Recombinant Human Interleukin-1 Receptor-Associated Kinase 4, His-tagged
| Cat.No. : |
IRAK4-5437H |
| Product Overview : |
Recombinant humanfull length IRAK4, His-tagged. No special measures were taken to activatethis kinase. |
- Specification
- Gene Information
- Related Products
| Cat. No. : |
IRAK4-5437H |
| Description : |
IRAK4 is an important mediatorin the signal transduction of Toll-like receptor (TLR) and IL1R familymembers. IRAK4 is involved in the Toll-like receptor signaling pathwayleading to Apoptosis. IRAK4 has molecular functions like protein binding, ATPbinding, kinase activity and magnesium ion binding. Toll/IL-1 receptor familymembers like IRAK4 are central components of host defense mechanisms in avariety of species. One well conserved element in their signal transductionis the Ser/Thr kinase activity which couple early signaling events in areceptor complex at the plasma membrane to larger signalosomes in thecytosol. |
| Source : |
Insect cells |
| Species : |
Human |
| Form : |
Liquid in 50 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.05% Triton X-100 + 2 mM DTT +50% glycerol. |
| MolecularWeight : |
55.6 kDa |
| Storage : |
Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles. |
| OfficialSymbol : |
IRAK4 |
| Gene Name : |
IRAK4 interleukin-1receptor-associated kinase 4 [ Homo sapiens ] |
| Synonyms : |
IRAK4; interleukin-1receptor-associated kinase 4; IPD1; REN64; NY-REN-64; EC 2.7.11.1; IRAK-4;NY-REN-64 antigen |
| Gene ID : |
51135 |
| mRNA Refseq : |
NM_001114182 |
| Protein Refseq : |
NP_001107654 |
| MIM : |
606883 |
| UniProt ID : |
Q9NWZ3 |
| Chromosome Location : |
12q12 |
| Pathway : |
Activated TLR4 signalling; Apoptosis;Cytokine Signaling in Immune system; IL-1 Signaling Pathway; IL1-mediatedsignaling events; Immune System; Innate Immune System; Interleukin-1signaling; Leishmaniasis; Measles; MyD88 cascade initiated on plasmamembrane; Neurotrophin signaling pathway; Signaling by Interleukins; TRAF6mediated IRF7 activation in TLR7/8 or 9 signaling |
| Function : |
ATP binding; interleukin-1receptor binding; magnesium ion binding; nucleotide binding; protein binding;protein serine/threonine kinase activity; transferase activity |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
