CSF1
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Official Full Name
colony stimulating factor 1 (macrophage)
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Background
Macrophage colony-stimulating factor, or M-CSF, is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. Eukaryotic cells also produce M-CSF in order to combat intercellular viral infection. (See colony-stimulating factor.) M-CSF binds to the Colony stimulating factor 1 receptor. It may also be involved in development of the placenta. -
Synonyms
CSF1; colony stimulating factor 1 (macrophage); MCSF; MGC31930; macrophage colony-stimulating factor 1; CSF-1; lanimostim; OTTHUMP00000013362; OTTHUMP00000013363; OTTHUMP00000013364; OTTHUMP00000013365; macrophage colony stimulating factor; M-CSF;
- Involved Pathway
- Protein Function
- Interacting Protein
- CSF1 Related Articles
- CSF1 Related Research Area
CSF1 involved in several pathways and played different roles in them. We selected most pathways CSF1 participated on our site, such as Cytokine-cytokine receptor interaction, Cytokines and Inflammatory Response, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CSF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | IL8L1;CCL2;BMPR1AA;PRLR;IFN-a;EPO;TNFRSF12A;PRLRA;CXCR3.2 |
| Cytokines and Inflammatory Response | CSF1;CSF2;CSF3 |
| Hematopoietic cell lineage | IL1R1;GM-CSF;FCGR1;ITGA6;MS4A1;IL5RA;GYPA;GP1BA;IL7 |
| Integrins in angiogenesis | CSF1;MFGE8;EDIL3;ANGPTL3;CSF1R |
| Osteoclast differentiation | RELA;PIK3CD;TGFBR2;SFPI1;NFKB1;NFKB2;PPP3CC;LILRB4;TAB2 |
| PI3K-Akt signaling pathway | CHAD;EFNA2;SGK2;EFNA4;CSH;CSF1R;PRP2;CSH2;LOC608458 |
| Rap1 signaling pathway | CSF1;RGS14;PFN4;LOC608458;EFNA2;EFNA4 |
| Ras signaling pathway | BCL2L1;MAPK3;NRAS;RGL1;RASA3;HRAS;FGF16;MAPK9;GRB2 |
CSF1 has several biochemical functions, for example, cytokine activity, growth factor activity, macrophage colony-stimulating factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CSF1 itself. We selected most functions CSF1 had, and list some proteins which have the same functions with CSF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | GDF7;Il23a; Il12b;IFNG;BMP10;IL3;IL23;HMGB1B;IL26;Ifnz |
| growth factor activity | NRG1;CNTF;NOV;PRL2C3;MANF;FGF8B;CECR1;IL7;IL8L2 |
| macrophage colony-stimulating factor receptor binding | IL34;CSF1;STAP1 |
| protein binding | UHRF2;TECPR1;GCET2;HIST1H2AK;SPRYD7;UBE2E1;NATD1;RASAL2;STIP1 |
| protein homodimerization activity | TKT;CDA;PLDN;HPRT1;MTMR2;HMOX1;LGALS1;PDCD6IP;SMAD2 |
CSF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CSF1.
SGTA; FHL3; NOTCH2NL; adhC; MYC
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