Recombinant Human interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35), His-tagged

• Cat.No.: IL12A-132H
• Product Overview: Human RecombinantInterleukin-12 p35 His produced in E. coli is single, a nonglycosylated,polypeptide chain containing 197 amino acids fragment (57-253) with anamino-terminal hexahistidine tag.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: This gene encodes asubunit of a cytokine that acts on T and natural killer cells, and has abroad array of biological activities. The cytokine is a disulfide-linkedheterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kDsubunit that is a member of the cytokine receptor family. This cytokine isrequired for the T-cell-independent induction of interferon (IFN)-gamma, andis important for the differentiation of both Th1 and Th2 cells.
• Form: Interleukin-12 p35His-Tag is supplied in 20 mM Tris HCL pH 8 + 0.5 mM DTT + 50% glycerol.
• Purity: Greater than 95.0%as determined by analysis by RP-HPLC and SDS-PAGE.
• Storage: Store at 2-4°C ifentire vial will be used within 2-4 weeks. Store, frozen at -20°C for longerperiods of time. Please avoid freeze-thaw cycles.
• OfficialSymbol: IL12A
• Pathways: Africantrypanosomiasis; Allograft rejection; Amoebiasis; Chagas disease (Americantrypanosomiasis); Cytokine-cytokine receptor interaction; Herpes simplexinfection; IL12-mediated signaling events; IL27-mediated signaling events;Influenza A; Jak-STAT signaling pathway; Legionellosis; Leishmaniasis;Measles; Pertussis; RIG-I-like receptor signaling pathway

Gene Information

• Gene Name: IL12A interleukin 12A (naturalkiller cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1,p35) [ Homo sapiens ]
• Synonyms: IL12A; Interleukin12A (natural killer cell stimulatory factor 1, cytotoxic lymphocytematuration factor 1, p35); P35; CLMF; NFSK; NKSF1; IL-12A; interleukin-12subunit alpha; CLMF p35; IL35 subunit; IL-12 subunit p35; IL-12, subunit p35;OTTHUMP00000213703; OTTHUMP00000213704; OTTHUMP00000213705; interleukin 12,p35; interleukin-12 alpha chain; NF cell stimulatory factor chain 1; NK cellstimulatory factor chain 1; cytotoxic lymphocyte maturation factor 1, p35;cytotoxic lymphocyte maturation factor 35 kDa subunit; natural killer cellstimulatory factor 1, 35 kD subunit; Interleukin-12 subunit alpha; Cytotoxic lymphocyte maturation factor 35 kDa subunit
• Gene ID: 3592
• mRNA Refseq: NM_000882
• Protein Refseq: NP_000873
• MIM: 161560
• UniProt ID: P29459
• Chromosome Location: 3p12-q13.2
• Function: interleukin-12 betasubunit binding ; Contributes to cytokine activity; contributes togrowth factor activity; interleukin-12 receptor binding; interleukin-27binding; protein heterodimerization activity; protein binding