Recombinant Human IL13, His-Biotin-tagged
Cat.No. : | IL13-16H |
Product Overview : | A DNA sequence encoding the mature form of human IL-13 (Leu25 - Asn146) with 6 His tag on the N-Terminus was expressed in E. Coli. This protein was purified by Ni-NTA column. That protein was conjugated with water soluble biotin. |
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Description : | This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. |
Source : | E. Coli |
Species : | Human |
Tag : | His&Biotin |
Form : | Lyophilized 50 ug of human IL-13 Biotinylated in 50 ul of PBS Carry free. |
Molecular Mass : | 14 KD |
AA Sequence : | Human IL-13 (Leu25 - Asn146) Biotinylated |
Purity : | >95%, by SDS-PAGE |
Applications : | ELISA |
Storage : | Store lyophilized protein at -20 °C or -70 °C. Protect it from light. Lyophilized protein is stable for up to 6 months from date of receipt at - 20 °C to -70 °C. Upon reconstitution, this protein can be stored at -20 °C for a few weeks or at -70 °C in a manual defrost freezer for long term storage (six months). Aliquot reconstituted protein to avoid repeated freezing / thawing cycles. |
Reconstitution : | Add 100 ul deionized water to the vial to prepare a working stock solution at 500 ug/mL. Allow to set at least 30 minutes at 4 °C, mix well. |
Protein length : | Leu25-Asn146 |
Gene Name : | IL13 interleukin 13 [ Homo sapiens (human) ] |
Official Symbol : | IL13 |
Synonyms : | IL13; P600; IL-13; interleukin 13; interleukin-13 |
Gene ID : | 3596 |
mRNA Refseq : | NM_002188 |
Protein Refseq : | NP_002179 |
MIM : | 147683 |
UniProt ID : | P35225 |
Chromosome Location : | 5q31 |
Pathway : | Cytokine-cytokine receptor interaction; Cytokines and Inflammatory Response; Fc epsilon RI signaling pathway |
Function : | cytokine activity; interleukin-13 receptor binding; protein binding |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewEffective in Th2 cell differentiation.
Good for cytokine assays.
High yield in expression.
Q&As (10)
Ask a questionFlow cytometry quantifies IL13 receptor expression on cells.
Transgenic models illuminate IL13's in vivo functions.
ELISA quantifies IL13 secretion in cell cultures accurately.
siRNA knockdown uncovers IL13's specific cellular effects.
Co-immunoprecipitation identifies IL13 signaling partners.
Differential techniques distinguish IL13 and IL4 signaling pathways.
Reporter gene assays gauge IL13-driven transcription.
Microarray analysis profiles IL13-induced gene expression.
Experimental methods reveal IL13's impact on tissue remodeling.
Site-directed mutagenesis identifies key residues in IL13 receptor binding.
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