Recombinant Human IRAK4 Protein, His tagged

Cat.No. : IRAK4-35H
Product Overview : Recombinant Human IRAK4 Protein with His tag was expressed in E. coli.
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Description : This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.
Source : E. coli
Species : Human
Tag : C-His
Molecular Mass : The protein has a calculated MW of 39 kDa.
AA Sequence : MPFCDKDRTLMTPVQNLEQSYMPPD SSSPENKSLEVSDTRFHSFSFYELK NVTNNFDERPISVGGNKMGEGGFGV VYKGYVNNTTVAVKKLAAMVDITTE ELKQQFDQEIKVMAKCQHENLVELL GFSSDGDDLCLVYVYMPNGSLLDRL SCLDGTPPLSWHMRCKIAQGAANGI NFLHENHHIHRDIKSANILLDEAFT AKISDFGLARASEKFAQTVMTSRIV GTTAYMAPEALRGEITPKSDIYSFG VVLLEIITGLPAVDEHREPQLLLDI KEEIEDEEKTIEDYIDKKMNDADST SVEAMYSVASQCLHEKKNKRPDIKK VQQLLQEMTASLEHHHHHH
Purity : > 90% by SDS-PAGE
Storage : Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Concentration : 0.17 mg/mL
Storage Buffer : Sterile 50 mM Tris, 250 mM NaCl, pH7.8
FACS: 1. Short IRAK4 <br />2. BSA
Gene Name : IRAK4 interleukin-1 receptor-associated kinase 4 [ Homo sapiens ]
Official Symbol : IRAK4
Synonyms : IRAK4; interleukin-1 receptor-associated kinase 4; NY REN 64; renal carcinoma antigen NY-REN-64; IPD1; REN64; IRAK-4; NY-REN-64;
Gene ID : 51135
mRNA Refseq : NM_001114182
Protein Refseq : NP_001107654
MIM : 606883
UniProt ID : Q9NWZ3

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What conditions are associated with IRAK4 dysregulation? 11/04/2020

Rheumatoid arthritis, lupus, inflammatory bowel diseases, and certain cancers may involve IRAK4.

Are there any ongoing clinical trials involving IRAK4 inhibitors? 10/07/2020

Yes, several trials are investigating IRAK4 inhibitors' effectiveness and safety in various diseases.

What are the methods used to target IRAK4 in treatment? 11/25/2017

Small molecule inhibitors and monoclonal antibodies are primary methods for modulating IRAK4 activity.

How does the expression of IRAK4 differ in healthy individuals and those with autoimmune diseases? 11/01/2016

Individuals with autoimmune diseases often show increased IRAK4 expression compared to healthy individuals.

How does IRAK4 inhibition impact the immune response? 01/17/2016

By blocking IRAK4, the overactive immune response in certain diseases can be suppressed.

Customer Reviews (3)

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11/16/2021

    Its potency and specificity make it a valuable tool for studying specific biological pathways or mechanisms.

    03/01/2020

      Their technical expertise and experience in the field allow them to provide invaluable guidance and assistance.

      07/16/2018

        They can offer insights on experimental design, optimal usage protocols, and troubleshoot any challenges that may arise during the course of the trial.

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