Recombinant Human CTSD protein, GST-tagged

Cat.No. : CTSD-2758H
Product Overview : Recombinant Human CTSD protein(P07339)(67-403aa), fused to N-terminal GST tag, was expressed in E. coli.
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Source : E. coli
Species : Human
Tag : GST
Form : If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Molecular Mass : 63.8 kDa
Protein length : 67-403aa
AA Sequence : IPEVLKNYMDAQYYGEIGIGTPPQC FTVVFDTGSSNLWVPSIHCKLLDIA CWIHHKYNSDKSSTYVKNGTSFDIH YGSGSLSGYLSQDTVSVPCQSASSA SALGGVKVERQVFGEATKQPGITFI AAKFDGILGMAYPRISVNNVLPVFD NLMQQKLVDQNIFSFYLSRDPDAQP GGELMLGGTDSKYYKGSLSYLNVTR KAYWQVHLDQVEVASGLTLCKEGCE AIVDTGTSLMVGPVDEVRELQKAIG AVPLIQGEYMIPCEKVSTLPAITLK LGGKGYKLSPEDYTLKVSQAGKTLC LSGFMGMDIPPPSGPLWILGDVFIG RYYTVFDRDNNR
Purity : Greater than 90% as determined by SDS-PAGE.
Storage : Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Reconstitution : Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%.
Gene Name : CTSD cathepsin D [ Homo sapiens ]
Official Symbol : CTSD
Synonyms : CTSD; cathepsin D; cathepsin D (lysosomal aspartyl protease) , CPSD; ceroid lipofuscinosis; neuronal 10; CLN10; lysosomal aspartyl protease; lysosomal aspartyl peptidase; ceroid-lipofuscinosis, neuronal 10; CPSD; MGC2311;
Gene ID : 1509
mRNA Refseq : NM_001909
Protein Refseq : NP_001900
MIM : 116840
UniProt ID : P07339

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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What is the relationship between CTSD proteins and cognitive function? 05/02/2022

There is an association between CTSD proteins and cognitive function. In some neurodegenerative diseases, abnormal accumulation and deposition of CTSD proteins may affect neuronal signaling and synaptic function, leading to a decline in cognitive function.

What is the relationship between changes in CTSD protein levels and disease? 12/13/2021

In some neurodegenerative diseases, levels of the CTSD protein may change. For example, people with Alzheimer's disease may have elevated levels of the CTSD protein. These changes may help in the diagnosis of the disease and in the assessment of the course of the disease.

For people with cognitive decline, how do you assess their CTSD protein levels? 01/19/2021

For people with cognitive decline, their CTSD protein levels can be assessed by a blood or cerebrospinal fluid sample. This evaluation can help doctors understand whether the cause of cognitive decline is related to a neurodegenerative disease.

How can treatment be used to alter the level or function of the CTSD protein? 11/14/2020

It is currently no treatment that directly targets the CTSD protein. However, some medications can reduce symptoms of neurodegenerative diseases, such as cholinesterase inhibitors such as donepezil, which can increase acetylcholine levels in synapses, which can improve cognitive function.

Is CTSD protein involved in Parkinson's disease? 02/08/2020

People with Parkinson's disease may have reduced levels of the CTSD protein. This decrease may be associated with neuronal death and impaired synaptic function. In addition, CTSD protein may also be associated with motor symptoms in patients with Parkinson's disease.

In which diseases does the CTSD protein play a role? 12/11/2019

CTSD proteins play a role in Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. It may change in these diseases, leading to structural alterations and impaired signaling of neuronal synapses.

Customer Reviews (3)

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Reviews
07/12/2021

    Good at western-blot experiments.

    03/28/2021

      In experiments, the biocompatibility performed well.

      03/02/2021

        The experimental conditions are broad, and the experimental results are accurate and repeatable.

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