Recombinant Human IL22 Protein

Cat.No. : IL22-512H
Product Overview : Recombinant human IL22 protein
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Description : This gene is a member of the IL10 family of cytokines that mediate cellular inflammatory responses. The encoded protein functions in antimicrobial defense at mucosal surfaces and in tissue repair. This protein also has pro-inflammatory properties and plays a role in in the pathogenesis of several intestinal diseases. The encoded protein is a crucial cytokine that regulates host immunity in infectious diseases, including COVID-19 (disease caused by SARS-CoV-2).
Species : Human
Form : Lyophilized
Protein Length : 179
AA Sequence : MAALQKSVSSFLMGTLATSCLLLLA LLVQGGAAAPISSHCRLDKSNFQQP YITNRTFMLAKEASLADNNTDVRLI GEKLFHGVSMSERCYLMKQVLNFTL EEVLFPQSDRFQPYMQEVVPFLARL SNRLSTCHIEGDDLHIQRNVQKLKD TVKKLGESGEIKAIGELDLLFMSLR NACI
Purity : > 98%
Applications : WB; ELISA; FACS; FC
Stability : This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
Storage : At -20 centigrade.
Storage Buffer : PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
Reconstitution : Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
Gene Name : IL22 interleukin 22 [ Homo sapiens (human) ]
Official Symbol : IL22
Synonyms : IL22; interleukin 22; interleukin-22; IL 10 related T cell derived inducible factor; IL 21; IL 22; IL D110; IL TIF; ILTIF; MGC79382; MGC79384; TIFa; TIFIL 23; zcyto18; cytokine Zcyto18; IL-10-related T-cell-derived inducible factor; IL-10-related T-cell-derived-inducible factor; IL-21; IL-22; IL-TIF; IL-D110; TIFIL-23;
Gene ID : 50616
mRNA Refseq : NM_020525
Protein Refseq : NP_065386
MIM : 605330
UniProt ID : Q9GZX6

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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Reviews
04/07/2021

    High specificity.

    03/29/2021

      Good for Th17 differentiation.

      07/07/2016

        Effective in gut repair assays.

        Q&As (10)

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        What is IL22's role in gut epithelial repair? 02/05/2022

        IL22 enhances gut epithelial repair mechanisms.

        What are the downstream targets of IL22 signaling? 12/27/2021

        IL22 activates STAT3 to modulate downstream targets.

        How does IL22 interact with other cytokines in inflammation? 10/06/2021

        IL22 interacts synergistically with IL-17 during inflammation.

        Is IL22 involved in the pathogenesis of autoimmune diseases? 06/25/2021

        IL22 is involved in the pathogenesis of autoimmune diseases like Crohn's.

        Does IL22 have a role in metabolic syndrome? 02/23/2021

        IL22 is implicated in metabolic syndrome by affecting insulin sensitivity.

        How is IL22 expression regulated in psoriasis? 09/05/2018

        IL22 expression is upregulated in psoriasis.

        Does IL22 expression change during viral infections? 07/26/2018

        IL22 expression is upregulated during viral infections like Hepatitis C.

        Does IL22 contribute to anti-tumor immunity? 03/14/2018

        IL22 contributes to anti-tumor immunity by activating NK cells.

        How does IL22 modulate T-cell differentiation? 10/30/2017

        IL22 promotes Th22 cell differentiation.

        What impact do IL22 polymorphisms have on its function? 09/25/2017

        IL22 polymorphisms affect its binding affinity and signaling.

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