Recombinant Rat Fgf23 protein, His-tagged

Cat.No. : Fgf23-903R
Product Overview : Recombinant Rat Fgf23(aa 25-251) fused with His tag was expressed in Yeast.
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Description : FGF23 is a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR).
Source : Yeast
Species : Rat
Tag : His
Form : 20 mM Tris, pH 8.0, 500 mM NaCl, 50% glycerol
Molecular Mass : 27.5 Kd
AA Sequence : YSDTSPLLGS NWGSLTHLYT ATARNSYHLQ IHRDGHVDGTPHQTIYSALM ITSEDAGSVV IIGAMTRRFL CMDLRGNIFGSYHFSPENCR FRQWTLENGY DVYLSPKHHY LVSLGRSKRIFQPGTNPPPF SQFLARRNEV PLLHFYTARP RRHTRSAEDPPERDPLNVLK PRPRATPIPV SCSRELPSAE EGGPAASDPLGVLRRGRGDA RRGAGGTDRC RPFPRFV
Storage : Long term: -80 centigrade; Short term: -20 centigrade. Avoid freeze-thaw cycles.
Gene Name : Fgf23 fibroblast growth factor 23 [ Rattus norvegicus ]
Official Symbol : Fgf23
Synonyms : FGF23; fibroblast growth factor 23; FGF-23;
Gene ID : 170583
mRNA Refseq : NM_130754
Protein Refseq : NP_570110
UniProt ID : Q8VI82
Chromosome Location : 4q42
Pathway : Downstream signaling of activated FGFR, organism-specific biosystem; FGFR ligand binding and activation, organism-specific biosystem; FGFR1 ligand binding and activation, organism-specific biosystem; FGFR1c and Klotho ligand binding and activation, organism-specific biosystem; FGFR1c ligand binding and activation, organism-specific biosystem; FGFR2 ligand binding and activation, organism-specific biosystem; FGFR2c ligand binding and activation, organism-specific biosystem;
Function : fibroblast growth factor receptor binding; fibroblast growth factor receptor binding; growth factor activity; type 1 fibroblast growth factor receptor binding; type 1 fibroblast growth factor receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What role does FGF23 play in chronic kidney disease? 06/12/2022

FGF23 levels are elevated in chronic kidney disease, contributing to mineral imbalance.

How is FGF23 implicated in cardiovascular health? 04/04/2022

High FGF23 levels are associated with increased cardiovascular risk.

How does FGF23 regulate phosphate and calcium homeostasis? 03/24/2022

It decreases renal phosphate reabsorption and 1,25-dihydroxyvitamin D production.

Are there known genetic mutations that affect FGF23 production or activity? 01/27/2022

Mutations in FGF23 or related proteins can lead to dysregulated phosphate metabolism.

What therapeutic strategies are being explored to modulate FGF23 levels? 05/16/2020

Strategies include phosphate binders and FGF23 antibodies to manage elevated FGF23 levels.

In which tissues is FGF23 predominantly produced and secreted? 04/28/2020

FGF23 is primarily produced in bone.

What is the primary function of FGF23 in the body? 10/29/2019

FGF23 regulates phosphate and vitamin D metabolism.

Customer Reviews (3)

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07/23/2022

    Excellent results, high purity. -

    07/17/2021

      Reliable and effective product. -

      11/26/2020

        Quick delivery, product works. -

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