rat Csf1 E.coli N/A
Rat Csf1-13R Active Recombinant Rat Csf1 HEK293 N/A
Rat Csf1-14R Active Recombinant Rat Csf1 CHO N/A
Rat Csf1-179R Recombinant Rat Csf1 protein, His/S-tagged E.coli His/S
Rat Csf1-15R Recombinant Rat Csf1 Human Cell N/A
Rat Csf1-2161R Recombinant Rat Csf1 Protein, His&GST-tagged E.coli N-His&GST Glu261-Leu427
Rat Csf1-1342R Recombinant Rat Csf1 protein, His-KSI-tagged E.coli N-His-KSI 156-360aa
Rat Csf1-387RG Active GMP Recombinant Rat Csf1 protein HEK293 DNA sequence encoding Rat M-CSF(NP_076471.3) was expressed with His tag at the C-terminal.
Rat Csf1-221C Active Recombinant Rat Csf1 Protein CHO
Rat Csf1-333C Active Recombinant Rat Csf1 Protein (155 aa) E.coli 155
Rat CSF1-42R Active Recombinant Rat CSF1 Protein E.coli
Rat Csf1-6845R Recombinant Rat Csf1 Protein (Gln33-Arg254) Mammalian cells Tag Free Gln33-Arg254
Bovine CSF1-4398B Recombinant Bovine CSF1 Protein Yeast N/A 223aa
Cynomolgus/Rhesus CSF1-339C Active Recombinant Cynomolgus/Rhesus CSF1 protein(Met1-Asn190), His-tagged HEK293 C-His Met1-Asn190
Cynomolgus/Rhesus CSF1-340C Recombinant Cynomolgus/Rhesus CSF1 protein(Met1-Asn190), hFc-tagged HEK293 C-hFc Met1-Asn190
Homo sapiens (Human) RFL21736HF Recombinant Full Length Human Granulocyte-Macrophage Colony-Stimulating Factor(Csf2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (18-144)
Human, Cynomolgus CSF1-565HB Active Recombinant Human/Cynomolgus CSF1 protein, His-tagged, Biotinylated HEK293 His
Mus musculus (Mouse) RFL36342MF Recombinant Full Length Mouse Macrophage Colony-Stimulating Factor 1(Csf1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (33-552)
Chicken CSF1-4112C Recombinant Chicken CSF1 Mammalian Cell His
Chicken CSF1-4393C Recombinant Chicken CSF1 Protein Yeast N/A 240aa
  • Background
  • Quality Guarantee
  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

What is csf1 protein?

Csf1, also known as colony-stimulating factor 1, is a protein that plays a crucial role in the regulation of immune cell function and development. It is primarily produced by cells of the macrophage lineage, such as monocytes and tissue-resident macrophages.

What is the function of csf1 protein?

The main function of Csf1 is to promote the survival, proliferation, and differentiation of monocytes and macrophages. It acts as a growth factor, stimulating the production of these immune cells and enhancing their ability to carry out their immune functions. Csf1 also plays a role in bone development and remodeling, as well as the regulation of female reproductive functions.

Csf1 related signaling pathway

The signaling pathway of CSF1 involves the binding of CSF1 to its receptor, CSF1R (colony-stimulating factor 1 receptor). Upon binding, CSF1 induces the dimerization and autophosphorylation of CSF1R, leading to the activation of downstream signaling molecules such as phosphatidylinositol 3-kinase (PI3K), Akt (protein kinase B), and mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinases (ERKs) and p38 MAPK.

Activation of these signaling molecules regulates various cellular processes, including cell proliferation, survival, differentiation, migration, and phagocytosis. CSF1-mediated signaling is vital for the development and function of macrophages, which are essential components of the immune system and play crucial roles in immune responses, tissue homeostasis, and inflammation.

Csf1 Related Diseases

CSF1 plays a crucial role in various diseases and conditions. Imbalances in CSF1 signaling have been implicated in the development and progression of certain cancers, such as breast cancer, ovarian cancer, and prostate cancer. Overexpression of CSF1 has been associated with increased tumor growth, angiogenesis, and metastasis.

In addition, dysregulation of CSF1 signaling has been linked to inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease. CSF1 promotes the recruitment, differentiation, and activation of macrophages, which play a key role in driving chronic inflammation in these conditions.

Biomedical Application of csf1 Protein

The biomedical applications of Csf1 protein are wide-ranging. Csf1 therapy has been explored in preclinical and clinical studies as a potential treatment for bone-related disorders like osteoporosis and osteoarthritis. Csf1 has also been investigated as a therapeutic target in inflammatory and autoimmune diseases, with the aim of modulating immune cell function and reducing inflammation. In the field of oncology, targeting Csf1 signaling has been explored as a strategy to inhibit tumor growth and metastasis by blocking the recruitment and activation of tumor-associated macrophages. Additionally, Csf1 is being investigated as a potential biomarker for disease prognosis and therapeutic response in certain cancers.

High Purity

CSF1

Fig1. SDS-PAGE (CSF1-1962H)

High Bioactivity & Detection Sensitivity

CSF1

Fig2. The protein has a calculated MW of 26.0 kDa. The protein migrates as 36-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

CSF1

(L. Moffat, 2013)

Fig3. Confirmation of antibody specificity. Detection of porcine CSF1R via Western blot. (B) Ba/F3 parent cell line and (C) cloned pEF6pCSF1R-Ba/F3 cell line were stained with an anti-mouse IgG-FITC secondary only control (black line) and pCSF1R mAb ROS3B10 with anti-mouse IgG-FITC secondary (red line).

CSF1

(Kristin A Sauter, 2014)

Fig4. Effect of anti-CSF1R treatment on Paneth and goblet cells of the intestine. (A) Four-percent, PFA-fixed, 5 μm cryosections of ileum from control (rat IgG) or anti-CSF1R-treated (M279) mice were immunostained to detect lysozyme (red) in granules of Paneth cells within intestinal crypts, counterstained with F-actin (blue); original scale bars, 50 μm.

CSF1

(Jiwei Hou, 2024)

Fig5. Overexpression of CSF-1R in CD206+ M2 macrophages. (C) Immunohistochemistry staining of CSF-1R and CD206 in the lung sections of IPF patients. Representative images are shown.

CSF1 involved in several pathways and played different roles in them. We selected most pathways CSF1 participated on our site, such as Cytokine-cytokine receptor interaction, Cytokines and Inflammatory Response, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CSF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionPDGFC;IL23R;TNFSF4;CSH;CCL15;FAS;CCR8;IFNB;EDA
Cytokines and Inflammatory ResponseCSF3;CSF2;CSF1
Hematopoietic cell lineageFLT3;ITGB3;CD24;Il6ra;CD1A;IL5;ITGA6;ITGA1;HLA-DRB1
Integrins in angiogenesisEDIL3;ANGPTL3;CSF1;MFGE8;CSF1R
Osteoclast differentiationPPP3CA;SFPI1;IKBKG;MAPK12;IL1R1;RAC1;CYLD;MAP2K6;MAPK10
PI3K-Akt signaling pathwaySGK2;PRP2;CSH;CSF1;EFNA3;CSF1R;EFNA4;CHAD;PIK3AP1
Rap1 signaling pathwayEFNA2;RGS14;PFN4;CSF1;EFNA4;LOC608458
Ras signaling pathwayCDC42;NGF;IGF1;PRKCB;FGFR3;SOS1;GRB2;FLT4;PIK3R2

CSF1 has several biochemical functions, for example, cytokine activity, growth factor activity, macrophage colony-stimulating factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CSF1 itself. We selected most functions CSF1 had, and list some proteins which have the same functions with CSF1. You can find most of the proteins on our site.

Function Related Protein
cytokine activityLIF;Ctf2;IFNA6;IL4;IL1A;IL34;INHBAA;NODAL;INHBA
growth factor activityFGF8;IL8L2;FGF1A;INHBAA;IGF2B;MACC1;INHBAB;PGF;FGF22
macrophage colony-stimulating factor receptor bindingCSF1;STAP1;IL34
protein bindingMGP;PTPRS;SDCCAG8;FBXL3;ZBTB16;NCKAP1;ZNF622;CUL1;FGFR1OP
protein homodimerization activityKLHL7;CHRNA7;TGFB1;NBL1;WHRN;PDGFA;HEYL;STK4;CPNE1

CSF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CSF1.

SGTA; FHL3; NOTCH2NL; adhC; MYC

Research Area

Related articles

Moffat, L; Rothwell, L; et al. Development and characterisation of monoclonal antibodies reactive with porcine CSF1R (CD115). DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 47:123-128(2014).
Sauter, KA; Pridans, C; et al. Pleiotropic effects of extended blockade of CSF1R signaling in adult mice. JOURNAL OF LEUKOCYTE BIOLOGY 96:265-274(2014).
  • Reviews
  • Q&As

Customer Reviews (3)

Write a review
Reviews
10/30/2017

    The CSF1 protein is renowned for its exceptional quality and reliability, making it an ideal choice to fulfill my experimental requirements.

    03/10/2017

      With its high purity and stability, this protein ensures dependable and accurate results, which are crucial for the success of my research endeavors.

      06/09/2016

        Whether it is for investigating cellular pathways, studying protein functions, or exploring signaling cascades, the CSF1 protein offers unparalleled versatility and performance.

        Q&As (5)

        Ask a question
        How does CSF1 affect cancer progression? 09/20/2022

        CSF1 is implicated in tumor-associated macrophages, influencing tumor growth, invasion, and the tumor microenvironment.

        What are the potential side effects of CSF1 therapy? 07/11/2022

        Side effects may include immune-related adverse events, inflammation, and alterations in white blood cell counts.

        Can CSF1 therapy be combined with other treatments? 08/26/2020

        Yes, there is ongoing research on combining CSF1-targeted therapies with other immunotherapies or conventional treatments to enhance efficacy.

        What are the challenges in developing CSF1-based therapies? 09/26/2019

        Challenges include maintaining the balance of immune responses, potential off-target effects, and variability in patient responses.

        In what ways is CSF1 being researched for neurological disorders? 10/01/2018

        Studies are exploring its role in neuroinflammation, neuroprotection, and potential therapeutic interventions for conditions like Alzheimer's disease.

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