Recombinant Mouse Fgf23 Protein, Myc/DDK-tagged

• Cat.No.: Fgf23-2998M
• Product Overview: Purified recombinant protein of mouse full-length fibroblast growth factor 23 (Fgf23), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: This gene encodes a member of the fibroblast growth factor family. The encoded protein regulates phosphate homeostasis and vitamin D metabolism. Mutation of the related gene in humans causes autosomal dominant hypophosphatemic rickets (ADHR). The secreted protein is further cleaved into N- and C-terminal chains, which results in loss of function.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 27.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Fgf23 fibroblast growth factor 23 [ Mus musculus (house mouse) ]
• Official Symbol: Fgf23
• Synonyms: FGF23; fibroblast growth factor 23; FGF-23
• Gene ID: 64654
• mRNA Refseq: NM_022657
• Protein Refseq: NP_073148
• UniProt ID: Q9EPC2

Reviews

07/23/2022

Excellent results, high purity.

07/17/2021

Reliable and effective product.

11/26/2020

Quick delivery, product works.

Q&As

What role does FGF23 play in chronic kidney disease?

FGF23 levels are elevated in chronic kidney disease, contributing to mineral imbalance.

How is FGF23 implicated in cardiovascular health?

High FGF23 levels are associated with increased cardiovascular risk.

How does FGF23 regulate phosphate and calcium homeostasis?

It decreases renal phosphate reabsorption and 1,25-dihydroxyvitamin D production.

Are there known genetic mutations that affect FGF23 production or activity?

Mutations in FGF23 or related proteins can lead to dysregulated phosphate metabolism.

What therapeutic strategies are being explored to modulate FGF23 levels?

Strategies include phosphate binders and FGF23 antibodies to manage elevated FGF23 levels.

In which tissues is FGF23 predominantly produced and secreted?

FGF23 is primarily produced in bone.

What is the primary function of FGF23 in the body?

FGF23 regulates phosphate and vitamin D metabolism.