Recombinant Human Interleukin-1 Receptor-Associated Kinase 4, His-tagged

• Cat.No.: IRAK4-5437H
• Product Overview: Recombinant humanfull length IRAK4, His-tagged. No special measures were taken to activatethis kinase.

Specification

• Species: Human
• Source: Insect Cells
• Tag: His
• Description: IRAK4 is an important mediatorin the signal transduction of Toll-like receptor (TLR) and IL1R familymembers. IRAK4 is involved in the Toll-like receptor signaling pathwayleading to Apoptosis. IRAK4 has molecular functions like protein binding, ATPbinding, kinase activity and magnesium ion binding. Toll/IL-1 receptor familymembers like IRAK4 are central components of host defense mechanisms in avariety of species. One well conserved element in their signal transductionis the Ser/Thr kinase activity which couple early signaling events in areceptor complex at the plasma membrane to larger signalosomes in thecytosol.
• Form: Liquid in 50 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.05% Triton X-100 + 2 mM DTT +50% glycerol.
• MolecularWeight: 55.6 kDa
• Storage: Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: IRAK4
• Full Length: Full L.

Gene Information

• Gene Name: IRAK4 interleukin-1receptor-associated kinase 4 [ Homo sapiens ]
• Synonyms: IRAK4; interleukin-1receptor-associated kinase 4; IPD1; REN64; NY-REN-64; EC 2.7.11.1; IRAK-4;NY-REN-64 antigen
• Gene ID: 51135
• mRNA Refseq: NM_001114182
• Protein Refseq: NP_001107654
• MIM: 606883
• UniProt ID: Q9NWZ3
• Chromosome Location: 12q12
• Pathway: Activated TLR4 signalling; Apoptosis;Cytokine Signaling in Immune system; IL-1 Signaling Pathway; IL1-mediatedsignaling events; Immune System; Innate Immune System; Interleukin-1signaling; Leishmaniasis; Measles; MyD88 cascade initiated on plasmamembrane; Neurotrophin signaling pathway; Signaling by Interleukins; TRAF6mediated IRF7 activation in TLR7/8 or 9 signaling
• Function: ATP binding; interleukin-1receptor binding; magnesium ion binding; nucleotide binding; protein binding;protein serine/threonine kinase activity; transferase activity