Recombinant Human Interleukin-1 Receptor-Associated Kinase 4, His-tagged

• Cat.No.: IRAK4-5437H
• Product Overview: Recombinant humanfull length IRAK4, His-tagged. No special measures were taken to activatethis kinase.

Specification

• Cat. No.: IRAK4-5437H
• Description: IRAK4 is an important mediatorin the signal transduction of Toll-like receptor (TLR) and IL1R familymembers. IRAK4 is involved in the Toll-like receptor signaling pathwayleading to Apoptosis. IRAK4 has molecular functions like protein binding, ATPbinding, kinase activity and magnesium ion binding. Toll/IL-1 receptor familymembers like IRAK4 are central components of host defense mechanisms in avariety of species. One well conserved element in their signal transductionis the Ser/Thr kinase activity which couple early signaling events in areceptor complex at the plasma membrane to larger signalosomes in thecytosol.
• Source: Insect cells
• Species: Human
• Form: Liquid in 50 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.05% Triton X-100 + 2 mM DTT +50% glycerol.
• MolecularWeight: 55.6 kDa
• Storage: Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: IRAK4

Gene Information

• Gene Name: IRAK4 interleukin-1receptor-associated kinase 4 [ Homo sapiens ]
• Synonyms: IRAK4; interleukin-1receptor-associated kinase 4; IPD1; REN64; NY-REN-64; EC 2.7.11.1; IRAK-4;NY-REN-64 antigen
• Gene ID: 51135
• mRNA Refseq: NM_001114182
• Protein Refseq: NP_001107654
• MIM: 606883
• UniProt ID: Q9NWZ3
• Chromosome Location: 12q12
• Pathway: Activated TLR4 signalling; Apoptosis;Cytokine Signaling in Immune system; IL-1 Signaling Pathway; IL1-mediatedsignaling events; Immune System; Innate Immune System; Interleukin-1signaling; Leishmaniasis; Measles; MyD88 cascade initiated on plasmamembrane; Neurotrophin signaling pathway; Signaling by Interleukins; TRAF6mediated IRF7 activation in TLR7/8 or 9 signaling
• Function: ATP binding; interleukin-1receptor binding; magnesium ion binding; nucleotide binding; protein binding;protein serine/threonine kinase activity; transferase activity

Reviews

11/16/2021

Its potency and specificity make it a valuable tool for studying specific biological pathways or mechanisms.

03/01/2020

Their technical expertise and experience in the field allow them to provide invaluable guidance and assistance.

07/16/2018

They can offer insights on experimental design, optimal usage protocols, and troubleshoot any challenges that may arise during the course of the trial.

Q&As

What conditions are associated with IRAK4 dysregulation?

Rheumatoid arthritis, lupus, inflammatory bowel diseases, and certain cancers may involve IRAK4.

Are there any ongoing clinical trials involving IRAK4 inhibitors?

Yes, several trials are investigating IRAK4 inhibitors' effectiveness and safety in various diseases.

What are the methods used to target IRAK4 in treatment?

Small molecule inhibitors and monoclonal antibodies are primary methods for modulating IRAK4 activity.

How does the expression of IRAK4 differ in healthy individuals and those with autoimmune diseases?

Individuals with autoimmune diseases often show increased IRAK4 expression compared to healthy individuals.

How does IRAK4 inhibition impact the immune response?

By blocking IRAK4, the overactive immune response in certain diseases can be suppressed.