Recombinant Human IL22 Protein, hIgG2 Fc-tagged

• Cat.No.: IL22-83H
• Product Overview: Recombinant Human Interleukin-22 is produced by our Mammalian expression system and the target gene encoding Ala34-Ile179 is expressed with a hIgG2 Fc tag at the C-terminus.

Specification

• Description: Interleukin-22(IL-22) is a member of a group of the IL-10 family, a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells. IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction. It can initiate and regulate innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. Biological activity of IL-22 is initiated by binding to a cell-surface complex consisting of IL-22R1 and IL-10R2 receptor chains. IL-22 biological activity is further regulated by interactions with a soluble binding protein, IL-22BP. IL-22BP and an extracellular region of IL-22R1 share sequence similarity. In some cases, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by cytokine IL-17A.
• Source: Human Cells
• Species: Human
• Tag: hIgG2 Fc
• Form: Lyophilized from a 0.2 um filtered solution of PBS, pH7.4.
• Protein Length: Ala34-Ile179
• AA Sequence: APISSHCRLDKSNFQQPYITNRTFM LAKEASLADNNTDVRLIGEKLFHGV SMSERCYLMKQVLNFTLEE VLFPQSDRFQPYMQEVVPFLARLSN RLSTCHIEGDDLHIQRNVQKLKDTV KKLGESGEIKAIGELDLLFM SLRNACIGGGGSGGGGSGGGGSERK CCVECPPCPAPPVAGPSVFLFPPKP KDTLMISRTPEVTCVVV DVSHEDPEVQFNWYVDGMEVHNAKT KPREEQFNSTFRVVSVLTVVHQDWL NGKEYKCKVSNKGLPA PIEKTISKTKGQPREPQVYTLPPSR EEMTKNQVSLTCLVKGFYPSDIAVE WESNGQPENNYKTTPPMLD SDGSFFLYSKLTVDKSRWQQGNVFS CSVMHEALHNHYTQKSLSLSPGK
• Endotoxin: Less than 0.1 ng/ug (1 EU/ug).
• Purity: >95%
• Storage: Lyophilized protein should be stored at < -20 centigrade, though stable at room temperature for 3 weeks.
  Reconstituted protein solution can be stored at 4-7 centigrade for 2-7 days.
  Aliquots of reconstituted samples are stable at < -20 centigrade for 3 months.
• Quality Statement: Purity: Greater than 95% as determined by reducing SDS-PAGE.
• Shipping: The product is shipped at ambient temperature.
  Upon receipt, store it immediately at the temperature listed below.

Gene Information

• Gene Name: IL22 interleukin 22 [ Homo sapiens (human) ]
• Official Symbol: IL22
• Synonyms: Interleukin-22; IL-22; Cytokine Zcyto18; IL-10-related T-cell-derived-inducible factor; IL-TIF; TIFa; IL-21; IL-22; ILTIF; IL-D110; zcyto18; TIFIL-23
• Gene ID: 50616
• mRNA Refseq: NM_020525.5
• Protein Refseq: NP_065386.1
• MIM: 605330
• UniProt ID: Q9GZX6