Recombinant Human IL2RG Protein, Fc-tagged

• Cat.No.: IL2RG-323H
• Product Overview: Recombinant human IL2RG protein with Fc tag was expressed in HEK293.

Specification

• Description: The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder.
• Source: HEK293
• Species: Human
• Tag: Fc
• Form: Lyophilized
• Molecular Mass: 53.5 kDa
• Protein Length: 369
• AA Sequence: MLKPSLPFTSLLFLQLPLLGVGLNT TILTPNGNEDTTADFFLTTMPTDSL SVSTLPLPEVQCFVFNVEYMNCTWN SSSEPQPTNLTLHYWYKNSDNDKVQ KCSHYLFSEEITSGCQLQKKEIHLY QTFVVQLQDPREPRRQATQMLKLQN LVIPWAPENLTLHKLSESQLELNWN NRFLNHCLEHLVQYRTDWDHSWTEQ SVDYRHKFSLPSVDGQKRYTFRVRS RFNPLCGSAQHWSEWSHPIHWGSNT SKENPFLFALEAVVISVGSMGLIIS LLCVYFWLERTMPRIPTLKNLEDLV TEYHGNFSAWSGVSKGLAESLQPDY SERLCLVSEIPPKGGALGEGPGASP CNQHSPYWAPPCYTLKPET
• Purity: > 98%
• Applications: WB; ELISA; FACS; FC
• Stability: This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
• Storage: At -20 centigrade.
• Concentration: 1 mg/mL
• Storage Buffer: PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
• Reconstitution: Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.

Gene Information

• Gene Name: IL2RG interleukin 2 receptor, gamma [ Homo sapiens (human) ]
• Official Symbol: IL2RG
• Synonyms: IL2RG; interleukin 2 receptor, gamma; CIDX, combined immunodeficiency, X linked , IMD4, SCIDX1, severe combined immunodeficiency; cytokine receptor common subunit gamma; CD132; gammaC; gamma(c); CD132 antigen; common gamma-chain; IL-2R subunit gamma; IL-2 receptor subunit gamma; severe combined immunodeficiency; combined immunodeficiency, X-linked; common cytokine receptor gamma chain; interleukin-2 receptor subunit gamma; P64; CIDX; IMD4; SCIDX; IL-2RG; SCIDX1
• Gene ID: 3561
• mRNA Refseq: NM_000206
• Protein Refseq: NP_000197
• MIM: 308380
• UniProt ID: P31785

Reviews

10/13/2022

Solubility is very good and can be easily dissolved in various buffers.

05/13/2022

Quality I use is very good and I have recommended this product to my colleagues and friends.

05/16/2021

The anti-pollution ability is very strong, not easy to be polluted.

Q&As

Are there any side effects of using this protein?

The use of IL2RG may cause chest tightness, skin itching, allergies and other side effects, you need to contact the doctor for timely treatment.

What is the dosage and use method of IL2RG?

The dosage and use method of IL2RG need to be determined according to the condition and individual situation, and need to be prescribed by a clinician.

Does IL2RG have a role and what is the mechanism?

Enhances the immunity of the human immune system by increasing the number and improving the function of immune cells in the body.

Which diseases is IL2RG used to treat?

IL2RG is mainly used in the treatment of immune deficiency diseases, such as systemic eosinophilic granulomatosis, X-linked immunodeficiency disease, etc.

What measures can be taken to mitigate the possible risks of IL2RG?

In view of possible risks, the use of IL2RG should be strictly in accordance with the doctor's advice, and avoid changing the dosage and frequency of medication.

What are the pharmacological characteristics of IL2RG?

IL2RG pharmacological features are contained in vivo to enhance the immunity of the human immune system by increasing the number of immune cells and improving their function.