| Description : |
IL-21, also known as Interleukin-21, is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumor responses. It has broad immunoregulatory activity and can modulate both humoral and cell-mediated responses. It is important in the regulation of haematopoiesis and immune responses, and can influence lymphocyte development. It is produced by activated T cell, and it influences proliferation of T and B cells and cytolytic activity of natural killer cells. It may be a critical factor in the control of persistent viral infections. It has a potential predicating significance for survival Time in patients in the development of sporadic CRC. It binds to the IL-21R and can activate janus kinase JAK1, JAK3, STAT1, and STAT3 in EDgamma-16 cells. Recombinant human was expressed in E.coli and purified by using conventional chromatography techniques. |
| Source : |
E.coli |
| Species : |
Human |
| Form : |
Liquid. Phosphate buffer saline (pH 7.4). |
| Bio-activity : |
The activity is determined by IFN-g ELISA in a using NK-92 cell. The ED50 for this is less or equal to 4 ng/ml. |
| Molecular Mass : |
15.5 kDa |
| Protein length : |
30-162 aa |
| AA Sequence : |
MQGQDRHMIR MRQLIDIVDQ LKNYVNDLVP EFLPAPEDVE TNCEWSAFSC FQKAQLKSAN TGNNERIINV SIKKLKRKPP STNAGRRQKH RLTCPSCDSY EKKPPKEFLE RFKSLLQKMI HQHLSSRTHG SEDS |
| Endotoxin : |
< 1.0 EU per 1 ug of protein (determined by LAL method) |
| Purity : |
> 95 % by SDS - PAGE |
| Notes : |
For research use only. This product is not intended or approved for human, diagnostics or veterinary use. |
| Storage : |
Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 or -70 centigrade. Avoid repeated freezing and thawing cycles. |
| Concentration : |
0.25 mg/ml (determined by Epoch assay) |
