Active Recombinant Human IL4R Protein

• Cat.No.: IL4R-01H
• Product Overview: CHO cell-derived Recombinant Human sIL-4 Receptor α corresponding to 209 amino acid residues of the extracellular domain of IL-4Rα without tag was expressed inn CHO.

Specification

• Description: This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
• Source: CHO
• Species: Human
• Bio-activity: The ED50 was determined by its ability to inhibit the IL-4 dependent proliferation of human TF-1 cells is ≤ 5.0 ng/mL (in the presence of 0.5 ng/mL of IL-4), corresponding to a specific activity of ≥ 2 × 10^5 units/mg.
• Molecular Mass: 23.9 kDa
• AA Sequence: GNMKVLQEPTCVSDYMSISTCEWKM NGPTNCSTELRLLYQLVFLLSEAHT CIPENNGGAGCVCHLLMDDVVSADN YTLDLWAGQQLLWKGSFKPSEHVKP RAPGNLTVHTNVSDTLLLTWSNPYP PDNYLYNHLTYAVNIWSENDPADFR IYNVTYLEPSLRIAASTLKSGISYR ARVRAWAQCYNTTWSEWSPSTKWHN SYREPFEQH
• Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Gene Information

• Gene Name: IL4R interleukin 4 receptor [ Homo sapiens (human) ]
• Official Symbol: IL4R
• Synonyms: IL4R; interleukin 4 receptor; CD124; IL4RA; IL-4RA; interleukin-4 receptor subunit alpha; IL-4 receptor subunit alpha; IL4R nirs variant 1; interleukin 13 receptor; interleukin-4 receptor alpha chain
• Gene ID: 3566
• mRNA Refseq: NM_000418
• Protein Refseq: NP_000409
• MIM: 147781
• UniProt ID: P24394