Recombinant Human IL22, Fc-tagged

Cat.No. : IL22-342H
Product Overview : The extracellular domain of human IL-22 (aa 34-179) is fused to the N-terminus of the Fc region of human IgG1.
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Description : Interleukin-22 (IL-22), also known as IL-10 related T cell derived inducible factor (ILTIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. IL-22 has been shown to activate STAT1 and STAT3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal T cells upon anti-CD3 stimulation in humans. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R(CRF29) and IL-10Rbeta(CRF24), belonging to the class II cytokine receptor family.
Source : CHO Cells
Species : Human
Tag : Fc
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Purity : ≥98% (SDS-PAGE)
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Storage : Short Term Storage: +4°C; Long Term Storage: -20°C. Avoid freeze/thaw cycles.
Gene Name : IL22 interleukin 22 [ Homo sapiens ]
Official Symbol : IL22
Synonyms : IL22; interleukin 22; interleukin-22; IL 10 related T cell derived inducible factor; IL 21; IL 22; IL D110; IL TIF; ILTIF; MGC79382; MGC79384; TIFa; TIFIL 23; zcyto18; cytokine Zcyto18; IL-10-related T-cell-derived inducible factor; IL-10-related T-cell-derived-inducible factor; IL-21; IL-22; IL-TIF; IL-D110; TIFIL-23;
Gene ID : 50616
mRNA Refseq : NM_020525
Protein Refseq : NP_065386
MIM : 605330
UniProt ID : Q9GZX6
Chromosome Location : 12q15
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem;
Function : cytokine activity; interleukin-22 receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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04/07/2021

    High specificity.

    03/29/2021

      Good for Th17 differentiation.

      07/07/2016

        Effective in gut repair assays.

        Q&As (10)

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        What is IL22's role in gut epithelial repair? 02/05/2022

        IL22 enhances gut epithelial repair mechanisms.

        What are the downstream targets of IL22 signaling? 12/27/2021

        IL22 activates STAT3 to modulate downstream targets.

        How does IL22 interact with other cytokines in inflammation? 10/06/2021

        IL22 interacts synergistically with IL-17 during inflammation.

        Is IL22 involved in the pathogenesis of autoimmune diseases? 06/25/2021

        IL22 is involved in the pathogenesis of autoimmune diseases like Crohn's.

        Does IL22 have a role in metabolic syndrome? 02/23/2021

        IL22 is implicated in metabolic syndrome by affecting insulin sensitivity.

        How is IL22 expression regulated in psoriasis? 09/05/2018

        IL22 expression is upregulated in psoriasis.

        Does IL22 expression change during viral infections? 07/26/2018

        IL22 expression is upregulated during viral infections like Hepatitis C.

        Does IL22 contribute to anti-tumor immunity? 03/14/2018

        IL22 contributes to anti-tumor immunity by activating NK cells.

        How does IL22 modulate T-cell differentiation? 10/30/2017

        IL22 promotes Th22 cell differentiation.

        What impact do IL22 polymorphisms have on its function? 09/25/2017

        IL22 polymorphisms affect its binding affinity and signaling.

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