Recombinant Canine IL-13
| Cat.No. : | IL13-62C |
| Product Overview : | Canine IL-13 was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified. |
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| Description : | Interleukin 13 (IL-13) is secreted by many cell types, but especially T helper type 2 (Th2) cells. IL-13 is an important mediator of allergic inflammation and disease. In addition to effects on immune cells, IL-13 is implicated as a central mediator of the physiologic changes induced by allergic inflammation in many tissues. The functions of IL-13 overlap considerably with those of IL-4, especially with regard to changes induced on hematopoietic cells, but these effects are probably less important given the more potent role of IL-4. Thus, although IL-13 can induce immunoglobulin E (IgE) secretion from activated human B cells, deletion of IL-13 from mice does not markedly affect either Th2 cell development or antigen-specific IgE responses induced by potent allergens. In comparison, deletion of IL-4 abrogates these responses. Thus, rather than a lymphoid cytokine, IL-13 acts more prominently as a molecular bridge linking allergic inflammatory cells to the non-immune cells in contact with them, thereby altering physiological function. |
| Source : | Yeast |
| Species : | Canine |
| Form : | Lyophilized |
| Molecular Mass : | 12.3 kDa |
| AA Sequence : | SPSPVTPSPT LKELIEELVN ITQNQASLCN GSMVWSVNLT AGMYCAALES LINVSDCSAI QRTQRMLKAL CSQKPAAGIS SERSRDTKIE VIQLVKNLLT YVRGVYRHGN FR (112) |
| Applications : | The Canine IL-13 protein can be used in cell culture, as an IL-13 ELISA Standard, and as a Western Blot Control. |
| Storage : | -20 C |
Products Types
| ◆ Recombinant Protein | ||
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| ◆ Lysates | ||
| IL13-1336MCL | Recombinant Mouse IL13 cell lysate | +Inquiry |
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| IL13-1894CCL | Recombinant Cynomolgus IL13 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionFlow cytometry quantifies IL13 receptor expression on cells.
Transgenic models illuminate IL13's in vivo functions.
ELISA quantifies IL13 secretion in cell cultures accurately.
siRNA knockdown uncovers IL13's specific cellular effects.
Co-immunoprecipitation identifies IL13 signaling partners.
Differential techniques distinguish IL13 and IL4 signaling pathways.
Reporter gene assays gauge IL13-driven transcription.
Microarray analysis profiles IL13-induced gene expression.
Experimental methods reveal IL13's impact on tissue remodeling.
Site-directed mutagenesis identifies key residues in IL13 receptor binding.
Customer Reviews (3)
Write a reviewEffective in Th2 cell differentiation. -
Good for cytokine assays. -
High yield in expression. -
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