Recombinant Human CTSD Protein, His-tagged
|Product Overview :||Recombinant human CTSD protein with His tag was expressed in HEK293.|
- Gene Information
- Related Products
|Description :||This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.|
|Molecular Mass :||43.6 kDa|
|Protein Length :||412|
|AA Sequence :||MQPSSLLPLALCLLAAPASALVRIP LHKFTSIRRTMSEVGGSVEDLIAKG PVSKYSQAVPAVTEGPIPEVLKNYM DAQYYGEIGIGTPPQCFTVVFDTGS SNLWVPSIHCKLLDIACWIHHKYNS DKSSTYVKNGTSFDIHYGSGSLSGY LSQDTVSVPCQSASSASALGGVKVE RQVFGEATKQPGITFIAAKFDGILG MAYPRISVNNVLPVFDNLMQQKLVD QNIFSFYLSRDPDAQPGGELMLGGT DSKYYKGSLSYLNVTRKAYWQVHLD QVEVASGLTLCKEGCEAIVDTGTSL MVGPVDEVRELQKAIGAVPLIQGEY MIPCEKVSTLPAITLKLGGKGYKLS PEDYTLKVSQAGKTLCLSGFMGMDI PPPSGPLWILGDVFIGRYYTVFDRD NNRVGFAEAARL|
|Purity :||> 98%|
|Applications :||WB; ELISA; FACS; FC|
|Stability :||This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.|
|Storage :||At -20 centigrade.|
|Concentration :||1 mg/mL|
|Storage Buffer :||PBS (pH 7.4-7.5). Sterile-filtered colorless solution.|
|Reconstitution :||Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.|
|Gene Name :||CTSD cathepsin D [ Homo sapiens (human) ]|
|Official Symbol :||CTSD|
|Synonyms :||CTSD; cathepsin D; cathepsin D (lysosomal aspartyl protease) , CPSD; ceroid lipofuscinosis; neuronal 10; CLN10; lysosomal aspartyl protease; lysosomal aspartyl peptidase; ceroid-lipofuscinosis, neuronal 10; CPSD; MGC2311;|
|Gene ID :||1509|
|mRNA Refseq :||NM_001909|
|Protein Refseq :||NP_001900|
|UniProt ID :||P07339|
|◆ Recombinant Protein|
|CTSD-2752H||Recombinant Human CTSD Protein, His (Fc)-Avi-tagged||+Inquiry|
|CTSD-913R||Recombinant Rhesus Macaque CTSD Protein, His (Fc)-Avi-tagged||+Inquiry|
|Ctsd-2369M||Recombinant Mouse Ctsd Protein, His-tagged||+Inquiry|
|CTSD-877H||Recombinant Human CTSD Protein, His-tagged||+Inquiry|
|CTSD-2103H||Recombinant Human CTSD Protein, GST-tagged||+Inquiry|
|◆ Native Protein|
|CTSD-5325D||Active Native Human CTSD protein||+Inquiry|
|CTSD-26411TH||Active Native Human Cathepsin D protein||+Inquiry|
|CTSD-1648H||Active Native Human Cathepsin D||+Inquiry|
|CTSD-1735HCL||Recombinant Human CTSD cell lysate||+Inquiry|
|CTSD-3023MCL||Recombinant Mouse CTSD cell lysate||+Inquiry|
|◆ Assay kits|
|Kit-0264||Cathepsin D Inhibitor Screening Kit||+Inquiry|
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
There is an association between CTSD proteins and cognitive function. In some neurodegenerative diseases, abnormal accumulation and deposition of CTSD proteins may affect neuronal signaling and synaptic function, leading to a decline in cognitive function.
In some neurodegenerative diseases, levels of the CTSD protein may change. For example, people with Alzheimer's disease may have elevated levels of the CTSD protein. These changes may help in the diagnosis of the disease and in the assessment of the course of the disease.
For people with cognitive decline, their CTSD protein levels can be assessed by a blood or cerebrospinal fluid sample. This evaluation can help doctors understand whether the cause of cognitive decline is related to a neurodegenerative disease.
It is currently no treatment that directly targets the CTSD protein. However, some medications can reduce symptoms of neurodegenerative diseases, such as cholinesterase inhibitors such as donepezil, which can increase acetylcholine levels in synapses, which can improve cognitive function.
People with Parkinson's disease may have reduced levels of the CTSD protein. This decrease may be associated with neuronal death and impaired synaptic function. In addition, CTSD protein may also be associated with motor symptoms in patients with Parkinson's disease.
CTSD proteins play a role in Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. It may change in these diseases, leading to structural alterations and impaired signaling of neuronal synapses.
Customer Reviews (3)Write a review
Good at western-blot experiments. -
In experiments, the biocompatibility performed well. -
The experimental conditions are broad, and the experimental results are accurate and repeatable. -
Ask a Question for All CTSD Products
Required fields are marked with *
My Review for All CTSD Products
Required fields are marked with *